Cancer is the leading cause of death in dogs over 10 years of age, with over 50% of older dogs developing the disease. Eventually, 1 in 4 dogs die of cancer. Whilst understanding of the disease is still developing, we can’t help but want to explore functional ingredients that may be adjunct to therapy, useful in prevention or demonstrate benefits when diagnosed. We still have a long way to go, but there is increasing evidence that certain compounds can demonstrate anti-tumour and anti-cancer properties. We’ve included some of our favourites. Bitter Melon Bitter melon, also known as bitter gourd or Momordica charantia (which is why we stick to bitter melon) is a tropical vine belonging to the gourd family. It is closely related to zucchini, squash, pumpkin and cucumber. It is most widely used in Asian cuisine but is cultivated around the world. It has pointed ends with spikes on the rind. Its distinctive appearance is matched with it’s sharp taste. It’s called bitter melon for a reason. Bitter melon packs a few punches in terms of nutrient content, one cup provides 93% of a human’s daily reference intake of vitamin C, 44% of a human’s vitamin A intake, 17% folate, 8% potassium, 5% zinc and 4% iron. Bitter melon is also a good source of catechin, gallic acid, epicatechin and chlorogenic acid which are all antioxidant compounds. Bitter melon has been seen to control blood sugar and decrease cholesterol, but it is also deemed to have cancer-fighting properties. In studies of concentrated use, bitter melon was seen to effectively kill cancer cells. It has been seen to modulate cell genes, promote apoptosis and reduce proliferation. Findings here Not only that, but bitter melon also contains phytol and lutein which suppress pro-inflammatory cytokines. Studies have demonstrated anti-tumour activity in cases of breast, colon, pancreatic, prostate, skin and cervical cancer. There has also been inhibition of cancer cells in leukaemia and other miscellaneous cancers like adreno cortical, lung adenocarcinoma, nasopharyngeal and head and neck squamous cell carcinomas. Findings here That said, bitter melon has been associated with diarrhoea, vomiting and stomach pain so like with any new additions to any diet, it should be eaten in moderation. If using therapeutically, seek the advice of a qualified professional. Findings here Turmeric Is there anything this spice can’t do? Curcumin in the active ingredient in turmeric has received much attention for its antioxidant, anti-inflammatory, antimicrobial and antiviral properties. We are looking at it for its anticancer potential. It has been reported to modulate growth factors, enzymes, transcription factors, kinase, inflammatory cytokines and pro apoptotic and anti apoptotic proteins. In short, this compound, alone or combined, could be of benefit in cancer therapy. Curcumin has down regulated human lung cancer lines and also inhibited cell proliferation and induced apoptosis in lung cancer. It has also been seen to suppress and modulate leukemic cells. In cases of lymphomas, curcumin was seen as an adjunct to radiation therapy. Curcumin has demonstrated suppression, inhibition, and apoptosis in cases of gastric cancer, colorectal cancer, pancreatic,hepatic, prostate, brain tumours and squamous cell carcinomas. Findings here The biggest concern in using curcumin is its scarce bioavailability. For this reason, much attention is being paid to liposomal curcumin. Findings here Liposomal formulation is thought to have greater growth inhibitory and pro-apoptotic effects on cancer cells. Not only that but liposomal formulations often contain additional supports like vitamin A, folic acid, and hyaluronic acid. Ginger Ginger is loved for its anti-inflammatory properties in cancer therapy. Inflammation, or rather pro-inflammatory cytokines contribute to carcinogenesis by influencing the survival, growth, mutation, proliferation, differentiation and movement of tumour cells. It is proposed that ginger has anti-inflammatory and therefore anti-cancer potential. Ginger contains active phenolic compounds such as gingerol, paradol and shogoall that have antioxidant, anticancer, anti-inflammatory and anti-angiogenesis properties. Ginger has demonstrated significant reductions in inflammatory signalling in cancer cases. Findings here Not only that but in cases of liver cancer, it has induced apoptosis, inhibited formation, decreased expression and suppressed cell proliferation. In cases of pancreatic cancer it has down regulated signalling and cell survival indicators, inhibited expression, decreases metastasis, inhibited cell proliferation and induced apoptosis. Ginger has decreased incidence of colon tumours and it has been reported that intragastric treatment of ginger increases survival time. Findings here Adjunct to other therapy, ginger has been seen to improve cellular immunity and decrease fatigue, pain and stress in cancer patients. It is also noted to reduce nausea. Ginger is widely used in traditional Chinese and Indian medicine, it is thought to stimulate digestion, absorption, relieve constipation and flatulence. In Chinese medicine it is thought to improve the flow of bodily fluids and is therefore used to stimulate blood circulation. The active compounds found reduce the formation of pro-inflammatory prostaglandins and thromboxane therefore lowering the clotting ability of the blood, it should therefore be used with caution alongside blood thinning medication. Mushrooms Not just the divine starter found in your local restaurant, there is an overwhelming interest in the medicinal properties of mushrooms. The chief properties include anti-oxidant, anti-diabetic, hypercholesteraemic, anti-tumour, anti-cancer, immunomodulatory, anti-allergic, nephroprotective and anti-microbial. Those genus credited with success against cancer include: Phellinus, Pleurotus, Agaricus, Ganoderma, Clitocybe, Antrodia, Trametes, Cordyceps, Xerocomus, Calvatia, Schizophyllum, Flammulina, Suillus, Inonotus, Inocybe, Funlia, Lactarius, Albatrellus, Russula, and Fomes. These medicinal mushrooms have demonstrated cell inhibition, significant reduction in tumour sizes, inhibited proliferation and reduced metastasis. Shiitake mushrooms for example have been seen to suppress leukaemia cell proliferation and maitake mushrooms have induced cell apoptosis. Reishi mushrooms exhibit anti-cancer effects alone and in combination with chemotherapy and radiotherapy. Lions mane mushrooms are seen to significantly reduce tumour weights and cordyceps displays potent growth inhibition, tumour shrinkage and increased lifespan. Findings here In a study carried out on dogs, a compound derived from the coriolus versicolor, turkey tail mushroom, demonstrated the longest survival times reported for hemangiosarcoma. Findings here Mushrooms are renowned for their immune boosting effects, if you’d like to learn more about them, then check out our blog here. Foraging mushrooms is seemingly on the rise, so it pays to note that mushroom poisoning can occur due to
Anxiety…the word that gets 337,000,000 hits on google. Many of us and our dogs would say, around that many things make us anxious in any one day, but anxiety for the dog can sadly be very life-limiting. Common signs include panting in the absence of exercise, pacing, salivating in the absence of food, inappropriate vocalisation, hyper-arousal, or lethargy and repetitive or compulsive behaviour. Not only that, but there are recognised cases of separation anxiety in the dog where they will dig at exit points, toilet inappropriately and the above behaviours become worse when separated from their guardian. Causes of anxiety are vast, what some dogs will find exciting, others will find stressful. This is where a better understanding of anxiety lies. In humans, anxiety is defined as a fear or worry, whereas stress is a response to a threat or situation. In the dog, if we consider separation anxiety, whilst dogs may respond to the trigger of you picking your keys up, or getting your coat, they exhibit a stress-response. Seeing as bonfire night is upon us, we thought we would talk about how to support and modulate this stress response. Stress is a response in the autonomic nervous system. The sympathetic nervous system primes for flight or flight. The parasympathetic nervous system then comes along to balance it all out, and primes to rest and digest. Whilst this is a very generic overview of the stress-response, there are many processes that are going on, on the inside. To this end, certain nutrients can support and modulate stress responses and help to maintain a balanced system. Magnesium Often noted as the ultimate chill pill, magnesium is an essential nutrient that many are deficient in. Its low levels are regularly established incases of depression in humans, so it is clear it plays a role in mood modulation and the stress response. Findings here Magnesium affects a number of neurotransmitter systems. Firstly, it inhibits excitatory neurotransmitters. Excessive excitation can lead to the death of brain cells, which affects the overall structure and functioning of the brain. Magnesium also acts as a cofactor in the serotoninergic system. As we know serotonin is the happy chemical, and low levels of magnesium are regularly linked to low serotonin levels. Not only that, but magnesium excretion is increased during times of stress. Catecholamines and corticosteroids enhance the shift of magnesium from inside the cell to outside of the cell leading to increased urinary excretion. In turn, low magnesium levels increase the release of stress-associated hormones. This unfortunately creates a cycle of a reduced resistance to stress. Magnesium is found in leafy greens, nuts and seeds. The ones packing the highest punch are spinach and pumpkin seeds. Magnesium is also necessary for calcium absorption, so balancing these levels is key. High levels of calcium increase the need for magnesium. High dosages of vitamin D can also induce magnesium depletion. As an aside, magnesium competes with fluoride in the body and will decrease absorption, minimising the impact of fluoride in the body. Knowing that magnesium is a key player in many of the systems necessary for balanced mood and can be depleted further in times of stress, it pays to add magnesium rich foods to your dog’s diet. L-Theanine An amino acid found in tea leaves; its relaxing effects have been noted in humans for a while now. This is appearing to be true for our canine companions too. In mammals, L-Theanine can cross the blood-brain barrier within an hour after administration. It appears to remain in the plasma and brain for several hours after. L-Theanine isseen to facilitate the generation of alpha waves which are indicative of a relaxed but awake and alert state. L-Theanine helps regulate the usual stress responses like increased blood pressure, heart rate and cortisol secretion. In dogs, L-Theanine treatment has been seen to reduce anxiety scores during storms in fear of humans. Findings here There is also evidence for L-Theanine improving cognitive function and performance in test situations. Findings here It is thought that because of its similarity to glutamate, it can interact with the same receptors, therefore playing a role in neuroprotection against glutamate toxicity. There are also reports of increased GABA activity in the brain following L-theanine administration and we know that GABA is the brakes of the brain. Findings here Green tea contains the highest L-theanine content, and in moderation is perfectly safe to offer to your dog. Alternatively, there are a number of L-theanine supplements available. Findings here Vitamin D Every tissue in the body has vitamin D receptors, but it is the ones in the brain we are most interested in. Vitamin D activates genes that regulate the immune system and release neurotransmitters. In humans, vitamin D receptors are found in the same brain regions that are linked with depression, so we know it has an impact on mood; seasonal affective disorder ties in with this. It is thought that vitamin D plays a role in calcium balance in neurons, which helps to balance excitatory and inhibitory pathways in the brain. Not only that but vitamin D is linked to the regulation of nerve growth factor which is essential in neuronal survival. Offspring of vitamin D deficient mothers often experience learning and memory problems with altered grooming behaviours, and we know that grooming in most mammals is calming and comforting. Findings here The long and the short of it, vitamin D deficiency is regularly noted in cases of anxiety. Findings here Dog’s don’t have the same ability to synthesis vitamin D from the sun as we do, so they rely solely on dietary sources. Sources of vitamin D include oily fish, red meat, liver, and eggs. There are several health issues that affect absorption of vitamin D, like IBD and exocrine pancreatic insufficiency along with having a low-fat diet. Supplementation is an option but being fat soluble be mindful of levels. Magnesium assists in the activation of Vitamin D, so ensure adequate levels of Mg before you
Whilst carbs are generally demonised in human and pet health, if you want to reap the rewards of fibre, you’ll have to play fair with carbohydrates. So, let’s look at carbs for what they really are. A carbohydrate is a molecule made up of carbon, hydrogen, and oxygen, which is why you may often see them noted CHO. Their primary function is to provide energy. Carbohydrates are made up of three components, fibre, starch, and sugar. Sugar is a simple carb. Having fewer molecules to digest and breakdown, it sends an immediate burst of glucose into the blood stream. This is the one that tends to cause a ruckus. Fibre and starch, however, are complex carbs, having longer chains of molecules. Starch takes longer to digest, having a more gradual effect on the body and fibre is a non-digestible complex carbohydrate. So, whilst fibre possibly doesn’t get the attention it deserves, and carbohydrates are routinely demonised, the heath benefits are often overlooked. Fibre, you may be surprised to learn, can be a key player in maintaining absolute gut health and supporting anxious behaviours. 1) Fibre to support your dog’s gut barrier If fibre and resistant starch can’t be digested, what happens to it? It gets fermented by the bacteria living in the gut. This produces short-chain-fatty acids, also known as SCFAs. The most common SCFAs produced are acetate, butyrate and propionate and they all have unique roles. They provide fuel for intestinal epithelial cells, which strengthen the gut barrier and butyrate is known for its role keeping the junctions of the barrier nice and tight. Not only that but SCFAs are able to stimulate mucus production, which is vital for creating a barrier between the external environment and the underlying gut epithelial layer. Mucin production plays an important role in protection from harmful pathogens and immunity. Findings here 2) Fibre to support your dog’s well-bein As you have seen, non-digestible fibre gets fermented into SCFAs in the gut. SCFAs also exert effects on the brain. Not only have all examples of SCFAs been found in the brain, suggesting they can cross the blood-brain-barrier, they appear to modulate neurotransmitters and neurotrophic factors. Neurotransmitters are chemical messengers used by the body’s nervous system. Acetate has been shown to affect levels of glutamate and GABA. Glutamate is an excitatory neurotransmitter and is involved in virtually every major excitatory brain function. GABA is the brakes; it is an inhibitory neurotransmitter. GABA facilitates sleep and reduces both mental and physical stress, creating a calm mood for your dog. In the same strand, it seems all SCFAs can affect levels of tryptophan which is the enzyme involved in the synthesis of serotonin and we all know that serotonin is the happy chemical! Generally, the inclusion of dietary fibre has been deemed a highly appealing approach, which is simple and relatively low risk if you are looking to help support your dog’s mental well-being. Findings here 3) Fibre as a prebiotic for your dog Here is another word you may have come across, but along with probiotics and synbiotics, not really understood which one is which, or whether either even does anything! Well, prebiotics were first defined as “non digestible food ingredients that beneficially affect the host by selectively stimulating the growth and/or activity of one or limited number of bacteria in the colon, thus improving host health.” So, possibly without even knowing, if you included non-digestible fibre in your dog’s diet, you were likely including prebiotics already. All prebiotics are fibre. But not all fibre is prebiotic. Prebiotic substances have demonstrated the ability to manipulate the gastrointestinal ecosystem of the dog, improving the composition of their microbiota and overall improving immune system function in dogs. Short-chain-fructooligosaccharides and oligofructose seem to modulate the intestinal microbiota and aid absorption of certain minerals, whereas mannooligosaccharide exhibits a positive effect on immune system function. Yet is it noted that supplement studies are carried out on healthy dogs; little evidence exists considering the role in canine disease. That said, there are a range of foods that contain naturally occurring prebiotics including dandelion greens, berries, bananas, flaxseed, apples, carrots, asparagus and of course mushrooms! 4) Fibre for your dog’s heart Cardiovascular disease is an inflammatory disease and diet is often considered the cornerstone for CVD treatment. Many studies have demonstrated that high amounts of dietary fibre can significantly reduce the risk of CVD. It is thought that fibre reduces cholesterol and fatty acid absorption and reduces glucose absorption along with decreasing insulin secretion. SCFAs, which are fermented from dietary fibre, also have anti-inflammatory properties and inflammation is central to complications associated with CVD. Findings here 5) Fibre for your dog’s overall health Dietary fibre adds bulk to the stool, which can alleviate cases of constipation. Not only that, but healthy bowel movements are essential to anal gland health in the dog. On its journey, dietary fibre attracts water and turns it to gel during digestion, this not only slows the absorption of glucose but can trap potentially harmful substances. In the same strand, it can speed the transit of food through the digestive system which facilitates regular bowel movements. Findings here Commonly Used Fibre Although fibre is generally an umbrella term, there are fibres within fibres. Cellulose consists of glucose units bound by linkages that can only be broken down by microbial enzymes, those found in the colon. Cellulose is an effective stool bulking agent. Pectins are found in the skins of fruits, being water soluble and rapidly fermentable. Gums are viscous and sticky polysaccharides found in the seeds of plants; they tend to have a variable fermentation rate. Psyllium husk is a form of soluble fibre, it contains mucilage which swells when in contact with fluid, forming a gel. Psyllium can help to improve faecal consistency. Fructo-oligosaccharides are polymers than contain up to nine sugars. FOS enters the colon intact and then is fermented by bifidobacterial and lactobacillus. FOS is fermented into SCFAs. This fermentation also reduces intestinal pH which can inhibit the growth
Traditional Chinese medicine focuses on healing the root cause of disease; encompassing a range of modalities from herbal medicine, mind-body exercise, acupuncture and of course nutrition. Nutrition encompasses food energetics which are based on the idea that certain foods have certain profiles and can subsequently be used to change the profile of the body. Yin energy is cold or cool, and there are certain foods which have cooling properties. Yang energy is warm or hot, and there are certain foods which are warming. There are also neutral foods,which are thought to have little impact on body profile. It is also thought that flavours can act upon certain organ systems and therefore create a desired health benefit. Not only that, but TCM also advocates a seasonal approach to good health. Creating a holistic view of health, it is easy to nod in agreement with many of the TCM ideas, so let’s explore them in a little more detail. Yin and Yang Yin Yang theory forms the basis of TCM; the idea that balance is key. When a deficiency exists, it should be toned up. When an excess exists, it should be reduced. If there is too much heat, it should be cooled. When there is too much cold, it should be warmed. If dampness is present, it should be dried and so on. Yin and Yang is also assigned based on heat signs. Heat and cold can be both deficient and excess; the goal is to be in harmony. Generally speaking, active, young, and outgoing pets are described as yang. Whereas older, quiet, and shy pets are described as yin. Some animals will self-regulate, the older quiet yin cat may choose to sleep in a warm window, whereas the young yang,excited puppy might jump in the water to cool off. However, we can help yang animals remained balanced by adjusting the environment. For the yang pet, provide cooling environments and foods. Include plenty of shade, air conditioning,fans, and misting. Offer fish, turkey,banana, duck, celery, kelp, spinach and broccoli. For the yin pet, provide warming environments and foods; space to sunbathe, heaters and blankets. Offer mutton, deer, chicken, ginger, chicken liver, squash, and pumpkin. Maintaining the yin-yang balance is key to ultimate health and TCM dictates that its disharmony is the basis of all disease. Yang Excess Yang excess is produced by the invasion of excessive heat, yin us unable to counteract the warming properties so an excess heat condition appears. Treatment requires the heat to be dispelled. Clinical signs: Acute onset Short course Younger age No general weakness Hyperactive High fever Red or purple tongue Strong and fast pulse Yin Excess Yin excess occurs when there is an invasion of excessive coldness. Clinical signs: Acute onset Short course Younger age No general weakness Pain Swelling or oedema Loose stool Pale or purple tongue Strong and slow pulse Yang Deficiency Yang deficiency occurs when yang is lower than normal, but yin is at its normal level. The warming properties of yang are insufficient to equalise the cooling properties, resulting in a cold condition. Clinical signs: Chronic onset Long course Older age Coldness at extremities Edema Loose stool Urinary incontinence Chronic pain/weakness Weakness in rear limbs Infertility Pale tongue Weak and deep pulse Yin Deficiency Yin deficiency is when yin is lower than normal, but yang remains stable. This heat condition is named a false heat. Clinical signs: Chronic onset Long course Older age General weakness Thirsty Lower degree of fever Restless or anxious Prefers cool Red and dry tongue Thready and fast pulse These patterns are then used, by a qualified practitioner, to classify clinical conditions and develop a treatment plan. TCM for Itchy Dogs Whilst the clinical manifestation of skin issues overall becomes quite complex in TCM, the general thought is that most conditions are heat invasions, with damp elements and yin deficiencies. When presented with seasonal allergies, eczema, itching, erosions with pus, alopecia, hot spots and dermatitis, a cooling diet is recommended. In cases of geriatric dryness or dandruff and chronic skin conditions a neutral or cooling diet is recommended. Cooling meats include turkey, ocean fish, rabbit, and white fish. Cooling vegetables include spinach, broccoli, celery, kelp, cabbage, cucumber, and melon. Sesame and flaxseed oil are also cooling. Low Fat Fish Neutral meats include pork, bison, duck, beef liver, pork liver, goose, mackerel, sardines, herring, salmon, and tuna. Neutral vegetables include carrots, green beans, peas, and shiitake mushrooms. Olive oil is also classed as neutral. If we are to consider foods to drain damp, they include beef, beef kidney, lamb kidney, mackerel, and sardines. Along with parsley, lettuce, parsnip, pumpkin,and seaweed. TCM for Skeletal Health With many skeletal issues facing dogs, it is no surprise we want to know if we can use food energetics to our advantage. What is particularly interesting, is that cases of rheumatoid arthritis can present as either hot or cold. The cold pattern is described in humans (dogs have yet to learn how to speak) as cold feelings in the limbs and joints, stiffness, or pain in a joint or muscle which is relieved by applying warmth. Symptoms increase with exposure to cold. The heat pattern is associated with hot, red, and swollen joints with severe pain generally relieved by applying cold. Although diagnosed across the board as rheumatoid arthritis, both hot and cold patterns exhibit different biological markers. Both patterns share the same expressed genes, but they appear to have different signalling pathways. T cell proliferation and the secretion of pro-inflammatory cytokines appear to be increased in hot pattern RA patients. There also appears to be more severe collagen destruction in hot pattern RA too. Cold pattern RA appears to have a higher rate of protein and fat mobilisation demonstrating a more obvious muscle breakdown. Cold pattern patients also demonstrate a reduced hypothalamic-pituitary-axis function which is associated with a decreased stress response which goes someway to explain the higher fatigue level reported in cold pattern RA. Findings here RA, to most is considered
If you are interested in your own nutrition, chances are you’ve come across chia seeds in some sort of smoothie. Touted as a super-food, Chia, also known as Salvia Hispanica, packs a whole lot of punch in those small seeds! Not only beneficial to us humans, but chia can be a beneficial supplement for our canine friends. What is Chia? The word Chia is an adaptation of the Spanish word “chian” or “chien.” Originating from Nahuati, it means oily. This gives you a good way of remembering the benefits of the herbaceous plant; the seeds have a particularly high fat content. Grown worldwide, it tends to favour mountainous regions in Argentina, Peru, Paraguay, Ecuador, Mexico and Australia. It is also grown in Europe, but in greenhouses. Nutritional Composition Chia seeds are high in nutritional value, and seemingly across the board! Their high fibre content, gram for gram, exceeds that of nuts, cereals and other seeds. They pack a whopping 35g of fibre per 100g, flaxseed coming in a close second with 27-28g per 100g. Corn and rice come in around 6-8g of fibre per 100g! Findings here High consumption of fibre has been linked with reduced risk of heart disease, diabetes and a range of cancers. Not only that, but dietary fibre contributes to feelings of satiety so it’s helpful in weight management. Findings here Protein content comes in around 24g per 100g, but what is impressive is the range of amino acids contained! Chia seeds contain arginine, leucine, phenylalanine, valine and lysine. They also contain endogenous amino acids, mainly glutamic and aspartic acids, alanine, serine and glycine. Your dog’s body utilises amino acids to make proteins which help him break down food, grow and develop, repair body tissue and perform a range of other body functions. They can also be used as a source of energy. There are 9 amino acids which cannot be made by the body and as such need to come from food. These are: histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine. As you compare, Chia seeds contain many of the essential amino acids needed in the body. You then have non-essential amino acids which the body can produce by itself; these include alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, proline, serine, and tyrosine. There are also certain acids that are deemed conditional, so if you are particularly interested, you can research this further. If we return to the content of chia seeds, arginine is involved in protecting the intestine and in nervous system function. It also has a role in blood pressure regulation. Glycine has a role in most bodily functions. It is a precursor in intestine proliferation, energy generation in skeletal muscle, immune system function, nervous system function and cardiovascular protection. Findings here Chia seeds are also high in a range of minerals. Phosphorus 860-919mg/100g Essential for bone and teeth formation. Findings here Calcium 456-631mg/100 Calcium is essential in bone and teeth health, blood clotting, nerve impulse, regulating heart rate and maintaining general homeostasis in cells. Findings here Potassium 407-726mg/100g Necessary for the normal functioning of cells, nerves and muscles. Findings here Magnesium 335-449mg/100g Essential in bone and teeth formation and for normal nerve and muscle function. Findings here Their vitamin content is as follows: Vitamin B1 0.6mg/100g Vitamin B2 0.2mg/100g Niacin 8.8mg/100g It’s not surprising that with the mineral content of chia seeds, studies have shown that long term dietary intake of chia is associated with increased bone density. Findings here Chia seeds are also particularly high in Omega 3 Fatty Acids. Studies show around 65% of the oil content is Omega 3! No other food to date has even come close to the same content. Omega 3 has a range of benefits in the body. It promotes healthy cells, immune system, eyes, brain, joints, skin and coats. When discussing the nutritional benefits of Chia specifically, studies have shown the following: They are cardio protective They may help to control diabetes Potential to decrease LDL cholesterol and increase HDL cholesterol Control blood pressure Stabilise blood glucose levels Vision support Supports cognitive function and brain development Anti-inflammatory Anti-viral Findings here Their anti-inflammatory properties have been found of benefit in cases of joint pain and rheumatoid arthritis. Findings here Studies have also shown chia seeds have been supportive when used as a complementary treatment for chronic kidney disease. Findings here It’s easy to see why chia are touted as a super-food. They do pack a whole lot of nutritional punch, for both you and your dog. They are easy to store, and they don’t taste of much, which makes them easy to slip in with even the fussiest of eaters. Chia is non-allergenic, so suitable for most dogs. Of course, check with a health care professional before feeding them. Be mindful, chia can absorb multiple time sits own weight in water, so if you aren’t feeding in a gel form (seeds soaked in water before feeding), ensure your dog has access to fresh water. If you want to check out our what we do, check us out. Consultations Thanks for reading. Team MPN x
Vitamin B12, also known as cobalamin, is a water-soluble vitamin which means no matter how much it is absorbed; any excess will be excreted via urine. It is critical for a range of functions in the body and if you have looked in any multivitamin aisles in the supermarket, it is one of the well-known B complex vitamins. A common deficiency in human vegetarians,disorders of cobalamin metabolism are seemingly increasing in small animal medicine. The causes of deficiency range from chronic gastrointestinal disease to hereditary disease, but what is clear is the health impact of low levels. Suboptimal B12 levels result in: Blood cell count abnormalities Disorders of lipid and protein metabolism Failure to thrive Anorexia Lethargy Vomiting Mood disorders/cognitive decline Slow healing Shortness of breath Muscle weakness Unsteady movement Increased homocysteine levels Functional folate deficiency Because the human body’s stores of B12 can seemingly last 3-6 years, low levels may take a while to be noticed. This seems to be true in our four-legged friends too. So, without further ado, let’s take a look at why it’s so important. Vitamin B12 is essential for DNA and RNA synthesis and for cellular energy production. All cells in all bodies need to know what they are doing and they need energy to do them! There are no known naturally occurring bioactive forms of B12 in plant sources. This is because B12 is synthesised by the bacteria in the gastrointestinal tract of animals, and then absorbed by the host animals. B12 is concentrated in their tissues, which is then eaten by other animals. Sources of B12 include red meat, fish, dairy and eggs. This is why human vegetarians and vegans are often low in it. Once ingested, dietary protein is partially digested by pepsin (digestive enzyme) and hydrochloric acid (HCI). Here Cbl (cobalamin) is released and binds to another protein called haptocorrin. Haptocorrin is then digested by pancreatic proteases (things that breakdown protein); freeing Cbl which can then bind to intrinsic factor. This then forms the B12 complex which travels through the small intestine. Here, there are receptors for intrinsic factor. The complex is internalised into the ileal enterocyte, and then released into the plasma, binding to a plasma protein. B12 is then delivered to those body parts that use and need it. And, there are certain many parts of the body that need and use it. Methionine Cycle B12 plays a vital role in the methionine cycle, which is involved in a range of cellular functions, particularly converting homocysteine to methionine. Methionine can be converted into sulphur-containing molecules which protect tissues,modify DNA, and ensure correct functioning of cells. Methionine also plays a role in creating new proteins in the body, which is essential when older proteins degrade. Whilst it has a role in a range of functions, there have been suggestions that cancer cells too are methionine dependent. Yet, when methionine is replaced with its precursor homocysteine, cancer cell growth is inhibited. Findings here That said, methionine is a key player in producing glutathione. Glutathione is often referred to as the body’s master antioxidant. It is composed of the three amino acids cysteine, glycine and glutamate. Glutathione is an important part of the body’s defence systems. Free radicals are like the exhaust fumes of work, work that the body carries out on a day to day basis. An imbalance in free radicals can result in oxidative stress, something which glutathione can alleviate. Glutathione depletion is often linked with low immune function and increased infection. It has also been found to be protective of skin, lens, cornea and retina damage. Findings here The balance of homocysteine is important,and B12 (along with B6) has the greatest effect on those levels. High levels of homocysteine are often linked to the early development of heart disease, along with Alzheimer’s (in humans), birth defects, blood clots, endothelial damage, and stroke. Resistance to Insulin Mouse studies have suggested that restricted B12 and methionine resulted in an increased resistance to insulin. Insulin is the gatekeeper for glucose getting into cells. Without insulin, glucose remains in the blood without a party to go to. It is argued that the restriction resulted in the lower availability of molecules that are vital to the process of DNA methylation (regulator of gene expression). These gene expressions were modulators underlying the development of resistance to insulin. Findings here Lipid (Fat) Metabolis Low levels of B12 have been noted to increase levels of adiposity, triglycerides, and total cholesterol. It is suggested that deficiency inhibits the oxidation of fatty acids. In these cases, there is also an increase in pro inflammatory cytokines. Findings here The dysregulation of lipid metabolism raises another interesting element. The nervous system has a rich lipid composition. Myelin sheaths are sleeves of fatty tissue that protect nerve cells. These nerve cells carry messages around the body. This is why low levels of B12 can lead to peripheral neuropathy. Without sufficient B12, the myelin sheath is damaged (demyelination) resulting in the disruption of nerve signals between the spinal cord and different parts of the body. This is the same mechanism that occurs in degenerative myelopathy. Whilst it is generally deemed a genetic condition in dogs (specific to certain breeds), in human studies, low levels of B12 have been associated with the condition. B12 deficiency is often a differential diagnosis to degenerative cervical myelopathy in humans too. Findings here Humans with low B12 often report progressive tingling in fingers and toes, without the ability to speak, it is unclear whether these symptoms affect our dogs too, but certainly poses food for thought in itchy cases. Findings here Anaemia The most recognised deficiency of B12 is anaemia. B12 is involved in the formation of healthy red blood cells; anaemia is when the body doesn’t have enough of them. Pernicious anaemia is usually a result of malabsorption of B12 due to a lack of intrinsic factor, the protein found in the stomach. Without enough B12, the red blood cells don’t divide normally (thanks to
Around 75% of dogs are believed to have a vitamin D deficiency! Findings here Rickets! Unlike bands from decades gone by, its comeback isn’t appreciated. In human health, cases of rickets are dramatically increasing. Sadly, there are also new cases appearing in the pet world. Take the 6-month old female giant schnauzer who was presented to a veterinary college with a 1-month history of lameness and difficulty walking. She would also have episodes of yelping in pain with unknown triggers. The diagnosis? A vitamin D deficiency (with secondary hyperparathyroidism). Findings here Vitamin D is often classed as one of the essential vitamins (or hormones) to overall health, so let’s take a look at it in a little more detail. So, what is Vitamin D? Despite its name, Vitamin D is actually a hormone that promotes calcium absorption. In human health, you will have heard it referenced as the sunshine vitamin as it is produced in the skin in response to sunlight (UV) exposure. In studies of hip fractures in humans, there appears to be a seasonal variation; more occur during winter months and fracture patients often have low vitamin D status. When supplemented with Vitamin D and calcium, incidences of fractures often reduce. Findings here So, vitamin D is particularly important in bone health. This is no different for our pets. However, unlike herbivores and omnivores,cats and dogs are unable to synthesise Vitamin D adequately in the skin. There is no seasonal change in concentrations and studies have shown that when fed a diet deficient in Vitamin D, puppies develop rickets which could not be prevented by exposure to UVB light. Findings here This means that cats and dogs are dependent on dietary sources of Vitamin D. There are two forms of Vitamin D. Vitamin D2 is also known as ergocalciferol that occurs in plants and Vitamin D3, known as cholecalciferol, is created in the skin during exposure to UV light and occurs in animals. Cholecalciferol (D3) is of greatest nutritional importance to both cats and dogs and luckily it can be obtained from the consumption of animal products that contain it. It is defined as a fat-soluble vitamin, which means it can be stored in the body’s fatty tissue. It’s true what they say, you are what you eat, or in this case, your pet. Once vitamin D3 is formed in the skin (of animals who can do so), it binds and is then either stored or transported to the liver. Both D2 and D3 are biologically inactive and must undergo two more steps to be activated. This involves both the liver and the kidneys. Vitamin D3 is first absorbed through the intestines, then converted in the liver to 25- Hydroxyvitamin D (or 25VitD). The active form of vitamin D that the body uses is 1,25-dihydroxyvitamin D, also called calcitriol. Vitamin D plays an indirect role in bone health by managing calcium levels in the body. It controls absorption of calcium in the intestine and the amount of calcium excreted by the kidneys. If Vitamin D levels are low, then the intestines struggle to absorb calcium. Calcium is key to bone mineralisation(hardening), without calcium, bones are unable to form correctly. Not only that, but due to the lack of circulating calcium, the body mobilises it from the bones by way of increased parathyroid hormone. This not only weakens the bones, but it also creates a new issue, namely secondary hyperparathyroidism. High levels of parathyroid hormone and low levels of calcitriol (the active form of Vitamin D) often lead to myopathy (muscle fibre weakness). Interestingly, biopsies have shown that vitamin D deficiency often results in predominantly type II muscle fibre atrophy. This maybe particularly relevant to those breeds who have more type II than type I fibres (speedy dogs vs. sled dogs). Findings here In humans, vitamin D deficiency manifests as back-pain, muscle atrophy, weakness and bone tenderness. Most dogs are stoic – they are great at hiding pain; they can’t tell you that they have back-ache. It takes an observant owner to notice the more subtle symptoms of this deficiency, but the more obvious symptoms of Vitamin D deficiency include: Simultaneous deficiency/imbalance in calcium/phosphorus Rickets (soft and weak bones in young dogs) Osteomalacia (soft and weak bones in adult dogs) Osteoporosis (weak bones leading to fractures) Neurological abnormalities Hypocalcemia (low calcium levels) Elevated parathyroid hormone (symptoms include bone pain, depression, kidney stones, hypertension, cardiac arrhythmias, and kidney failure) Posterior paralysis Ataxia (neurological issues including gait abnormality, difficulty walking, tremors) Quadriparesis (weakness in all four limbs) Whilst Vitamin D is usually associated with skeletal issues, low levels are often associated with autoimmunity, infectious disease, diabetes, cardiovascular disease, obesity, neuromuscular disorders and cancer. It must be noted that kidney disease can affect the conversion and metabolism of Vitamin D and so should be cautiously supplemented in kidney disease and status should be checked if kidney disease has been diagnosed. Vitamin D and Autoimmunity Increasing evidence is demonstrating a strong association between vitamin D signalling and biological processes that regulate immune responses. Vitamin D has been found to inhibit pro-inflammatory activity and cytokine production. It is thought to promote TH2 responses which may be protective in autoimmune disease. Vitamin D is also required for the production of natural killer cells which are known for killing virally infecting cells. Findings here Infectious Disease Much like with autoimmune disease, calcitriol is thought to suppress pro-inflammatory cytokines and up regulate anti-inflammatory cytokines. Since the inflammatory response associated with many infectious diseases often increases severity and mortality, the ability to reduce inflammation may improve outcomes. Studies have shown that incases of infectious disease, Vitamin D concentrations were lower than anon-infected control. Findings here Diabetes There is growing evidence that Vitamin D deficiency could be a contributing factor in the development of both type 1 and 2 diabetes. It is thought that cells found in the pancreas that secrete insulin contain vitamin D receptors. Studies have also shown that when treated with a therapeutic dose, vitamin
Many dogs experience some kind of joint problem in their lifetime. This can be due to some kind of injury, strains, sprains, fractures, hip or elbow dysplasia, knee problems like torn cruciate ligaments, patellar luxation and Arthritis. Did you know 1 in 5 dogs suffer from Arthritis? So, what exactly is Arthritis and which is the most prevalent in dogs. Arthritis refers to many related conditions involving inflammation of one or more of the joints. Osteoarthritis (OA) or degenerative joint disease (DJD) is the most common we see in dogs today and is named because the problem is caused by the bones (Osteo). Arthritis in pets can also be caused by infection (septic arthritis or bacterial arthritis) or by the body attacking itself in an immune system malfunction (Rheumatoid Arthritis). The risk of Arthritis increases with age but it can develop at any age. Larger and giant breeds are most likely to get OA so it would be sensible to start adding supplements to support their joints at approximately a year old. A study that was carried out during 2013 found that 200,000 UK dogs were affected. Risk factors associated with osteoarthritis diagnosis included breed (e.g. Labrador, Golden Retriever), being neutered, higher bodyweight and being older than eight years. Research here What is inflammation Inflammation is a normal part of the immune response. Think of the last time you scraped your skin, got a bug bite, or had a pesky splinter you just couldn’t get out. Chances are the affected area got swollen and red, even hot or painful. This is inflammation at work, and in cases of acute injury, it’s a good thing! The inflammatory response is basically your immune system gathering defences to the injured tissue, helping to protect and heal the affected area. This is done by increasing blood flow to the area, gathering immune cells, causing pain to stop you from using injured tissue, and protecting the tissue in other ways that we call Acute Inflammation. Many of the chronic diseases afflicting today’s dogs result from Chronic Inflammation which isn’t such a good thing and can be avoided in some cases. The conventional veterinary community, typically relies on non-steroidal anti-inflammatory drugs (NSAID’s), commercial prescription diets and Adequan injections to treat OA in dogs. In some cases, certain vets may also recommend glucosamine and chondroitin. Ironically, most commercial prescription OA diets contain grains, gluten and/or white potato-all of which can promote inflammation. These diets can also contain a pro-inflammatory ratio of omega-6 to omega-3 fatty acids. NSAID’s – prolonged use can cause damage or injury to tissues of the liver, kidneys and bone marrow (Dodds& Lassin, 2013). Arthritis or DJD can affect one or more joints and is one of the most frequent causes of lameness in dogs. Osteo Arthritisis characterised by: deterioration of the joint cartilage called articular cartilage; a formation of bony growths or spurs on the joints, calledosteophytes; changes in the subchondral bone (the bone below the articular cartilage); and joint inflammation. These changes occur following alterations in both the biomechanical and biochemical properties of the joints (Logaret al., 2007; Sanchez & Balligand, 2005; Zhang et al.,2012). Some might say it is in the genes. Historically doctors have viewed and treated arthritis as a structural disease that involves the breakdown of cartilage and its subsequent effects on the joints, but that view is changing with thanks to a new tool to measure gene expression, including reverse transcription-polymerase chain reaction (RT-PCR),differential display and DNA microarray analysis. Even if we have genetics to consider, nutritional intervention can help support and hopefully prevent this from occurring or at least progressing. Possible Causes of joint issues Leaky Gut Leaky gut syndrome has become an epidemic in people and animals. About 70-80% of the immune system is housed in the gut, so making sure it’s in tip-top shape is key to good health. Since balance of bacteria in our gut influences the balance of our immune system, an unbalanced gut microbiota with too many opportunistic pathogens, can shift the immune system to an increased inflammatory state. Gut Guardian can help address leaky gut. Gut Guardian Inflammatory diet The role of inflammation in many diseases is significant, especially in pets that aren’t receiving a high number of dietary antioxidants. Inappropriate foods such as kibble are ultra-processed and inflammatory. They may contain grains, lectins, gluten and white potato that promote inflammation in the body. Kibble is cooked at high heat, a process called extrusion, that destroys many vital nutrients and enzymes. Your dry food will contain anywhere between 18-60% carbohydrate and we know that sugar raises inflammation. Common meats used in these foods are often chicken and pork. Both high in omega-6, pushing inflammation further, if not coupled with a good omega 3 source. Feed a species appropriate, fresh whole foods diet if possible, preferably raw or lightly cooked. Fresh foods are lower in carbohydrate content and are naturally anti inflammatory compared to carbohydrate foods. Natural sources to support joints are oily fish; salmon, sardines, herring and mackerel as these are the best source of DHA and EPA that are proven to help reduce inflammation. If your dog can’t eat fish due to an intolerance or just doesn’t like it, algae oil is a good plant-based alternative that you can find on the link below. Other sources, that contain smaller amounts of vitamin D foods are organic beef liver and egg yolks. Plant based Vitamin D can be found in parsley, alfalfa, nettle, dandelion and rosehips. Unlike us humans, dogs get very little vitamin D from the sunlight on their skin, so nearly all their vitamin D must come from their diet. Link here for a variety of carefully selected supplements by Green’s for joint health. Drugs, other toxins and over vaccination Avoid unnecessary steroids, antibiotics and (NSAIDs) all of which lead to an unbalanced gut microbiota. Prescription deworming, flea and tick prevention that contain pesticides can play havoc on the immune system so these should be avoided and used only
Whilst we don’t like to bash pet foods and understand that people are often looking for convenience and economical options, we always feel it’s important to highlight why dry food is not a good option for your pet. Fresher food always prevails in my clinic and there are thousands of people who will testify to the wonderful effects of a fresh food diet. There’s a myth that feeding fresher foods is a lot more expensive. Like anything, there is something to suit all budgets and well we believe, if you have invested your time and love into a furry member of the family, then it’s worth considering the best options to support their health. Before we begin to look at dry foods, its important to understand a little more about our dogs and where they have come from to understand their needs. We have domesticated dogs for around 30,000 years. Dogs are facultative carnivores which means their main diet should be a meat based diet but they can survive on other foods if required. Cat’s are obligate carnivores, meaning they are solely carnivorous and wouldn’t survive without a meat based diet. Dogs are a species of canid but domesticated dogs are the closest related ancestors to the grey wolf. We have changed the shape and size of domestic dogs but there has been very little evolutionary change to the digestive system. A domestic dog’s digestive system is designed to eat fresh raw meat and bones (this is where their high and relative need for calcium and phosphorus come from). The first dry food was only produced in 1957 by Purina and since the 1970s, the average age of a dog has gone from 17yrs to 11yrs. Nutrition is not solely responsible for this drop but feeding ultra processed foods, plays a huge huge part in your dog’s longevity and quality of life. Dry food Is made by the extrusion process, extruded food goes through four extremely high heat processes, so you can imagine what that does to the nutrients. You are left with something that is dead “food” void of nutrients, antioxidants, enzymes, fatty acids and probiotics. The food is then sprayed with a layer of fat and flavour enhancers to make it palatable to dogs, then sprayed with a pre mix of synthetic vitamins and minerals. As if all this is not bad enough, food that contains protein and carbohydrates when heated to high temperatures, causes glycemic end products to be formed. AGE’s have been linked to free radical damage, cancer and premature ageing. The other big issue with pet food is the amount of glyphosates, a chemical herbicide (weed killer) used on crops such as wheat, corn, soy and potatoes, commonly used on ingredients found in pet foods. When certain brands were tested for glyphosates, the amounts were considerably higher than expected. Glyphosates are deemed carcinogenic and linked to cancer and many other diseases. We know one in two dogs will get cancer in his/her life time. Research here Another concern with dry food, is most contain a huge amount of carbohydrates. As we know, our dogs are facultative carnivores and our cats, obligate carnivores, which means they need a meat based diet to thrive. Both cats and dogs have no to little nutritional requirements for dietary carbohydrates. They can obtain everything they require from a diet that contains only protein and fat. Energy metabolism in both cat and dog can be based on fat oxidation and the breakdown of protein to produce glucose. Carbohydrates=sugar and can cause a host of problems including systemic inflammation. If your cat or dog has IBS, IBD, arthritis, allergies, bad breath, constant ear infections, urinary issues, obesity, yeast infections, kidney disease, liver disease, thyroid issues, cancer and more, then the first thing to do is look to the food you are feeding, and go from there. Structurally, carbohydrates (starches mostly) are essential to dry pet food manufacturing as commercial extruded pet foods use these starches to give the food structure and texture. Even some canned dog foods contain a carbohydrate source to create a gelling agent. Frequently used carbohydrate sources used in dry food/pet food include grains such as rice, maize, corn, potatoes, legumes, and fillers such as milled beet. The carbohydrate content is not given in dry food but you can work it rather easily. Some popular fed dry foods have shocking results! In most cases there’s more carbohydrates in the food than protein! Most of these dry foods are almost half a bag of carbohydrates. If you want to work out the amount of carbohydrates in your dogs food add the percent of: Protein Fat Ash Fibre Moisture (if not stated 8%) together then subtract the amount from 100, this will leave you the percent of carbohydrates in the food. Here are some of the most common dry food brands: JAMES WELLBELOVED protein 20% Carbohydrates 48% JAMES WELLBELOVED GRAIN FREE protein 21% Carbohydrates 46.8% MILLIES WOLFHEART LAMB AND VEG Protein 19% Carbohydrates 45.5% EDEN protein 45% Carbohydrates 18.5% WAINWRIGHT GRAIN FREE protein 25% Carbohydrates 40% AVA MEDIUM ADULT protein 26% Carbohydrates 46.6% HARRINTONS GRAIN FREE protein 25% Carbohydrates 44.5% BURNS protein 18.5% Carbohydrates 57.8% ROYAL CANIN protein 25% Carbohydrates 45% CANAGAN protein 33% carbohydrates 32.5% TAILS protein 22.3% Carbohydrates 46.9% AKELA Protein 39% Carbohydrates 20.5% ORIJEN protein 38% Carbohydrates 23% HILLS IDEAL BALANCE protein 23.5 Carbohydrates 44.1% AATU protein 32% Carbohydrates 43% BARKING HEADS protein 26% EDGAR AND COOPER Protein 25% carbohydrates 41% STEP UP TO NATURALS protein 22% Carbohydrates 47.2% BAKERS protein 21% Carbohydrates 50% WAGG Protein 21% Carbohydrates 49.8 PEDIGREE protein 21% Carbohydrates 42.9 The Ideal Omega-6 to Omega-3 ratio for pet food is 4:1. This can go up to 6:1 quite comfortably but reaching a higher ratio than this can cause a huge amount of systemic inflammation. The average dry food offers 20:1 and can go as high as 50:1. This is another blog to venture. A required percentage of moisture in your pet’s food should
There’s some mixed feelings about mushrooms but they get a lot of press and rightly so. They are wonderful and each have a magical affect with direct correlation and clinical research to immune and organ support. There are a lots of species of mushrooms and not all medicinal but most magical. Mushrooms help to regenerate, prevent, protect and intervene with certain disease states and the research is growing. The magical mushrooms we will look at today are Maitake, Shiitake, Reishi, Cordyceps, Coriolus and AHCC (active hexose correlated compound). These mushrooms offer nutritional abundance and amazing cell and immune function: Minerals such as potassium, selenium, sodium,zinc, phosphorus Sugars such as mannitol, xylose, glucose, galactose, mannose Vitamins such as b complex, folic acid, vitamin D Proteins essential amino acids Lipids such as phospholipids, sterols, free fatty acids, mono-, di- and triglycerides Polysaccharides such as glycogen and beta-D-glucans Enzymes such as proteolytic The most powerful of all of these are the polysaccharide fraction, mainly beta-glucans, responsible for the immune-modulating effects. Fungal beta-glucans have been shown to activate leukocytes, which depend on structural characteristics of beta-glucans. Findings here Polysaccharopeptides are protein-bound polysaccharides (carbohydrates) that are found in many mushrooms. Krestin (PSK) and Polysaccharide Peptide (PSP) are two types of polysaccharopeptides. Both PSK and PSP possess powerful immune-boosting properties. They promote immune response by both activating and inhibiting specific types of immune cells and by suppressing inflammation. Due to their ability to naturally strengthen the immune system, PSP and PSK are commonly used as anti-cancer agents in conjunction with human surgery, chemotherapy and/or radiation in countries like Japan. Maitake (Grifola frondosa); may help to regulate blood sugar, support heart health, boost the immune system, particularly in cancer care. In fact maitake has shown the most promise in helping support cancer patients. In 2004, an in vitro study showed the effectiveness in 3 types of dog cancer, CF33- Mammary cancer cells, CF21-Connective tissue cancer cells and CL1- Lymphoma cancer cells. The significant study showed that the D-fraction of maitake held the ability to inhibit the growth of the CF21 and CF33 cancer cells. Findings here Shiitake (Lentinula edodes); contain ergothioniene, an active compound that provides potent antioxidant, anti-inflammatory and regenerative properties, as well as lentinan, a compound that may help fight against bacterial, viral and parasitic infections. Shiitake is shown to support liver function, lower blood cholesterol levels, help regulate blood sugars, support skin conditions, used in supporting the immune system in prostate or breast cancer. Findings here Reishi (Ganoderma lucidum): a powerful medicinal mushroom that has been found to possess immune-modulating and immune-potentiating capabilities. Reishi has been characterised as a wonder herb, helping with possible inflammation and allergic reaction. Reishi may help with liver function, fatigue, cancer, skin disorders, digestive issues and possible leaky gut. Findings here Cordyceps Sinensis; may help endurance and stamina during exercise, may have anti-ageing properties due to it containing an enzyme called super oxide dismutase. May have a potential anti-tumor effect, may help to modulate blood sugars, support heart health and help to fight inflammation. Findings here Turkey Tail (Coriolus versicolor); contains a variety of powerful antioxidants and other compounds that may help boost your dog’s immune system and even help fight certain cancers. possessing powerful immune-boosting properties. They promote immune response by both activating and inhibiting specific types of immune cells and by suppressing inflammation. A test-tube study found that turkey tail extract modified gut bacteria composition by increasing populations of beneficial bacteria such as Bifidobacterium and Lactobacillus whilst reducing potentially harmful bacteria such as Clostridium and Staphylococcus. Findings here AHCC® (active hexose correlated compound); is a natural substance extracted from certain species of basidiomycetes, a class of mushrooms that includes shiitake. Research on a canine study showed AHCC treatment might be effective for improvement of clinical state and anti-tumor effect. Findings here Findings here Mushrooms are a wonderful addition and one to explore if you wish to add them to your pet’s plate. As always, we are here to help, so check out our services, click the link below. Consultations MPN Team x
Oh yeah baby Cancer in Pets Part 2! Are you excited (maybe not the right question)? Just a word to the wise, if you haven’t yet read part 1, it would be helpful to get a grasp on immunity and what to consider diet wise first. It won’t ruin part 2 (a bit like watching Home Alone 2 before Home Alone), it’s not a deal breaker but kinda nice to get some back story and structure. Cancer in Pets Part 1 So we now know what type of diet to consider in cancer but we need to compliment this route by looking at immunity and supplement choices, to help support the body and rid the body of as many toxins as possible. After all, Dr Thomas Seyfried did demonstrate that cancer is triggered by toxic overload. When looking at every client, once we have considered genetics, history and presenting symptoms, we then look at the 8 systems in functional medicine. This allows us to approach it with a framework, piecing things together like a jigsaw. Functional medicine isn’t diagnostic, it looks at the what, why and the how. In our consultations we look at the pathophysiology’s in great depth and consider a number of other processes not even mentioned here (we want you to read on). The 8 systems Stress; we know this to be a trigger for cancer. Stress releases cortisol, this tends to shut down the digestive system somewhat. We know this leads to leaky gut and mass inflammation in the body if extended periods of stress are experienced. This type of inflammation is TH2 dominant and cancer is a TH2 dominant disease. If we know there is a lot of stress, we would address this to try and help mediate this response and reduce some inflammation. Immunity; Immunity is effected by absolutely everything and when your pet has cancer this is an immune malfunction and must be treated as such. This is where we look at TH1 and TH2 and help support it with mushrooms, herbs, probiotics and so forth. Stress, detoxification, digestion and pretty much every system greatly impacts immunity so we need to look at everything closely and support all processes. Detoxification; detoxification encompasses the lymphatics, digestion, kidneys, liver and gallbladder. We would look and have particular questions for each system within detoxification. If these systems aren’t in check and in particular the liver, cancer can become a monster. The liver is the powerhouse. It breaks down and filters pretty much everything in the body including toxins and if this isn’t working well, we need to address it. We would definitely look at phase 1 and phase 2 of detoxification pathways in the liver to ensure support during this difficult time. Digestive health; microbiotia is very important to help immune signalling and detoxification. If this isn’t in good balance and your pet is exposed to a lot of allergens, pathogens, toxins and so forth, this can trigger leaky gut and inflammation. Making sure bacteria, acid levels, enzyme production and the integrity of the gut are all in balance is essential for a robust environment to ensure well-being and support in cancer. Reproductive health; this is often an issue as most animals have been desexed and so this has a knock on effect regarding the hormonal system, the immune system and the neurological system. This is very particular to each and every pet but is definitely closely correlated to immunity and in some cases can be the driving factor of certain cancer. Cardiovascular health; heart and kidney function are closely correlated. Strong heart and kidney health is essential in cancer. Methylation is a process that is considered here. We know poor methylation can lead to high homocysteine which appears to be a health marker in heart disease and cancer. Hormones; we tend to just think of sexual hormones but actually hormones come under the endocrine system. These are responsible for a number of things such as growth and development, metabolism, sexual function, reproduction and mood. Serotonin (your feel good hormone), Gaba (the relaxing hormone), Insulin (blood sugar regulation), Cortisol (the stress hormone) and Thyroid (for metabolism) are just to name a few. Hormones such as insulin are inflammatory and high blood levels of insulin indicate a higher risk of cancer which is why we don’t advocate much sugar in your pet’s diet (PERIOD). Structure; making sure connective tissue and the skeletal system are strong is also an essential part of the health matrix. In cancer there is a lot of free radical damage and connective tissue can easily become damaged. This is why antioxidants (in the right form) are essential. Reducing inflammation is key. So lets look at some supplements that may help support your pet. Supplements As a generic approach we would look at the stress, digestion, immune support and detoxification in cancer support. Supplements are an important consideration in cancer but seeking advice from a health care professional is ALWAYS advised. Here are my top 6 supplements Ashwaganda; we love me a bit of Ashwaganda. Ashwagandha is one of the most important herbs in Ayurveda, a form of alternative medicine based on Indian principles of natural healing that has been used for over 3,000 years. It’s a beautiful adaptogenic herb that supports the stress response and immunity in your pet. It’s classically known as a nervine tonic but this beauty has many strings to its bow. The clinical studies and research so far is very promising.The more I formulate with and research this herb, the more I am in awe (and in love). Some research here on Ashwaganda! Probiotics; your dogs microbiome is as individual as they are. Microbiome is a community of thousands of different diverse bacteria, fungi and virus, all working together to fuel health and immunity. Gut microbiotia is essential in health and driven/affected by diet, stress, environmental conditions and so on. Probably the most important bacteria phylum in your dog is Bacteroidetes. These bacteroidetes produce short chain fatty acids that
Cancer is the second most common reason clients consult with MPN. Cancer is an epidemic! It’s estimated that almost 50% of cats and dogs will die from some form of cancer. When considering the full picture of health, at MPN we look at genetics, breeding, health of pregnancy, birthing, weening, environment, nutrition and the functionality of all 8 body systems (neurological, digestive, cardiovascular etc). In order to truly understand your pet’s needs, all these factors must be taken into consideration to obtain the best plan. Particular breeds or certain breeding will transcript coding that makes cancer more likely in certain cats and dogs, however this isn’t exclusive to genes and breeding. This is prevalent and likely in pets who experience chronic inflammation and experience an immune malfunction due to a number of factors. What is cancer Cancer is the uncontrolled growth of abnormal cells in the body. Cancer develops when the body’s normal control mechanisms cease to work. Old cells do not die and form new, abnormal cells that can grow at a fast rate. These extra cells may form amass of tissue, called a tumour. The Immune system In 2013, Dr Thomas Seyfried demonstrated that cancer is a metabolic dysfunction of the mitochondria (energy producing organelles in cells), triggered by toxin overload. That is the very nature of cancer but how we end up there is very much to do with the immune system. In order to support cancer one of the major contributing factors is the immune systems functionality and how it responds to invading cancer cells. Cancer is an inflammatory disease. I see Cancer as an ‘immune malfunction’ where a consistent imbalance in the immune system, tips into inflammation. In more than basic terms, the immune system is split into 2 phases, Th1 and Th2. In a healthy pet, Th1 and Th2 cells are maintained in a carefully regulated balance. If a bacterium enters the body, it activates Th2 cells that dominate the network to begin a cascade of immune events leading to an antibody response that clears the infection. If a virus enters cells in the body, it activates Th1 cells which dominate and instruct the killer cell response to clear infected cells. Once the infection is cleared, suppressor cells are activated to shut down the dominate response and bring the network back into a resting state. If the suppressor cells do not act to bring the network back to a resting state, a pathological Th1 or Th2 dominated immune system results. A Th2-dominated immune system is characteristic of cancer patients where the killer cell response in TH1 is suppressed (recognising defective cells). Patients with advanced cancer often have impaired cell-mediated immunity associated with a switch from Th1 to Th2. Research shows that cancer patients, exist in a state of Th2-mediated “chronic inflammation”. Findings suggest that Th2 dominance status encourages carcinogenesis (the initiation of cancer formation). There’s a lot we know about immunity but still so much we don’t. It’s a complex issue but understanding the very basics can help us look at things differently and can help to support your pet. Cancer diet Nutrition is obviously a key factor in supporting cancer. We find the fresher the food the better. Natural, fresh, homemade, and perhaps raw are best (it depends on the immune function: I often suggest lightly cooked dependent on the individual). Intense processed food is definitely not the best choice for optimum health. We know dry food can lead to more inflammation from independent research. Most dry food contains around 35-50% sugars, due to the starch content that binds it all together. Cancer LOVES sugar, this was documented years ago but has never been much of a focus with regards to cancer care until more recent years. We also know from recent research from Dog Risk at the University of Helsinki, that a controlled study of dry fed and raw fed dogs, raised disease markers when fed dry food. The study demonstrated clear data of increased plasma homocysteine in the variations of the dry fed dogs as opposed to raw. We know that homocysteine is a marker for disease and closely linked to cardiovascular complications and other disease states. Recent advances have shown that increased plasma homocysteine could be correlated to cancer also. We are not necessarily advocating raw, in fact in some cases we actively recommend lightly cooked but the above demonstrates differences in metabolites, in dry verses fresh. Fresh always seems to prevail with the best results. It is important to know that not all foods will suit your pet and looking into this is an imperative part of the process. Immune mediated responses can arise from food sensitivities, food allergens, environmental allergens and toxins on a daily basis and sometimes owners aren’t aware of this. This can lead to a permanent state of inflammation. An allergic response is a TH2 response so consistently being exposed to allergens can put your pet in a permanent state of TH2. See above to know that this isn’t groovy for cancer patients or general well-being. Allergies and cancer can by hyperlinked. In fact, histamine (a compound often released in response to an allergy) is commonly known to induce tumour proliferation and immune suppression in certain cases. Ketogenic Diet The ancient Greek practitioners were well known for using ketogenic diets and although it seems more of a new concept and revelation, it’s been around for donkey’s years, so we can’t lay claim to creation. That said, there is a lot of information and research regarding the benefits of keto diets and cancer amongst other disease. In fact, there’s thousands of research papers, many based on animals. There is even a wonderful centre in America called Keto Pets Sanctuary who specialise in keto research. A ketogenic diet is based on moderate protein, high fat and very low carbohydrate. The ratio usually required to induce ketones is fat to protein 2:1. That is a very high fat diet and should be fed with caution. If a diet provides a high fat content, glycogen
