This might be as dry as a rice cake and to be honest, we thought we might be able to put you to sleep but all joking aside, although this blog doesn’t give you exact solutions, you can see how we look at allergies and how we approach itchy pets with great knowledge and success. Now put on the kettle and don’t read this horizontally in bed; falling asleep is guaranteed. Although this is from a scientific and pathophysiological perspective, I’m yet to meet a conventional veterinarian who looks at itchy pets in the same way. Allergy/itching is one of the most prevalent problems seen by vets and My Pet Nutritionist to date. It’s almost become our life’s work to understand how and why this happens as we get clients everyday with the same issues. Natural means is really the only way to go to solve this issue but to do this successfully, we need to understand the complex immunity and physiological pathways and address is with nutrition and supplements. In short, itching and allergies are due to an overactive and underachieving immune system as well as possible genetic and nutritional snips and deficiencies. The immune system is so finely tuned you wouldn’t get your breath. There’s so much we don’t know and some of the following has thin scientific research. In more than basic terms the immune system is split into 2 parts, Th1 and Th2 (actually there is a more newly discovered TH3 and TH17 but let’s not complicate things). Both parts should work in harmony and balance. Th1 and Th2 cells are maintained in a carefully regulated balance. If a bacterium enters the body, it activates Th2 cells that dominate the network to begin a cascade of immune events leading to an antibody response that clears the infection. If a virus enters cells in the body, it activates Th1 cells which dominate and instruct the killer cell response to clear infected cells. Once the infection is cleared up, suppressor cells are activated to shut down the dominate response and bring the network back into what we call a resting state. If the suppressor cells do not act to bring the network back to a resting state, a pathological Th1-or Th2 dominated immune system results. A Th1 dominated immune system is characteristic of food intolerances and autoimmune diseases, such as type 1 diabetes where the immune system is attacking normal tissues. A Th2-dominated immune system is characteristic of allergies and cancer and so forth. The incessant itching arises from an excessive and dominant reaction in the immune system. In Th2 allergic reactions (IGE), histamine is the compound released. There are several things we need to consider to piece it all together. Breeding has a lot to do with it and can dominate how well they will be in life, unless you have people like us on board. Factors to be considered are: Genetics; it’s like a lottery and no matter what kennel club certifications you have there are no guarantees. Certain breeds are always more at risk. Foetal development and birth; how healthy is the mother, what is she fed and how many litters she has sired previously, all come into play. Certain breeds don’t experience the healthy birthing through the canal such as some French Bull dogs. C-section is proven to under develop the much needed microbiota in your pet’s gut and can pre determine how balanced immunity will be. During pregnancy the mother is TH2 dominant which means so is your pup or kitten when born, this is cleverly put back into balance during weaning. Breast feeding and weaning; feeding from mother and getting the first colostrum and being fed like this for a good 10-12 weeks is so important for immunity and reactions. Many people arrive home with their new pet at 8 weeks’ old which is way too young. This might not allow for puppy or kitten to modulate immunity and come out of TH2 dominance and balance nicely. Environmental challenges in the early months; Initial vaccinations are important but timing is essential in allowing the immune system to respond accordingly. Also being exposed to different proteins and a healthy diet helps build a positive immunity and reaction to foods in future months.The first few months determine a lot and you don’t always have control over this. How our pet interfaces with the world, very much dictates whether immune dysfunction comes into play from the above points. The below considerations need to be looked at in its entirety not individually. Causative factors of itching to be considered: Physiological and emotional stress; we know stress triggers inflammation and a TH2 dominance, those with allergies are naturally be more TH2 dominant. Intestinal permeability; allowing for the escape of undigested proteins and pathogens through the gut wall and directly into the bloodstream, evoking prolonged inflammatory immune responses. Stress, diet, poor microbiota and environmental toxins can all destroy epithelial mucosa that cause intestinal permeability. Altered gut microflora; c-section, early weening, stress, diet, hormones and so on can effect gut bacteria and immunity. Hormonal imbalances; cortisol, oestrogen, thyroid hormones are actively associated with histamine behaviour and imbalance of immunity TH2 dominance. We de sex most of our dogs and wonder why they have so many issues. I’m glad no one gave me a hysterectomy in my first few years of life. Diet & nutritional deficiency; poor or an inappropriate diet can trigger TH1 or TH2 dominance and so will make reactions worse. Some foods such as wheat, grains, soy, gluten and corn are known foods to elicit reactions but it can get really complicated. Vitamin D and zinc are the most prevalently deficient in animals with allergies. Genetics; certain genetic polymorphisms affect immune TH1/TH2 dominance, DAO/MAO polymorphisms mean genetically your pet is less able to metabolise/breakdown histamines in the body. We know histamine to be the most related immune response to intolerances and allergies (a.k.a Histamine intolerance). Blog on Histamine Intolerance here. Heavy metal toxicity; we don’t need
Many clients come to My Pet Nutritionist with their itchy pet, usually dogs, in complete dismay after trying several things to alleviate the itch. Some of these wonderful people have gone all out, trying a fresh diet, raw food, supplements, testing for food and environmental allergies, food sensitivities and so on. Whilst being armed with lots of information and avoiding the ‘supposed culprits’ the itching has not got any better. If anything, at times, it seems worse. We have specialised in functional medicine for a very long time and in the exciting world of human nutrition, we are closely studying genomes, genetic polymorphisms and how nutrition can influence health, based on our genetic make-up. Welcome to the world of epigenetics and nutrigenomics! Although we are studying the dog genome (not cats of yet), we are far behind in comparison to the world of human nutrition. Dogs in particular share a lot of the same pathophysiology in function and disease. We have therefore applied a lot of what we have learnt and researched in the human arena to pet’s health and gaining some great results. In particular, with itchy dogs and what we know in human nutritional terms as ‘histamine intolerance’. Histamine is a necessary part of physiological functions in animals such as protecting against infection and inflammation. It regulates gut function, especially the release of gastric acid as part of the breakdown of proteins in the digestion of food, it acts as a neurotransmitter affecting cognitive function and in dogs helps to deal with anxiety. Histamine is either stored or inactivated by degradative enzymes, Histamine-N-methyltransferase or Diamine Oxidase (DAO). DAO will reside in the GI tract where nearly all histamine from food is metabolised (destroyed/eliminated) by DAO. Due to genetics or nutritional deficiency DAO and Histamine-N-methyltransferase production can be lacking and therefore histamine can build up and here in lies the problem. Histamine can also be naturally occurring in foods or can release additional histamine known as a ‘histamine liberators’. Those naturally containing high histamine foods are often fermented such as kefir and sauerkraut and other foods such as tomato and spinach. Foods known as liberators are those such as strawberries, citrus fruits and nuts. Histamine levels only continue to rise the longer the food sits within the gut and ferments. You’ll find many nutritionists are recommending fermented foods for digestive health and itchy dogs. This can make the problem 10 times worse until the issue at hand is resolved. Even certain drugs such as antihistamines can cripple DAO function and make symptoms worse. So you see, even if you remove foods that you know your dog to be intolerant or allergic to, if they eat foods containing or releasing high amounts of histamine or don’t naturally produce enough enzymes to break them down, symptoms won’t be relieved. In our practice we go on a naturally low occurring histamine diet, considering the reactivity of the immune system, improve DAO and methylation function by adding in certain nutritional ingredients such as magnesium, vitamin C, B6, methyl folate etc, all whilst considering every system within the body. To find out more or to book a consultation with MPN, please check us out. We hope this helps folks! MPN Team x
Looking from a holistic perspective, there are many factors as to why a dog may be predisposed to being itchy. This could be genetics, the environment and how effective a dog’s immune and detoxification system is. We live in a highly toxic environment where our pets are often over vaccinated, fed highly processed diets and have those genetic predispositions we just mentioned. Puppies are also all too often weaned off of mother’s milk too early, to allow for a fully acquired immune system. There are a few reasons why your pet could be itchy but either way, it’s a physiological, immunological response that needs to be put back into balance. Whilst detecting the reasons why, addressing the inflammation caused, can sometimes be tricky. Hundreds of cats and dogs have come to us with the complication of knowing what elicits the reaction but even still, can’t get a handle on the scratching. This is where we use a layered approach to looking at all elements of the physical body. The cause of itching in dogs is largely due to allergies. Approximately 1 in 5 dogs have allergies that are often diagnosed as Atopic or Contact Dermatitis. This could be from a number of allergens such as grass, moulds, foods, household items and parasites. Allergies in dogs often manifests in constant scratching, rashes, ear infections, weeping eyes and hotspots and can become a real problem for dogs and their owners. It’s actually one of the most common complaints we see in clinic today. So your cat or dog is probably scratching, licking their paws, backs of legs and belly. They may also be sneezing, have weeping eyes and ear problems. To start to fix a problem, we need to know what is causing it. There are generally 3 main reasons why your dog may be itchy. Understanding the causes can help us in our steps to an itch free dog. 1. Environmental allergies. This is caused by inhaled allergens and this could be to certain pollens, dust, mould, household products and may be all year around or just seasonal. An environmental allergy accounts for the majority of dermatitis in dogs. 2. Food allergies are less common but intolerances and sensitivities are very common. The most common food suspects are corn, maize, chicken, beef, soy and gluten but the list can be endless. 3. Contact allergies.This is often a reaction to parasites such as fleas, or mange, grass or household products such as detergent you’ve used to wash bedding for example.Flea contact dermatitis is probably the most common of all of these. It’s important you get a diagnosis by your vet or a clinic like My Pet Nutritionist, as we need to know what your dog is reacting to. In rare cases itching can be due to more serious disease such as kidney disease or thyroid disease, so make sure you get this checked out by a professional. Many tests for sensitivities and allergens are not very accurate but for foods we currently use Nutriscan. http://www.nutriscan.org Environmental allergy testing is some of the most accurate and we suggest going to your vet for this. Allergies are caused by an overactive immune system that perceives harmless substances as threats and intolerances caused by poor functioning gut health. Once we identify those substances, removing them are important but we still need to consider other steps to get results. Imagine your immune system is a scale. It’s tipped far one way and we need to get it back into balance. Quite often, if the offending allergens, foods etc are removed, your pet can still experience itching. Each positive step you take is one step closer to that scale being completely in balance. Supporting digestive health can be a first step in aiding allergies and intolerances. Nutrition Poor quality food in itself generally depletes the body and immune system. You see, it’s all about the immune system working effectively for an itchy dog. Many commercial diets are lacking in antioxidants and enzymes that are abundant in fresh, raw foods and lightly cooked foods. These elements are essential to well-being but are killed by high heat processing in all of the cooked, packaged dry and tinned foods on the shelves today. Dry food for example contains very high starch content even if your dog food does not contain grain. The starch is required to stick the kibble together and starch equals a high sugar content. Sugar is bad for your cat and dog as the sugar can feed different bacteria, virus, yeast and cancer. Not to mention itching dogs. If you suspect your pet has a food allergy or sensitivities and you haven’t done a test yet or the test is inconclusive, then an elimination diet also known as a ‘feeding trial’ can be a thorough way to detect the offending foods. An elimination diet involves feeding an extremely simplified diet for 12 weeks observing any signs of intolerance such as itching, diarrhoea, weeping eyes and a yeasty smell. After 12 weeks of a simplified and uniform recipe, we start introducing different protein sources and sticking to one per week and observing reactions. It’s always good to start with single proteins your cat or dog has not previously been introduced to such as kangaroo or horse. Don’t feed treats other than the pure meat you are feeding for main meals that week. Treats if possible should be avoided. Clean filtered bottled or even better still, distilled water should be given, not regular tap water. Sometimes we check for allergies and intolerances and there aren’t any. This could be simply because the coat and skin is dry and there’s a lack of omega oils in the diet (this should always be considered first), but sometimes and more often there’s an issue called Histamine Intolerance. Detoxify General lifestyle choices and toxic overload, challenges the immune system and puts it under more pressure every day. To help the itch, we must remove toxicity in your cat and dog’s life. Your
