If you read our latest blog then you will understand the important role the cardiovascular system has on maintaining homeostasis, and more. With many breeds predisposed to health issues, it pays to consider if there are dietary compounds which can support heart health. Here at My Pet Nutritionist, it’s something we deal with regularly, so we thought we’d put together our top nutrients for heart and cardiovascular health. Magnesium Taurate One of the most abundant minerals in the body, along with calcium and phosphorus, magnesium is essential to bodily function. Whilst there is some disagreement on the numbers, anywhere from 60-70% of the body’s magnesium is found in bone; the rest is in cellular fluid and soft tissue. Magnesium deficiencies have been linked with cardiovascular disorders, including high blood pressure and abnormal rhythms and there are a number of mechanisms in which magnesium supports heart health and function. Magnesium naturally competes with calcium which is essential in generating heart muscle contractions. Calcium stimulates the muscle and magnesium counters it which helps them to relax (this is also why magnesium is used in cases of spasms). When magnesium levels are low, calcium can overstimulate heart muscles causing a rapid or irregular heartbeat. Magnesium is thereforekey to maintaining balance. Magnesium taurate contains the amino acid taurine and it’s this combination that supports healthy blood pressure; to this end it is suggested that this form bolsters heart health. Methylated B Vitamins There are eight B vitamins: B1 Thiamin B2 Riboflavin B3 Niacin B5 Pantothenic Acid B6 Pyridoxine B7 Biotin B9 Folate B12 Cobalamin These vitamins are involved in many functions as they help a variety of enzymes do their jobs – they help release energy from macronutrients and transport oxygen and energy containing nutrients around the body. Studies have noted that suboptimal serum levels of folic acid, vitamin B12 and vitamin B6 may underlie the development of heart disease. It is suggested that such deficiencies lead to inadequate production of S-adenosyl-methionine, creating a state of hypomethylation. This, in turn, may damage the DNA in arterial cells. Methylation is a biochemical process which involves the addition of a ‘methyl group’ to other molecules and is dependent on the availability of a number of key nutrients. When these B vitamins are supplemented in their methylated form, it’s almost like it’s one less job for the body to do. Omega 3’s How Omega-3 Fatty Acids May Affect the Heart: Lower triglyceride levels, increase HDL (ie, good cholesterol) Lower resting blood pressure Decrease platelet aggregation and prevent blockage of coronary artery Decrease risk of arrhythmias (abnormal heart rhythm) Increase compliance of arteries Decrease atherosclerosis Reduce inflammatory markers There is evidence of rapid declines in coronary heart disease mortality with the consumption of oils rich in alpha-linolenic acid. Findings Here Studies have demonstrated a significant reduction in risk of sudden cardiac death in humans consuming the most linolenic acid. A diet rich in linolenic acid has been associated with a lower incidence of calcified coronary plaques along with a reduced risk of cardiovascular mortality, which subsequently lowers the all-cause mortality levels in humans. Findings Here In Humans, the Lyon Diet Heart Study is perhaps the most well-known, and it separated 605 myocardial infarction survivors into two groups, one group was placed on a low-fat diet, and the other on a Mediterranean diet including margarine enriched in linolenic acid (1.1 g/day). After a two-year follow-up, the incidence of cardiovascular disease, including cardiac mortality, decreased dramatically (73%) in the intervention group. This raised the possibility that the inclusion of linolenic acid in the diet can significantly improve cardiovascular health. Evidence has suggested that omega-3 supplementation has reduced the incidence of atrial fibrillation in dogs and as we know, atrial fibrillation is a heart condition that causes an irregular and abnormally fast heart rate. Findings Here There is also data which suggests omega-3 supplementation significantly affects survival rates in those dogs suffering with heart failure secondary to DCM. Findings Here It is thought that the effect of omega-3 is multifactorial, but they include significant effects on sodium, potassium, and calcium channels. It is also considered that omega-3’s reduces platelet aggregation, which mitigates risks of clots and therefore won’t impede blood flow to the heart. Findings Here COQ10 Coenzyme Q10 (CoQ10) is an essential compound of the body which is synthesized in the mitochondrial inner membrane. It has many important functions in human body. Firstly, it can be named the key-component of electron transport chain in mitochondria necessary for ATP production and secondly, in addition to its important role in electrons’ transport, COQ10 can act as an intercellular antioxidant, protecting the plasmatic membrane against peroxidation. Oxidative stress is considered to be an essential player in the development of cardiovascular disease, and it is this theory that suggests antioxidants’ like COQ10 can subsequently lower the risk. In the body, COQ10 is found in all systems of organs. The highest concentration of ubiquinone is noted in the tissues of the heart, kidneys, liver and muscles. In humans, three out of four patients with heart diseases have low levels of CoQ10. It was noticed that CoQ10’s plasma levels in patients with ischemic heart disease and dilated cardiomyopathy are much lower than in healthy ones. Depending on the severity of heart injury, circulating level of COQ10 decreases in direct proportion to disease progression. Furthermore, heart failure is related to a chronic pro-inflammatory state and there are increasing studies that establish anti-inflammatory properties of COQ10. CoQ10 deficiency is frequently encountered in dilated cardiomyopathy, and this may be reversible by the COQ10 administration. In a prospective, randomized, double-blinded, placebo-controlled trial in children with dilated cardiomyopathy, COQ10 administration for 6 months resulted in improvement of diastolic function and a lower mean score for the index of cardiac failure. Findings Here Hawthorn Hawthorne is widely used in Europe as a cardiotinic and for congestive heart failure. The principle active components in hawthorn leaves, berries, and blossoms are flavonoids. One of these flavonoids, proanthocyanidin, has especially important cardiovascular effects. Mechanisms
Kennel cough is a broad term covering any infectious or contagious condition of dogs where coughing is one of the main symptoms. It’s sadly a common occurrence in the dog population, so let’s take a look at what it actually is and our top tips for prevention and management. Did you know several viruses and bacteria can cause kennel cough, and often at the same time? They include (but are not limited to): Adenovirus type-2 (distinct from the adenovirus type 1 that causes infectious hepatitis), Parainfluenza virus Bordetella bronchiseptica. Canine Adenovirus Type 2 Infection CAV-2 infection is a common but transient contagious disease of the respiratory tract of dogs, it tends to cause mild fever, nasal discharge, coughing, and poor weight gain. Viral entry is generally by inhalation of infected particles followed by viral replication in the cells of the upper respiratory tract, mucous cells of the trachea and bronchi, bronchiolar epithelial cells, and others. Infection with CAV-2 is generally deemed mild unless complicated with a secondary bacterial infection or coinfections with other viruses like distemper virus. Experimental work suggests CAV-2 reinfection may lead to hyperreactive airways, which is a nonspecific condition where the bronchial mucosa becomes highly responsive to irritation caused by cold air, gases, or cigarette smoke. Canine parainfluenza virus (CPIV) This virus is a highly contagious ribonucleic acid virus that causes respiratory disease in dogs. Dogs with CPIV may exhibit no clinical signs or mild clinical signs of a dry, harsh cough for around and up to 7 days, with or without fever and nasal discharge. These signs are generally more severe in those dogs with viral or bacterial coinfections. CPIV suppresses the innate branch of the immune system, resulting in the loss of cilia and ciliated epithelium, making the host more favourable for coinfections. This is why it is of concern for immunocompromised dogs, along with puppies, or the senior dog. CPIV survives on nonporous surfaces for 4 to 12 days, but it is susceptible to a range of disinfectants. Bordetella bronchiseptica B bronchiseptica is a gram-negative, aerobic coccobacillus that is often implicated as a complicating factor in dogs with concurrent viral respiratory infections. After B bronchiseptica colonises the airways, it can evade the immune system by expressing various virulence factors that lead to: Direct cellular injury of respiratory epithelium Impaired immune recognition Disrupted immune clearance It seemingly manages to paralyze the mucociliary apparatus—a key component of the respiratory tract’s local defence mechanisms. The mucociliary apparatus moves inhaled debris and potentially harmful pathogens away from the lower respiratory tract, decreasing the risk of colonisation by these organisms. By doing this, B bronchiseptica not only improves its own virulence and chance for colonisation, but also paves the way for infections of the lower respiratory tract. In cases of infection, some dogs suffer mild disease including nasal discharge and intermittent coughing, whereas others develop severe pneumonia. Canine Infectious Respiratory Disease Complex (CIRD) The coinfection of these pathogens, among others, manifests as CIRD and they act synergistically to causes respiratory illness. This is why a multifaceted approach to prevention and subsequent management is crucial. Immune Function As you have likely noticed, CIRD is an attack on the immune system. The pathogens hijack many defences which results in the lingering symptoms. So, a well-functioning immune system is the first part of your dog’s defence against kennel cough. Vitamin C contributes to immune defence by supporting various cellular functions of both the innate and adaptive immune system. Vitamin C helps encourage the production of white blood cells known as lymphocytes and phagocytes, which as you know if you read our guide to the immune system, they help protect the body against infection. Your Pet’s Immune System Vitamin A helps maintain structural and functional integrity of mucosal cells in innate barriers (skin, respiratory tract etc). It is also important for the functioning of natural killer cells, macrophages, and neutrophils. In the adaptive immune response, vitamin A is necessary for the functioning of T and B cells and therefore for the generation of antibody responses to an antigen. Vitamin A also supports the Th2 anti-inflammatory response. In the innate immune system, vitamin B6 helps regulate inflammation and has roles in cytokine production and natural killer cell activity. In the adaptive immunity system, vitamin B6 plays a role in the metabolism of amino acids, which are the building blocks of cytokines and antibodies. B6 is also involved in lymphocyte proliferation, differentiation and maturation and it maintains Th1 immune responses. Stock or broth made by boiling chicken bones is a great option and contains gelatin, chondroitin and other nutrients that are helpful in gut healing in immune function. Zinc is a particular powerhouse when it comes to immune function. It has antioxidant effects protecting against reactive oxygen species, it helps modulate cytokine release and also helps maintain skin and mucosal membrane integrity (that first line of defence). In the adaptive immune response, zinc has a central role in cellular growth and differentiation of immune cells. It plays a role in T cell development and activation and supports the Th1 response. We find vitamin D receptors throughout the immune system which demonstrates the role it plays in its function. Vitamin D stimulates immune cell proliferation and cytokine production, and it helps protect against infection caused by pathogens. It also demonstrates an inhibitory effect in adaptive immunity, suggesting that it is in fact an immune modulator. This is often why we notice increased cases of autoimmunity where there is low vitamin D. Further to this, we often note higher rates of infection (with a range of pathogens) when there are existing health issues that involve: The gut Thyroid Kidneys Liver function 7 Steps to Optimal Gut Health Liver Health Kidney Disease Therefore, ensuring you take a holistic approach to your dog’s health is vital. But, we do have some tricks up our sleeves when it comes to dealing with kennel cough in dogs. Mushrooms Mushrooms are thought to have antimicrobial, anti-inflammatory, cardiovascular-protective, antidiabetic, hepatoprotective, and anticancer
It turns out September is Happy Cat Month. Now, if you’re like us here at My Pet Nutritionist, we sometimes get a little lost if certain appreciation days are National or International, but either way, what better time to share some of our top tips for keeping your feline friend both happy and healthy? 1) Species Appropriate Diet Cats have evolved as hunters that consume prey containing high amounts of protein, moderate amounts of fat, and minimal amounts of carbohydrates. The cat has seemingly evolved as a strict or obligate carnivore; meaning they nutrients they require are found in animal tissue. As such, the consensus is that there is no current nutritional basis for energy to be supplied by carbohydrates; providing other nutrients are being supplied. There is also evidence that there is limited amylase activity in the pancreas and small intestine (even compared to dogs), which may explain why some cats will not tolerate high starch diets. The fact that cats are also defined as hypercarnivores (small carnivorous mammal with a proportionally large brain) indicates they have a high brain glucose demand. This high demand simply could not be met by carbohydrates present in a natural prey diet; and so, cats therefore have a higher rate of gluconeogenesis (the production of glucose from non-carbohydrate sources). It is considered that due to the limited intestinal enzyme capacity, consumption of excessive amounts of digestible carbohydrates will not lead to glucose absorption, but rather a substrate for increased microbial fermentation, causing gastrointestinal adverse effects. In similar tests to dogs, cats are able to target their nutrient intake. When given the choice, they will specifically aim for a high intake of protein. In times of low protein, they will opt for an increased fat intake to achieve balance. When carbohydrate intake was high, this limited intake of other nutrients and resulted in deficits – for that reason, a carbohydrate ceiling is proposed for the cat. Findings Here 2) Limit Toxin Exposure Whenever the body is exposed to something, it must do something with it. In the case of toxic substances, it must make it less toxic, hence the word detoxification (de=remove or reverse). Detoxification pathways fall into three phases. The first two phases are concerned with breaking down the toxin in the body, and phase three is concerned with excreting it. For us to manage ours and our cat’s toxic load, all three phases need to be working optimally. Phase one is particularly nutrient demanding, and it produces a lot of reactive oxygen species in the process (those cheeky things that result in oxidative damage which destroys and damages cells). Phase two is also nutrient demanding, but drafts in many different processes depending on the compounds being detoxified. Phase three deals with getting rid of them once and for all, and occurs in the gut, skin, liver and kidneys. So, it stands to reason that optimal organ function is helpful here. The issue is that the cat is playing catch up. They aren’t as efficient at these processes as other species, like us, and when we are increasing toxin burden year on year, it becomes problematic. They have even demonstrated a total inactivation of certain genes responsible for certain phenol detoxification. So, whilst limited toxin exposure is important for us all, it’s even more important for our cats. Where possible, limit exposure to: Plastics Mould Smoke Air pollution Heavy metals VOCs – air fresheners, cleaning products, fabric softeners The Struggle of The Cat in Our Toxic World Is Your Toxic Home Affecting Your Pet 3) Offer Fresh Filtered Water Cats don’t naturally have a thirst drive, they evolved to survive in hot, desert climates. But when they have access to their natural diet, a large percentage of that would contain moisture. Dry food increases thirst behaviour: this is demonstrated in dog studies time and time again, but there is still a mismatch between the cat’s evolutionary thirst (or lack thereof) and the moisture in their diet. Water is possibly the single most important nutrient for the body. 1) It functions as a solvent that facilitates reactions and also transports nutrients around the body. 2) Water is able to absorb heat from the processes occurring in the body, without the overall body temperature changing too much. 3) It further contributes to temperature regulation by transporting heat away from working organs through the blood. 4) Water is crucial in the digestive process; it is a key player in hydrolysis, which is the splitting of larger molecules into smaller molecules (through the addition of water). 5) The kidneys also use large quantities of water when eliminating waste. A high moisture diet is beneficial to the cat to ensure they are hydrated, but fresh filtered water should also be offered. As in point two, toxin exposure should be limited and even in the most developed countries there is contamination. Chlorine, heavy metals, plastic fibres and pharmaceutical compounds are regularly found in tested tap water, which all pose risks to our feline friends. The Importance of Water 4) Let them Hide! Cats get stressed. There is no denying that. But they are often a little more subtle in their anxieties than other animals. As in humans, cats will have the same response to stress. They may choose to fight, flight, or freeze. When they fight, they become aggressive and defensive. Flight will see them withdrawing from the threat and perhaps running away. When cats freeze, they crouch, lie still, and try to avoid any attention. There is a ladder of response in most animals, and this is no different in cats. They will often show subtle signs of discomfort or stress. If the trigger doesn’t disappear, the behaviours will progress. You may start with the flat ears, then the pupils will dilate. You may have a low growl or a silent hiss. Them running off or lashing out with their teeth and claws may be a few steps up the ladder. For some cats, there are triggers
One of the most controversial discussions in the pet world is the link between diet and heart health – sadly, there are a number of reasons why heart function can be compromised, including genetics. Here at My Pet Nutritionist, we don’t think you can look at a health issue without considering the normal functioning of the system, so we thought we’d explore heart health in a little more detail. Let’s get cracking. The Cardiovascular System The cardiovascular system includes the heart and blood vessels (veins and the arteries). The function of the heart is to pump blood. The right side of the heart pumps blood to the lungs, where oxygen is added to the blood and carbon dioxide is removed from it. The left side pumps blood to the rest of the body, where oxygen and nutrients are delivered to tissues, and waste products are transferred to the blood for removal by other organs (like the kidneys). The heart is a hollow, muscular organ, divided into 4 chambers. There are upper chambers on both the left and ride sides of the heart called the left and the right atria. There are also 2 lower chambers called the left and right ventricles. A series of valves keep blood flowing in one direction through the heart. Each ventricle has an inlet and outlet valve. A heartbeat is actually the sounds of different valves closing. How does a Heart Beat? The heart beats because of electrical currents. Rhythmic electrical impulses or discharges cause the contraction of muscle fibres in the heart. At rest, the discharge is around 120 times per minute in a cat and 60-120 times per minute in the dog. Heart sounds are produced by the rapid acceleration and deceleration of blood and the resulting vibrations in the heart due to the circulation of blood. In dogs, 2 heart sounds can normally be distinguished. Calcium plays important roles in the electrical activity and pumping function of the heart. Calcium particles enter the heart muscle during each heartbeat and contribute to the electrical signal. When calcium is removed, relaxation is triggered. Potassium too plays a vital role at a cellular level. It’s movement in and out of cells helps maintain a regular heartbeat. Low levels of potassium lead to irregular contractions. When there is a high level of a compound in the body, it is termed, hyper, when there are low levels of a compound in the body, it is termed hypo. Sadly, too high and too low levels of all the above can result in irregularities in heart function. Hypokalaemia – low potassium Severe hypokalaemia is likely to cause skeletal muscle weakness, cardiac arrhythmias, and electrocardiographic abnormalities. Causes: Excessive diuretic therapy Vomiting and diarrhoea Diabetes Medications – steroids Conditions including Cushing’s Syndrome and liver failure. Hyperkalaemia – high potassium In this case, cardiac arrhythmias are common. Causes: Insulin deficiency Certain medications (NSAID’s, ACE-inhibitors) Potassium containing antibiotics Hypercalcaemia – high calcium Hypercalcaemia may present as fatigue, depression, confusion, anorexia, nausea, vomiting, constipation, peptic ulceration, or pancreatitis. Cardiac arrhythmias can occur. Causes: Parathyroid related Vitamin D intoxication Hyperthyroidism Vitamin A intoxication Cancer-related Renal failure Hypocalcaemia – low calcium Cardiac arrhythmias will be noted. Causes: Decreased intake of Vitamin D Vitamin D malabsorption Parathyroid related Acute renal failure Sodium is also important for heart health. It initiates contraction in muscles, in both skeletal and cardiac. Sodium deficiency is associated with restlessness, tachycardia, polyuria, and dry and tacky mucous membranes. The current minimum requirement for sodium has been established at 13.3mg/kg bw for dogs, but a higher quantity is suggested for bitches during gestation and lactation. In addition, greyhounds and sled dogs are allocated a higher requirement based on their high levels of exercise. At present, commercially available dog foods provide sodium intakes in excess of minimum requirements. Whilst some posit that dogs are increasingly adaptable to sodium intake, a study carried out in 2003 identified 82 dogs with dilated cardiomyopathy. They established that those with congestive heart failure ate significantly more sodium than those dogs without congestive heart failure. It pays to note that 25% of total daily sodium intake came from treats and table scraps, however. Findings Here Heart Murmurs Heart murmurs are vibrations that can be heard coming from the heart or major blood vessels and generally are the result of turbulent blood flow or vibrations of heart structures, such as part of a valve. Murmurs are typically described by their timing, their intensity, and their location. Not every murmur indicates a heart disorder, however. A heart murmur is like when you hit some white water on a usually calm river. Congenital Murmurs and Acquired Murmurs Congenital murmurs are associated with heart defects that the pet was born with. However, sometimes the defect is only detected later in life. An acquired murmur is a murmur that a pet acquires during their life. These can be benign, but more often (especially in dogs) are associated with developing heart disease. Heart Disease causing Murmurs Mitral valve disease (MVD) is a common acquired heart disease accounting for about 75% of cardiac disease seen in dogs in general practice. Prevalence of MVD increases with age and can be seen in high-risk breeds such as the Cavalier King Charles Spaniel. It is most common in small-medium sized breed dogs. Dilated cardiomyopathy (DCM) is the other main acquired heart disease seen in dogs. It can be primary in origin or secondary to dietary deficiencies or doxorubicin toxicity (chemotherapy medication). DCM has been reported in Dobermans and Golden Retrievers but other large or giant breed dogs have also been described. DCM is characterised by ventricular dilatation and systolic dysfunction. This poor systolic function means that a heart murmur is often low grade in its intensity. As DCM is regularly considered an inherited condition, it has been posited that certain breeds may need higher concentrations of amino acids like taurine and l-carnitine. Taurine and Heart Healt Taurine is the most abundant intracellular sulphur-containing amino acid. Although it can be
Here at My Pet Nutritionist we often deal with dogs who have either a congenital or acquired liver shunt. There is often some misunderstanding around liver shunts because in medicine there are procedures where a “shunt” is inserted into the brain to drain excess spinal fluid – but a liver shunt is a little different, so let’s take a look at what they are and considerations to make in any treatment plan. Liver Function The liver processes blood and the substances found within it. In a healthy animal, blood draining from the intestines passes immediately through the liver for nutrients to processed and for toxic compounds to be removed. The blood then re-enters main circulation. But in an animal with a portosystemic shunt (liver shunt), a significant volume of blood bypasses the liver, enters main circulation and heads to the heart where it can be pumped around the body. As the blood being pumped around the body is technically unfiltered, toxic compounds can build up. In addition, the liver is unable to break down nutrients or regulate the body’s energy balance. In most cases, a liver shunt is caused by a birth defect. This is known as a congenital portosystemic shunt. But acquired shunts can also occur – this is usually linked to primary liver disease, or a disease involving the normal blood vessels into the liver. Symptoms of a Liver Shunt: Stunted growth Poor muscle development Abnormal neurological behaviour – disorientation, staring into space, circling or head pressing, seizures Drinking/urinating too much Vomiting Diarrhoea Lethargy In addition, if a shunt is secondary to liver disease, then you would also note additional symptoms associated with poor liver function including: Loss of appetite Jaundice Fluid retention Liver Guard Congenital Liver Shunts In this instance, your puppy will be born with their shunt. At present there are 33 breeds that are significantly more likely to have a liver shunt than the general population. They include: Havanese Yorkshire Terrier Maltese Pug Miniature Schnauzer Standard Schnauzer Shih Tzu Bernese Mountain Dog Bichon Frise Irish Wolfhound Old English Sheepdog Of interest however, is that in Yorkshire Terriers, the incidence of shunts has increased more than 11 times in the past two decades. In addition, when mating two surgically corrected Yorkshire Terriers, they produce normal offspring. This poses questions around simple autosomal recessive inheritance. Findings Here When the foetus is developing, they will have a large shunt known as the ductus venosus; this carries blood quickly through the foetal liver to the heart. A congenital shunt develops if the ductus venosus fails to collapse at birth and remains intact and open after the foetus no longer needs it, or if a blood vessel outside of the liver develops abnormally and subsequently remains open after the ductus venosus closes. Small breeds tend to suffer extrahepatic liver shunts, which are just one abnormal blood vessel outside of the liver. These are most amenable to surgical correction. A single shunt located inside of the liver is more common in larger breeds and known as intrahepatic – these are still best treated with surgery, but the procedure is more challenging. Surgery for liver shunts focuses on blocking the blood flow through the abnormal vessels so that more of it travels through the liver. Dogs with acquired shunts on the other hand, tend to have multiple abnormal vessels and are often poor candidates for surgery due to their underlying health issues. Acquired Liver Shunts In cases of liver disease, blood flow can become compromised leading to what is known as portal hypertension – or simply, high blood pressure. Like water, blood likes to take the path of least resistance and so APSS (acquired portosystemic shunts) are formed. Clinical parameters would indicate underlying hepatic concerns. In both cases of congenital and acquired, reduced blood flow to the liver also results in atrophy which subsequently affects function. But the liver is a rather unique organ, it is the only one that can regenerate, therefore appropriate intervention and management is essential. Liver Guard Considerations To Make The most common treatment regime (in addition to surgery if appropriate) usually includes a diet change and ensuring intestinal health. The conventional concern with many liver issues is protein intake. When protein is broken down in the body, left behind is ammonia. The liver plays a key role in metabolising ammonia ready for it to be excreted by the kidneys into urine, but when blood flow bypasses the liver, ammonia builds up in the blood and enters systemic circulation – this is what leads to many neurological issues alongside poor liver function. Traditionally, dietary management has included protein restriction to reduce ammonia absorption from the colon, but more recently it is considered that colonic absorption is only significant in those fed poor-quality diets, that contain poorly digestible protein. In addition, it has been established that those with chronic liver disease may develop muscle wasting from being in a long-term catabolic state – with low protein diets leading to increased muscle protein catabolism. Findings Here Therefore we would advocate a fresh-food diet, with highly digestible protein sources. The general school of thought is 2g of protein per kg of body weight. Findings Here Antibiotics are often prescribed in an attempt to reduce intestinal bacterial overgrowth, but there are other considerations to make with regards to intestinal health. Motility – if food sits too long in any one place, problems can start to occur. Stress is one of the key factors which impair motility, so consider your dog’s exposure to any stressful stimuli. In addition, fibre can aid intestinal transit. 5 Reason’s Why Fibre is Your Dog’s Best Friend There are additional factors that can skew the microbial population in your dog’s gut too. What Can Cause Gut Dysbiosis What Can Help Gut Dysbiosis Whilst the liver is unable to effectively metabolise and detoxify, it is important to support this process as much as possible, starting with not overloading it in the first place. Opt for filtered water Feed
Sadly, here at My Pet Nutritionist this is a condition that we are seeing more and more, so we thought we’d pop a blog together to explore, what it is, common causes and considerations to make. So, let’s get cracking. What is Cushing’s Disease? Cushing’s disease in dogs, also known as hyperadrenocorticism, is a condition where a dog’s body produces too much of the stress hormone cortisol. Hyper meaning too much, adreno meaning the adrenal gland and corticism refers to the outer part, or cortex of the adrenal gland. Cushing’s in dogs is the opposite to Addison’s disease, which is when the body doesn’t produce enough hormones. That’s a blog for another day. Both decreased and excessive production of this hormone can be life threatening. The role of Cortisol We tend to know about cortisol as the common stress hormone – but it tends to get a bad rap. Cortisol doesn’t cause stress, it’s just what is produced in response to it. Cortisol is a glucocorticoid (steroid hormone) that is produced from cholesterol in the adrenal glands located on top of each kidney. It is normally released in response to waking up, exercise and of course during stress. But cortisol also plays a role in nutrition. It is involved in energy regulation as it helps select the right type and amount of substrate (like fat or protein) the body needs to meet the physiological demands it is under. When chronically elevated it can have deleterious effects on weight, immune function, and subsequent chronic disease. One of the main functions of cortisol is to reduce inflammation in the body – which is great, but over time these efforts suppress immune function. Chronically elevated cortisol can lead to immune dysfunction which paves the way for sensitivities, and it also increases the risk of gastrointestinal issues. As you can see cortisol has wide ranging functions throughout the body, so it’s easy to see how Cushing’s Disease may not always be diagnosed straight away. Symptoms Include: Increased hunger Increased thirst Frequent urination Hair loss Slow hair regrowth Abdominal swelling (pot belly) Thinning skin or lesions Lethargy Excessive panting Skin Infections. Causes of Cushing’s Disease in Dogs Pituitary Gland Tumou The most common cause of Cushing’s disease is a tumour of the pituitary gland (which is located at the base of the brain). The tumour may be either benign (harmless) or malignant (cancerous). The tumour causes the pituitary gland to overproduce a hormone (ACTH) that stimulates the adrenal glands to produce cortisol. You’ll also remember ACTH for it’s role in the stress response. As the pituitary gland produces more ACTH, it triggers the adrenal glands to produce more cortisol. Adrenal Gland Tumour Cushing’s disease may be the result of a benign or malignant tumour of the adrenal gland itself (adenoma or carcinoma, respectively). If the tumour is benign, surgical removal is considered. Excessive Cortisol from Prolonged Use of Steroids The third type of the disease is called Exogenous Cushing’s Disease. It is caused when there is excessive administration of an oral or injectable steroid. Although the steroids may have been given for a legitimate medical reason, in this case, their excess has become harmful. Glucocorticoids (GCs) are a group of drugs structurally and pharmacologically similar to the hormone cortisol with various functions including anti-inflammatory, immunosuppressive, anti-proliferative, and vaso-constrictive effects. They are often used as replacement therapy in cases of Addison’s Disease, but also as symptomatic treatment in cases of: Allergies Asthma Sickness/nausea Autoimmunity Chronic inflammatory disease like IBD Steroid-responsive dermatoses Arthritis Preterm delivery They are liked because as in cortisol’s natural role, glucocorticoids lead to suppression of the immune system and decreased inflammation. But the downstream effects of glucocorticoids include: Decreased cytokine production Decreased phagocytosis Decreased number of lymphocytes, macrophages, monocytes, eosinophils, and basophils (all immune cells) And of course, the exogenous administration can lead to Cushing’s Disease. In these cases, collaboration with a qualified professional will establish whether steroid usage can be reduced safely. As noted, the most common cause of Cushing’s Disease is a tumour in the pituitary -so where does this come from? Tumours Generally, the first step to cells becoming cancerous is unusual DNA (deoxyribonucleic acid) structure. DNA contains the instructions that us and our pets need to develop, live, and reproduce. These instructions are found in every cell and are passed down from parents to their offspring. Every cell must undergo growth, and then it must die. Each cell has a finite number of times it can reproduce, which is why we age. Cancer cells on the other hand, do not – they grow, the body is unable to kill them and so they continue to grow. DNA was largely considered destiny for many years and although DNA cannot be altered, it’s expression can. When our pets are born, they may have been given rogue genes that could cause cancer to grow, but their environment and lifestyle choices can help make that decision too. These choices can make cancer cells grow, or equally, prevent them from dying. Nutrition is, not surprisingly one of those choices to consider. The nutrients required for DNA replication include folate, vitamin B12, magnesium, zinc and iron. For the maintenance of DNA methylation and chromosome stability, the nutrients folate, vitamin B12 are of particular importance. To prevent DNA oxidation, provision of vitamin C, vitamin E, zinc, manganese, and selenium is necessary. For DNA damage sensing and repair, niacin, zinc, iron and magnesium are critical. Evidence suggests that deficiency in these micronutrients can increase DNA replication stress and genomic instability. In addition, deficiency here is thought to increase susceptibility to DNA damage caused by endogenous and/or environmental toxins. The bottom line? Certain changes in DNA can cause pituitary cells to produce a tumour – these changes can be inherited but they can also be acquired by outside exposures from pollution, environmental contaminants, nutrition and more. If you would like to know more about genes and gene expression, check out our blog here: How Nutrition Affects Your
Did you know that body wasting is found in 65-90% of patients with advanced liver disease? These patients often develop micronutrient deficiencies which ultimately results in malnutrition. Being a more common disease than we’d like to see here at My Pet Nutritionist, it is clear that there are nutritional implications in any treatment plan. For that reason, we thought we’d explore liver disease in a little more detail, with specific reference to food choices. What is Liver Disease? Liver disease can present in many different ways – it can range from chronic hepatitis, acute liver failure, portosystemic shunts to hepatic encephalopathy. For more information on these specific manifestations, check out our blog here. Here you will also find any signs and symptoms to look out for. But before we get into what happens when it goes wrong, let’s look at what a healthy liver does. The major functions of the liver include: Bile production: Bile helps the small intestine breakdown and absorb fats, cholesterol, and those fat soluble vitamins. Bile consists of bile salts, cholesterol, bilirubin, electrolytes, and water. Absorbing and metabolising bilirubin: Bilirubin is formed by the breakdown of haemoglobin. The iron released from haemoglobin is stored in the liver or bone marrow and used to make the next generation of blood cells. Supporting blood clots: Vitamin K is necessary for the creation of coagulants that help clot the blood. Bile is essential for vitamin K absorption and is created in the liver. If the liver does not produce enough bile, clotting factors cannot be produced. Fat metabolisation: Bile breaks down fats which makes them easier to digest. Metabolising carbohydrates: Carbohydrates are stored in the liver, where they are broken down into glucose and siphoned into the bloodstream to maintain normal glucose levels. They are stored as glycogen and released whenever energy is needed. Vitamin and mineral storage: The liver stores vitamins A, D, E, K, and B12. The liver stores iron from haemoglobin in the form of ferritin, ready to make new red blood cells.The liver also stores and releases copper (which is why copper toxicity in dogs is associated with liver failure). Filters the blood: The liver filters and removes compounds from the body, including hormones and compounds from outside the body, like medications. For more information on detox, check out our blog here. Immunological function: The liver is part of the mononuclear phagocyte system. It contains high numbers of Kupffer cells that are involved in immune activity. These cells destroy any disease-causing agents that might enter the liver through the gut. Production of albumin: Albumin is a protein found in the blood. It transports fatty acids and steroid hormones to help maintain pressure and prevent the leaking of blood vessels. It is the higher circulating albumin found in dogs that suggests they possess an increased fat oxidation capacity, in comparison to humans. Synthesis of angiotensinogen: This hormone raises blood pressure by narrowing the blood vessels when alerted by production of an enzyme called renin in the kidneys. But perhaps the most interesting function of the liver, is its ability to regenerate. In mice, if two thirds of their liver is removed, the remaining tissue can regrow to its original size within 5-7 days! In humans, this process takes slightly longer, but it can still occur. In dogs, the mechanism is thought to occur similarly to that in the mouse., but maximum response is seen after three days, as opposed to 24-hour peak in rat regeneration. Findings here Liver Guard This regeneration is helped by a number of compounds, including growth factors and cytokines like: hepatocyte growth factor insulin transforming growth factor-alpha epidermal growth factor interleukin-6 norepinephrine Micronutrients to Support Liver Health Almost all chronic liver diseases are under the background of elevated oxidative stress. Great sources ofessential antioxidants are foods rich in vitamin C, vitamin E, and trace element selenium. Plant foods also contain compounds that have antioxidant activity, such as ascorbic acid, beta-carotene, coenzyme Q10, curcumin, ellagic acid, epigallocatechin gallate, lipoic acid,lycopene, N-acetyl cysteine, quercetin, and resveratrol. Blueberries This versatile berry contains anthocyanins, an antioxidant, protecting the liver from oxidative stress. Studies have found that in the livers of rats, such protective compounds found in fruits like blueberries slowed the development of scar tissue, and may be useful in the prevention of hepatic fibrosis. CruciferousVegetables (Brussel sprouts, broccoli) Not only does this family of vegetables provide a wide range of nutrients and health benefits, they also have the added ability of increasing the liver’s natural detoxification enzymes and improving overall liver function by decreasing oxidative stress. Findings here Nuts Nuts, which are high in healthy fats and Vitamin E (a powerful antioxidant) as well as other phytochemicals, have shown potential for treating non-alcoholic fatty liver disease by reducing inflammation and fat accumulation in the liver. Fatty fish (mackerel, tuna, salmon, trout) Consuming fatty fish that are high in omega-3 fatty acids regularly can modulate inflammation and enzyme levels. Findings here A review of plant-based foods for liver health indicated the following as beneficial: broccoli carrots collard greens kale sweet potato cabbage banana papaya pomegranate watermelon Findings here Patients with liver disease are advised to avoid nightshade plants like tomatoes and eggplant as they can become hepatotoxic. Macronutrients to Support Liver Health The liver plays a crucial role in the metabolism of proteins along with carbohydrates and fats. It carries out four main functions in protein metabolism. The first is the formation of blood proteins. These blood proteins include clotting factors, carrier and transport proteins, hormones, apolipoproteins, and other proteins involved in homeostasis and the maintenance of pressure, such as albumin. The liver is also involved in amino acid interconversion. Amino acids are divided into two groups, essentials—those that the body is unable to produce,which must be obtained from the diet and non-essentials, those that the body can synthesise. The liver is able to alter the structure of amino acids and transfer amino radicals to a keto acid to produce the amino acids needed for the body. This process is critical in many body functions, especially gluconeogenesis. The third function is amino acid deamination, or breakdown, the by-products
Being the most common clinical condition in adult dogs, periodontal disease raises the flag on why dental care is so important in optimal canine health. Sadly, here at My Pet Nutritionist, we see it, a lot. Periodontal disease begins when bacteria in the dog’s mouth forms to create a substance called plaque. The plaque sits on the surface of the teeth and with the help of saliva, it hardens to form tartar. Not only does it sit on the teeth, plaque and tartar seeps into gum lines which causes inflammation. Over a period of time, this inflammation and presence of bacteria causes damage to the structures surrounding the teeth; causing receding gum lines and eventually tooth loss. These bacteria can also travel to other parts of the body, causing a range of additional health concerns. So, let’s look at periodontal disease in more detail and what we can do to prevent it! But, before we get to the diseased mouth, let’s take a look at a healthy mouth. The Canine Mouth Puppies are born without teeth and they then develop 28 of them. They will shed these between 4-6 months of age as their 42 adult teeth erupt. A dog will possess: incisors canines premolars and molars Incisors are used for cutting food; dogs have 6 upper (maxilla) and 6 lower (mandible). Next come the canines, which are used to grab and tear food, there are 2 canines in the mandible and 2 in the maxilla. The premolars are used for chewing, tearing, and biting; there are 8 in both the mandible and maxilla. Finally, molars are used to crush food; dogs have 4 in the maxilla and in the mandible. Teeth in fact provide the first step of digestion, but over their lifetime and in consideration of genetics and poor hygiene, many dogs will lose most, or all of their teeth. Dental Disease From the moment a tooth erupts it is exposed to food, saliva, and bacteria. Periodontal disease occurs when there is a buildup of bacteria in the mouth, which forms plaque. Eventually,this hardens to form tartar. This can sit in the gum line causing inflammation, known as gingivitis. Left untreated, further harm occurs which results in periodontitis, where teeth fall out and damage can occur to the surrounding bone. Signs your dog has dental disease: Bad breath Pawing at his mouth Reluctance to eat Food or toys will have blood on them Smaller breeds are statistically more likely to suffer with periodontal disease, as are brachycephalic breeds. Their teeth are often closer together which means food and bacteria can more easily get stuck. But what is also interesting is that it is generally accepted that the inflammation and resulting tissue damage is due to an improperly regulated immune response to bacterial infection, and not solely from the bacterial pathogens themselves. This suggests that if your dog already has immune mediated health concerns, then they may be at a higher risk of dental disease. Findings here The point to make is that gingivitis is thought to be reversible, whereas periodontitis is not. Not only is the mouth and teeth a concern, but the bacteria found in the mouth of your dog can be released into the circulatory system, which then travels through the body. It has been found to damage cardiac tissue causing endocarditis (infection and inflammation in the heart). Studies have also shown that periodontal disease is linked to increased insulin resistance and kidney, and liver issues. Findings here All things considered, prevention is certainly better than cure, so what can we do? 1) Avoid ultra-processed refined foods Ultra-processed food is defined as any food that undergoes multiple processes like extrusion and milling. They may also contain added ingredients that are highly manipulated. Sadly, many dry based dog foods fall directly under this definition. In human Hunter-gatherer studies, it is demonstrated that cavities and gum disease were a rarity, and this remains in modern times; Aboriginals living a traditional lifestyle do not generally get dental disease until they adopt a Western diet. There are a number of reasons for this. The mouth, just like the gut contains its own microbiome. It is a community of microbes that maintain balance; the good guys can keep the bad guys in check. Not only do ultra-processed foods skew the balance in the mouth, but they do also the same in the remainder of the digestive tract. As we know, the gut houses much immune tissue, and so it does in fact train the immune response. As we mentioned early, it is thought that much of the damage originating in the mouth is due to an improperly regulated immune response and not solely the bacterial pathogens themselves. For this reason, we would advocate the removal of an ultra-processed diet for oral and gut microbiome health. For more information on the microbiome in your dog, check out our blog here. 2) Dental Sticks There are a number of chews on the market promoting oral health, but it is actually the mechanism of chewing that helps to reduce build up. Chewing stimulates saliva which produces anti-bacterial agents, helping to keep the mouth clean. Not only this but the abrasion that occurs during chewing helps to scrape deposits off the teeth. What type of chew is best? Here’s what the data suggests: Raw bones reduced mouth bacteria by 79% Daily brushing reduced it by 70% and, Marketed dental chews reduced it by 54-60%. Findings here Raw bones lead the way in reducing bacteria,and the added bonus? You know exactly what you are feeding. There is no long list of ingredients to consider. If you are opting for raw bones, ensure they are a manageable size for your dog; chicken necks and wings are a great place to start if you’ve never fed them before! If you’d learn to learn more about the benefits of chewing for your dog, check out our blog here. 3) Diet It is thought that periodontal disease may be related to
Have you ever noticed that the wolves found in Yellowstone are rarely obese? Even the alpha males, who in theory could have access to all the kill they choose, maintain a lean weight. Do they perfectly balance their calories in with their calories out? Whilst not impossible, it’s a slight stretch of their intuition and it demonstrates on a simplistic level, why the CICO model doesn’t really answer enough questions when exploring the concept of obesity. In our last My Pet Nutritionist blog article, we explored a range of ideas that can contribute to obesity in pets, but there are many more schools of thought, so we thought we’d explore another in a separate article. One of them being hormones. All of the fat found in cells is stored in the form of triglycerides. Fatty acids are converted into triglycerides for storage and then for fat to be used as energy, they are freed back into fatty acids. Getting fat is the process where triglycerides are created more quickly than they are broken down. This flow of fatty acids is regulated by a range of enzymes and hormones. This isn’t surprising when we consider the role of growth hormone, it is what drives the growth of children and adolescents. If you are considering bodybuilding, steroid hormones are used to increase bulk and if you take a trip down memory lane, chickens were injected with hormones in the 50’s to increase their size too! Findings here It seems that, on a simplistic level, certain hormones cause fat cells to suck up fatty acids more readily than they otherwise would or slow down the rate at which triglycerides are converted back. Both oestrogen and testosterone have been shown to decrease the rate at which certain cells take up free fatty acids, which results in keeping the fat cells relatively small (and why in humans you will notice differences in fat gain between males and females). This is why after neutering your pet, you are advised to monitor their weight as more often than not, they gain weight. This issue here is demonstrated by a study conducted in the early 1970’s. A professor named George Wade wanted to explore how animals regulated their fat supplies. He had two groups of rats and removed their ovaries. The first group then was given free access to food and they could eat as much as they desired. They subsequently ate more than they had before the surgery and became obese. The second group were restricted to the same number of calories they had eaten before the surgery. Their environment was also kept the same. But this second group too became obese it just occurred through a different mechanism. They simply became less active. With the removal of the hormones, it is thought that the uptake of the free fatty acids was unregulated, resulting in more fatty tissue. With the drop in lipid levels, group one sought to replace the circulating levels with more food, but with the absence of food in the second group, they simply became less active to account for the shortfall. The implication of hormones in fat regulation is also demonstrated when lesions in the brain disrupt the hypothalamus. The ventromedial hypothalamus is one of the most hormonally active areas in the brain, and lesions here have resulted in the development of obesity. Leptin largely exerts its influence in the hypothalamus and leptin has a crucial role in regulating food intake and maintaining metabolic homeostasis (balance). Being another hormone, leptin is secreted mainly by adipocytes. Plasma leptin levels are significantly associated with body mass index and total body fat. It is generally accepted that total fat mass is the strongest predictor of circulating leptin. The discovery of leptin made it clear that adipose tissue (fat tissue) is not only a regulator of body weight but also an endocrine organ with feedback loops between the brain and peripheral tissues. Leptin levels decrease during fasting or energy restriction and increase during refeeding, overfeeding and sometimes during times of stress. Several metabolic and hormonal factors influence the synthesis and secretion of leptin in the body such as cytokines, cortisol, catecholamines, fatty acids, glucose, and insulin. Which brings us to another hormone that is intricately involved in obesity in our pets. Insulin Insulin is deemed an anabolic hormone; it works to accelerate the rate at which nutrients are put together to make new tissues. Insulin is well known for its role in clearing glucose from the bloodstream and regulating blood sugar balance. We’ll use the dry fed dog to explore this a little further. When carbohydrates are digested by the dog, they are broken down into glucose. Carbohydrates can be complex (being longer chains of molecules and taking a little longer to be broken down) or simple (broken down quickly and easily). Ultimately, when they exit the digestive tract and find themselves in the bloodstream, they exist as glucose. When blood sugar levels start to creep up, insulin is called to action. Insulin is like the porter in the hotel; it shuttles glucose out of the bloodstream and opens the doors of where it needs to go. This can be to cells or muscles to be used as energy, but if it isn’t needed there, it can be stored (in adipose tissue). Think of it like when you’ve got an early check out and leave your luggage at reception until you’re due at the airport. But what insulin also does is blocks the conversion of triglycerides back; this makes absolute sense as it wants to prioritise the use of glucose as energy to get it out of the blood stream! But what this means is that insulin is in fact a fat regulator. Now we know glucose can be generated from non-carbohydrate sources through gluconeogenesis, but the issue for the dry fed dog, is that these diets often score incredibly high on their carbohydrate content. Due to the range on the market, it can be anywhere up
Hyperthyroidism is commonly accepted as the most common feline endocrine disorder. These are the words found in a Journal of Feline Medicine and Surgery. Here at My Pet Nutritionist, this worries us for two reasons. 1) That hyperthyroidism is such a common disorder 2) That it is accepted Being noted as an epidemic, we think it deserves a little attention. So, let’s explore hyperthyroidism in a little more detail, and what, if anything we can do about it. Until the late 1970’s, there appear few references to hyperthyroidism in the cat. Were there sudden developments in veterinary science, or was something else afoot? What is the thyroid? The thyroid gland is part of the endocrine system. It is a small butterfly shaped gland in the neck. One of the main functions is to produce hormones to regulate the body’s metabolism (the process that turns food into energy). These are more commonly referenced as T3 and T4. Hyperthyroidism is when the thyroid is hyperactive – there is an increased production of thyroid hormones. Symptoms of Hyperthyroidism: Weight loss Increased appetite Increased thirst Increased activity Increased heart rate Poor coat condition Mild/moderate diarrhoea (yet some cats can demonstrate generalised weakness lethargy and loss of appetite) Many cases of hyperthyroidism can be medicated, and so complications are rare, but they can include: Cardiovascular changes High blood pressure Kidney damage (more commonly asa result of treating hyperthyroidism) Diagnosis is usually based on enlargement of the thyroid glands, but this is not always visible. A blood test will confirm levels of thyroid hormones. Treatment is generally with thioamides, which in short act as anti-thyroid medication. They do not cure, simply control, but they must be administered daily. Side effects of this medication can include poor appetite, vomiting and lethargy. Although in some cases, the thyroid gland has been removed. So, what causes hyperthyroidism? So far, there are two main categories of risk factors for hyperthyroidism in the cat. – Nutritional deficiencies – Exposure to thyroid-disrupting compounds There are too genetic risk factors associated with hyperthyroidism, for example Siamese or Persian cats are less likely to suffer with the condition where as domestic shorthaired are the more commonly affected. Findings here Nutritional Deficiencies As claimed in the Journal of Feline Medicine and Surgery, “the feeding of commercially prepared cat food is one leading candidate as a major risk factor for the development of thyroid pathology and hyperthyroidism in cats.” It claims that all epidemiological studies to date have identified feeding an increased proportion of commercially prepared cat food is a risk factor. There are arguments that in the last few decades, the cat food industry has been on a bit of a rollercoaster with iodine. First, they considered high iodine was implicated in hyperthyroidism, so they significantly dropped levels, and since, iodine content has ranged from non-detectable to extremely high, depending on the manufacturer. Iodine is a key element in the synthesis of thyroid hormones. Low iodine results in low thyroid hormone,which spurs the pituitary gland to increase its secretion of thyroid stimulating hormone (we all want to survive after all). Persisting high TSH leads to enlarged thyroid glands. Interestingly, when studied, cats fed a commercially prepared diet who were relatively deficient in iodine, were four times more likely to develop hyperthyroidism than cats supplemented with iodine. Findings here Simple iodine supplementation is not the answer to the question, as is it considered merely a co-factor in a range of causes. Others include, exposure to thyroid-disrupting compounds in the environment, drinking water or diet. Interest in this first appeared with the introduction of fire-retardant chemicals in many household items. The rates of hyperthyroidism seemingly increased with the introduction of these products. Findings here Cats are hyper-carnivorous and have lower activity of certain enzymes involved in both phase I and phase II detoxification pathways. These phases are responsible for breaking down toxic substances in the body (both internally produced and externally exposed). This therefore limits their ability to metabolise toxins. This poor metabolism of xenobiotics is thought to alter the structure and function of the thyroid gland, not only that but there are considerations that it too effects the elimination of T4 hormone, of which leads to high circulating levels. There is evidence which correlates high levels of toxic compounds with feline hyperthyroidism, these compounds are also higher than found in humans that the cats live with (suggesting issues in metabolism). There is a risk associated with commercial food that contain isoflavones and phthalates coming from soy and corn. Both of these compounds are known as endocrine disrupters. These vegetable substrates are detoxified by a particular pathway which is known to be slow in cats. Findings here Being an indoor cat is seen as a risk factor because of the exposure to persistent organic pollutants. Dust is a matrix collecting a range of volatile chemicals released from indoor products like flooring, textiles, furniture, and of course human skin (containing beauty or cleaning products). The heightened exposure is thought to be due to cat grooming behaviour – licking the dust off their coats and ingesting it. Findings here Certain flame-retardant compounds have also been found in commercial cat foods, and data has suggested that the cat liver struggles to metabolise these compounds. These PBDEs (polybrominated diphenyl ethers) contain bromine atoms which mimic iodine and so they may interact with thyroid binding proteins. Cats with hyperthyroidism have also demonstrated higher levels of PFAS which are polyfluoroalkyl substances which are found in products with grease repelling functions, like surface sprays, and floor polishes. Findings here Interestingly, there is a correlation between litter use and hyperthyroidism in cats. Those that use litter boxes more often, are more likely to receive a diagnosis. That along with receiving treatment for ectoparasites. Findings here BPA exposure has also been linked to hyperthyroidism in cats. As we know BPA is found in food, air and soil! Again, cats have a slower pathway in eliminating it. BPA binds to thyroid receptors, competitively displacing hormones. So, what can we do
The prevalence of chronic kidney disease in the cat is seemingly on the up. Generally, what goes up, must come down, but when we look at the factors underlying kidney disease, there is a real concern that this may not happen. Currently, it is suggested that 1 in 3 cats suffer with some form of kidney disease. So, what can we do about it? Let’s take a look at kidney disease in a little more detail, why the kidneys are so important and some of the underlying factors that contribute to the development of it. What is kidney Disease Chronic kidney disease in cats is a prolonged process marked by the irreversible loss of kidney function. It is suggested that the early stages of CKD are often missed in cats, likely because many are outdoor cats so urination and drinking behaviours may not be as easily noted, along with vomiting etc. Kidney disease is generally associated with ageing pets; like all things, kidneys too get tired as they get older. But there are new concerns, well, new in 2014, that younger cats are seemingly presenting with the disease too. Where 30-50% of cats 15 years of age or older suffer with CKD, 13% of those under the age of 4 also suffer. Symptoms of Kidney Disease in the Cat: Increased thirst Increased urination Reduced appetite Weight loss Vomiting Fatigue Weakness Bad breath There are 4 stages of kidney disease in the cat, they are based on serum creatinine concentration: stage 1 through 4, with 2 being mild, 3 being moderate and 4 being severe. Findings here Why are the kidneys so important? The two bean shaped organs have vital functions in the body. They monitor fluid levels in the body, control and process waste and release vitamins, minerals and hormones. Their main function is to collect waste products and turn them into urine. Blood enters the kidney though arteries and splits into nephrons. The nephron splits into two nifty mechanisms to filter the blood. This includes the glomerulus and tubule. The glomerulus is like a sieve, allowing certain compounds from the blood into the tubule. The tubule then senses whether any of these compounds are needed around the body. If so, they are absorbed into the body. The tubule also senses waste products, like urea which is produced during the break down of protein. It redirects urea as urine which travels down the ureter, into the bladder to be excreted. The kidneys also activate vitamin D, and release hormones such as erythropoietin which is needed to produce red blood cells and renin which regulates blood pressure. Without the kidneys, the body would be full of blood that hadn’t been sieved and full of harmful waste. It also wouldn’t be receiving the vitamins and minerals, which, without being dramatic, are in fact critical to life. Causes of Kidney Disease There are genetic predispositions to developing kidney disease; certain breeds that are more likely to suffer with kidney issues include the Persian, Siamese, Ragdoll, Russian Blue and MaineCoon. But other than acute renal failure caused by poisoning (plants, pesticides etc), there are other factors that can contribute to kidney issues. As we have established, one of the kidney’s main role is to filter helpful and harmful compounds in the blood. It stands to reason that the more harmful compounds it must process, the sooner it reaches its retirement party! It is often suggested that chemical exposure isa progression factor in the disease and sadly cats are regularly exposed to cleaning agents, pesticides, and many more environmental toxins. These can be ingested, inhaled, or exposed transdermally (through the skin). The foods fed to cats can also impair kidney function. Mycotoxins are a diverse group of chemicals produced by a diverse group of fungi. However, mycotoxins, can be nephrotoxic (toxic to the kidneys). Studies have demonstrated that anywhere between 62% to 100% of cat foods sampled had mycotoxin contamination. Findings here There are also reports of melamine toxicity in cats, resulting in kidney damage. You guessed it; the source of melamine was contaminated food. Findings here Mild dehydration is also a risk factor for kidney disease. This is a concern because of the moisture content in many commercial foods. Dry-based cereal foods rank low on moisture,with dogs demonstrating increased drinking to counterbalance their water requirement. Cats, however, have an evolutionary low thirst-drive. Cats are obligative carnivores, meaning they get what they need from animal tissue. Therefore, they would naturally get moisture from their whole prey kills. But they are no longer getting the same level of moisture with a dry based diet and their thirst-drive hasn’t yet caught up (in evolutionary terms)! Starch also poses a risk for developing periodontal disease. Wait, what has periodontal disease got to do with the kidneys? And what has starch got to do with cats? Stick with us. Starch is the storage form of energy in plants; and then becomes a source of sugar in an animal’s diet. Bacteria found in the mouth feed off these starches and form a biofilm called plaque. This slowly degrades the tooth and surrounding structures. Not only that but the frequency of eating can contribute to the development of periodontal disease. Saliva can perform a clean-up between meals, but this becomes less of an option for the cat who is free fed throughout the day. The long and the short of it, many dry-based foods contain starch, which is a risk for periodontal disease. Periodontal disease is regularly implicated as a risk factor for kidney disease due to the relocation of oral bacteria throughout the body. Despite this, there are also things that can help mitigate the risks associated with kidney disease. Water intake is of utmost importance in all kidney patients. Therefore, a high moisture diet is essential. When offering drinking water, ensure it is filtered to remove any potential harmful compounds before they even get into the body. Protein restriction in kidney cases is much discussed and often controversial. Surely
Whilst every diet under the sun has been touted for its weight loss properties, keto has been liked for its benefit incases of epilepsy and cancer. A ketogenic diet consists of high fat, with moderate to low protein and very low carbohydrate. This in a nutshell, forces the body to use fat instead of glucose for energy. There are two reasons this poses food for thought for the canine with cancer. Firstly, we’ll head back to the early 1900’s and pop into the lab with some sea urchins. Otto Warburg was massively interested in the chromosomes of sea urchin eggs. He wanted to understand how they fuelled their growth. Warburg found that they increased their oxygen consumption significantly as they grew. Turning his attention to a rat tumour, he expected the same. But he was wrong. Instead, the cancer cells fuelled their growth by glucose and broke it down without oxygen. To Warburg, this made no sense, but this effect as he found, is estimated to occur in many cancers. High concentrations of glucose are seen to significantly increase the proliferation of cancer cells. Findings here Not only that, but glucose has been noted to disappear from the urine of patients with diabetes after they have been diagnosed with cancer, suggesting it is recruited to cancerous areas and consumed in high amounts. Findings here Diets low in carbohydrate were thought to starve cancer cells, in essence. Glucose normally stimulates pancreatic cells to release insulin which allows glucose to enter cells and provide energy. When glucose is scarce, the body senses the need to make an alternative form of energy for cells. The liver then produces ketones and fatty acids, which provide for normal cells, but do not benefit cancer cells. It also pays to mention at this point, not only is the keto diet low in carbohydrate but it is also moderate in protein. Where low protein is no friend to anyone, protein can still be converted to glucose if consumed in high amounts through the process of gluconeogenesis, so it should be monitored. Being in a state of ketosis has seen a decrease in glucose uptake at tumour sites and also demonstrated no evidence of progression. Findings here In short, there are many studies which have demonstrated benefits of a ketogenic diet in cancer, whether as an adjuvant to traditional therapy or stand alone. Findings here The other reason why the ketogenic diet is such an interesting concept for the canine is due to their greater capacity for fat oxidation. Compared to humans, high fat diets for the dog have been seen to increase stamina and maximise energy production in healthy controls. Relative to metabolic body size, dogs metabolise free fatty acids at twice the rate of humans. It is thought that dog albumin (a protein made by the liver, whose main role is transport of various substances) can bind more fatty acids. This is deemed an endurance-adaptation in the species. Findings here So not only are dogs adept at using fat for energy, in the canine with cancer, low carbohydrate diets have demonstrated clear benefits. That said, the ketogenic diet has been seen to cause some potential side effects. The acute side effects of high fat intake are typically lethargy, nausea and vomiting, but this can be seen in many dietary changes. There are also reports of some deficiencies in trace minerals like selenium, copper and zinc, but conclusions merely indicate the potential need for supplementation if considering this diet. There are reports of elevated LDL cholesterol and kidney stones in humans consuming a ketogenic diet long term, but it is unclear how this translates to the canine. Findings here Despite this, literature reviews still conclude that the ketogenic diet has a protective role against tumorigenesis (the production or formation of a tumour or tumours) and that it does indicate a prolonged survival, reducing the risk of experiencing the pre-defined endpoint. Findings here The issue in commercial pet food is, on average, more than 45% is carbohydrate. The ketogenic diet for the canine shifts this to less than 10%. It is observed that dogs routinely enter a state of ketosis using 82% fat, 17% protein and 1% carbohydrate. After around 120 days, they may be able to maintain ketosis on a lower formulation like 69% fat, 30% protein and 1%carbohydrate. But as we know, all dogs are different and regular monitoring will inform the appropriate formulation. Findings here Due to the high content of carbohydrate found in commercial food, a switch to fresh food is essential. Whilst fruits are, for example, are still carb rich, the inclusion of low carb fibrous veggies can still provide certain micronutrients. There is also evidence that fasting alongside keto can be of benefit in cancer cases. It is argued to bring about the state of ketosis sooner. There is also evidence that fasting has been seen to reduce the side effects of chemotherapy or radiation therapy. However, there is a concern that when fat stores are exhausted, muscle breakdown will begin in order to fuel gluconeogenesis, resulting in muscle atrophy. It is concluded that this pairing may not be suitable for all patients, especially in underweight cases. It should also not be attempted without the supervision of a qualified practitioner. Findings here The other thing to be mindful of is using the ketogenic in liver cancer. Whilst ketosis is well tolerated by a normal, healthy and functioning liver, it is essential to seek the advice of a qualified practitioner when increasing the demands on an already compromised body system. Individual case studies have highlighted that a ketogenic has been utilised in cases of liver cancer to some efficacy, but this was under close monitoring. Findings here As highlighted by many professionals, if using keto in a medical condition, it becomes a medical diet. It should therefore be treated as such. To avoid many of the noted side effects, supplementation can be useful, but this is specific to the individual dog. Ketosis is also a
