Here at My Pet Nutritionist, we consult for a huge number of families with an enormous variety of health concerns in their pets. Once diagnosed by a veterinarian, our packages aim to support your pet with a more natural view. One of the conditions we are asked about a lot, is Hypophosphatemia. This is a condition that occurs in both dogs and cats, so this blog may be a handy read for both owners of cats and dogs. Hypophosphatemia is the clinical term for low phosphorous levels being present in the blood. This condition is far more common in dogs than it is in cats. Hypophosphatemia is associated with a host of other health conditions, and can cause a variety of health conditions in itself. Some of the conditions commonly caused by Hypophosphatemia include: Bone Diseases: Rickets is a bone disease often caused by low phosphorous levels, and is specifically a bone growth disease – it ultimately causes bone softening to occur, as well as deformities, especially in puppies and kittens! Another common bone disease caused by Hypophosphatemia is Osteomalacia which is a very similar bone softening disease, but found more commonly in adults. Muscle Weakness: muscles may become weaker, and the pet may become more physically unstable, and may appear slimmer with little muscle tone. Respiratory problems: in rare, severe cases, respiratory issues can occur as a result of low blood phosphorous. Heart Failure: another rare condition to come of low phosphorous levels, in the more severe cases. Seizures: again, while rare, seizures can occur as a direct result of severe Hypophosphatemia. Findings Here Findings Here Symptoms and Causes The clinical presentation of Hypophosphatemia changes depending on the severity of the deficiency in your pet. The trickier side of these symptoms, is that they are common in a variety of health issues, not just Hypophosphatemia! This can make diagnosis more difficult. If your pet has mild Hypophosphatemia, you can expect to see some of, or all of the following symptoms: Muscle weakness: a change in gait, difficulty climbing stairs, weakness when getting up from a bed or laying position, or difficulty standing for long periods. Reduced, or total loss of appetite: pets may have a reduced appetite, or stop eating all together. Lethargy: unwillingness to be active for usual periods of time. Pets may be less alert. Disorientation: leaning or wobbling when standing may occur Findings Here If your pet has severe Hypophosphatemia, you may see the above symptoms, as well as some of the following: Seizures: neurological activity can occur due to the lack of phosphorous in the blood. Ataxia: loss of coordination is another possible neurological symptom often seen in those with a severe deficiency of phosphorous in the blood. Constipation: this can occur due to paralysis of the intestines, meaning faecal matter cannot be pushed through the digestive system in order to be expelled. This condition is called Ileus. Irregular Heartbeat: arrythmias can be detected by your vet using a stethoscope. This is a symptom of severe blood phosphorous deficiency. Haemolytic anaemia and Haemolysis: abnormalities in red blood cell counts during bloodwork may show red blood cell destruction. These conditions are a symptom of severe Hypophosphatemia. Breathing difficulties: these often come hand in hand with heart conditions, and are a symptom of Hypophosphatemia. Findings Here When we look into the possible causes of Hypophosphatemia, there are a number of possible reasons for it’s onset. Let’s take a look at them: Dietary Deficiencies: if the pet’s diet is lacking in phosphorous, hypophosphatemia is a risk. This may be found in those fed a poor quality diet. Renal Disease: disease in the kidneys can cause hypophosphatemia through two pathways – increased excretion of phosphorous in urine, and reduced ability to reabsorb phosphorous in the kidneys. Hyperparathyroidism: when the parathyroid gland (which is involved in the calcium:phosphorous ratio) is overactive, phosphorous loss is increased. Cushing’s Disease (Hyperadrenocorticism): phosphorous imbalances are common in those with Cushing’s Disease. Fatty Liver Disease (Hepatic Lipidosis): this disease in cats is a contributor to phosphorous loss. Diabetic Ketoacidosis: severe phosphorous loss can be caused by this condition which occurs as a result of complications in diabetic animals. Poor Intestinal Absorption: in those with poor gut health, absorption of phosphorous in the gut can cause deficiencies. Phosphorous Redistribution: deficiencies in phosphorous occur when there is a shift from extracellular fluid (the blood) to intracellular fluid (the cells in the body) Specific Intravenous Therapies: some IV fluids can cause a reduction in phosphorous in the blood. Findings Here Findings Here Findings Here Diagnosis Diagnosis of Hypophosphatemia is a simple process. Your veterinarian will take a blood sample, and analyse it. The test is called a ‘Serum Phosphate Test’. Once this analysis is complete, your vet will inform you as to whether your pet’s phosphorous levels are within the ‘normal’ range of results. Findings Here Conventional Treatment When it comes to treatment your vet may offer, they will first and foremost look at underlying causes. Each individual cause will have a different treatment plan, so it is important to work with your vet on these. Depending on the severity of your pet’s Hypophosphatemia, phosphorous supplementation will be advised. More severe cases may have phosphorous supplementation intravenously, but most cases will be advised to give oral supplements. Some veterinarians will also advise on changing your pet’s diet to one with extra phosphorous. Frequent check ups will be carried out by your veterinary team to keep an eye on your pet’s blood phosphorous levels. Findings Here Findings Here A Natural Approach to Hypophosphatemia As always, our approach is often supported by veterinary care, so we tend to look at this as a complementary approach as opposed to alternative. Here are some of our considerations: Feed fresh: Poor dry food will most likely be lacking in various micronutrients despite its ‘complete and balanced’ label. Nutrient levels may be affected due to the numerous periods of exposure to high heat and the subsequent nutrient loss. Synthetic nutrients are often sprayed
At My Pet Nutritionist, we help a lot of dogs and cats with kidney and liver disease. These can be caused by many other health aspects, and both require management with diet, supplements, and lifestyle changes, alongside conventional veterinary medicine. Those who we have helped with kidney or liver disease will have been recommended, and formulated a gently cooked diet, specific to the pet’s condition. Why do we recommend a cooked diet for these pets? Find out with us in this blog post as we look at kidney and liver function, and why when diseased, these require a cooked diet! Role of the Kidneys In order to understand why a cooked diet is best for kidney and liver disease, it’s important to know what the kidney and liver do, what stresses them, and what kidney and liver disease are. First up, kidneys. The mammalian body has two kidneys, which are shaped much like a bean (hence the bean commonly used in Mexican cookery among other cuisines being called a ‘kidney bean’; this is the shape of your pet’s, an your own kidneys). They are found in the abdomen of your pet, either side of the spine for dogs, and just below the spine for cats. The kidneys are an incredibly important organ, and without them, the body would be extremely toxic. Kidneys are essentially the body’s built in filter! They remove waste products and substances from both the blood, and the urine. The level of many components of a health blood stream is largely controlled by the kidneys, which also contributes to control of blood pressure. The kidneys are also involved in the endocrine system, which stimulate red blood cell production, and help to regulate calcium homeostasis. You can learn more about kidney function here. As with any organ, it is important to refrain from overstressing the kidneys. There are various factors which may contribute to added pressure on the kidneys such as: High blood pressure High blood sugar (diabetic pets can be more at risk of kidney disease) High sodium levels in the diet Prolonged use of NSAID drugs High phosphorous levels in the diet Processed foods Too much protein in the diet Poor quality protein in the diet Dogs and cats with kidney disease can be at stage 1-4, each stage worsening. When the kidneys are under immense pressure, kidney disease often occurs. We do see a lot of cases of Chronic Kidney Disease (CKD), as well as other kidney diseases in practice at My Pet Nutritionist. Kidney disease can be trickier to diagnose in cats because they often urinate and drink where the owner is unable to monitor, but is seen in a staggering 1 in 3 cats! Symptoms of kidney disease include: Drinking excessively (polydipsia) Increased urination (polyuria) Vomiting and diarrhoea Rapid weight loss Reduced appetite Anaemia (pale gums and tongue) Increased blood pressure Loss of eyesight Reduced bone density You can learn more about kidney disease for cats here and for dogs here. Role of the Liver Next up, the liver. The liver is a sort of triangle shaped organ, which sits inside the ribcage in both cats and dogs. It consists of 6 lobes, and is extremely important! Much like the kidneys, blood passes through the liver to be cleaned. It plays many roles in the body, such as: Detoxification of the blood from certain medications and environmental toxins Converts ammonia to urea Produces bile, which breaks down fats Breaks down nutrients in the blood, and makes them useable Synthesises some proteins for healthy blood plasma Stores iron Converts excess glucose to glycogen, which is stored in the liver, and can be used as an energy source Regulates blood clotting Helps to remove bacteria from within the blood stream Removes bilirubin from the blood When it comes to stressing the liver, there are various consumables which can put added pressure on the liver, and ultimately cause it to become sluggish, and often results in the onset of liver disease. Feeding a high fat diet puts a huge strain on the liver, as it is unable to produce enough bile quickly enough to digest the fats. High carbohydrate (or sugary) diets can also add pressure on the liver, as well as diets too high in salt. Liver Guard We also need to look at reducing the chemical intake of your pet! Since the liver plays a role in blood detoxification of certain medications, it is wise to use natural flea and worm preventatives, since the often prescribed pharmaceutical chewable options on the market sadly release toxins into your pet’s blood stream, making extra work for the liver. A lot of reports from pet owners with pets affected by these chewable flea, tick and worm treatments have reported a reduction in liver function, or the onset of liver disease! Those with liver disease, often caused by frequent overworking of the liver, tends to be more common in dogs than in cats, but is seen in both species. The symptoms you may see in liver disease patients include: Loss of appetite Rapid weight loss Vomiting and diarrhoea Neurological activity such as seizures (hepatic encephalopathy) Jaundice (yellowing to the eyes and skin) Excessive drinking (polydipsia) Excessive urination (polyuria) Reduction in blood clotting Abdominal bloating You can learn more about liver disease for cats and dogs here. Why Cooked Food? When our customers come to us with a pet with liver or kidney disease, we recommend they switch to a cooked diet. Cooked food is very much the most appropriate option for pets with kidney or liver disease, for a few reasons: Lower phosphorous levels for kidneys: when a pet has kidney disease, feeding low phosphorous is incredibly important because when the kidneys are damaged, they struggle to remove phosphorous from the blood. While phosphorous is an important nutrient for strong bones and teeth, as well as muscular recovery, in excessive amounts, it can affect bone health, and cardiovascular health. When the ingredients in a properly balanced recipe
Here as My Pet Nutritionist, we see customers with pets with a host of different diagnoses. Diet and lifestyle play a huge role in the management of such conditions, and this is no different when your pet has been diagnosed with Hypokalaemia. Find out more about this condition in this blog post, where you can learn what it is, how to spot symptoms, conventional treatments available, and how you can help your dog by tweaking their diet and lifestyle. What is Hypokalaemia? Hypokalaemia is a deficiency of potassium in the bloodstream. We can break the word down into three parts; ‘hypo’ meaning there is not enough of something, ‘kal’ being related to the chemical formula of potassium, and ‘aemia’ meaning in relation to the blood. Potassium is an electrolyte, and is an essential mineral, stored mostly inside cells. It plays a huge role in the body, including keeping nerve function healthy, ensuring the muscles and heart function correctly, and aiding the transport of both nutrients, and waste around the body. Those with hypokalaemia are deficient in potassium, which plays havoc on nerve, muscle and heart function as the change in concentration of potassium disrupts electrical charges and cell signals from passing through the cells properly. Nutrient absorption and waste remove may also reduce. Hypokalaemia mostly affects the nervous system, the cardiovascular system (which is as a result of hypokalaemia of the nervous system, as the lack of electric signalling from the brain to the heart causes irregular heartbeat which can ultimately lead to death), and the musculoskeletal system. This condition can happen in both dogs and cats, but is more common in dogs than it is in cats. Symptoms of Hypokalaemia There are a variety of symptoms you may see in your pet prior to diagnosis, however milder cases may be symptom-free until the deficiency is severe, when symptoms start to show. These symptoms can include: Lethargy/fatigue Vomiting Severe constipation Increased thirst Increased urination Weight loss Muscle wastage Changes to gait (stiffness, posture/head position, and walking on the back of their feet, not the sole) Irregular heartbeat If your pet is showing any number of these symptoms, it is important you seek veterinary attention as soon as possible. Causes of Hypokalaemia So what causes hypokalaemia? This certainly isn’t a straight forward, one answer fits all situation, so let’s take a look at the potential causes of hypokalaemia in pets. In the event that too much potassium is lost from the body due to polyurea (excessively urinating), excessive defecating, vomiting or other bodily fluid loss, Hypokalaemia is a risk. This is often seen as a secondary health complication to chronic kidney disease (CKD), cardiac issues, or cancer, but most commonly with CKD. Those with CKD, cardiac issues or cancer may notice symptoms after some time, as the damage caused on cells in the body causes potassium loss, which is often not replaced in the diet. Findings Here As potassium can only be sourced through the diet, the lack of a properly balanced diet, low food intake (such as those with anorexia), or reductions in the amount of food eaten by the individual each day either due to illness, or weight loss where daily food allowances have been reduced too quickly, can all lead to Hypokalaemia. The recommended amount of potassium per day for a dog is 1g per 15kg (33lbs) bodyweight. For a cat, the recommended daily amount of potassium is 0.33g per 4kg (9lbs) bodyweight. Findings Here Findings Here Findings Here Dogs and cats with metabolic conditions may also be at risk of developing hypokalaemia. Those with diabetes mellitus are among the more common to experience a lack of potassium in the bloodstream. Findings Here The use of some medications such as most cardiac medications which are diuretics can lead to hypokalaemia too, however this is a tricky problem to solve, as the medications with the potential to cause hypokalaemia, are often life saving, and required. Findings Here Diagnosing Hypokalaemia As hypokalaemia is very often associated with other diseases, most commonly CKD, your veterinarian will run a urinalysis – this is where you take a sample of your dog or cat’s urine, which is then analysed in a lab to check your pet’s kidney function. abnormal function of the kidneys could point to hypokalaemia being the reason for your pet’s stiff gait, muscle wastage, or other symptoms commonly displayed by pets with the condition. Alongside a urinalysis, your veterinarian will take a sample of your pet’s blood, which will be analysed in a lab to determine current concentrations of potassium in the blood serum. Abnormal levels of potassium will be easily identified via this blood test. As cardiac issues often come hand in hand with hypokalaemia, due to the lack of ability to send electric signals to the muscle to encourage it to work, many veterinarians will also run an ECG on your pet to ensure their heart is in good working order. This is often carried out following diagnosis of hypokalaemia. Auscultation (listening to parts of the body with a stethoscope) will be carried out, as it should be with any veterinary appointment, regardless of reason. This will quickly check for any signs of arrhythmia, from where the veterinarian may proceed to using an ECG. Findings Here Conventional Treatment Options When treating, or managing hypokalaemia, the ‘conventional’ treatments are very much similar to the natural support you can provide your cat or dog. The ultimate goal, is to raise potassium levels! In the more severe cases, where the pet is extremely unwell, unable to walk, constantly vomiting, defecating and urinating, the pet will be given a potassium rich mixture via intravenous drip. Depending on the condition, and medical history of the pet in question, the veterinarian will be able to determine how fast the potassium drip should be administered – too fast, and the heart may be affected by an irregular heartbeat! Your veterinarian may recommend a specific diet, and will also recommend giving your dog daily potassium
Kidney disease is a common issue we see here at My Pet Nutritionist. In the dog world, there is a lot of confusion over what the diet of a dog with kidney disease should consist of, and if it should be low in phosphorous, or low in protein. We are here to help clear up the confusion! A Bit About Kidney Disease… Chronic Kidney Disease, abbreviated to CKD, happens in 4 stages. In order to understand the need for lower phosphorous and protein, we need to take a little look into the four stages. Stage 1 At this stage, there is no build up of toxins in the bloodstream, unlike in later stages. With often normal blood and urinalysis results, dogs with stage 1 kidney disease often have no clinical symptoms. This makes it very difficult to diagnose early on. Stage 2 During stage 2, toxins begin to build in the blood, and the kidneys begin to lose their function. When the kidneys begin to decline, they often begin to leak protein into the urine, which would give a higher protein reading in a urinalysis than is expected of a healthy individual. Blood pressure in these individuals may rise, but otherwise, clinical symptoms are rare at this stage. Stage 3 Once the diseased has progressed to stage 3, clinical symptoms are common, and include excessive drinking and urination. Following urinalysis, protein levels will be much higher, and blood pressure will further increase. Stage 4 Due to the degradation of the kidneys at stage 4, both protein and creatinine levels are high. Protein levels in the urine become incredibly high, and the blood pressure would be very high. Conventional treatments Upon diagnosis of CKD, your veterinarian may wish to flush the kidneys – this aims to remove toxins. This can help resume normal kidney function, but may not work for all dogs. A lower protein and phosphorous diet will likely be recommended. This diet should not be acidic either! We don’t want phosphorous to flood the bloodstream , so many vets with recommend a phosphorous binder, which is a drug designed to stop phosphorous from entering the bloodstream. Due to raised blood pressure in those with CKD, blood pressure medication may be prescribed. As a last resort, once all other medical avenues have been explored the vet may decide to perform kidney dialysis. What Type of Food Should We Feed Your vet will likely recommend a ‘prescription’ renal diet. These come in both wet and dry variations. Wet or fresh food contains 65-75% moisture, and dry food only contains 8-10% moisture. With the level of dehydration when feeding dry food, it can impact the kidneys further, and is not something we recommend. If using a veterinary diet, it may be a better option to go for the wet version. With this in mind, a fresh diet, tailored to suit a dog with kidney disease, would be the absolute best option. A balanced recipe, with low phosphorous and low-medium protein, would be ideal. We have two fantastic balanced recipes, ideal for those suffering with kidney disease in stages 1 and 2; one tripe based, and one beef based. For those with later stage kidney disease, a consultation is necessary. Where raw is a fantastic diet in general, we would recommend feeding a cooked diet in the event your dog is diagnosed with kidney disease, as cooking further reduces phosphorous. To learn more about kidney disease, and how other lifestyle changes can help those with CKD, please read our blog here! Why Should We Feed a Low Phosphorous Diet? People often wonder what the link is between phosphorous and the kidneys, and therefore why it should be fed in very low quantities to dogs who have kidney disease. When the kidneys are damaged, they struggle to remove phosphorous from the blood. While phosphorous is an important nutrient for strong bones and teeth, as well as muscular recovery, in excessive amounts, it can affect bone health, and cardiovascular health. Studies show that greater excretion of phosphorous in the urine reduces the risk of cardiovascular disease. When the kidneys are functioning as normal, excretion of phosphorous is very normal; but when the kidneys are not able to function as normal, urinary excretion of phosphorous reduces due to their inability to remove it from the bloodstream, which leads to a greater risk of cardiovascular disease. Findings Here When looking at bone and tooth health, we need to consider the calcium-phosphorous ratio. When these are balanced properly, they work together to form strong bones and teeth, and help keep them in tip-top condition. Unfortunately, when there is an imbalance, and there is too much phosphorous in the body, calcium is pulled from the boned and teeth. Removing calcium from the bones and teeth causes them to become softer and weak. Findings Here Findings Here Why Should We Feed a Low Protein Diet? As previously mentioned, one of the main symptoms of kidney disease, is having high protein levels in urine. Studies show that high protein intake can be linked to proteinuria; protein in the urine. When a dog has low functioning kidneys, consumption of protein in ‘normal’ amounts causes immense stress and pressure on the kidneys, which then adds to the build-up of toxins in the blood. Not only does the amount of protein consumed affect the kidneys, but also the type, and quality of protein. Some of the best options for a protein for those suffering from kidney disease include beef, tripe, chicken, eggs, and fish. It’s very important to feed a diet still containing protein, however. Feeding too little can cause muscle wastage, slower healing from injury, cognitive inabilities, and slower metabolism. Aim to feed a low-moderate amount of protein, as part of a balanced recipe for kidney disease patients. Findings Here Findings Here If your dog has kidney disease, especially in the later stages, we would highly recommend booking in with one of our team for a consultation to help keep your dog
In a previous My Pet Nutritionist blog we looked at the function of the urinary system; if you missed it, you can check it out! As you will know, any system that is compromised, results in a range of signs and symptoms. Kidney disease or compromise ideally needs the support of knowledgeable practitioner, but there are many of us who simply want to get our pets off to the best start and support their health before things go rogue. So, we thought we’d do a one stop shop of nutrients that are particularly helpful for supporting general kidney health. B Vitamins Along with vitamin C, the B vits are water soluble and there are eight of them: B1 Thiamin B2 Riboflavin B3 Niacin B5 Pantothenic Acid B6 Pyridoxine B7 Biotin B9 Folate B12 Cobalamin These vitamins are involved in many functions as they help a variety of enzymes do their jobs – they help release energy from macronutrients and they help transport oxygen and energy containing nutrients around the body. B1 is involved in energy metabolism – it helps our dogs turn what they eat into energy. It also plays a role in nervous system function. In addition is helps metabolise certain neurotransmitters which as we know are chemical messages that are sent between the body and brain! Finally, B1 is involved in the synthesis of collagen and other proteins which contributes to structural health and wound healing. B2 or riboflavin is involved in energy production, and it is a cofactor of the master antioxidant glutathione, therefore adequate intake is essential to antioxidant capacities. Does My Dog Need Antioxidants B3 is necessary in the biosynthesis of fatty acids and also in energy production. It is essential for skin health, mucous membrane integrity and digestive and nervous system health. In addition, B3 is involved in DNA replication and repair, blood sugar regulation and also functions as an antioxidant. B5 is involved in energy production, the synthesis of fatty acids, cholesterol, steroid hormones and also vitamins A and D. It is essential in protein and amino acid synthesis along with the formation of the neurotransmitter acetylcholine which is the chief of the parasympathetic nervous system (the rest and digest side of the stress response). Vitamin B6 plays a vital role in the production of protein compounds (like haemoglobin), cells of the immune system, hormones, neurotransmitters, RNA, DNA and many enzymes. It is also involved in the manufacture of prostaglandins, which are produced at the site of injury or infection, largely controlling the inflammatory response. Vitamin B6 also activates the release of glycogen from the liver and muscles, for this reason it is essential to physical activity (and gets depleted in times of high demand). It also helps balance sodium and potassium which in turn, regulates bodily fluids and promotes the normal functioning of the nervous and musculoskeletal systems. Known as Vitamin H, for Haar and Haut (hair and skin), we know it more commonly as vitamin B7, or Biotin. This vitamin too helps the body convert food into energy; specifically, biotin is involved in gluconeogenesis, which as we know is the synthesis of glucose from non-carbohydrate sources. Biotin is also involved in fatty acid synthesis, which is important in energy metabolism but also key in skin health. Deficiency of biotin has been associated with immune depression and reduced collagen synthesis. Findings Here Of interest, the use of antibiotics decreases the bacterial population of the large intestine which increase the dietary requirement for biotin. Rancid fats also inactive biotin along with chlorine. Good dietary sources of B7 include liver, eggs, salmon, sardines, mushrooms. B9 is essential in growing and dividing cells. A lack of folate has the most impact on those rapidly dividing cells like those in the digestive system, the genital tract and of course red blood cells. B9 is key in the synthesis of structural and functional proteins, and the formation of the master antioxidant, glutathione, is indirectly dependent on folate. And finally, vitamin B12 is essential for DNA and RNA synthesis and for cellular energy production. All cells in all bodies need to know what they are doing, and they need energy to do them; B12 ensures this occurs. There are no known naturally occurring bioactive forms of B12 in plant sources. This is because B12 is synthesised by the bacteria in the gastrointestinal tract of animals, and then absorbed by the host animals. B12 is concentrated in their tissues, which is then eaten by other animals. Sources of B12 include red meat, fish, dairy, and eggs. Why Your Dog Needs B12 You can ensure a fresh food diet, rich in these B Vitamins, or with the guidance of a practitioner, consider supplementation in methylated form. Coenzyme Q10 Coenzyme Q10 (COQ10) is an essential compound of the body which is synthesized in the mitochondrial inner membrane. It has many important functions in the body. Firstly, it can be named the key-component of electron transport chain in mitochondria necessary for ATP production and secondly, it can act as an intercellular antioxidant. In the body, COQ10 is found in all systems of organs. The highest concentration of ubiquinone is noted in the tissues of the heart, liver, muscles and you guessed it, kidneys! In poor kidney function, levels of COQ10 are often depressed, and much research has indicated that COQ10 may have favourable effects on cardiac function, glucose metabolism, lipid profiles, inflammation and oxidative stress in patients with non-dialysis chronic kidney disease. Findings Here Cordyceps Cordyceps cicadae, a caterpillar-shaped medicinal mushroom that derives its nutrients from larvae of Cicada flammata Dist., has been utilized in Chinese herbal medicine for thousands of years. All Cordyceps species are endoparasitoids, living mainly on insects and other arthropods. It has been well evidence that the use of cordyceps has demonstrated beneficial effects in decreasing the progression of end-stage kidney disease. Findings Here it is largely thought this is due to its antioxidant, anti-inflammatory and immunostimulant properties. But that doesn’t mean we have to wait
In our last blog we considered the importance of minerals for your dog’s health, but we only got so far. There are further minerals, ones we deem trace minerals, which are also important to optimal health. So, let’s get cracking. Chromium Within human realms, chromium is mostly talked about for its role in modulating blood glucose levels. It is considered that chromium acts as a cofactor that can enhance the effects of insulin on target tissues. In states of chromium deficiency, abnormal glucose utilisation results along with increased insulin demands. Findings Here Along with potentiating the action of insulin, chromium increases uptake of amino acids into muscle, heart, and liver and enhances protein synthesis. It also plays a role in regulating blood lipids. Increased Risk of Deficiency: Diets high in sugars and refined carbohydrates (results in increased urinary excretion of chromium) Increased stress (physical activity, infection, trauma or illness) Pregnancy Ageing Sources of Chromium: Broccoli Turkey Chicken Brewer’s Yeast Cobalt One of the things you may not have realised about Cobalt is that it is an integral part of Vitamin B12 (cobalamin – get it?). Why Your Dog Needs Vitamin B12 Cobalt is therefore essential for the function of cells. It is involved in the production of red blood cells and the production of antibacterial and antiviral compounds that prevent infections. This mineral plays a key role in the metabolism of fats and carbohydrates as well as the synthesis of proteins and conversion of folate in their active form. In the nervous system, cobalt also plays a role in the prevention of demyelination, which is a condition that results in damage to the membrane that covers the nerve fibres in the brain and spinal cord. This ensures efficient nerve transmission. Copper Copper has a number of functions throughout the body including: Energy production in mitochondria Mobilisation and transfer or iron from storage sites to the bone marrow Synthesis of collagen and elastin in connective tissue Acts as an antioxidant (as zinc/copper superoxide dismutase) Supports synthesis of melanin in the skin Synthesis of adrenaline and noradrenaline in the nervous system Breakdown of serotonin, histamine and dopamine Increased Risk of Deficiency: High intakes of supplemental iron, molybdenum, or zinc Prolonged use of proton pump inhibitors (acid reducers) Gastrointestinal disorders (chronic diarrhoea, inflammatory bowel disease) Increased levels of oxidative stress (air pollution, toxin exposure) Signs of Deficiency: Anaemia Increased vulnerability to oxidative damage Reduced immune responses Abnormal skeletal growth Changes and loss of hair and skin pigmentation Lethargy Excessive copper build-up in the liver can cause liver disease in some dogs. Common breeds of dog that are affected include Bedlington terriers, Labrador retrievers, and Dalmatians. There are clear genetic implications found in Bedlington Terriers which prevents normal copper excretion. Three forms of the disease occur: (i) asymptomatic – in which signs are yet to develop, (ii) acute -seen in dogs up to six years of age, with the sudden onset of severe illness shown as depression, anorexia (not eating) vomiting and possibly jaundice (yellowing of mucous membranes, whites of eyes and skin), and (iii) chronic – seen in middle-aged dogs with signs of chronic liver damage and sometimes failure which may show vomiting, weight loss, jaundice and abdominal swelling. It is considered that many commercial dog foods report total copper levels as higher than recommended, and some home-made diets may not furnish adequate amounts of copper. Findings Here That said, data indicates that copper absorption is greater when diets are animal protein rather than plant protein. Findings Here Iodine An essential mineral, iodine is used by the thyroid gland to make thyroid hormones that control many functions in the body including growth and development. If you would like to learn more about the thyroid gland and the conditions that often affect it, check out our blogs here: Hypothyroidism Hyperthyroidism Hyperthyroidism in Cats Iodine can only be obtained from diet or in supplemental form. Of interest, concurrent deficiencies in selenium, iron or vitamin A may exacerbate the effects of iodine deficiency. Seaweed like wakame are rich in iodine, but other sources include eggs and poultry. Iron Functions: Oxygen transport Oxygen storage as myoglobin Energy production Cofactor for multiple enzymes Production of neurotransmitters and thyroid hormone There are two sources of iron, haem, and non-haem. Haem is found primarily in meat and meat products where non-haem is found in plants. Haem is generally well-absorbed, whereas non-haem absorption is largely affected by other factors. Common inhibitors of iron absorption are phytates, tannins, starch, and proton pump inhibitors. The body has three unique mechanisms for maintaining iron balance and preventing deficiency and overload: Storage of iron Reutilisation of iron Regulation of iron absorption Iron from food is mainly absorbed in the duodenum. Iron can be in ferrous state (Fe2+) or ferric state (Fe3+). Fe3+ is not directly absorbed, but Fe2+ is easily absorbed. In the intestine, Fe3+ is converted by ferric reductases into Fe2+. When required by the body, iron is transported by transferrin to bone marrow and other tissues. Iron is required for the transport of oxygen, oxygen storage in muscle and is also a component of energy production. After absorption, any iron that isn’t needed, is stored as ferritin in the liver, spleen, or bone marrow. During times of high need, iron is then released. Most of the iron in the body is contained within red blood cells. Red blood cells have been noted to have a life span of around 110-120 days but when they reach the end of their life span, they release iron. The resultant liberated iron can be reused to produce new erythrocytes in bone marrow, stored as ferritin or released back into systemic circulation. Iron deficiency anaemia is the common condition associated with decreased iron levels, resulting in low circulating haemoglobin and reduced myoglobin. Iron deficiency is also associated with lower T and B lymphocyte, macrophage, and neutrophil function. Your Pet’s Immune System On the other side of the scale, iron toxicity is generally associated with supplementation. At a
If you have been following any nutrition nerds (including us here at My Pet Nutritionist) then you will have likely come across the terms macro and micronutrients. We tend to reference them more commonly in the human realms, but that doesn’t mean that they don’t also apply to our canine companions (and feline for that matter). When we mention macronutrients we are referencing those needed in larger amounts in the body and they encompass protein, fat and carbohydrates. When we consider micronutrients we are looking at vitamins and minerals. Despite them being needed in micro amounts, they are still biologically necessary to all functions in the body. So, let’s take a look at minerals in a little more detail and see why your dog needs them. What is a Mineral? A mineral is a naturally occurring inorganic solid, with a definite chemical composition, and an ordered atomic arrangement. What on earth does this mean we hear you wonder? Well, let’s break it down. Minerals are naturally occurring, meaning they are not made by humans. They are inorganic, meaning they have never been alive. They are solid, meaning they are not liquid or gas. Each of them has a unique structure and arrangement which is how we know what they are. For the dog we are interested in 17 essential minerals. We have macrominerals which are needed in larger amounts and trace minerals which are needed in smaller amounts. Macrominerals Calcium You’ll likely be familiar with calcium as you were probably told to drink your milk so you would have strong teeth and bones. Calcium is the main structural component of skeleton and teeth, but it also plays a role in blood clotting. In addition, it is involved in the intracellular messaging triggering the contraction of muscle fibres. Calcium also plays a role in fat oxidation and it carries ATP (energy) with magnesium. There is an increased risk of deficiency in: Diets containing large quantities of phosphorus and sodium. Fat malabsorption (fat binds calcium, reducing absorption). Vitamin D deficiency. Diets containing large quantities of oxalates. Signs of Deficiency: Poor bone mineralisation, Muscle cramping and spasm, Increased irritability of nerve cells, Abnormal blood clotting and increased bleeding after trauma. Chloride Chloride is one of the most important electrolytes found in the blood. It plays a key role in controlling the amount of water and type of compounds that go in and out of cells. It therefore plays a crucial role in homeostasis. Chloride also contributes to muscle function and this includes the heart. This mineral helps red blood cells exchange oxygen and carbon dioxide too! Lastly, chloride supports digestive processes through its role in the production and release of hydrochloric acid in the stomach, and as we know, without this, foods won’t be properly digested and subsequently absorbed. Low levels of chloride are usually found alongside existing health issues which result in electrolyte imbalances. Sources of Chloride: Himalayan Salt Seaweed Magnesium Here at My Pet Nutritionist, we have a thing about Magnesium, for good reason. If you want to know more about this trusty mineral, then check out our full blog here: Why Is Magnesium So Important to Your Pet But the one often forgotten role of magnesium is the part it plays in energy, so we’ll do a recap. The bottom line is that insufficient micronutrient intake results in poor ATP production in the mitochondria. Remember that ATP is the currency of energy and the mitochondria is the powerplant of the cell, where it all happens. Magnesium and copper are star minerals for making ATP and without enough ATP or energy, the body hasn’t got enough resources to do what it needs to! In addition, a deficiency in magnesium can lead to mitochondrial damage. Signs and Symptoms of Deficiency: Muscle cramps and spasms Anorexia, nausea, vomiting Arrythmias Sodium and water retention Impaired action of vitamin D Increased Risk of Deficiency: Diets emphasizing processed foods and refined grains (largely nutrient deplete) Strenuous training Periods of rapid growth Intestinal malabsorption Medications (diuretics, steroids, laxatives) As a note, magnesium deficiency has also been linked to increased inflammatory cytokines, so this is a consideration to make in any chronic inflammatory condition. Findings Here Phosphorus Phosphorus in mainly used for the growth and repair of body tissues – it is a component part of bones, teeth, RNA and DNA. In the form of phospholipids, phosphorus is also a component of cell membrane structure and of the body’s key energy source, ATP. Many proteins and sugars in the body are phosphorylated. In addition, phosphorus plays key roles in regulation of gene transcription, activation of enzymes, maintenance of normal pH in extracellular fluid, and intracellular energy storage. A range of foods contain phosphorus, mainly in the form of phosphates and phosphate esters. Phosphorus in seeds for example, is in the form of phytic acid, the storage form of phosphorus. Because many species intestines lack the phytase enzyme, much phosphorus in this form is unavailable for absorption. Low phosphorus levels in the body can include anorexia, anaemia, proximal muscle weakness, skeletal effects (bone pain, rickets, and osteomalacia), increased infection risk, ataxia, and confusion. But in most cases, hypophosphatemia (low phosphorus) is caused by existing health conditions, such as hyperparathyroidism, kidney disorders, and diabetic ketoacidosis. In cases of chronic kidney disease, their ability to excrete phosphorus becomes compromised. This is why low phosphorus diets are often recommended. Kidney Disease Potassium Another electrolyte, potassium is also involved in energy production and membrane excitability and transport. Throughout the body there are a number of functions that are potassium dependent. If potassium is deficient, these enzymes or proteins are unable to carry out their job as they should. For example, one heat shock cognate protein, involved in protein folding, autophagy, apoptosis and cell stability requires potassium to carry out these functions. In a deficit, cell senescence results, along with DNA damage, carcinogenesis, and neurodegeneration. Findings Here The bottom line is that potassium helps nerves and muscles to function correctly, it maintains a
Dogs are considered senior at half of their life expectancy. For some, this can come around a little earlier than expected. Are there changes we need to make as our dog ages? Well, there are always things we can do to support their health of our companion. Let’s take a look Aging is defined as the process of becoming older and whilst we still haven’t got to grips with the biological process in its entirety, there are some things we do know. Cells are thought to have a finite number of times they can replicate and divide. It is known as the Hayflick Limit. When a cell has reached that limit, it cannot divide anymore and will break down by programmed cell death. It is this limited capability that we see as aging. This programmed cell death usually occurs when telomeres (protective structures found at both ends of chromosomes) reach a critical length. It is therefore considered that telomere length serves as a biological clock. Telomere shortening occurs at every DNA replication – so if there is an increased need for cell replication, they will become shorter. This is why we are particularly interested here at My Pet Nutritionist, because there is such a high turnover of cells in the liver, gastrointestinal tract and skin (all parts of the body that we see many issues with). Shorter telomeres can also induce genomic instability and this sadly, is one of the leading factors in cancer. Cells have planned programmes to divide, replicate and ultimately die (apoptosis) – they get these messages from genes. When genes are unstable, their messages get a little like Chinese whispers and so the cells go rogue – dividing and replicating, but not dying. This aberrant growth is implicated in cancer. Diet can also affect telomeres. A diet contain omega-3 fatty acids is associated with a reduced rate of telomere shortening, Telomere length is positively associated with the consumption of nuts and fruits, Consumption of a diet including Vitamin E, Vitamin C and beta-carotene is also associated with longer telomeres – the inclusion of antioxidant compounds protects against oxidative damage. Dietary restriction also reduces oxidative burden, reducing damage to DNA – for this reason it is regularly associated with improved lifespans. In a study in Labrador retrievers, results indicated that 25 % restriction in food intake increased median life span and delayed the onset of signs of chronic disease. Findings Here The bottom line? The consumption of a whole-food, nutrient dense diet with the inclusion of omega-3 fatty acids is beneficial for the aging pet. Caloric restriction is also a consideration to make. On the other side of the scale, are there things that can negatively affect telomere length? Processed meats, high consumption of sugar over time and high intake of refined grains is negatively associated with telomere length. In short, the consumption of these foods is associated with shorter telomeres. If telomeres are shorter, the cell hits its limit sooner and carries out its programmed death sooner. Findings Here Cognitive Canine Dysfunction Cognitive dysfunction syndrome (CDS) is a progressive neurodegenerative disorder of senior dogs. It’s generally considered the dog version of Alzheimer Disease. It is thought that one third of senior dogs will show signs of confusion, restlessness, and less enjoyment of life. It is a result of a decline in higher brain functions, through degeneration. A variety of studies in the veterinary field have supported the proposal of nutritional manipulation, particularly with antioxidants as part of the treatment regime in cases of CDS and reported significant effects of modified diets. Evidence has demonstrated a place for the following nutrients: Antioxidants Alpha-Lipoic Acid Vitamin C Vitamin E L-Carnitine Co-enzyme Q10 EPA and DHA Phosphatidylserine It is considered that nutritional adjustment provided brain strengthening components, signalling enhancers, metabolic support, and antioxidants. Findings Here What was particularly interesting from the above study is that time spent active increased alongside the nutritional adjustment. Being sedentary is a shortcut to poor immune function largely due to lymph function. The Lymphatic System The lymphatic system is a network of vessels and nodes that spans the entire body. It is critical for health and for the immune system to function properly. Your Pet’s Immune System Both blood and lymphatic systems share many functional, structural, and anatomical similarities, but lymphatics are unique. Unlike the blood system, which is a closed loop with the heart actively pumping blood to oxygenate our tissues, lymphatics are open-ended. Movement of lymph is governed by rhythmic daily muscle movements propelling the fluid along network. The lymph fluid, called chyle, which contains immune cells, permeates every nook of the body. Movement of lymph fluid through the lymphatic vessels transports immune cells around the body, where they patrol all the remote corners of the body, keeping a lookout for anything untoward. The lymphatics also bring immune cells together in hubs of immune activity called lymph nodes. If the flow of lymph stops or becomes impaired, this vital immune surveillance and defence function can become compromised. And being sedentary sadly results in compromised lymph function. Therefore, movement for the aging dog is still important to support vital immune function. Within reason. We can’t hide from the fact that degenerative musculoskeletal issues are common in the aging dog, so care must be taken. Can Nutrition Support Joint Health What Is Pain and How to Look For It Obesity and Musculoskeletal Health in Dogs Natural Arthritis Guide and Herbs to Help Dogs You’ll be forgiven for thinking that lifestage nutrition is a bit of gimmick, but there’s no denying that the demands placed upon the body and brain are different across different life stages. For that reason, nutritional adjustment may be appropriate, depending on individual circumstances, lifestyle and health needs. If you would like further support for your aging or senior pet, then please check out our services to see if we may be able to help. Thanks for reading, Team MPN x
If you have a Dalmatian, chances are, you’ve been told or have read that he should really be on a low purine diet. We could easily make a list of low purine foods for you, but that wouldn’t be true My Pet Nutritionist style, so let’s take a look at the function of purines, and although they affect a range of cellular processes, they can be somewhat problematic for some dogs. What are Purines? Purines are one of the most common chemical compounds on the planet. There are both endogenous and exogenous. Exogenous purines are absorbed by the body through the foods eaten, and endogenous purines are made by the body itself. Purines and pyrimidines are the two families of nitrogenous base that make up nucleic acids – in short, they are the building blocks of DNA and RNA. A, C, G and T are the letters of DNA code, and they stand for: Adenine Cytosine Guanine Thymine Adenine and Guanine are both purines, and the rule of base pairing means that a purine will always pair with a pyrimidine. Purines have a number of functions in the body: Signalling molecule Provide energy Control cell growth Part of essential coenzymes Contribute to nervous system function (including neuronal development). It’s easy to see that purines perform many important functions in the cell, and so the balance between its synthesis and degradation is essential. When purines are catabolised, the result is uric acid. In all other mammals, apart from humans and Dalmatians, uric acid is then converted to allantoin, which is a very soluble excretion product. For us humans and those unlucky dogs, we excrete uric acid, through the kidneys (with some excreted through the gastrointestinal tract). Now uric acid is suggested to behave as a potent antioxidant. It is also thought to maintain blood pressure under low salt conditions and has been seen to function as an anti-inflammatory in certain diseases, but when levels become too high, in a condition known as hyperuricemia, problems can ensue. In humans, this can result in diseases such as kidney stones and gout and may cause hypertension. In Dalmatians, high uric acid levels result in bladder stones. Bladder Stones Bladder stones are rock-like formations of minerals that form in the urinary bladder and are more common than kidney stones in dogs. There may be a large, single stone or a collection of stones that range in size from sand-like grains to gravel. The general signs of bladder stones similar to the signs of an uncomplicated bladder infection or cystitis. – Hematuria (blood in the urine) – Dysuria (straining to urinate). Hematuria occurs as the stones rub against the bladder wall, irritating and damaging the tissue and causing bleeding. Dysuria may result from inflammation and swelling of the bladder walls or the urethra (the tube that transports the urine from the bladder to the outside of the body), from muscle spasms, or from a physical obstruction to urine flow. Large stones may act almost like a valve or stopcock, causing an intermittent or partial obstruction at the neck of the bladder, the point where the bladder attaches to the urethra. Small stones may flow with the urine into the urethra where they can become lodged and cause an obstruction. If an obstruction occurs, the bladder cannot be emptied fully; if the obstruction is complete, the dog will be unable to urinate at all. If the obstruction is not relieved, the bladder may rupture. The Natural Guide to Urinary Tract Health for Pets Other causes of urate bladder stones include liver diseases such as portosystemic shunts. The Lowdown on Liver Shunts in Dogs Dalmatians demonstrate a genetic mutation which affects their urate transport in the liver and kidney. Of interest, additional studies have found the same mutation in some Bulldogs and Black Russian Terriers. That said, the haplotype is not fixed for these breeds and so it suggested the disease could be eliminated through selection of the gene pool. There are schools of thought that the diseased allele arose through selection for more distinctive spots on the dalmatian, as smaller spotted Dalmatians are less likely to suffer the condition. Findings Here This is a point to note, as not all Dalmatians do form stones. Genetic mutations aside, there are additional factors which can affect purine metabolism and subsequent uric acid formation. High levels of uric acid are often associated with: Kidney disease Liver disease Endocrine and metabolic conditions – diabetes for example There are also schools of thought that high levels of uric acid are implicated in poor pancreatic function too. Findings Here Uric Acid and The Microbiota It is thought that around 1/3 of uric acid excretion occurs via the intestinal pathway. When uric acid is excreted into the gut, it is then metabolised by resident bacteria. What is interesting is that when kidney function is impaired, uric acid will mainly be eliminated by the intestine as compensation. It’s not therefore not entirely surprising that there is a correlation between efficient uric acid metabolism and certain strains of bacteria found in the gut. Human studies have found a significantly reduced bacterial diversity in patients suffering with gout compared to controls. Findings Here If we get into the science of it, Escherichia coli is thought to secrete an enzyme known as xanthine dehydrogenase which participates in the oxidative metabolism of purines, so as much as we pop E.coli on our baddies list, in this instance, it actually helps us (in moderation)! Findings Here It does go to show however, that if you do have a dog who isn’t efficiently metabolising purines, their gut health should also be something to focus on. 7 Steps to Optimal Gut Health Low Purine Die There are a number of breeds who are listed for their purine metabolism problems, they include: Dalmatian Beagle Basset Hound Bulldogs Cocker Spaniel Bichon Frise Miniature Schnauzer Lhasa Apso Miniature Poodle Yorkshire Terrier Dachshund Irish Terrier Irish Setter Newfoundland Black Russian Terriers As yet, there are
One of the most popular herbicides in the world, it was first patented by Monsanto in 1974. Since then, glyphosate tolerant genetically modified crops were commercialised, paving the way for its increasing use, year on year. Here at My Pet Nutritionist, this makes our stomachs churn a little, and we’ll let you know why. What is Glyphosate? Glyphosate is a systemic, broad-spectrum herbicide. This means that it moves throughout the plant, and kills any plant not genetically modified to resist it. Glyphosate is a strong chelating agent; it creates complexes that immobilise the mineral micronutrients of the soil (calcium, iron,magnesium, manganese, nickel, zinc) making them unavailable to plants. It also acts as a powerful antibiotic – killing all bacteria in the soil. Due to its antibacterial properties, glyphosate has been reported to affect the gut microbiota of animals, killing the beneficial bacteria and leaving the pathogenic ones behind. This has been linked to adverse effects in farm animals, which feed on glyphosate-treated soya and corn feed. For more information on the importance of a diverse microbiome, checkout our blogs: Here Here Here Glyphosate and Health The International Agency for Research on Cancer (IARC) of the World Health Organisation (WHO), classified glyphosate as a “probable human carcinogen”, following a thorough analysis performed by 17 independent world leading experts from 11 countries using only publicly available studies. The conclusion on experimental animals was based on two experiments where mice had developed malignant tumours as a result of exposure to glyphosate alone. Findings Here. Glyphosate and Hormone Glyphosate alone and glyphosate-based products alter the hormone metabolism in different mammalian cell lines and have been reported to reduce the conversion of androgens to oestrogens (resulting in production of more male than female hormones). In experimental studies with mice, glyphosate-based products also alter the reproductive hormone metabolism and reduce fertility. Findings Here. Glyphosate, Growth and Development Experimental animals exposed to glyphosate have given birth to foetuses with increased heart malformations and abnormalities, absent kidneys, distorted ribs, lungs and skeleton, as well as embryonic deaths. Findings Here. Glyphosate and the Nervous System Glyphosate and glyphosate-based products have been seen to affect the growth and development of nerve cells also. Glyphosate has been reported to disrupt the function of brain nerve signalling, brain cell organelles (mitochondria) and cause neuronal cell death. Findings Here. Whilst these all offer food for thought; we’re going to focus on cancer research a little further. When concluding that it is a probable human carcinogen,researchers took into consideration the strong evidence of genotoxicity (DNA damage) and oxidative stress (tissue/cell damage) in humans and laboratory animals following exposure to glyphosate-pesticides and its metabolites. As we know, the first step to cells becoming cancerous is unusual DNA (deoxyribonucleic acid) structure. DNA contains the instructions that ours and our dog’s cells need to develop, live, and reproduce. These instructions are passed down from parents to their offspring. Every cell must undergo growth, and then it must die. Cancer cells on the other hand receive aberrant instructions. Of interest here is the concept that these instructions are passed down from parents to their offspring, and in relation to glyphosate, it has been established as genotoxic. Here, you not only have to consider your dog’s exposure to the product, but that the damage could be seen in future generations, and equally, your dog could be experiencing health issues because of their parent’s exposure. This is of particular concern when a study highlighted glyphosate has been found in several commercial cat and dog foods on the market. Findings Here. As it is sprayed on many crops, and most commercial foods are crop based, this is of little surprise. Glyphosate has been implicated in the disruption of proteins crucial to detoxification pathways; it affects the host’s ability to remove other environmental chemicals, causing them to be more nephrotoxic than they would otherwise be. This is why, many reviews are now linking glyphosate to kidney disease of unknown origin and non-alcoholic fatty liver disease. Findings Here. Again, this is a worry if these modifications can be passed from generation to generation. Are dogs becoming less efficient at removing environmental chemicals, in a world where we have never had more? We don’t know the answer to that question, but its certainly worth considering. If you would like to learn more about detoxification pathways and toxins found in the home, check out our blogs: Here Here Here How much are us and our pets actually exposed to? Many laboratory tests have demonstrated the possible absorption of glyphosate in the gastro-intestinal tract of humans and mammals, as well as absorption through inhalation, ingestion, and dermal contact. In 2012 the German magazine Oko-Test found traces of glyphosate in wheat flour, oats, and bread in 14 samples out of 20 analysed. In 2014 the Moms Across America group and the SustainablePulse information website reported the presence of glyphosate in human milk in 3 out of 10 samples. In 2015, the National University of La Plata in Argentinadetected traces of glyphosate in 85% of the sample tampons purchased in supermarkets and all analysed samples of medical gauze and cotton. In 2016, research conducted by Boston University and AbraxisLLC revealed the herbicide’s presence in 62% of conventional honeys and in 45% of organic honeys. In 2016, another two studies conducted by the Munich Institute of the Environment and the Consumer Magazine 60 Millions de Consommateurs, found traces of glyphosate in 14 beers, among the best known in Germany (Beck’s, Paulaner, Warsteiner, etc.) and in panty liners from the feminine hygiene company Organyc. In Italy, 100 food products based on flour and 26 samples of drinking water were analysed by the magazine Test-Salvagente, they found traces of glyphosate in half of the food and in two samples of water. Findings Here. The fact that it finds its way into so many different products really shines a light on how we need to pay attention to everything we are exposed to or expose our pets to – including their
Being the most common clinical condition in adult dogs, periodontal disease raises the flag on why dental care is so important in optimal canine health. Sadly, here at My Pet Nutritionist, we see it, a lot. Periodontal disease begins when bacteria in the dog’s mouth forms to create a substance called plaque. The plaque sits on the surface of the teeth and with the help of saliva, it hardens to form tartar. Not only does it sit on the teeth, plaque and tartar seeps into gum lines which causes inflammation. Over a period of time, this inflammation and presence of bacteria causes damage to the structures surrounding the teeth; causing receding gum lines and eventually tooth loss. These bacteria can also travel to other parts of the body, causing a range of additional health concerns. So, let’s look at periodontal disease in more detail and what we can do to prevent it! But, before we get to the diseased mouth, let’s take a look at a healthy mouth. The Canine Mouth Puppies are born without teeth and they then develop 28 of them. They will shed these between 4-6 months of age as their 42 adult teeth erupt. A dog will possess: incisors canines premolars and molars Incisors are used for cutting food; dogs have 6 upper (maxilla) and 6 lower (mandible). Next come the canines, which are used to grab and tear food, there are 2 canines in the mandible and 2 in the maxilla. The premolars are used for chewing, tearing, and biting; there are 8 in both the mandible and maxilla. Finally, molars are used to crush food; dogs have 4 in the maxilla and in the mandible. Teeth in fact provide the first step of digestion, but over their lifetime and in consideration of genetics and poor hygiene, many dogs will lose most, or all of their teeth. Dental Disease From the moment a tooth erupts it is exposed to food, saliva, and bacteria. Periodontal disease occurs when there is a buildup of bacteria in the mouth, which forms plaque. Eventually,this hardens to form tartar. This can sit in the gum line causing inflammation, known as gingivitis. Left untreated, further harm occurs which results in periodontitis, where teeth fall out and damage can occur to the surrounding bone. Signs your dog has dental disease: Bad breath Pawing at his mouth Reluctance to eat Food or toys will have blood on them Smaller breeds are statistically more likely to suffer with periodontal disease, as are brachycephalic breeds. Their teeth are often closer together which means food and bacteria can more easily get stuck. But what is also interesting is that it is generally accepted that the inflammation and resulting tissue damage is due to an improperly regulated immune response to bacterial infection, and not solely from the bacterial pathogens themselves. This suggests that if your dog already has immune mediated health concerns, then they may be at a higher risk of dental disease. Findings here The point to make is that gingivitis is thought to be reversible, whereas periodontitis is not. Not only is the mouth and teeth a concern, but the bacteria found in the mouth of your dog can be released into the circulatory system, which then travels through the body. It has been found to damage cardiac tissue causing endocarditis (infection and inflammation in the heart). Studies have also shown that periodontal disease is linked to increased insulin resistance and kidney, and liver issues. Findings here All things considered, prevention is certainly better than cure, so what can we do? 1) Avoid ultra-processed refined foods Ultra-processed food is defined as any food that undergoes multiple processes like extrusion and milling. They may also contain added ingredients that are highly manipulated. Sadly, many dry based dog foods fall directly under this definition. In human Hunter-gatherer studies, it is demonstrated that cavities and gum disease were a rarity, and this remains in modern times; Aboriginals living a traditional lifestyle do not generally get dental disease until they adopt a Western diet. There are a number of reasons for this. The mouth, just like the gut contains its own microbiome. It is a community of microbes that maintain balance; the good guys can keep the bad guys in check. Not only do ultra-processed foods skew the balance in the mouth, but they do also the same in the remainder of the digestive tract. As we know, the gut houses much immune tissue, and so it does in fact train the immune response. As we mentioned early, it is thought that much of the damage originating in the mouth is due to an improperly regulated immune response and not solely the bacterial pathogens themselves. For this reason, we would advocate the removal of an ultra-processed diet for oral and gut microbiome health. For more information on the microbiome in your dog, check out our blog here. 2) Dental Sticks There are a number of chews on the market promoting oral health, but it is actually the mechanism of chewing that helps to reduce build up. Chewing stimulates saliva which produces anti-bacterial agents, helping to keep the mouth clean. Not only this but the abrasion that occurs during chewing helps to scrape deposits off the teeth. What type of chew is best? Here’s what the data suggests: Raw bones reduced mouth bacteria by 79% Daily brushing reduced it by 70% and, Marketed dental chews reduced it by 54-60%. Findings here Raw bones lead the way in reducing bacteria,and the added bonus? You know exactly what you are feeding. There is no long list of ingredients to consider. If you are opting for raw bones, ensure they are a manageable size for your dog; chicken necks and wings are a great place to start if you’ve never fed them before! If you’d learn to learn more about the benefits of chewing for your dog, check out our blog here. 3) Diet It is thought that periodontal disease may be related to
Everyday, ours and our pet’s bodies are exposed to toxins. They are produced internally in the body, like lactic acid and consist of waste products from gut microbes, hormones, and neurotransmitters. But the largest threat is possibly those external toxins, like air pollution, chemicals from cleaning products and volatile organic compounds from the plug-in air diffuser in your lounge. Here at My Pet Nutritionists, when considering your pet’s well-being, detoxification is largely looked at as part of the health picture. It is thought that in the 25 years between 1970 and 1995, the volume of synthetic organic chemicals produced tripled from about 50 million tonnes to approximately 150 million tons, and this number has grown year on year since. Findings here These toxins can disrupt essential biological structures in the body. A toxin is defined as any substance that must be neutralised and eliminated to avoid its promotion of ill-health if left to accumulate. What surprises most people is that the body produces waste products every second of every day in the form of used hormones, neurotransmitters, or oxidised lipids. For this reason, even if we manage ours and our pet’s environments well, we still need to support our detoxification system, simply to eliminate the exhaust fumes of daily life. So, what is detoxification? Detoxification is carried out by a range of mechanisms and this comes in particularly handy if one pathway is overwhelmed, another can pick up the slack. We can think of it like a waterfall, water will always find a way down. In a healthy system, toxins will be able to find a way out. Initially, the body will attempt to detoxify at source. These locations include the intestinal mucosa, the respiratory mucosa, the microbiome,and the skin epidermis. Whilst these also provide a physical barrier to prevent toxin penetration, they also express a range of enzymes which are essential in sweeping toxins away. Detoxification falls into three phases. The first two phases are concerned with breaking down the toxin in the body, and phase three is concerned with excreting it. For us to manage ours and our dog’s toxic load, all three phases need to be working optimally. Liver Guard Phase I PhaseI is primarily undertaken by a superfamily of enzymes and they are predominantly concentrated in the liver (but are found in the oral and nasal cavity). t also includes enzymes like MAOs or monoamine oxidases to deal with neurotransmitters (those chemical messengers involved in mood and behaviour ) and PON1 or paraoxonase 1 dealing with pesticides and oxidised lipids. The names aren’t important, but the point is that at this stage the body needs to be efficiently producing these enzymes to metabolise the toxins. So, it stands to reason that this stage is particularly nutrient demanding and sufficient levels of key vitamins and minerals like vitamin A, C, E, B1, B2, B3 and iron, along with cysteine, are essential. This phase also generates high numbers of reactive oxygen species, or ROS leading to oxidative stress (there is also evidence of poor antioxidant capacity in obesity). These enzymes are also highly polymorphic – which means they are prone to altered gene expression. If you would like to know how gene expression can alter detoxification in the cat, then check out our blog here. But, whether the expression starts to cause problems can often depend on the nature and exposure to toxins. Once toxins have been passed through phase I, they are not finished with. Intermediate metabolites are produced, and they sit in the body. t’s almost like putting your rubbish in the outside bin, but missing collection day. The rubbish remains. Welcome to phase II Within phase II there are number of pathways and they are all responsible for detoxifying different compounds. Methylation The process of methylation deals with heavy metals, plastics, medications, mould,histamine, hormones, and neurotransmitters. This process requires nutrients like folate, vitamin B6, zinc and magnesium. Many environmental factors can limit methylation capacity including low dietary intake of co-factors, use of proton pump inhibitor medication, stress, use of anti-depressant medication, gut dysbiosis, high exposure to toxins and a high histamine diet. This can then become more of an issue in those with genetic SNPs in the genes that code for the enzymes involved. Poor methylation can also impair bile synthesis, which then impacts on cholesterol maintenance and glucose metabolism. Sulphation The process of sulphation deals with heavy metals, heavy smoke, hormones, neurotransmitters, plastics, phenols, and medications including antibiotics. Efficient sulphation requires an adequate supply of sulphur (included in cruciferous vegetables for example), but also iron, molybdenum and vitamin B12. Deficiency in any of these can result in an accumulation of sulphites and then an increased sensitivity to sulphite containing foods or supplements (MSM for example). Since this pathway modulates catecholamine levels, poor function can result in higher circulating levels too. Glutathione conjugation This deals with heavy metals, plastics, mycotoxins, mould, heavy smoke, pesticides, and medications like steroids. Glutathione is a master antioxidant so is also important in neutralising the reactive oxygen species produced in phase I. Steady supply of the enzymes in this pathway relies on vitamin B2. But what is also of interest is that the more the glutathione pathway becomes overloaded with long-term paracetamol use, the more depleted glutathione stores become, which places increased pressures on other Phase II pathways and Phase I processes. Low selenium also contributes to poorer enzyme function here. Glucuronidation Glucuronidation is involved in managing heavy metals, sex hormones, neurotransmitters, plastics, mould, alcohol, smoke, medications including paracetamol,non-steroidal anti-inflammatories, warfarin and immunosuppressants. Important nutrients in this process include vitamin B3, B6 and iron. The glucuronidation pathway is particularly affected by digestive health. Anything that promotes gut dysbiosis, like antibiotics, high sugar intake or the use of certain medications which later digestive function can result in toxins being recirculated throughout the body. This then results in increased oxidative stress, which has its own ramifications throughout the body. Acetylation Acetylation supports the detoxification of smoke, halides, tyramine, caffeine, neurotransmitters, histamine, and
