Christmas can be a little chaotic at the best of times; some of our companions love the attention from all the visitors, but some can get a little overwhelmed. There are many strategies that we can employ for our furry friends to get through this time of year unscathed, but we can also support them nutritionally too! Here are our top nutritional tips for canines this Christmas. Max Out On Magnesium! Magnesium excretion is increased during times of stress. Catecholamines and corticosteroids enhance the shift of magnesium from inside the cell to outside of the cell leading to increased urinary excretion. In turn, low magnesium levels increase the release of stress-associated hormones. This unfortunately creates a cycle of a reduced resistance to stress. Offer your dog plenty of magnesium rich foods like leafy greens, nuts and seeds. Time for Tea! L-Theanine is seen to facilitate the generation of alpha waves which are indicative of a relaxed but awake and alert state. L-Theanine helps regulate the usual stress responses like increased blood pressure, heart rate and cortisol secretion and it’s found in our trusty tea! Green tea packs the highest content, so brew up a cup of decaf and share it with your pooch this Christmas. Dose up on D! Did you know that Vitamin D deficiency is associated with increased anxiety scores? Whilst we know it plays a role in immune function, it also contributes to cognitive function along with mood and behaviour. Add plenty of fresh foods containing Vitamin D to your dog’s bowl, including: liver, fish and eggs! Mushrooms are a great source too, and if you keep them in the windowsill, you’ll get even more Vitamin D too! Always remember to saute mushrooms before feeding. Build Up Your B’s! B vitamins are heavily involved in the synthesis and breakdown of stress hormones. Whenever we or our dogs are stressed, we release a cascade of hormones that help us manage the threat in front of us. When the threat has passed, those hormones need to be broken down so our bodily functions can return to normal. It goes without saying, the more often our bodies have to do this, the higher the demand for B vitamins (and more). B vitamins are water-soluble, meaning they need to be replenished daily, and this is even without any stressors we may be facing. Offer your dog plenty of sources of B vitamins in their bowls like seafood, poultry, red meat, leafy greens and seeds! Our wonderful Calm Complex provides all of the above. br] br] Fill up on Ferments! This may not apply to all dogs; especially if you are tackling an itchy issue, but there is increasing data highlighting that poor microbial diversity in the gut is linked with increased scores of anxiety. A great way to support microbial diversity is to ensure the diet contains both pre and probiotic foods. Prebiotic sources include: mushrooms, dandelion greens, garlic, burdock root and more. Probiotic foods include fermented products like kefir. Aside from certain nutrients, we also know how important chewing is in engaging the parasympathetic nervous system – which is the rest and digest side of the stress response. This is why offering whole foods, which take some chewing, is great for your dog’s physical and emotional health. Why Dogs Need To Chew Other top (non-nutritional) tips for supporting your overwhelmed canine this Christmas: Set up a safe space – this can be a covered crate or simply a quiet spot somewhere in the house. Try to maintain as much of the routine as possible, Head out on walks when it’s quiet – when everyone is driving home for Christmas at the same time, it can get a little unnerving for your anxious pooch. If you would like any support with your pets, then please check out our services. Thanks for reading, MPN Team
Whether you are a seasoned raw feeder or simply want to include raw meaty bones as a way to support dental hygiene for your dog, knowing which bones to feed can be a bit of a minefield. It’s a question we get asked here a lot at My Pet Nutritionist, so we thought we’d put together a handy guide on feeding bones to your dog. We’ll look at the do’s and don’ts and the why’s and wherefores. Why Feed Bones? Depending on the approach you have in feeding your dog, bones will either provide recreational enrichment and dental health support, or a solid 10% of their diet. Bones as Enrichment and Stress Relief Study after study have demonstrated that chewing can counter the effects of stress. Not only does it reduce stress hormone levels, but it also limits sensory processing of external stressors. In short, it keeps your dog’s attention off things it doesn’t need to be paying attention to. At the same time, chewing is known to improve alertness; it shortens reaction time and increases vigilance. This is thought to be due to the increase in heart rate during the chewing task which increases cerebral blood flow and brain activity. So, chewing for the dog can help them rebalance their stress levels and also improve their alertness, which may be of interest if you are preparing training sessions In rest and recovery, chewing opportunities need to be in a quiet space where rest can be encouraged. The increase in heart rate and blood flow, soon dissipates, and with the limited processing of external stressors, the dog is prepared to rest. At the other end of the scale, to promote alertness, offer a chewing opportunity 15-30 minutes before training. This will vary from dog to dog, so it may take some time to find the sweet spot. What is also interesting, is the rate of force needed when chewing, especially when we are encouraging dogs to rest and recover. A strong chewing force induces a greater reduction in stress levels. So, in this situation, larger bones may be more appropriate. Bones for Dental Health Periodontal disease begins when bacteria in the dog’s mouth forms to create a substance called plaque. The plaque sits on the surface of the teeth and with the help of saliva, it hardens to form tartar. Not only does it sit on the teeth, plaque and tartar seeps into gum lines which causes inflammation. Over a period of time, this inflammation and presence of bacteria causes damage to the structures surrounding the teeth; causing receding gum lines and eventually tooth loss. Not only is the mouth and teeth a concern, but the bacteria found in the mouth of your dog can be released into the circulatory system, which then travels through the body. It has been found to damage cardiac tissue causing endocarditis (infection and inflammation in the heart). Oral health is gaining more and more attention in the human realms for its implication in a range of diseases. Much of this we can transfer to our canine companions which means optimising their dental health is of paramount importance. There are a number of chews on the market promoting oral health, but it is actually the mechanism of chewing that helps to reduce build up. Chewing stimulates saliva which produces anti-bacterial agents, helping to keep the mouth clean. Not only this, but the abrasion that occurs during chewing helps scrape deposits off the teeth. So, what type of chew is best? Here’s what the data suggests: Raw bones reduced mouth bacteria by 79%, Daily brushing reduced it by 70% and, Marketed dental chews reduced it by 54-60%. Findings Here As you can see, raw bones lead the way in reducing bacteria and therefore optimising dental health in the dog. Bones as a Source of Nutrition Bone starts as a cartilage model which gets slowly replaced. Osteoblasts are the cells that form new bone and they secrete osteoids. Osteoid tissue is simply unmineralized bone tissue. Soon after the osteoid is laid down, inorganic salts, like calcium and phosphorus are deposited which forms the hardened material that we know as bone. As you can see, calcium and phosphorus make up a large part of the skeleton, and so when these compounds are ingested by another animal, they ingest calcium and phosphorus (amongst others). In other words, when our dogs eat the bones of other animals, they are ingesting what that animal is built of. Whilst calcium is the main structural component of skeleton and teeth, it also plays a role in blood clotting. In addition, it is involved in the intracellular messaging triggering the contraction of muscle fibres. Calcium also plays a role in fat oxidation, and it carries ATP (energy) with magnesium. Calcium’s role in muscle function also includes maintaining the action of the heart muscle. Calcium particles enter the heart muscle cells during each heartbeat and contribute to the electrical signal that coordinates its function, so it’s also vitally important to cardiovascular health. Why Does My Dog Need Calcium Phosphorus in mainly used for the growth and repair of body tissues – it is a component part of bones, teeth, RNA and DNA. In the form of phospholipids, phosphorus is also a component of cell membrane structure and of the body’s key energy source, ATP. Many proteins and sugars in the body are phosphorylated. In addition, phosphorus plays key roles in regulation of gene transcription, activation of enzymes, maintenance of normal pH in extracellular fluid, and intracellular energy storage. As you can see, whilst they are important nutrients for skeletal health and integrity, both calcium and phosphorus also play other roles in the body. But bones are also a source of sodium and magnesium too! Why Does My Dog Need Minerals How To Feed Bones No cooked bones Feed the right size for the breed Avoid weight bearing bones Avoid hollow-marrow bones Weaning/Puppies Chicken necks, wings, feet, thighs Duck feet, necks Rabbit, cut Quail, cut
You’ll have noticed that we talk a lot about vitamins and minerals here at My Pet Nutritionist. There’s a reason. For your pet’s body to do the jobs it needs to, it needs certain compounds, and that includes vitamins and minerals. Vitamin B6 is one of the B complex vitamins, it is water-soluble and necessary for a range of functions. Let’s take a look at it in a little more detail. Vitamin B6 Vitamin B6, also known as pyridoxine, is a water-soluble vitamin that the body needs for several functions. It’s significant to protein, fat and carbohydrate metabolism and the creation of red blood cells and neurotransmitters. Vitamin B6 cannot be made by the body and so it must come from the diet. Vitamin B6 and Behaviour The central nervous system runs on these chemical messengers called neurotransmitters. They are like the carrier pigeons of the body. Vitamin B6 is involved in the synthesis of a range of these neurotransmitters, specifically dopamine, serotonin and GABA. As we know, dopamine is involved in the reward circuitry in the brain, serotonin is known as the feel good neurotransmitter and GABA is like the brakes of the nervous system; it helps calm things down. So, if we are looking for balanced and appropriate responses to those things experienced by our dogs, they need access to sufficient levels of the right neurotransmitter. B6 will therefore play a role. In human studies we have linked vitamin B6 deficiency to depressive symptoms. Findings Here It is also linked to irritability. Findings Here A mild deficiency of B6 down-regulates GABA and serotonin synthesis, leading to the removal of inhibition of neural activity by GABA. Disordered sleep, irrational behaviour, and compromised cardiovascular function can result. In addition, a loss of hypothalamus-pituitary control and therefore aberrant hormone excretion. Vitamin B6 also has a direct effect on immune function and gene transcription/expression and plays a role in brain glucose regulation. Vitamin B6 and Brain Health Vitamin B6 is involved in managing homocysteine levels. In many cases, high homocysteine levels are associated with cognitive impairment and decline. Deficiency in B6 is regularly linked to high levels of homocysteine found in the blood; therefore posing a risk to brain health. Ensuring sufficient levels of B6 can therefore regulate homocysteine levels, and protect cognitive function. Findings Here Vitamin B6 and Eye Health High levels of homocysteine are also associated with age-related macular degeneration and so, B6 can therefore be beneficial in protecting eye health. As we know, B6 helps regulate levels of homocysteine in the body and in studies, when taking a regular dose of B6 supplementation, the risk of age-related macular degeneration decreased by 35-40%. This data was derived from human studies and so we must be careful when extrapolating to pets, but it certainly provides food for thought. In addition, other B complex vitamins were supplemented, so it would be pertinent to establish if the combination was of more benefit than single supplement. Findings Here Vitamin B6 and Arthritis The high levels of inflammation in the body that result from arthritis may lead to low levels of vitamin B6. There have also been studies demonstrating that vitamin B6 can help modulate pro-inflammatory responses in cases of arthritis. Findings Here The bottom line? If your dog is suffering with a chronic inflammatory condition, it would be pertinent to monitor their vitamin B6 status. Vitamin B6 and Anemia Due to its role in haemoglobin production, the most common sign of low B6 is anaemia. Haemoglobin is a protein that delivers oxygen to cells. When there is low haemoglobin, cells don’t get enough oxygen. The result is anemia. Signs and Symptoms of B6 Deficiency: Lethargy Abnormal heart rhythm Cracked lips Mouth ulcers Weakened immune function Inflammation of the skin Confusion/irritability Food Sources: Pork Poultry Fish Organ Meats Eggs As vitamin B6 is a water-soluble vitamin, it needs to be replenished daily in the body. Risk of Depletion: Hormone demands – if your dog is stress, they are at risk of depletion without sufficient supply Undernutrition Malabsorption (digestive compromise) Pyridoxine-inactivating medications (phenobarbital for example). Here at My Pet Nutritionist, we advocate a fresh food diet which is rich in a variety of vitamins and minerals. If your dog is suffering with a chronic condition, it may well affect their nutritional status, please check out our services if you would like to find out more. Thanks for reading, MPN Team
In human realms, we trace the importance of iron back to the Egyptians, Hindus, Greeks and Romans. During the 17th Century, iron was used to treat chlorosis (green disease) which was a condition resulting from iron deficiency. But we didn’t really understand the importance of inorganic iron until around 1932 – this is when we found out about its role in haemoglobin synthesis. As we’re always a little behind in our canine findings, we possibly still to this day don’t respect this trusty mineral as much as we should, so here at My Pet Nutritionist, we thought we’d explore it in a little more detail and it’s importance in pet health. Functions of Iron Oxygen transport Oxygen storage as myoglobin Energy production Cofactor for multiple enzymes Production of neurotransmitters and thyroid hormone We understand the important role of iron when we look at how tightly regulated it is in the body. The body has three unique mechanisms for maintaining iron balance and preventing deficiency and overload: Storage of iron Reutilisation of iron Regulation of iron absorption Iron from food is mainly absorbed in the duodenum (the first part of the small intestine). Iron can be in ferrous state (Fe2+) or ferric state (Fe3+). Fe3+ is not directly absorbed, but Fe2+ is easily absorbed. In the intestine, Fe3+ is converted by ferric reductases into Fe2+ and then when required by the body, iron is transported by transferrin (a blood-plasma glycoprotein) to bone marrow and other tissues. Iron is required for the transport of oxygen, oxygen storage in muscle, and is also a component of energy production. After absorption, any iron that isn’t needed, is stored as ferritin in the liver, spleen or bone marrow. During times of high need, iron is then released. Most of the iron in the body is contained within red blood cells. Red blood cells have been noted to have a life span of around 115 days but when they reach the end of their life span, they release iron. The resultant liberated iron can be reused to produce new erythrocytes in bone marrow, stored as ferritin or released back into systemic circulation. Iron Disorders Iron deficiency anaemia is the common condition associated with decreased iron levels, resulting in low circulating haemoglobin and reduced myoglobin. In dogs, iron deficiency anaemia is usually secondary to some form of chronic blood loss, but it is also seen in puppies fed poor diets or who have severe parasitic infections. Signs of Iron Deficiency Anaemia: Pale gums Low energy Weight loss Laboured breathing Increased heart rate Signs of blood loss Iron deficiency is also associated with lower T and B lymphocyte, macrophage, and neutrophil function and so immune function can be significantly compromised. Your Pet’s Immune System On the other side of the scale, iron toxicity is generally associated with over-the-counter supplementation. At the cellular level, iron can impair metabolism in the heart, liver, and central nervous system. Iron is generally tightly bound to proteins in the body, preventing reaction, but in times of overload it becomes available in free form which disrupts oxidative phosphorylation, catalyses lipid peroxidation, forms free radicals and ultimately leads to cell death. It is this reactivity that ensures levels are tightly regulated in the body. This is largely through absorption regulation. There is no controlled mechanism for the excretion of excess iron, which would suggest that the average body would consistently possess sufficient levels. This sadly, is not the case. Daily losses for the average body are through the gastrointestinal tract via exfoliation of cells, and through the skin and urinary tract. Periods of growth and development have higher needs and pregnancy too increases the demand. Factors Affecting Absorption There are many dietary factors that affect absorption of iron and subsequently influence iron regulation in the body. There are two sources of iron: Haem is found primarily in meat and meat products Non-haem is found in plants. Haem is generally well-absorbed, whereas non-haem absorption is largely affected by other factors. Common inhibitors of iron absorption are phytates, tannins, starch, and proton pump inhibitors. Phytate binds to minerals, rendering them less available and they are commonly found in nuts, grains, pulses and tubers. Whilst tannins have been suggested to have antioxidant properties they play an inhibitory role in iron absorption. That said, unless you offer your dog tea on a regular basis, tannins are unlikely to be an issue. Proton pump inhibitors do exactly what they say on the tin. Gastric acid is secreted from cells found in the stomach. These cells contain proton pumps to secrete this very acid. Proton pump inhibitor medications come along and turn off these pumps, which stops the secretion of gastric acid. Unfortunately for us, stomach acid is important in releasing iron from ligands in food and in solubilizing ferric iron by converting it to ferrous form, so low levels of stomach acid can impair iron absorption and utilisation. Findings Here However, studies have demonstrated that when a multivitamin was administered alongside PPIs, iron absorption was not affected. The vitamin C found in the multivitamin is thought to be protective even alongside PPI medication. Vitamin C is seen as a potent facilitator of iron absorption because ascorbic acid reduces ferric to ferrous iron, which is therefore absorbable. Iron Regulation The central regulator of iron homeostasis is hepcidin. If hepcidin genes are removed, the host becomes loaded with iron. Iron is regulated through a negative feedback loop. Its presence stimulates hepcidin production and in turn blocks dietary iron absorption. In cases of iron deficiency, hepcidin is suppressed, allowing increased absorption of dietary iron. As the name suggests, hepcidin is a hormone produced in the liver and its synthesis is modulated by iron, inflammation and erythropoietic signalling. High hepcidin levels are noted during times of infection and in health issues like chronic kidney disease. Kidney Disease in Pets High hepcidin levels block intestinal iron absorption and macrophage iron recycling, effectively withholding iron from invading pathogens. Iron and Inflammation When inflammation is prolonged,
In October 2021, a well-known newspaper published an article which suggested vegan pet food is as healthy for cats and dogs as meat. A veterinary professor argued that his research showed that cats and dogs had as good, or better health outcomes on plant-based diets as they did when fed on meat products. However, what the headlines forget to mention is that he also said, this is on the proviso that these plant-based diets were carefully formulated with additional synthetic nutrients. A final note, these findings remain, at present, unpublished. Here at My Pet Nutritionist, we often get asked what the best diet is for our pets, so we thought we’d look into vegan and vegetarian diets in a little more detail. The vegetarian diet involves avoiding meat, fish and poultry products, the vegan diet involves avoiding all animal products, this includes dairy and even honey. How do they suit our cats and dogs? Let’s start with the cats. No matter where you look, the jury is in – cats evolved as hunters that consume prey containing high amounts of protein, moderate amounts of fat, and minimal amounts of carbohydrates. They are obligate carnivores. Building on this definition, they are actually hyper carnivorous. They are a small carnivorous animal with a proportionally large brain. What this means is that their high brain demand for glucose could not be met by a natural prey diet, if they were to only utilise carbohydrates as glucose. So, they are really good at producing glucose from non-carbohydrate sources like protein and fat. This natural evolution has made them quite poor at using carbohydrates, as demonstrated by their limited amylase activity in the pancreas and small intestine (even compared to dogs). The other element to consider for the cat is the well known amino acid taurine. Cats and humans are among the few mammals whose bodies do not make taurine, and therefore must obtain it from their diet. In humans, taurine deficiency is rare because taurine is common in meat and fish food products; and so in a meat-based diet, cats also should not become deficient. In the 1970’s, Quinton R. Rogers of UC Davis showed that a taurine deficiency could cause degeneration of the retina in cat’s eyes. Kittens born to taurine deficient mothers are often blind and show many abnormalities such as impaired gait. For this reason, in the 1908’s new cat feeding guidelines were introduced, stating a minimum level for taurine in cat food. But, in later years it was also found that taurine plays a role in regulating calcium entry into heart tissue every time it beats. Researchers soon noticed that cats presenting with dilated cardiomyopathy also had low levels of taurine. When taurine was supplemented in the diet, the cats recovered. Findings Here Arachidonic acid is another nutrient required by cats that is only available from animal sources and whilst it is an omega-6 fatty acid that is often demonised, it is actually a fatty acid that is essential for health. It is involved in the proper function of the brain and muscles. It, along with it’s metabolites is also involved in immune function and therefore resistance to parasites and allergen insult. Let’s move on to the dogs. A dog is a facultative carnivore, although some describe them as an omnivore. It is this definition that many believe allows our canine companions well adapted to a vegetarian diet, but again, the dog demonstrates poor utilisation of carbohydrates unless in a high energy need (like lactation or speed work) by their limited amylase activity. A survey of 86 vegetarian dogs in Germany, Switzerland and Belgium found that over 50% of the dogs were fed diets deficient in protein, essential amino acids, calcium, zinc, and vitamins D and B12. Findings Here Why Does My Dog Need Calcium Why Zinc is Important For Your Dog The Importance of Vitamin D for Cats and Dogs Why Your Dog Needs Vitamin B12 Many suggest that correct formulation by manufacturers will negate these issues, Kanakubo and colleagues examined 13 dry and 11 canned vegetarian diets for dogs and cats that were sold in all or most of the United States. Crude protein and amino acid concentrations were compared with AAFCO Dog and Cat Food Nutrient Profiles. Minimum CP concentrations for the specified species and life stages were met by 23 diets; the remaining diet passed appropriate AAFCO feeding trials. However, 25% (6/24) diets did not meet all AA minimum requirements. Findings Here During further exploration of the companies who manufacture vegetarian diets, some even go as far as suggesting they “do not advocate the singular feeding of vegetarian or vegan diets to carnivores such as dogs and cats. … It is designed for intermittent feeding or as a base to add different meats for sensitivities and allergies” If vegetarian diets are questioned on their ability to meet the nutritional needs of pets, vegan diets go one step further and avoid all animal products in their entirety, so do they suit our pets either? The Journal of Animal Physiology and Animal Nutrition published a case report of two cats in March 2021. A 2-year-old neutered Main Coon and a 1-year-old spayed domestic short hair presented to the nutrition service in France with lethargy. Dysorexia, lethargy and muscle waste was apparent and progressive weight loss occurred in follow up consultations. A macrocytic, non-regenerative anaemia with low serum folate were the main clinical features. The diet was analysed, and it was found to be a plant-based, vegan pet food. Many nutrients showed as below minimum recommendation. Folic acid supplementation improved dysorexia and with the reintroduction of animal-derived ingredients, appetite, weight, and normal mentation was restored in both cats. Case Report Here Investigations have subjected commercially available vegan cat foods to blind nutritional analyses by an independent laboratory. Data shows that many brands are deficient in taurine, methionine, and arachidonic acid, with additional brands also deficient in Lysine and Arginine. Many vegan diets are also deficient in several B
When we take on a dog, we make it our life mission to keep them healthy and happy; but this isn’t always easy. In an age of information, it can get confusing what to do for the best, so here at My Pet Nutritionist, we thought we’d pop together the top 5 mistakes dog owners can make which compromises health. 1) Over-Vaccinating There is no doubt that vaccination has been progressive in public health concerns, for both humans and pets, but they were never meant to make the host sick. For a number of reasons, the current vaccinations schedule for our pets, is. There is increasing evidence that over-vaccination is associated with the development or aggravation of immune-mediated disorders and chronic diseases in individual pets that are genetically predisposed. This is where titre testing can be useful. A titre is a simple blood test which establishes the levels of existing antibodies in the blood. Antibodies are produced when an antigen provokes a response from the immune system. This response can be from natural exposure or a previous vaccination. A positive test indicates that the patient does have protective levels of antibodies. A negative test indicates that the patient does not have protective levels of circulating antibody. However, it is worth noting here that a negative test result does not indicate susceptibility to disease. On the whole, test correlation with protection is fair to good. Canine adenovirus, distemper virus and parvovirus all correlate well. Feline calicivirus is fair to good, whereas herpesvirus is fair. Feline parvovirus correlates well. Findings Here Titre tests are routinely used to establish the efficacy of rabies vaccination for pet travel schemes. Findings Here These outcomes particularly shine when you compare them to the suspected adverse reactions for vaccination in small animals. Findings Here Titre testing is like checking your fuel gauge before you leave home. You want to make sure you have enough fuel to get to where you need to go. Why not check your dog needs a vaccine before you actually give it? Vaccinosis: Damage Vaccinations Can Cause Your Pet 2) Not Feeding A Fresh Food Diet Dogs are facultative carnivores. This means they thrive on a meat-based diet. Every cell in the body requires energy to carry out its role. Without getting caught up in biology 101, there are a number of cycles that occur in the body to produce energy. Dogs have this nifty ability to use this process known as gluconeogenesis – this produces glucose from non-carbohydrate sources. Dogs have a great capacity for using fat for energy. Not only do they reap the energy rewards from nutrients, but meat in it’s whole-food form contains a number of micronutrients which support body function. Why Does My Dog Need Minerals The issue with over-processed food is that it often becomes nutrient deplete during the process, and so, synthetic nutrients are added back in – makes a little more sense to offer them in their whole-food form in the first place doesn’t it? In addition, food is only as useful as its constituents; it all needs to be digested. Dogs have evolved on a whole-food diet for thousands of years, so their digestive system has figured out how to deal with it. It also makes sense to feed the system something it knows how to work its magic on doesn’t it? Why Dry Food Is Not Good For Your Pets What Is The Best Kind Of Pet Food 3) Using Toxic Chemicals in Your Home and Garden Every day, ours and our pet’s bodies are exposed to toxins. They are produced internally in the body, like lactic acid, and consist of waste products from gut microbes, hormones, and neurotransmitters. But the largest threat is possibly those external toxins, like air pollution, chemicals from cleaning products and volatile organic compounds from the plug-in air diffuser in your lounge. It is thought that in the 25 years between 1970 and 1995, the volume of synthetic organic chemicals produced tripled from about 50 million tonnes to approximately 150 million tons, and this number has grown year on year since. Findings Here Data way back in 2008 reported that dogs have perfluorochemicals in their systems 2.4 times higher than humans, and cats have fire retardant particles in their systems 23.4 times higher than humans. We can only imagine how this has panned out over recent years. The Environmental Working Group found that dogs and cats are contaminated with 48 out of 70 industrial chemicals found in plastics, food packaging, heavy metals, fire retardants and stain-proofing chemicals. In dogs, the findings established: Contamination with 11 carcinogens Contamination with 31 chemicals toxic to reproductive health Contamination with 23 neurotoxins Exposure included: Dog food bag coatings House dust Stain-proofed furniture Medications/pesticides Dog beds Carpets Plastic toys Shampoos Findings Here Check out our other blogs on how to avoid this and also ways to help! Does My Pet Need To Detox Is Your Toxic Home Affecting Your Pet 4) Overuse of Medications Whilst medications are lifesaving, there are often cases of overuse. Antibiotics are commonly inappropriately prescribed which can have long lasting effects on the health of your dog’s gut. Broad-spectrum antibiotics are exactly that – they take all the bugs (both the bad and the good). There is also the increasing concern around antibiotic resistance; this is when a microbe becomes more or fully resistant to antimicrobials which could previously treat it. For this reason, the EMA “is promoting the prudent use of antimicrobials in animals.” Source NSAIDs are also increasingly overused. During the inflammatory response, certain enzymes catalyse the production of compounds which cause pain, redness, and heat. NSAIDs work by blocking the activity of these enzymes and so inhibit the response. But these same enzymes, like many in the body don’t just carry out that role. They are also protective of the stomach mucosa for example, which means when you take out that enzyme, you also take out a layer of mucosal protection! This is why chronic
We sometimes talk about intolerances and allergies like this is the only thing that can cause your cat or dog’s itching. There can be so many reasons, layered reasons and some more serious than others. Here we explore some of the undetected and misdiagnosed reasons for your dog being itchy. Adrenal function The adrenal glands are located just in front of the kidneys. You will recognise them from when we discuss the stress response more often than not. The adrenal gland has 2 parts—the cortex and the medulla. The adrenal cortex is subdivided into 3 layers, and each layer produces a different set of steroid hormones. The outer layer produces the mineralocorticoids, which help regulate sodium and potassium salts. The middle layer produces glucocorticoids, which are involved in metabolising nutrients and reducing inflammation and immune responses. Finally, the inner layer produces sex hormones such as oestrogen, progesterone, and androgens. The adrenal medulla plays an important role in response to stress or low blood sugar levels in the body. It releases adrenaline and noradrenaline, both of which increase heart rate and blood pressure, increase blood sugar and slow digestion; the hallmark responses when us or our dogs are exposed to a stress trigger. The adrenal glands are part of the endocrine system – which is simply a system of glands that release chemical messengers called hormones. The endocrine system influences almost every cell, organ, and function in the body. So, if there is any issue in any part of it, things can start to go wrong. The two most common ways in which adrenal glands cause health issues are by producing too little or too much of certain hormones, which leads to hormonal imbalances. Hyperadrenocorticism (Cushing’s Disease) due to an excess of cortisol production frequently causes dogs to itch, lose hair, have thin skin with dark pigment, drink excessively and have recurring skin problems. But this raises another point, even if there are no physiological issues with the adrenal glands, high cortisol levels due to daily stress can also lead to itchy skin! Thyroid Function We’ll continue with the hormones for a minute and look at thyroid function. The thyroid is a butterfly shaped gland found in the neck. One of its main functions is to produce hormones to regulate the body’s metabolism, the process that turns food into energy. This too can produce too many hormones, or too few. These conditions are known as hyperthyroidism and hypothyroidism respectively. Hypothyroidism Hyperthyroidism Hyperthyroidism in Cats Skin issues are regularly noted in times of thyroid dysfunction, and this includes itchiness. Kidney Function Intense itchiness often accompanies late-stage kidney disease, and whilst the jury is out on the exact reasons behind it, it is thought that it’s relating to the build up of toxins in the body. This leads us nicely into the same itchy symptoms associated with early-stage liver disease, and this is considered for similar reasons. Detoxification Detoxification is carried out by a range of mechanisms, and this comes in particularly handy if one pathway is overwhelmed, another can pick up the slack. The Liver The liver neutralises a range of toxic chemicals, both those produced internally (waste from used hormones or neurotransmitters for example) and those from the environment, like air pollution, pesticides, and food additives. It does this by filtering the blood to remove large toxins, synthesising, and secreting bile and lastly enzymatically disassembling unwanted chemicals found in the body. Liver Guard Enzymatic Detoxification This enzymatical detoxification occurs in three phases. Phase I directly neutralises chemicals and changes them into new metabolites. These are then processed by phase II enzymes. This is known as the conjugation phase, which in short, liver enzymes attach small chemicals to the toxin. There are many ways in which this is done, it all depends on the type of chemical the liver is trying to manage. Phase I results in high levels of reactive oxygen species so antioxidant levels are key in modulating potential damage. Phase II is nutrient demanding and sufficient levels of key vitamins and minerals like vitamin A, C, E, B1, B2, B3 and iron are essential. Phase III is the elimination phase. For optimal excretion of toxins through the digestive system, gut health is vitally important. Maintaining the mucosal barrier is key for gut health along with supporting motility. The kidneys will also filter and process toxins from circulation, excreting them as urine. The skin also forms as an elimination pathway. This is why detoxification issues can result in skin issues. In cases of liver disease, it is considered that bile salt deposits under the skin, which results in itchiness. The most important thing to do to support detoxification is to avoid exposure in the first place, so consider how much you and your dog are exposed to: Pesticides Heavy smoke Phthalates Mould Medications like steroids, antibiotics, and painkillers Heavy metals Cleaning products Air fresheners Eating foods cooked at high temperatures (most commercial dry foods) This list is not exhaustive, but it is a place to start. This mechanism also applies to vaccines. There is increasing evidence that over-vaccination is associated with the development or aggravation of immune-mediated disorders and chronic diseases in individual pets that are genetically predisposed. The primary role of the immune system in dogs is to protect against foreign invaders, or abnormal cells that invade or attack. The immune system must distinguish between self and non-self. Substances that stimulate a response are antigens. These can be contained within bacteria, viruses or microorganisms or cancer cells. They may also exist on their own, like pollen or food particles. There are three lines of defence, physical barriers, nonspecific immunity, and specific immunity. But the immune system does not always function properly, it can be underactive and overactive. An underactive system puts the animal at risk of infection, but an overactive immune system can attack parts of its body that it misidentifies as being foreign. This is what happens in autoimmune conditions. The immune system can also overreact
Amongst the foods marketed for pets, grain free is sitting front and foremost. Whilst we specialise in a range of health issues here at My Pet Nutritionist, we also consult on the most appropriate diets for pets. One of the questions we have been asked, does my dog need a grain free diet? Well, we see huge benefits to a whole or cooked fresh food diet, which is technically grain free, but we know this isn’t what you mean, so let’s take a look at where grain free diets came from and how they have found their way into many homes around the world. Grain Free Diets The concept of a grain free diet likely came from human literature. Grains are in fact a staple in many traditional diets, but a number of books appeared on bookshelves resulting in people cutting this food group out. Grains include wheat, spelt, rye, corn, millet, rice, sorghum, and oats. You’ll notice that both gluten and non-gluten grains are included. In addition, many people opted to cut out products derived from grains like rice syrup or high-fructose corn syrup (which is actually great!). There were a number of reasons for the demonisation of grains. Firstly they were thought to contribute to inflammation in the body, and therefore be a causative factor in many inflammatory conditions. This could be due to the lectin content found in grains. Lectins are often described as an antinutrient and as they are found in potatoes, beans, lentils, peas, soybeans, nightshade vegetables and you guessed it, grains. Lectins are carbohydrate binding proteins present in most plants, especially seeds and tubers like cereals, potatoes, and beans. Their original purpose was protection. They would produce an inflammatory response in the animal that ate them – so they wouldn’t eat them again. Humans and Dogs are largely unable to digest them, but friendly bacteria in the gut can lend a hand. At high dietary levels, it is thought that lectins cause damage to the structure of the brush borders of the small intestine. In lectin fed rodents, the mucosal membrane in the small intestine was stripped, compromising the gut integrity. This compromise has also been linked to abnormal bacterial proliferation. Findings Here Furthermore, some bacteria responsible for urinary tract infections contain lectins specific for the sugar mannose and use these lectins to bind tightly to mannose-rich tissue in the bladder walls – therefore initiating infection. D-mannose supplementation provides a decoy for these bacteria. Lectins also cause discharge of histamine from gastric mast cells which stimulates acid secretion – and as you know, we obviously need stomach acid, but in the right amounts – not too much, or too little. In addition, animal and cell studies have found that active lectins can interfere with the absorption of minerals, especially calcium, phosphorus, and However, lectins are most potent in their raw state, so cooking can inactivate most lectins. They are also water-soluble, so soaking also removes them too! Grains have also been linked to: Anxious and depressive behaviour Chronic pain However, most studies to date have considered these issues alongside gluten containing grains. Researchers have therefore concluded that the issue may in fact be relating to gluten as opposed to the grain. Grain free diets have been linked to weight loss, reduced inflammation, and modulated blood sugar levels. However, to fully understand the role of grain free diets, it’s pertinent to pick this apart a little further. Many grains contain a carbohydrate content, when grains are refined and processed, like those found in many commercial foods, they become a calorie-rich but nutrient poor food. With the removal of the grain, by default, the calorie content is reduced. This same premise applies to inflammation. It is well established that refined grain intakes have been positively associated with risk of metabolic diseases as well as with inflammatory protein concentrations. Refined grains are milled, a process that strips out both the bran and germ to give them a finer texture and longer shelf life. The refining process also removes many nutrients, including fibre. Refined grains include corn flour and white rice. Whole grains on the other hand haven’t had their bran and germ removed by milling; therefore, all of the nutrients remain intact. Whole grains are sources of fibre and other important nutrients, such as selenium, potassium, and magnesium. Whole grains include millet, bulgur, buckwheat, barley, and oatmeal. This is relevant when we consider how grain free diets have been linked to modulating blood sugar levels. Grains are naturally a source of carbohydrates. As we know, when carbohydrates are ingested, without naturally occurring fibre, they are digested very quickly, and pass into the blood stream. This results in a spike in blood sugar, which insulin must come and manage. Refined grains are devoid of fibre. Whole grains on the other hand are rich in fibre which may help stabilise blood sugar levels. The take home here is when we are looking at the benefits touted in grain free diets, we must consider the grains that are being referenced. Grain Free Diets and Dilated Cardiomyopathy You will have come across the FDA link between grain-free dry dog foods and dilated cardiomyopathy (DCM). The issue is suggested to be related to a taurine deficiency. Cats and humans are among the few mammals whose bodies do not make taurine, and therefore must obtain it from their diet. In humans, taurine deficiency is rare because taurine is common in meat and fish food products. In the 1970’s, Quinton R. Rogers of UC Davis showed that a taurine deficiency could cause degeneration of the retina in cat’s eyes. Kittens born to taurine deficient mothers are often blind and show many abnormalities such as impaired gait. For this reason, in the 1980’s new cat feeding guidelines were introduced, stating a minimum level for taurine in cat food. But, in later years it was also found that taurine plays a role in regulating calcium entry into heart tissue every time it beats. Researchers
In a previous My Pet Nutritionist blog we looked at the function of the urinary system; if you missed it, you can check it out! As you will know, any system that is compromised, results in a range of signs and symptoms. Kidney disease or compromise ideally needs the support of knowledgeable practitioner, but there are many of us who simply want to get our pets off to the best start and support their health before things go rogue. So, we thought we’d do a one stop shop of nutrients that are particularly helpful for supporting general kidney health. B Vitamins Along with vitamin C, the B vits are water soluble and there are eight of them: B1 Thiamin B2 Riboflavin B3 Niacin B5 Pantothenic Acid B6 Pyridoxine B7 Biotin B9 Folate B12 Cobalamin These vitamins are involved in many functions as they help a variety of enzymes do their jobs – they help release energy from macronutrients and they help transport oxygen and energy containing nutrients around the body. B1 is involved in energy metabolism – it helps our dogs turn what they eat into energy. It also plays a role in nervous system function. In addition is helps metabolise certain neurotransmitters which as we know are chemical messages that are sent between the body and brain! Finally, B1 is involved in the synthesis of collagen and other proteins which contributes to structural health and wound healing. B2 or riboflavin is involved in energy production, and it is a cofactor of the master antioxidant glutathione, therefore adequate intake is essential to antioxidant capacities. Does My Dog Need Antioxidants B3 is necessary in the biosynthesis of fatty acids and also in energy production. It is essential for skin health, mucous membrane integrity and digestive and nervous system health. In addition, B3 is involved in DNA replication and repair, blood sugar regulation and also functions as an antioxidant. B5 is involved in energy production, the synthesis of fatty acids, cholesterol, steroid hormones and also vitamins A and D. It is essential in protein and amino acid synthesis along with the formation of the neurotransmitter acetylcholine which is the chief of the parasympathetic nervous system (the rest and digest side of the stress response). Vitamin B6 plays a vital role in the production of protein compounds (like haemoglobin), cells of the immune system, hormones, neurotransmitters, RNA, DNA and many enzymes. It is also involved in the manufacture of prostaglandins, which are produced at the site of injury or infection, largely controlling the inflammatory response. Vitamin B6 also activates the release of glycogen from the liver and muscles, for this reason it is essential to physical activity (and gets depleted in times of high demand). It also helps balance sodium and potassium which in turn, regulates bodily fluids and promotes the normal functioning of the nervous and musculoskeletal systems. Known as Vitamin H, for Haar and Haut (hair and skin), we know it more commonly as vitamin B7, or Biotin. This vitamin too helps the body convert food into energy; specifically, biotin is involved in gluconeogenesis, which as we know is the synthesis of glucose from non-carbohydrate sources. Biotin is also involved in fatty acid synthesis, which is important in energy metabolism but also key in skin health. Deficiency of biotin has been associated with immune depression and reduced collagen synthesis. Findings Here Of interest, the use of antibiotics decreases the bacterial population of the large intestine which increase the dietary requirement for biotin. Rancid fats also inactive biotin along with chlorine. Good dietary sources of B7 include liver, eggs, salmon, sardines, mushrooms. B9 is essential in growing and dividing cells. A lack of folate has the most impact on those rapidly dividing cells like those in the digestive system, the genital tract and of course red blood cells. B9 is key in the synthesis of structural and functional proteins, and the formation of the master antioxidant, glutathione, is indirectly dependent on folate. And finally, vitamin B12 is essential for DNA and RNA synthesis and for cellular energy production. All cells in all bodies need to know what they are doing, and they need energy to do them; B12 ensures this occurs. There are no known naturally occurring bioactive forms of B12 in plant sources. This is because B12 is synthesised by the bacteria in the gastrointestinal tract of animals, and then absorbed by the host animals. B12 is concentrated in their tissues, which is then eaten by other animals. Sources of B12 include red meat, fish, dairy, and eggs. Why Your Dog Needs B12 You can ensure a fresh food diet, rich in these B Vitamins, or with the guidance of a practitioner, consider supplementation in methylated form. Coenzyme Q10 Coenzyme Q10 (COQ10) is an essential compound of the body which is synthesized in the mitochondrial inner membrane. It has many important functions in the body. Firstly, it can be named the key-component of electron transport chain in mitochondria necessary for ATP production and secondly, it can act as an intercellular antioxidant. In the body, COQ10 is found in all systems of organs. The highest concentration of ubiquinone is noted in the tissues of the heart, liver, muscles and you guessed it, kidneys! In poor kidney function, levels of COQ10 are often depressed, and much research has indicated that COQ10 may have favourable effects on cardiac function, glucose metabolism, lipid profiles, inflammation and oxidative stress in patients with non-dialysis chronic kidney disease. Findings Here Cordyceps Cordyceps cicadae, a caterpillar-shaped medicinal mushroom that derives its nutrients from larvae of Cicada flammata Dist., has been utilized in Chinese herbal medicine for thousands of years. All Cordyceps species are endoparasitoids, living mainly on insects and other arthropods. It has been well evidence that the use of cordyceps has demonstrated beneficial effects in decreasing the progression of end-stage kidney disease. Findings Here it is largely thought this is due to its antioxidant, anti-inflammatory and immunostimulant properties. But that doesn’t mean we have to wait
In our last blog we considered the importance of minerals for your dog’s health, but we only got so far. There are further minerals, ones we deem trace minerals, which are also important to optimal health. So, let’s get cracking. Chromium Within human realms, chromium is mostly talked about for its role in modulating blood glucose levels. It is considered that chromium acts as a cofactor that can enhance the effects of insulin on target tissues. In states of chromium deficiency, abnormal glucose utilisation results along with increased insulin demands. Findings Here Along with potentiating the action of insulin, chromium increases uptake of amino acids into muscle, heart, and liver and enhances protein synthesis. It also plays a role in regulating blood lipids. Increased Risk of Deficiency: Diets high in sugars and refined carbohydrates (results in increased urinary excretion of chromium) Increased stress (physical activity, infection, trauma or illness) Pregnancy Ageing Sources of Chromium: Broccoli Turkey Chicken Brewer’s Yeast Cobalt One of the things you may not have realised about Cobalt is that it is an integral part of Vitamin B12 (cobalamin – get it?). Why Your Dog Needs Vitamin B12 Cobalt is therefore essential for the function of cells. It is involved in the production of red blood cells and the production of antibacterial and antiviral compounds that prevent infections. This mineral plays a key role in the metabolism of fats and carbohydrates as well as the synthesis of proteins and conversion of folate in their active form. In the nervous system, cobalt also plays a role in the prevention of demyelination, which is a condition that results in damage to the membrane that covers the nerve fibres in the brain and spinal cord. This ensures efficient nerve transmission. Copper Copper has a number of functions throughout the body including: Energy production in mitochondria Mobilisation and transfer or iron from storage sites to the bone marrow Synthesis of collagen and elastin in connective tissue Acts as an antioxidant (as zinc/copper superoxide dismutase) Supports synthesis of melanin in the skin Synthesis of adrenaline and noradrenaline in the nervous system Breakdown of serotonin, histamine and dopamine Increased Risk of Deficiency: High intakes of supplemental iron, molybdenum, or zinc Prolonged use of proton pump inhibitors (acid reducers) Gastrointestinal disorders (chronic diarrhoea, inflammatory bowel disease) Increased levels of oxidative stress (air pollution, toxin exposure) Signs of Deficiency: Anaemia Increased vulnerability to oxidative damage Reduced immune responses Abnormal skeletal growth Changes and loss of hair and skin pigmentation Lethargy Excessive copper build-up in the liver can cause liver disease in some dogs. Common breeds of dog that are affected include Bedlington terriers, Labrador retrievers, and Dalmatians. There are clear genetic implications found in Bedlington Terriers which prevents normal copper excretion. Three forms of the disease occur: (i) asymptomatic – in which signs are yet to develop, (ii) acute -seen in dogs up to six years of age, with the sudden onset of severe illness shown as depression, anorexia (not eating) vomiting and possibly jaundice (yellowing of mucous membranes, whites of eyes and skin), and (iii) chronic – seen in middle-aged dogs with signs of chronic liver damage and sometimes failure which may show vomiting, weight loss, jaundice and abdominal swelling. It is considered that many commercial dog foods report total copper levels as higher than recommended, and some home-made diets may not furnish adequate amounts of copper. Findings Here That said, data indicates that copper absorption is greater when diets are animal protein rather than plant protein. Findings Here Iodine An essential mineral, iodine is used by the thyroid gland to make thyroid hormones that control many functions in the body including growth and development. If you would like to learn more about the thyroid gland and the conditions that often affect it, check out our blogs here: Hypothyroidism Hyperthyroidism Hyperthyroidism in Cats Iodine can only be obtained from diet or in supplemental form. Of interest, concurrent deficiencies in selenium, iron or vitamin A may exacerbate the effects of iodine deficiency. Seaweed like wakame are rich in iodine, but other sources include eggs and poultry. Iron Functions: Oxygen transport Oxygen storage as myoglobin Energy production Cofactor for multiple enzymes Production of neurotransmitters and thyroid hormone There are two sources of iron, haem, and non-haem. Haem is found primarily in meat and meat products where non-haem is found in plants. Haem is generally well-absorbed, whereas non-haem absorption is largely affected by other factors. Common inhibitors of iron absorption are phytates, tannins, starch, and proton pump inhibitors. The body has three unique mechanisms for maintaining iron balance and preventing deficiency and overload: Storage of iron Reutilisation of iron Regulation of iron absorption Iron from food is mainly absorbed in the duodenum. Iron can be in ferrous state (Fe2+) or ferric state (Fe3+). Fe3+ is not directly absorbed, but Fe2+ is easily absorbed. In the intestine, Fe3+ is converted by ferric reductases into Fe2+. When required by the body, iron is transported by transferrin to bone marrow and other tissues. Iron is required for the transport of oxygen, oxygen storage in muscle and is also a component of energy production. After absorption, any iron that isn’t needed, is stored as ferritin in the liver, spleen, or bone marrow. During times of high need, iron is then released. Most of the iron in the body is contained within red blood cells. Red blood cells have been noted to have a life span of around 110-120 days but when they reach the end of their life span, they release iron. The resultant liberated iron can be reused to produce new erythrocytes in bone marrow, stored as ferritin or released back into systemic circulation. Iron deficiency anaemia is the common condition associated with decreased iron levels, resulting in low circulating haemoglobin and reduced myoglobin. Iron deficiency is also associated with lower T and B lymphocyte, macrophage, and neutrophil function. Your Pet’s Immune System On the other side of the scale, iron toxicity is generally associated with supplementation. At a
If you have been following any nutrition nerds (including us here at My Pet Nutritionist) then you will have likely come across the terms macro and micronutrients. We tend to reference them more commonly in the human realms, but that doesn’t mean that they don’t also apply to our canine companions (and feline for that matter). When we mention macronutrients we are referencing those needed in larger amounts in the body and they encompass protein, fat and carbohydrates. When we consider micronutrients we are looking at vitamins and minerals. Despite them being needed in micro amounts, they are still biologically necessary to all functions in the body. So, let’s take a look at minerals in a little more detail and see why your dog needs them. What is a Mineral? A mineral is a naturally occurring inorganic solid, with a definite chemical composition, and an ordered atomic arrangement. What on earth does this mean we hear you wonder? Well, let’s break it down. Minerals are naturally occurring, meaning they are not made by humans. They are inorganic, meaning they have never been alive. They are solid, meaning they are not liquid or gas. Each of them has a unique structure and arrangement which is how we know what they are. For the dog we are interested in 17 essential minerals. We have macrominerals which are needed in larger amounts and trace minerals which are needed in smaller amounts. Macrominerals Calcium You’ll likely be familiar with calcium as you were probably told to drink your milk so you would have strong teeth and bones. Calcium is the main structural component of skeleton and teeth, but it also plays a role in blood clotting. In addition, it is involved in the intracellular messaging triggering the contraction of muscle fibres. Calcium also plays a role in fat oxidation and it carries ATP (energy) with magnesium. There is an increased risk of deficiency in: Diets containing large quantities of phosphorus and sodium. Fat malabsorption (fat binds calcium, reducing absorption). Vitamin D deficiency. Diets containing large quantities of oxalates. Signs of Deficiency: Poor bone mineralisation, Muscle cramping and spasm, Increased irritability of nerve cells, Abnormal blood clotting and increased bleeding after trauma. Chloride Chloride is one of the most important electrolytes found in the blood. It plays a key role in controlling the amount of water and type of compounds that go in and out of cells. It therefore plays a crucial role in homeostasis. Chloride also contributes to muscle function and this includes the heart. This mineral helps red blood cells exchange oxygen and carbon dioxide too! Lastly, chloride supports digestive processes through its role in the production and release of hydrochloric acid in the stomach, and as we know, without this, foods won’t be properly digested and subsequently absorbed. Low levels of chloride are usually found alongside existing health issues which result in electrolyte imbalances. Sources of Chloride: Himalayan Salt Seaweed Magnesium Here at My Pet Nutritionist, we have a thing about Magnesium, for good reason. If you want to know more about this trusty mineral, then check out our full blog here: Why Is Magnesium So Important to Your Pet But the one often forgotten role of magnesium is the part it plays in energy, so we’ll do a recap. The bottom line is that insufficient micronutrient intake results in poor ATP production in the mitochondria. Remember that ATP is the currency of energy and the mitochondria is the powerplant of the cell, where it all happens. Magnesium and copper are star minerals for making ATP and without enough ATP or energy, the body hasn’t got enough resources to do what it needs to! In addition, a deficiency in magnesium can lead to mitochondrial damage. Signs and Symptoms of Deficiency: Muscle cramps and spasms Anorexia, nausea, vomiting Arrythmias Sodium and water retention Impaired action of vitamin D Increased Risk of Deficiency: Diets emphasizing processed foods and refined grains (largely nutrient deplete) Strenuous training Periods of rapid growth Intestinal malabsorption Medications (diuretics, steroids, laxatives) As a note, magnesium deficiency has also been linked to increased inflammatory cytokines, so this is a consideration to make in any chronic inflammatory condition. Findings Here Phosphorus Phosphorus in mainly used for the growth and repair of body tissues – it is a component part of bones, teeth, RNA and DNA. In the form of phospholipids, phosphorus is also a component of cell membrane structure and of the body’s key energy source, ATP. Many proteins and sugars in the body are phosphorylated. In addition, phosphorus plays key roles in regulation of gene transcription, activation of enzymes, maintenance of normal pH in extracellular fluid, and intracellular energy storage. A range of foods contain phosphorus, mainly in the form of phosphates and phosphate esters. Phosphorus in seeds for example, is in the form of phytic acid, the storage form of phosphorus. Because many species intestines lack the phytase enzyme, much phosphorus in this form is unavailable for absorption. Low phosphorus levels in the body can include anorexia, anaemia, proximal muscle weakness, skeletal effects (bone pain, rickets, and osteomalacia), increased infection risk, ataxia, and confusion. But in most cases, hypophosphatemia (low phosphorus) is caused by existing health conditions, such as hyperparathyroidism, kidney disorders, and diabetic ketoacidosis. In cases of chronic kidney disease, their ability to excrete phosphorus becomes compromised. This is why low phosphorus diets are often recommended. Kidney Disease Potassium Another electrolyte, potassium is also involved in energy production and membrane excitability and transport. Throughout the body there are a number of functions that are potassium dependent. If potassium is deficient, these enzymes or proteins are unable to carry out their job as they should. For example, one heat shock cognate protein, involved in protein folding, autophagy, apoptosis and cell stability requires potassium to carry out these functions. In a deficit, cell senescence results, along with DNA damage, carcinogenesis, and neurodegeneration. Findings Here The bottom line is that potassium helps nerves and muscles to function correctly, it maintains a
It’s a supplement that we often see adverts for, but when we talk about the antioxidant properties of certain nutrients, it’s easy to forget what that actually means in the body. So, we thought we’d compile a brief guide to antioxidants, what they are, what they do, and where we get them from. But first we need to know what a free radical is. Free Radicals Free radicals are created in the body from normal essential metabolic process like exercise, or during the conversion of food to energy. You can think of them like the exhaust fumes of work. But they can also be a result of external exposure to x-rays, smoke, air pollution, industrial chemicals and the ozone. When maintained at low or moderate concentrations, free radicals play several beneficial roles for the host. They are needed to synthesize some cellular structures and are used by the immune system to fight pathogens. Phagocytes synthesise and store free radicals, in order to be able to release them when invading pathogenic microbes have to be destroyed. Free radicals also play a key regulatory role in intracellular signalling cascades, in many cell types like fibroblasts, endothelial cells, vascular smooth muscle cells, cardiac myocytes, and thyroid tissue. The most well-known free radical acting as a signalling molecule is nitric oxide (NO). It is an important cell-to-cell messenger required for a proper blood flow modulation, involved in thrombosis, and is crucial for the normal neural activity. NO is also involved in nonspecific host defence, required to eliminate intracellular pathogens and tumour cells. The issue is when the number of free radicals outweighs the body’s ability to cope with them. When this occurs, so does oxidative stress. Oxidative Stress Oxidative stress can be responsible for the induction of several diseases, both chronic and degenerative, as well as speeding up body ageing processes and causing acute pathologies. It can damage cells, and even DNA is prone to oxidative stress. Oxidative stress has been associated with: Cancer development Cardiovascular disease Neurological disease Respiratory disease Arthritis Kidney disease Delayed sexual maturation Findings Here And so, the body has put in place several strategies to counteract the effects of free radicals and oxidative stress, based on enzymatic (e.g., SOD, CAT, and GPx) and nonenzymatic (e.g., lipoic acid, glutathione, ʟ-arginine, and coenzyme Q10) antioxidant molecules. In addition, there are several exogenous antioxidant molecules of animal or vegetable origin, introduced by diet or by nutritional supplementation. Antioxidants Antioxidants neutralise free radicals – they do have a few tricks up their sleeve to do this, but in many cases, they donate an electron to stabilise the free radical. In this process, they don’t themselves become destabilised, so they stop the cycle. Nutritional Antioxidants: Vitamin E The term vitamin E encompasses several molecules (α-, β-, γ-, and δ-tocopherol and α-, β-, γ-, and δ-tocotrienol) synthesized by vegetables and contained in edible oils and seeds, as well as in food that has been artificially enriched. In mice prone to allergic disease, supplementing allergic mothers (at the time of mating) with α-tocopherol was enough to inhibit pup allergic responses. It has been also observed, from in vivo experiments, that α– and γ-tocopherol supplementation of allergic and nonallergic pregnant mice can alter the allergic responsiveness development in offspring of mice. Findings Here Flavonoids Flavonoids are a class of polyphenolic compounds. They are a class of natural compounds extensively present in foods of vegetal origin (fruits, oils, seeds, etc). Flavonoids could be further classified into flavonols (e.g., quercetin, rutin), flavanones (e.g., naringenin, hesperidin), flavanols (e.g., epicatechin, gallocatechin), flavones (e.g., luteolin, apigenin), and anthocyanins (e.g., pelargonidin, malvidin). These flavonoids exert their anti-oxidative action in several ways including direct trapping and scavenging of free radicals, decreasing leukocyte immobilization, and regulation of nitric oxide and xanthine oxidase activity. Not only that, but flavonoids are also thought to be: Neuroprotective Hepatoprotective Geroprotective Anticancer Cardioprotective Antimicrobial Anti-inflammatory Great sources of flavonoids include: Ginger Carrots Turmeric Cruciferous vegetables, garlic Apple Green tea (decaf) Berries Vitamin C Ascorbic acid (vitamin C) is a water-soluble compound classified under the group of natural antioxidants. Ascorbate reacts with ROS therefore quenching them. Sources include: Peppers Strawberries Raspberries Blackberries Broccoli Antioxidants and Ageing Aging and the production of free radicals can lead to oxidative damage to proteins, lipids and nucleotides that, in turn, may cause neuronal dysfunction and ultimately neuronal death. Several mechanisms are in place that balances the production of free radicals. But with age, it is possible that these protective mechanisms begin to fail. Researchers have often found increased oxidative end products in the aged canine brain. Furthermore, low Vitamin E levels are regularly noted in the brains of aged dogs with cognitive dysfunction. Oxidative damage may also be associated with behavioural decline. To this end, dietary modification, and the use of antioxidants has been noted to improve cognitive performance in the ageing dog. Findings Here If you would like to learn more about the ageing dog, check out our blog here: Keeping Your Senior Dog Healthy Contributory Nutrients Despite molecules possessing obvious antioxidant capacity, certain trace minerals such as selenium, copper, zinc, and manganese are also important to enzymes that specifically detoxify free radicals. Selenium – organ meats, seafood, nuts, Copper – shellfish, seeds, nuts, organ meats, Zinc – oysters, red meat, poultry, nuts, Manganese – mussels, nuts, leafy vegetables, The bottom line? The body does possess its own antioxidant defences, but they can get overwhelmed. When this occurs, it results in oxidative stress which has been linked with a range of chronic health conditions. Free radicals can be produced internally, from normal day to day processes, but exposure in the environment also increased the burden. This includes toxin exposure. It’s best to limit exposure in the first place, but there is also value in providing nutritional defences too! A fresh, wholefood diet can include a range of antioxidant compounds, but check out our other blogs around toxin exposure for reducing burden. Does My Pet Need To Detox Is Your Toxic Home Affecting Your
