Here at My Pet Nutritionist, we help customers tackle a host of different health conditions and concerns. Some diseases our customers’ dogs come to us with are common, and simple, others are not so common, and more complex. Exocrine Pancreatic Insufficiency is one of the not-so-common examples of health concerns we have helped customers with. While it is rare, and not tested for as standard, we are beginning to see more and more cases of EPI, so this blog post will be a great educational tool for those who want to learn more about EPI, as well as those who’s pet has been diagnosed with it. What is EPI? EPI, as its commonly called, is shortened from Exocrine Pancreatic Insufficiency. ‘Exocrine’ is the system to do with the body’s enzymes. The pancreas is an important part of the digestive system, and also an important part of the exocrine and endocrine systems. The pancreas is an organ, located in the right side of the abdomen, close to your dog’s stomach. There are two parts to the pancreas – the exocrine pancreas and the endocrine pancreas. The endocrine pancreas releases the hormone, Insulin, which controls blood sugar levels. The exocrine pancreas releases enzymes responsible for food digestion, particularly the macronutrient, protein. In those suffering with EPI, the pancreas is unable to produce enough of these enzymes, which leads to major malnutrition, unless treated daily. EPI is an incurable disease, and requires daily management to keep symptoms at bay. Findings Here Symptoms of EPI There are a number of symptoms associated with Exocrine Pancreatic Insufficiency. Many of these symptoms are common symptoms of other health conditions, which makes diagnosis of EPI quite tricky, but the symptoms can be severe, and in some cases life threatening. Here’s some of the main symptoms you could expect from a dog suffering with EPI include: Rapid weight loss Lack of ability to put weight on Insatiable appetite Chronic diarrhoea Mucus in the stool Vomiting Lethargy/fatigue If your dog has a number of these symptoms, it is extremely important you have your dog assessed by a veterinarian, as EPI dogs can go downhill very quickly. Findings Here Diagnosis of EPI Exocrine Pancreatic Insufficiency is rarely routinely tested for upon first signs of symptoms, and is regularly misdiagnosed. As the disease is quite rare, and little is taught about it in initial veterinary qualifications, dog owners who suspect this disease often have to specifically request for testing for EPI in their initial consultations. So how is EPI diagnosed? There are two tests carried out in those with suspected EPI. A fasted blood test, and a faecal test. Once the sample has been taken, the test used is called a Canine Trypsinogen-like Immunoassay (or cTLI for short!). For this test, pets must be starved for a minimum of 6 hours – this is usually best done overnight. Trypsinogen is a non-activated enzyme; known as a proenzyme. The pancreas of healthy individuals secretes Trypsinogen into the small intestine with other enzymes in the mix, where it converts to Trypsin – the activated form, which is used to digest proteins. It is very much normal for Trypsinogen to be detected in blood tests of healthy animals, because a little Trypsinogen leaks into the blood stream where it is circulated around the body. How do cTLI results differ for those with EPI? The results from a cTLI of a dog with EPI will show as low to no Trypsinogen when analysed. This is because those suffering with EPI have a reduced functionality of the pancreatic tissues, resulting in less Trypsinogen being secreted into the intestine, and therefore less leaking into the bloodstream, if any. Findings Here Another blood test is usually carried out in cases where EPI is suspected, to test for levels of Vitamin B9 (Folate) and Vitamin B12 (Cobalamin). While these vitamins aren’t directly related to the pancreas, they can easily be affected by a poorly functioning pancreas due to the affect EPI has on the microbiome of the gut. Blood serum analysis for Vitamin B12 will be low, as EPI can lead to B12 deficiency, whereas serum analyses for Folate will usually come back in excess. You can read more about high Folate and it’s relationship with low Vitamin B12, and how these are affected by the pancreas in our blog here. Findings Here Let’s move onto the faecal testing side of EPI diagnosis. The test carried out is called a Faecal Elastase Test. This test is for another of the pancreatic enzymes used during digestion, called Elastase. As with all enzymes, Elastase performs a specific job – it’s role in digestion is to help break down fats, carbohydrates and proteins, for use by the body for energy, growth, and cell maintenance. Healthy individuals with a well functioning pancreas will have elastase in their stools, however those with EPI will not produce as much elastase due to damaged pancreatic tissues, so elastase would be lacking in faecal samples. Findings Here Causes of EPI There are various reasons a dog may have EPI – it can be congenital (present from birth), hereditary (genetically inherited), or acquired (through trauma or disease). Congenital and hereditary causes are self-explanatory – it’s important to source puppies from health tested breeding pairs, with no history of EPI in their immediate or extended genetic lines. If you are opening up your heart and home to a rescue dog, there is a small chance of congenital or hereditary EPI, as you don’t know the history of the dog’s genetic lineage, however it is a rare disease, so it wouldn’t be on the forefront of our minds when considering a rescue dog. Should you experience the symptoms listed in this blog post, hopefully our guide will help you and your rescue dog should the need arise. As with many diseases we write about here at My Pet Nutritionist, there are some breeds which are genetically predisposed to EPI, including: West Highland White Terriers German Shepherds Akitas Border
Graves Disease is an autoimmune disease involving the endocrine (hormone) system, specifically the thyroid, which we see from time to time here at My Pet Nutritionist. It can be a worrisome diagnosis for any pet owner, and it’s important that owners of pets with Graves Disease understand what it is, and how they can tailor their pet’s diet and lifestyle to keep on top of symptoms; which ultimately extends their pet’s comfort. That’s where we come in, to provide you our Ultimate Guide to Graves Disease in Pets. What is Graves Disease? Graves Disease is the non-clinical, or common, name for autoimmune Hyperthyroidism. You may have heard about Hypothyroidism quite regularly on social media and other platforms where pet owners connect, particularly on dog based platforms; but you may not have seen much discussion on Hyperthyroidism. Graves Disease is rare, but possible, in dogs but tends to be more of a frequent trouble for our feline companions. It can be found in us humans, too! So what exactly is Graves Disease? What happens when your pet has it? If you want the short answer, the thyroid gland in your pet is overactive – it’s working over time! We feel it’s important to understand more about it though, so read on! Graves Disease is an autoimmune condition. Autoimmunity tends to occur due to a damaged immune system, or in individuals with a genetically compromised immune system. The body essentially attacks itself, as it recognises various proteins and other substances in the body, as foreign. The thyroid is a gland which produces various hormones, essential for a healthy life. The hormones produced and secreted by the thyroid are called triiodothyronine (T3), and thyroxine (T4) – these help regulate the body’s metabolic rate. When there is a deficiency in these hormones, important bodily processes slow down, which causes a host of health issues. Now, when these hormones are too abundant, effects on the body can be equally as disruptive. We will discuss symptoms next. Symptoms of Graves Disease There are various symptoms of Graves Disease which you may notice in your cat or dog. Let’s take a look at some of the main symptoms: Weight loss, often rapid Diarrhoea Nausea/vomiting Swelling of the neck and face Increased urination Increased drinking Increased appetite Difficulty swallowing Shortness of breath and increases heart rate Change in pitch of bark Reduced eyesight capabilities Behavioural changes, including anxiety depression, and/or hyperactivity. Causes of Graves Disease The cause of Graves Disease is very much unknown. There is very little research into the causes of Graves Disease. It is often describes as ‘idiopathic’, meaning there’s no known cause. Some studies suggest that one known cause of Graves Disease in dogs (though rare) is as a result of a rapidly spreading cancer, called thyroid carcinoma. In cats, some cases of Graves Disease are secondary to a non-cancerous tumour forming on the thyroid gland called Adenomas. Like in dogs, in rare occasions, malignant tumours known as adenocarcinomas can cause the development of Graves Disease by causing the over production of hormones. It is possible that deficiencies in the diet may contribute to onset of Hyperthyroidism, as well as exposure to chemicals and toxins absorbed by the body, including flea and tick products which are toxins, and end up in the bloodstream, which disrupts the normal functioning of the thyroid. Diagnosing Graves Disease The first step in a diagnosis of Graves Disease, is a physical examination of the neck area of your pet. The purpose of this, is to feel for an enlarged thyroid gland. Secondly, the vet will take a blood sample to test for hormone levels in the blood. If the reading comes back with a value higher than the ideal’ threshold for each hormone, it’s very likely your pet has Graves Disease. If the T3 readings are high, but the T4 readings are ideal, more tests may be required, which would be discussed with the vet. These tests may include further bloodwork, and a urinalysis, which will show potential secondary defects to the heart and kidneys. As the thyroid is involved hormonally with the vast majority of the body’s organs, imperfect bloodwork in relation to other organs, could help show a problem with the thyroid. Conventional Treatments As always, here at My Pet Nutritionist, we like owners to be able to make an informed choice with their dog’s health, and encourage the use of conventional treatments where necessary in life potentially endangering situations, and situations where quality of life becomes the biggest importance. This is of course, alongside as much natural support as possible, and feeding a fresh, therapeutic diet. More on this later – let’s take a look at the conventional treatments your veterinarian may offer. There are various approaches which may be taken. As carcinomas are one of the most common, treatable reasons a dog or cat may have Hyperthyroidism, most are based around treating the cancer. Radioactive Iodine Therapy Radioactive Iodine Therapy is fairly common in practices which offer it as a treatment. The radioactive iodine is injected into the bloodstream, which makes its way to the thyroid gland. The thyroid gland takes the iodine up, causing radiation to be emitted. The emitted radiation then destroys any cancerous tissues around the thyroid, but does not cause any damage further afield. This treatment often results in normal levels of hormone production within mere weeks of the injection, making it extremely effective in curing hyperthyroidism. This treatment option has to be undertaken in a specialist veterinary hospital with licencing to carry and use radioactive substances. The pet must also be kept in the surgery until their levels of radiation are safe for handling. Findings Here Findings Here Medication Some drugs may be offered, to inhibit the production and release of hormones from the thyroid. As the thyroid is overactive, slowing it down is imperative to managing Graves Disease. This method will not cure, but can support the pet in reducing flare ups and secondary health implications. Being the
Here at My Pet Nutritionist, we see many dog owners worrying about the condition of their dog’s skin. The appearance of keratosis, and risk of secondary infection can be concerning, but there are things we can do to help those suffering with it. Keep reading to find out what it is, and how we can help those with it. What is Keratosis? Usually referred to as Hyperkeratosis, the condition presents as hardened, thickened, and often cracked and very dry skin. The term ‘keratosis’ stems from overgrowth of keratin in the skin. When too much keratin is produced, the skin becomes less supple. Unfortunately, hyperkeratosis often leads to secondary infection when it is not treated promptly. Those with keratosis will usually find it on the paw pads, and nose. While it can happen elsewhere on the body, these are the most common places it is found in our dogs. Many owners ask if keratosis is painful for their dog. Unfortunately keratosis can be very sore and uncomfortable for them, especially those with cracked skin, and secondary infection. The areas can become very inflamed too, which adds to the pain sensation. Causes of Keratosis There are various factors which can lead to your dog getting keratosis. Let’s have a look at some of these. Age is a huge factor in those with keratosis. It is commonly seen in older dogs, of any breed, but it is most commonly seen in elderly cocker spaniels, boxers, beagles, basset hounds, and various bull breeds. Findings Here Infectious Disease Survivors can be more prone to keratosis, specifically those who have had a systemic infection (an infection which affects the whole body), such as leishmaniasis and distemper. Internal upset in the body, very often presents externally as a skin reaction. The skin is very often an outward sign of inward stress. Findings Here Findings Here Systemic Autoimmune Disease such as systemic lupus and pemphigus foliaceus can also lead to keratosis, again, as an outward sign of inward stress. Findings Here Genetic predisposition is a very common cause of keratosis. It is incredibly important not to overlook lineages/parentage of your dog. This is obviously not easily achievable in most rescue dogs, but if you are planning on buying a puppy from a breeder, a history of skin related issues in the breeding stock is very worth asking for. Labradors are particularly prone to hereditary keratosis of the nose, and usually starts between the age of 6 and 12 months, with recurrent flare ups throughout the dog’s lifespan. A lot of healthy individuals who have no other visible reason for the onset of keratosis, will be diagnosed with having idiopathic (no identifiable cause) keratosis. Findings Here Inadequate Diet Type. The method of feeding being used can also affect the possibility of the dog getting keratosis. As always, we would recommend a fresh food diet, as these are minimally processed, and allow ingredients to provide unaltered nutrition. Zinc Deficiency can cause keratosis. Some breeds of dog, namely the husky and the malamute, cannot absorb zinc efficiently, by genetic predisposition. Many other breeds of dog who grow at a rapid rate, mostly giant breeds, may also struggle to absorb zinc efficiently. One of the main reasons we see in a variety of individuals of many breeds, large and small, is zinc deficiency, leading to keratosis – it is the second most common mineral deficiency, and can be tested for through hair analysis and blood testing at the same time. The lack of zinc can contribute to keratosis as it causes the abnormal production of keratin. Findings Here Findings Here Trauma, particularly to one particular area of the skin, keratosis is common. This is because the cells in the skin, called keratinocytes, react to the repeated trauma by producing excess keratin, with the aim of hardening the skin for protection. This is often why many dogs suffer with keratosis on their paw pads; from repeated walking on hard surfaces. Elderly or overweight dogs who sleep or lay frequently on hard floors often struggle with keratosis due to repeated pressure on certain parts of the body. Findings Here Supporting the Body Externally Recovery from keratosis is a two pronged attack, using internal, and external methods. So what can we do externally to help our dogs suffering with keratosis? As keratosis presents as dry skin, the most important thing to do, is moisturise it. Moisturising the area is imperative to healing keratosis. There are so many natural, and very effective products you can use to moisturise. Coconut oil is one of the most popular, and readily available on the market. Other products include an array of natural snout and paw balms from various companies. Look out for those which do not contain unnatural ingredients – look out for products made from one, or a mix of a couple natural oils such as seed oils and coconut oils, and often a combination of dog friendly essential oils and other seed oils. Apply your chosen moisturising product twice per day, and try to avoid letting your dog lick it off. Supporting the Body Internally The second prong of the two-pronged approach, is internal supplementation, and dietary changes. First we’ll look at diet. A fresh diet would be ideal – these give plenty of moisture, vs dry food which contains very little moisture. Fresh foods are also not ultra-processed, so are much more gut, and therefore skin friendly, as there are huge links with the gut and skin health when we look at the gut-skin axis, for which more information can be discovered in our blog. The vast majority of dry foods on the market have been shown to not meet minimum nutritional guidelines, so deficiencies linked to keratosis are very possible. Using balanced fresh food can be much easier to balance, as we know what is in it. Let’s take a look at supplements. In breeds with a zinc deficiency predisposition, it is important to supplement with zinc. Other breeds shouldn’t require this. The other
Immunity is no doubt at the forefront of most pet owner’s minds. Everyone wants their pets to live a long and healthy life, so keeping a strong immune system is essential. Here at My Pet Nutritionist, we help many pet owners through their own experiences of disease in their pets, so we thought we would put together this blog on the cornerstones for a strong immune system in your pets. 1. Gut Health Gut health is key to general health of all species, whether it be human, canine, feline, or even smaller furry pets! Virtually all aspects of health can be improved through good gut heath. Around 70% of the immune system is found in the gut! Quite a staggering figure, but a very important fact to keep in mind when it comes to our pets’ health. In an unhealthy gut, the immune system becomes massively impaired, leading to a potential multitude of health issues, including those allergy dogs we so often help here at My Pet Nutritionist. Many things can damage the gut, including chemical flea and worm treatments, poor diets which are processed and/or high in ingredients containing lectin, contact with household and garden chemicals and much more. It’s imperative to gut health, to feed fresh, and limit the exposure to all toxins! Using a mucilage herb for those with damaged guts, helps to heal the gut; these include slippery elm, marshmallow root, and deglycyrrhised liquorice. Teaming these with a probiotic allows the gut to flourish, as a damaged gut will leak the good bacteria which forms a large part of the immune system. Gut Guardian 2. Methylation DNA Methylation is a very important chemical process within the body. This process includes the chemical modification of DNA during replication of cells. Gene expression can be altered through methylation too. So, why is this process an important part of keeping the immune system strong? Various malignant cells, including those for lymphoid cells (produces immune cells B, T and NK) and myeloid cells (related health issues, such as Mast Cells) replicate through a process called hematopoiesis, making these cells ‘hematopoietic stem cells’ (HSCs). Myeloid cells are not ones we want replicating in the body, as they can lead to various types of tumour. Here’s where the process of Methylation comes in to play! Methylation has the ability to regulate HSC differentiation – in other words, it reduces the risk of the Myeloid cells replicating, and forming tumours, but increases differentiation of lymphoid cells. For more information on the types of cells involved in immune responses, read our blog here! Findings Here Findings Here Findings Here 3. Healthy Brain and Endocrine System The Endocrine System is what keeps the body’s organs in good health, through homeostasis. The endocrine system and immune system used to be thought to work independently from one another, but more recently, it was discovered that the two systems work hand in hand to keep the body healthy, and control infection. The immune system uses a mixture of immune receptors and cytokines to fight infection, and the endocrine system uses hormones to regulate metabolism in the body’s organs. As an example, one of the most important regulations aided by both systems, is the metabolism of glucose. Insulin is produced by the endocrine system to regulate glucose levels in the blood, and helps the body to fight infection. Cytokines aid the body during glucose spikes by increasing responsiveness of the peripheral organs to the endocrine system. When the organ becomes more responsive to the signals from the endocrine system, greater amounts of the required hormone can be produced. The brain produces so many important hormones for health of the body, and to help fight a variety of infections, so it is important to keep the brain healthy and free from inflammation. Supplementing your pet’s diet with plenty of omega 3 is a great way to keep inflammation down. To read more about the endocrine system, and the importance of hormones, read our blog here! Findings Here Findings Here 4. Circulation and Lymphatics The lymphatic and circulatory systems are an important part of immunity, and keeping the immune system strong. The lymphatic system is responsible for draining excess fluid from bodily tissues, removing cellular waste, absorption of fat soluble vitamins from dietary sources, and helping to fight infections. The circulatory system works with the lymphatic system to transport the cellular waste and excess fluid around the body, and away from the relative organs. The interstitial fluid (found between tissues) is what provides the body’s cells with important nutrients, and a way of removing any waste from the cells. The lymphatic system acts as a taxi for antigens and antigen-presenting cells to transport them through the body to places of infection. This enables the antigens to fight the infection in question, and expel waste. Findings Here Findings Here 5. Detoxification Finally, detoxification is essential for immune health. The body is exposed to a host of toxins, just by going through daily life. We live, generally, in a very toxic world, so detoxifying the body is essential. Detoxification aids methylation, which as discussed above, is a very important process for a strong immune system. Liver Guard Heavy metals can be picked up and consumed very easily in our pets – traces can be found in food, and heavy metals are also in abundance in vaccinations. Those who have received vaccinations during their lives, whether only one has been given at an appropriate age as a puppy, or they’re given regularly (if given regularly, over vaccination occurs, making the risk of vaccinosis higher; read more here) the likelihood that your pet has heavy metals in the bloodstream is high. Heavy metals disrupt metabolic functions in vital organs, as well as reducing the ability to efficiently absorb vitamins and minerals from dietary sources. Detoxification can be achieved through feeding a fresh, preferably organic diet, minimising exposure to environmental and veterinary toxins, occasionally offering Epsom salt baths, supplementing the diet with milk thistle (this
A diagnosis of Diabetes in your pet can feel quite daunting. We decided to put together this guide on diabetes in pets, to bring all you may need to know about diabetes, and caring for a diabetic pet, into a handy, bitesize guide! What is Diabetes? Diabetes is a condition causing blood sugar levels to become too high. There are three types of diabetes; Type 1, type 2, and Diabetes Insipidus. Type 1 is found in around 0.2 to 1% of dogs, but type 2 diabetes is not found in dogs; it is however, found in cats. Diabetes Type 1, is most commonly found in adult dogs between the ages of 6 and 9. Diabetes Insipidus is another type of diabetes, unrelated to type 1 or 2, but with similar symptoms. Findings Here Symptoms of Diabetes Symptoms of diabetes in pets include: Polydipsia (excessive water consumption; read more here!) Polyuria (excessive urination; read more here!) Increased appetite Weight loss (often rapid) Recurring skin and urinary infections Clouded eyes A dog with diabetes may present with any number of these symptoms, so if your dog is displaying one or more of these, it’s best to have a full vet check. Findings Here What Causes Diabetes? A huge part of the cause of diabetes in dogs, is down to genetic predisposition. Breeds predisposed to the potential to develop diabetes include: Miniature schnauzer Dachshund Beagle Poodle Samoyed Keeshond German Shepherd Golden Retriever Labrador Retriever Bichon Frise Pug Cocker Spaniel Diabetes can also be caused by other ongoing medical problems. It can be a secondary condition to Cushing’s Disease, Pancreatitis and obesity. Those suffering with pancreatitis flare ups are at risk of diabetes due to the damage on the organ, caused by regular periods of intense inflammation. The pancreas secretes insulin which regulates blood sugar levels. When insulin is not able to be produced due to damage to the pancreas, blood sugar spikes occur, which leaves dogs at a high risk of diabetes. 30 to 40% of dogs with diabetes, also have pancreatitis. Obesity, like in humans, is a common predecessor for diabetes as it contributes to insulin resistance. Resistance to insulin, means less control of blood sugar levels. Findings Here Diagnosis of Diabetes To test for Diabetes, your veterinarian will take bloods and urine samples. In the urine sample, they will test levels of glucose and ketones. If there is a significant abnormality in these results, the blood glucose level will be tested. If glucose levels are very high in the blood sample, and found in the urine sample, a diagnosis of diabetes can be made. During testing for diabetes mellitus (Type 1), other significant markers for other conditions may be found, so your veterinarian may start treatment for other conditions as well as diabetes. If your dog’s urine is extremely dilute, diabetes insipidus may be a diagnosis your vet may consider. Findings Here Monitoring, and Medical Intervention Insulin Therapy After diagnosis, the first thing your vet will work out, and prescribe, is the right insulin dose for your dog. The vet will teach you how to give an insulin injection, either by syringe, or VetPen. These will need to be given regularly alongside monitoring, to ensure your dog’s blood sugar levels stay consistent and within a normal range. Findings Here Monitoring Glucose Levels Traditionally, your vet will teach you how to monitor urine glucose levels at home. Urine can be tested using urine strips, just as you would in the human world. The vet may also teach you to test your dog’s blood glucose levels. They will provide you with a portable glucose meter, which you will use in tandem with blood test strips. Bloods may be taken, and analysed regularly by the vet to keep an eye on blood glucose levels and ensure the insulin dosage is correct. More recently, some veterinary practices have been offering the Freestyle Libre device worn by many human diabetics. This is a device inserted into and attached to the skin, which reads blood glucose levels. When the owner needs to check glucose levels, they simply use their accompanying mobile phone application which connects to the device. This is an expensive option, but very fail safe, and easy. Findings Here Findings Here Spaying Females Your veterinarian will recommend you spay your female dog if they are diagnosed with diabetes. One of the female sex hormones, called progesterone, can sadly interfere with insulin usage in the body, which could cause a blood sugar spike. Findings Here Supporting the Body Naturally Diet As with anything, we always recommend feeding a fresh diet. Why is this so important for diabetes sufferers? The carb content in dry foods causes a spike in blood sugar levels. Forcing a raised blood sugar level on a diabetic dog will put a huge amount of pressure on the organs, and can cause hospitalization. When looking at the ingredients list of dry foods, there may be very few ingredients which appear to be carbohydrates; however, these do add up! The carb content of dry foods isn’t specifically listed, only protein, fat, moisture and ash. If you add those up, and deduct from 100, you will get the percentage of carbs in the food. Most dry foods are between 20 and 70% carbs! Three very important components of a diabetic dog’s diet, are fibre, fat, and protein. Fibre, fat and protein help to stabilise blood sugar levels as the consumption of these macronutrients causes the digestion of carbs to slow down, ultimately slowing down their absorption into the blood. Because the absorption of the sugars from carbohydrates is slowed, blood sugar levels stay more controlled, and are more unlikely to spike. Findings Here The moisture level of fresh food, also helps keep the urine suitably dilute, and not concentrated in glucose or ketones. You will need to keep the amount fed each day the same, as this is what your dog’s insulin dose is based upon. If the dog is fed more than normal, the
Here at My Pet Nutritionist, we see a lot of arthritis cases. There are numerous types of arthritis in existence, some of which can be autoimmune responses. We thought we would put together a short guide on the two most commonly seen types of autoimmune arthritis; Immune-Mediated Polyarthritis and Rheumatoid Arthritis. What is Autoimmunity? Autoimmunity is sadly fairly common in both humans and pets and is often overlooked. When an individual has an autoimmune disease, the immune system releases antibodies and T-Killer Cells (cells of the immune system which target and kill cells infected with viruses and cancers) even when they are not in the presence of a necessary target, which causes them to attack normal, previously healthy parts of the body. In layman’s terms, the body attacks itself! Autoimmunity can be linked to Leaky Gut, and Leaky Gut can be linked with arthritis. Read our blogs on these topics below! The Connection Between Leaky Gut and Autoimmunity – Part 1 The Connection Between Leaky Gut and Autoimmunity – Part 2 The Link Between Leaky Gut and Arthritis Immune Mediated Polyarthritis Immune Mediated Polyarthritis (shortened to IMPA) is a painful degenerative joint disease. The term ‘immune mediated’ refers to a group of conditions which are caused by abnormal immune system activity, often due to upregulation of some immune cells, causing the body to attack itself. Symptoms of IMPA include: Pain and swelling in multiple joints Fever Lethargy General stiffness Weight loss Difficulty standing for long periods Enlarged lymph nodes Nausea, vomiting and diarrhoea One of the causes of IMPA, is infection of Leishmania. Leishmaniasis is a parasitic disease, where the host is infected with Leishmania, which is spread by sand flies. It is not present in the UK, bar in imported dogs, or those who have travelled abroad, and contracted it there. We see many cases in rescued foreign street dogs. The synovial fluid (the fluid located between joints of all mammals) of the dogs affected in a study, was tested, and found to have the inflammatory markers typical of a dog suffering with IMPA. All other pathways of IMPA were ruled out. Findings Here Vaccine Induced IMPA is probably one of the biggest risks, and one often overlooked during diagnosis of IMPA. There are various reports of cases whereby dogs have developed IMPA within 3 weeks post vaccination. Minimally vaccinating is essential to reduce this risk! Findings Here Findings Here One study based in Canada, discusses the various clinical abnormalities which accompanied IMPA in various IMPA positive dogs. These clinical signs included leukocytosis (increased white blood cell production), nonregenerative amaemia (lack of red blood cells due to reduced activity by the bone marrow), high alkaline phosphatase (ALP in blood tests), and hypoalbuminemia (disrupted albumin production, resulting in blood vessels drying up). There was no common age range between cases – cases were present from all ages; young to elderly. Findings Here Rheumatoid Arthritis Rheumatoid Arthritis (shortened to RA) is an autoimmune related degenerative joint disease. It’s symptoms include: Joint pain and stiffness in numerous joints Swelling in joints Weight loss Fatigue and lethargy Loss of strength Those suffering with RA often do so in a mirrored fashion – the pain will usually be the same on both sides of the body; both knees, both hips etc. RA can be triggered following infection of the bacteria Borrelia burgdorferi, which is transmitted from infected ticks to host; you may be more familiar with the term ‘Lyme Disease’. Findings Here During drug trials for this disease, where RA is concerned, a combination of pharmaceuticals were required to have any effect, as opposed to any of the individual options used in the trial. Findings Here Part of the immune system contains the Dog Leukocyte Antigen (DLA) Complex – this is a part of the immune system which distinguishes the body’s proteins from foreign proteins, viruses and bacteria. Within this complex, lays numerous alleles (pairs of genes – one from each of the dog’s parents), including the DRB1 allele, which is said to influence the susceptibility of an individual to be subject to developing RA, if it contains a certain amino acid. Findings Here A protein called Zonulin plays a part in Rheumatoid Arthritis (RA). It is synthesised by cells in the liver and intestine, and it’s roll in the body is to regulate the gut permeability, specifically Tight Junction Barrier Cells within the gut wall. When Zonulin is overrepresented, the gut permeability cannot be controlled, and allows useful and harmful substances to enter the blood stream, which are then detected as threats by the immune system. The upregulation of Zonulin, paired with the downregulation of Tight Junction Barrier Cells, causes more leakage of particles into the body, which in turn causes major inflammation throughout the joints in the body, sometimes resulting in Rheumatoid Arthritis. As with other autoimmune conditions, specific strains of good bacteria in the microbiome being leaked and attacked can cause the onset of RA. Findings Here Findings Here Findings Here Supporting the Body Gut Work Due to the relation between autoimmunity and Leaky Gut, its essential to keep the gut in good condition. Supplements such as Marshmallow Root, Slippery Elm or glutamine are great for this, especially paired with a good, clean probiotic to help recolonise the gut. Findings Here Findings Here Findings Here Diet Ensure you are not feeding any pro-inflammatory foods! High carb, processed diets like dry food are very pro-inflammatory and will add to the body’s inflammatory response. Stick to a fresh diet, whether it’s raw or cooked. It’s also imperative to keep on top of any allergies – both food and environmental. When we keep on top of allergies, and remove allergens
In Part 1, we discussed what Leaky Gut is, what autoimmunity is, and possible causes and symptoms of both. Read on to find out how they are linked, and more about the autoimmune diseases most commonly affected by Leaky Gut, as well as how we can support the body through diet, and supplements. How are Leaky Gut and Autoimmunity linked? A healthy gut microbiome is incredibly important as around 90% of the immune system is located in the gut! That’s quite a staggering figure, but it shows the importance of keeping the gut healthy and the microbiome strong. Let’s take a deeper look at some of the most common autoimmune diseases, and their link with Leaky Gut. Thyroid Issues One of the main issues with Leaky Gut and Autoimmunity, involves the thyroid. The body attacks the thyroid tissue as it recognises it as a foreign body. The reason the body sees thyroid tissue as a threat, is down to molecular mimicry. When the immune system releases antibodies to get rid of a threat, they bind at what is known as the ‘active site’, or ‘antigen binding site’. Antibodies are Y shaped proteins, and on the tips of the Y, the binding sites are found. These are a specific shape, to match the proteins on the antigens (the threatening particles). Take a look at the diagram at the top of this blog! Despite food particles clearly being very different to thyroid tissue cells, some of the attached proteins are the same shape on both the food particle and on the thyroid tissue cells. Gluten and Casein (dairy) are particularly alike to thyroid tissue cells, so when an antibody detects the protein it fits with, and binds to it, there’s a high chance it may be thyroid tissue instead of its real target; the food particle. Findings Here Findings Here Inflammatory Bowel Disease (IBD) A condition we hear a lot about, particularly on a professional basis as well as on social media posts when people ask advice on their poorly pets, is Inflammatory Bowel Disease. As per it’s name, this involves inflammation in the bowel, which can be as a result of Leaky Gut. When looking at IBD, diet is so important – many processed foods contain emulsifiers, which can include Cellulose Gum, and Polysorbate-80 (though this one is most inhuman foods, not pet foods). These have been found to interrupt interactions between the bacteria in the intestine, and the gut wall; resulting in the gut wall being less protected than it would be without the presence of these substances. This lack of positive interaction, teamed with the already permeable gut wall (due to Leaky Gut) can cause the onset of IBD. Findings Here Small Intestine Bacterial Overgrowth (SIBO), Yeast, and Candida can also contribute to IBD (and are all symptoms of Leaky Gut), which causes inflammation of the bowel, which further increases the risk of IBD onset. Studies show a huge affect on gut permeability when up-regulation of the protein called Zonulin is present. Zonulin helps regulate the permeability of the small intestine, but is detrimental in high numbers as it causes the gut to become more permeable. It is secreted by numerous organs within the body, and can be linked to Leaky Gut and the onset of IBD. Findings Here Findings Here Findings Here Immune-Mediated Haemolytic Anaemia (IMHA) IMHA is one of the more worrying autoimmune diseases, with a mortality rate close to 70%. There are many reasons a dog may be diagnosed with IMHA, including Vaccine Induced IMHA. When a dog has IMHA, the body is attacking it’s own red blood cells, which are important for transportation of oxygen from the lungs to all parts of the body for healthy muscle usage. IMHA can be caused in some rare cases, by a deficiency in Vitamin B12, which can be linked back to Leaky Gut. IMHA is also often as a knock on effect of other autoimmune diseases like Systemic Lupus Erythematosus. Findings Here Findings Here Diabetes Largely linked to Leaky Gut, Diabetes mellitus often requires lifelong medication. Similarly to the mimicry of thyroid tissues by antigens like Gluten and Casein, the onset of diabetes can be facilitated through normal cells being attacked incorrectly by the antibodies circulating the bloodstream. With diabetes cases, the immune reactions affect, and damage pancreatic beta cells (responsible for producing and secreting insulin), which then causes the over-production of cytokines, which in turn causes insulin resistance within the body. Healing the gut, and decreasing gut permeability may help relieve sufferers of diabetes symptoms. Studies show Type 1 Diabetes can be caused as a result of gut damage, but can also cause gut damage. Findings Here Findings Here Findings Here Findings Here Immune-Mediated Trombocytopenia (ITP) ITP is a platelet disorder, in which sufferers are unable to properly clot blood due to low platelet counts. Pathogenesis of ITP as a result of leaky gut has been proven to be due to imbalances in the gut microbiota, and the presence of cytokines which interfere with metabolism of fats. Patients with Leaky Gut, as we know, have a very imbalanced microbiome as bacteria leaks out through the channels in the gut wall. Certain strains of bacteria play an essential role at keeping ITP at bay, but are found to be of low levels in those diagnosed with ITP. When these helpful bacteria are leaked from the gut, cytokine production is increased, which then affects the metabolism of fats, which in turn causes pathogenesis of ITP because the lack of fat metabolism causes a lack of available fatty acids to enable the blood to clot. Findings Here Findings Here Findings Here Rheumatoid Arthritis The previously mentioned protein called Zonulin plays a part in Rheumatoid Arthritis (RA); a joint related autoimmune condition. Just like in IBD, when Zonulin is over-represented, the gut permeability cannot be controlled, and allows useful and harmful substances to enter the blood stream, which are then detected as threats by the immune system. The upregulation of
At My Pet Nutritionist, we regularly help people with their pets suffering with Leaky Gut Syndrome. There is a lot of evidence to link Leaky Gut with a variety of autoimmune diseases; issues we so very often offer support for. Read on to learn more about Leaky Gut, and the role it plays in autoimmunity. What is Leaky Gut? The condition is growing more and more common in both us humans, and our canine counterparts, and can lead to some pretty serious health issues, long term. The name ‘Leaky Gut’ does somewhat give the game away, but let’s look deeper into what actually happens in the gut of a normal dog,compared to one with Leaky Gut. In healthy individuals, after eating, the food passes through the gut. The gut consists of the stomach followed by the small intestine, followed by the large intestine (known as the ‘colon’), through which nutrients from the digested food are absorbed, before the waste is pushed out through the rectum, then anus. To enable a large surface area, for optimum nutrient absorption, the small intestine is lined with small finger-like structures called villi, which themselves are covered in even smaller finger-like structures, known as microvilli. The gut also houses lots of good bacteria to aid digestion – the colonies of good bacteria, along with yeast cells, any viral particles, or parasitic burdens, are collectively known as the ‘microbiome’. The gut wall is extremely thin, to allow efficient nutrient absorption. The cells lining the gut stay close together, and are supported by the interactions of immune cells, and good bacteria in the gut. In those suffering with Leaky Gut, inflammation occurs in the gut for various reasons, which causes the tight intestine wall to permeate, creating microscopic channels between the cells. Proteins/partially undigested foods then leak out through these channels and are detected by the immune system as a threat, causing a histamine response to occur, which is why one of the most common symptoms of Leaky Gut, is food intolerances. Other symptoms of Leaky Gut include: – Autoimmune Diseases – Issues with stools or sickness – Joint issues – Yeast – Problems concerning other major organs in the body – Hypothyroidism – Changes in behaviour; often anxious behaviour and short tempered behaviour Possible Causes of Leaky Gut include: – Over-use of vaccines; the adjuvants damage the gut flora – Use of certain pharmaceuticals ^ Flea, tick, and worm medications; they disrupt the gut microbiome by not only eradicating the visiting parasites (or often lack thereof), but the good bacteria too. ^ Antibiotics; these wipe out the good and bad bacteria ^ Antihistamines; these can interfere with the production of mucus in the gut, and can also interfere with the proper functioning of Diamine Oxidase (DAO), which is the enzyme responsible for breaking down, and removing histamine from within the gut. ^ NSAIDs and Steroids; these can cause ulcerations in the gut and interfere with mucosal production. – SIBO and Yeast overgrowth; Small Intestine Bacterial Overgrowth and Yeast damage the gut lining – Diet; feeding a dry food diet can put stress on the gut. Kibble often contains Glyphosate, which is an antibiotic herbicide and is toxic, as well as very damaging to the gut. Diets inclusive of legumes and other high-lectin content pulses, nightshades and vegetables may contribute to Leaky Gut as lectin causes poor gut integrity. Microscopic moulds often found on kibbles, known as mycotoxins are also detrimental to gut health, contributing to Leaky Gut. – Stress can have a huge effect on the gut integrity, as stress leads to inflammation – Ageing; as our dogs age, the microbiome becomes less diverse which leads to gut damage. Findings Here Findings Here Findings Here Findings Here Read our full Gut Dysbiosis blog here What is Autoimmunity? To better understand the link between Leaky Gut and Autoimmunity, we need to understand more about autoimmunity, what it is, and how it affects our pets (and us too!). Autoimmunity is sadly fairly common in both humans and pets and is often overlooked. When an individual has an autoimmune disease, the immune system releases antibodies and T-Killer Cells (cells of the immune system which target and kill cells infected with viruses and cancers) even when they are not in the presence of a necessary target, which causes them to attack normal, previously healthy parts of the body. In layman’s terms, the body attacks itself! There are more than 80 different autoimmune diseases in existence, though not all of these affect dogs. Some of the most common autoimmune diseases we see in dogs are: – Hypothyroidism – Inflammatory Bowel Disease (IBD) – Immune-Mediated Haemolytic Anaemia (IMHA) – Diabetes – Immune-Mediated Trombocytopenia (ITP) – Rheumatoid Arthritis – Hypoadrenocorticism (Addison’s Disease) – Periodontal Disease – Degenerative Myelopathy – Immune-Mediated Polyarthritis (IMPA) – Systemic Lupus Erythematosus (SLE) – Discoid Lupus Erythematosus (DLE) Symptoms of Autoimmunity These will, of course, vary depending on which autoimmune disease an individual has, but general signs and symptoms of autoimmunity, which may spark a look into further investigation with your veterinarian, include: – Constant lethargy – Racing, or very slow heartbeat – Weight loss (often dramatic) – Increased panting – Collapse – Excessive drinking and urination – Seizure activity – Discolouration of gums and skin – occasionally yellowish as a result of jaundice. – Hair loss or coat texture changes – Regular vomiting and diarrhoea – Increased temperature – Behavioural changes, including aggression or depression Findings Here Read Part 2 here to find out more on the autoimmune diseases affected by Leaky Gut, and how we can support the body, naturally. If you feel your dog may be experiencing Leaky Gut, or an autoimmune disease, seek veterinary attention, and book in for a consultation with one of our team! Team MPN x
Being a fairly common health complaint in dogs, particularly larger breeds of dog, here at My Pet Nutritionist we feel it’s important to understand what Laryngeal Paralysis is, what it looks like, what causes it, and how to support the body. We will discuss all these points in this blog! What is Laryngeal Paralysis? Laryngeal Paralysis is a disease which involves the Larynx; commonly known as the ‘voice box’. The larynx is a box-like structure which connects the throat to the windpipe (trachea); and is comprised of various plates of cartilage known as ‘Arytenoid Cartilages’, housing the vocal cords. As well as enabling vocalization in all mammalian species, the Larynx closes off the top of the trachea to ensure food and water are not inhaled. When an animal takes a deep breath, the larynx opens wider to allow for more air to be taken in. The larynx is surrounded by muscles called ‘Laryngeal muscles’ which help keep it stable. As with all muscles, if the nerves inside become damaged, it causes the muscle to relax. If the laryngeal muscles become weakened or paralysed due to nerve damage, the cartilage of the larynx will collapse inwards, as the cartilage is no longer stabilised by the muscles. When the muscles are weak or paralysed and the larynx collapses, this is called Laryngeal Paralysis. Laryngeal paralysis can be congenital (present at birth), hereditary (passed on genetically through generations) or acquired (due to trauma or as a knock-on effect from other health conditions). Like many conditions, some breeds are at a higher risk of developing Laryngeal Paralysis than others. Generally speaking, this disease affects larger breeds of dog. Most commonly affected, is the Labrador Retriever. Different breeds are more commonly affected by different types of Laryngeal Paralysis. Breeds most at risk of acquired Laryngeal Paralysis, usually in middle aged to older dogs: Labrador Retriever Great Dane Irish Setter Newfoundland St. Bernard Breeds most at risk of hereditary and congenital Laryngeal Paralysis: Leonberger Bouvier des Flandres Siberian Husky Bulldogs (various types) Studies also show a higher risk of developing Laryngeal Paralysis for neutered male dogs over entire males, or entire/neutered females. Findings Here Findings Here Findings Here Symptoms There are many symptoms for Laryngeal Paralysis; let’s take a look! Excessive/Noisy Panting Dogs with the condition will likely pant more than is normal for that dog, especially during humid weather and when stressed or after exercise, and this panting is often quite noisy. Lethargy They may become lethargic or wish not to exercise as a result of Laryngeal Paralysis. Change in Bark Many owners notice a change in the dog’s bark; just like in humans when one’s voice may change, a dog’s bark also has the capability to change if they have a collapsed larynx. Choking, Coughing or Gagging When eating or taking a drink, the dog may choke, cough or gag – this is due to the windpipe not being fully shut off from the throat, and the width of the larynx being extremely narrow. Coughing may mechanically force the larynx to open and allow food and water to enter. As drinking and eating becomes more difficult, those suffering with Laryngeal Paralysis are also more susceptible to Aspiration Pneumonia. Behavioural Anxiety You may notice an increase in behavioural anxiety due to the feeling of vulnerability, as well as respiratory distress due to the narrow opening of the collapsed larynx. Dehydration As water intake becomes more difficult for those suffering with the disease due to the narrow opening, the dog may become dehydrated. Gums will become greyish, dark red or purple due to lack of proper blood circulation as a result of dehydration. The gums also become tacky when the dog is dehydrated. Difficulty Thermoregulating Dogs with Laryngeal Paralysis are more susceptible to heatstroke, even in mildly warm temperatures, is another symptom of Laryngeal Paralysis, and can result in collapse. If your pet is showing signs of heatstroke (vomiting, shaking, seizures, lethargy, panting, glassy eyes, agitated whining, drooling, accelerated heart rate, unconsciousness) it’s imperative to seek veterinary care immediately (though don’t put your dog in a hot car!). Your dog may display multiple of the above symptoms of varying degree. Diagnosis So, how would the vet diagnose Laryngeal Paralysis? There are a few routes to diagnosis of Laryngeal Paralysis, but all will start off by looking at the medical history of the dog, and clinical presentations. Some vets may run X-rays of the chest to rule out problems within the chest cavity, and run blood panels, and urinalysis to rule out infection before examination of the Larynx itself. To avoid sedation, there is evidence to suggest that a suitable method of formal diagnostic testing for Laryngeal Paralysis is by performing an echolaryngography, through the use of ultrasound. Large dogs can be tested on the floor or table, while smaller breeds can happily reside on the lap of the sonographer to reduce risk of false results due to stress. Echolaryngography is a safe, and effective way to diagnose Laryngeal Paralysis. Findings Here Findings Here Another common method, used to diagnose lightly sedated dogs in order to reduce risk of false results due to full anaesthesia (which may cause the laryngeal muscles to relax), is through a transnasal laryngoscopy, where a video endoscope tube is inserted through the nostrils and down the throat to have a good visual of the larynx working. Studies prove this method to be as accurate as a traditional laryngoscopy, whereby the patient may require heavier sedation due to potential gag reflexes following intubation by mouth. Findings Here Findings Here Findings Here Causes Trauma Trauma to the neck area is often a cause of Laryngeal Paralysis. This can be through repeated use of unsuitable training tools which constrict around the neck, poorly fitting flat collars on dogs who pull, or even through freak accidents involving the neck area such as dog bites and subsequent deep wounds. We see many dogs who sadly develop Laryngeal Paralysis following a general anaesthetic; likely due
Osteoarthritis is a common clinical and pathological endpoint from a range of joint disorders that ultimately lead to structural and functional decline of the joint with associated lameness and pain. A multimodal approach is necessary to support your dog who sadly suffers with osteoarthritis, but we thought we’d take a look at the evidence for any herbs that have supported this chronic condition. What is Osteoarthritis? Osteoarthritis, a common pain-causing condition of synovial joints, affects millions of human and non-human animals worldwide. These non-human animals include our trusty dogs. Osteoarthritis, also referred to as osteoarthrosis or degenerative joint disease, is a disease of the entire joint organ, including all its associated tissues, but is most frequently associated with the loss and dysfunction of articular cartilage. Risk Factors for Osteoarthritis: In humans, reported risk factors for the development of osteoarthritis are both systemic and local causes including genetics, age, sex, obesity, previous joint trauma, along with underlying diseases such as cruciate ligament rupture. Recent literature has indicated that up to 20% of dogs over 1 years old suffer with osteoarthritis. Findings Here Primary Vs. Secondary Osteoarthritis Primary osteoarthritis is described as largely idiopathic but can be associated with several risk factors including aging and obesity. Secondary osteoarthritis, where underlying disease processes or injuries play a role in the development of osteoarthritis, is believed to be the most common form in dogs. Secondary osteoarthritis is considered to have a genetic component exacerbated through aspects of lifestyle that impact body condition, such as diet and exercise. Disease processes and pre-existing conditions often influence the development, for example cruciate ligament disease is a common cause of pelvic limb lameness and can result in osteoarthritis development in breeds of all sizes. In addition, dysplasia, commonly occurring in the hip or elbow, describes the failure of normal joint formation during development and can lead to joint conditions causing pain and lameness, and can subsequently progress to osteoarthritis. To understand if any herbs could support this condition, we first need to establish its pathology. The Pathology of Osteoarthritis Osteoarthritis is characterised by joint cartilage degeneration, changes in the underlying bone and synovitis. In addition, there is an increase in pro-inflammatory mediators which promote immune responses, increase oxidative stress, inhibit collagen and proteoglycan synthesis, and diminish chondrocyte proliferation. Furthermore, MMPs are produced which induces the degradation of articular cartilage. For the most part, these changes result in pain, joint stiffness, loss of flexibility, tenderness, grating sensation, bone spurs and swelling. If we are to support this condition, we are looking to modulate inflammation, tackle increased oxidative stress and support the synthesis of those compromised compounds where possible. In turn, we are looking for a reduction in pain and symptoms with an improved quality of life. Herbs for Osteoarthritis (OA) in Dogs Boswellia spp. Boswellia, also known as frankincense, has been used for centuries in traditional Ayurvedic medicine. This herb exhibits anti-inflammatory activity. One clinical trial found that oral supplementation of Boswellia extract for more than 4 months significantly improved physical function by reducing pain and stiffness in OA patients compared to placebo, without causing serious adverse events. Majeed et al. found that OA patients receiving oral B. serrata extract for 8 weeks demonstrated significant improvement in their Visual Analog Scale (VAS), Japanese Knee Osteoarthritis Measure (JKOM), and their Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores in comparison to placebo. Findings Here Curcuma spp. Roots of Curcuma are used as a spice commonly known as turmeric. Curcumin, a polyphenol extract of turmeric, is well known for its anti-inflammatory and antioxidant effects, and it has a long history of use in traditional Chinese and Ayurvedic medicine. Treatment with Curcuma has been found to strongly inhibit the production of inflammatory mediators. Researchers have demonstrated that human patients randomized to Curcuma domestica trails experienced significant improvement in Western Ontario and McMaster Universities Osteoarthritis Index scores in comparison to baseline over a 4-week period and less abdominal pain and discomfort compared to ibuprofen. Findings Here Another human trial demonstrated that curcumin had comparable efficacy, but better safety and fewer adverse effects than diclofenac. Findings Here Withania somnifera Withania somnifera (Ashwagandha) is an Ayurvedic medicine known for its anti-inflammatory and analgesic effects. Withania somnifera extract has been shown to slow the degradation of bovine Achilles tendon type I collagen by inhibiting the activity of collagenase. Treatment with W. somnifera has also decreased swelling, redness, deformity, and ankylosis in a collagen-induced arthritis rat model. It has been demonstrated that an aqueous extract of W. somnifera showed a significant chondroprotective effect on damaged human OA cartilage via diminishing the gelatinase activity of collagenases. In a 12-week human clinical trial, treatment with W. somnifera extract was associated with significant reductions in the mean WOMAC and Knee Swelling Index in comparison to baseline and placebo. A significant reduction in scores for pain, stiffness, and disability was also observed. Findings Here Ginger The anti-inflammatory activities of ginger have been widely investigated in patients as well as in vitro and in vivo models. Several clinical trials have been performed to assess the effects of ginger on OA pain-relief. Researchers have found that patients treated with ginger extract had lower VAS scores and gelling or regressive pain compared to placebo. Another study revealed that ginger extract was associated with reducing knee pain and WOMAC indices, although it was associated with gastrointestinal side effects. Further researchers have suggested that topical ginger extract significantly improved knee pain, stiffness, physical function, and patient global assessments following 12 weeks of knee OA treatment. What happens when we combine herbs and supplements? There is evidence of synergistic effects when different herbs are combined, including improvement in therapeutic outcomes and safety. Supplementation with boswellia combined with N-acetyl-D-glucosamine and ginger for 6 months, was found to significantly improve pain-free walking distance and WOMAC signs/symptoms for patients with moderate knee OA in comparison to standard OA management. Boswellic acid combined with methylsulfonymethane (MSM) has been found to improve knee OA pain management and functional recovery along
Around 75% of dogs are believed to have a vitamin D deficiency! Findings here Rickets! Unlike bands from decades gone by, its comeback isn’t appreciated. In human health, cases of rickets are dramatically increasing. Sadly, there are also new cases appearing in the pet world. Take the 6-month old female giant schnauzer who was presented to a veterinary college with a 1-month history of lameness and difficulty walking. She would also have episodes of yelping in pain with unknown triggers. The diagnosis? A vitamin D deficiency (with secondary hyperparathyroidism). Findings here Vitamin D is often classed as one of the essential vitamins (or hormones) to overall health, so let’s take a look at it in a little more detail. So, what is Vitamin D? Despite its name, Vitamin D is actually a hormone that promotes calcium absorption. In human health, you will have heard it referenced as the sunshine vitamin as it is produced in the skin in response to sunlight (UV) exposure. In studies of hip fractures in humans, there appears to be a seasonal variation; more occur during winter months and fracture patients often have low vitamin D status. When supplemented with Vitamin D and calcium, incidences of fractures often reduce. Findings here So, vitamin D is particularly important in bone health. This is no different for our pets. However, unlike herbivores and omnivores,cats and dogs are unable to synthesise Vitamin D adequately in the skin. There is no seasonal change in concentrations and studies have shown that when fed a diet deficient in Vitamin D, puppies develop rickets which could not be prevented by exposure to UVB light. Findings here This means that cats and dogs are dependent on dietary sources of Vitamin D. There are two forms of Vitamin D. Vitamin D2 is also known as ergocalciferol that occurs in plants and Vitamin D3, known as cholecalciferol, is created in the skin during exposure to UV light and occurs in animals. Cholecalciferol (D3) is of greatest nutritional importance to both cats and dogs and luckily it can be obtained from the consumption of animal products that contain it. It is defined as a fat-soluble vitamin, which means it can be stored in the body’s fatty tissue. It’s true what they say, you are what you eat, or in this case, your pet. Once vitamin D3 is formed in the skin (of animals who can do so), it binds and is then either stored or transported to the liver. Both D2 and D3 are biologically inactive and must undergo two more steps to be activated. This involves both the liver and the kidneys. Vitamin D3 is first absorbed through the intestines, then converted in the liver to 25- Hydroxyvitamin D (or 25VitD). The active form of vitamin D that the body uses is 1,25-dihydroxyvitamin D, also called calcitriol. Vitamin D plays an indirect role in bone health by managing calcium levels in the body. It controls absorption of calcium in the intestine and the amount of calcium excreted by the kidneys. If Vitamin D levels are low, then the intestines struggle to absorb calcium. Calcium is key to bone mineralisation(hardening), without calcium, bones are unable to form correctly. Not only that, but due to the lack of circulating calcium, the body mobilises it from the bones by way of increased parathyroid hormone. This not only weakens the bones, but it also creates a new issue, namely secondary hyperparathyroidism. High levels of parathyroid hormone and low levels of calcitriol (the active form of Vitamin D) often lead to myopathy (muscle fibre weakness). Interestingly, biopsies have shown that vitamin D deficiency often results in predominantly type II muscle fibre atrophy. This maybe particularly relevant to those breeds who have more type II than type I fibres (speedy dogs vs. sled dogs). Findings here In humans, vitamin D deficiency manifests as back-pain, muscle atrophy, weakness and bone tenderness. Most dogs are stoic – they are great at hiding pain; they can’t tell you that they have back-ache. It takes an observant owner to notice the more subtle symptoms of this deficiency, but the more obvious symptoms of Vitamin D deficiency include: Simultaneous deficiency/imbalance in calcium/phosphorus Rickets (soft and weak bones in young dogs) Osteomalacia (soft and weak bones in adult dogs) Osteoporosis (weak bones leading to fractures) Neurological abnormalities Hypocalcemia (low calcium levels) Elevated parathyroid hormone (symptoms include bone pain, depression, kidney stones, hypertension, cardiac arrhythmias, and kidney failure) Posterior paralysis Ataxia (neurological issues including gait abnormality, difficulty walking, tremors) Quadriparesis (weakness in all four limbs) Whilst Vitamin D is usually associated with skeletal issues, low levels are often associated with autoimmunity, infectious disease, diabetes, cardiovascular disease, obesity, neuromuscular disorders and cancer. It must be noted that kidney disease can affect the conversion and metabolism of Vitamin D and so should be cautiously supplemented in kidney disease and status should be checked if kidney disease has been diagnosed. Vitamin D and Autoimmunity Increasing evidence is demonstrating a strong association between vitamin D signalling and biological processes that regulate immune responses. Vitamin D has been found to inhibit pro-inflammatory activity and cytokine production. It is thought to promote TH2 responses which may be protective in autoimmune disease. Vitamin D is also required for the production of natural killer cells which are known for killing virally infecting cells. Findings here Infectious Disease Much like with autoimmune disease, calcitriol is thought to suppress pro-inflammatory cytokines and up regulate anti-inflammatory cytokines. Since the inflammatory response associated with many infectious diseases often increases severity and mortality, the ability to reduce inflammation may improve outcomes. Studies have shown that incases of infectious disease, Vitamin D concentrations were lower than anon-infected control. Findings here Diabetes There is growing evidence that Vitamin D deficiency could be a contributing factor in the development of both type 1 and 2 diabetes. It is thought that cells found in the pancreas that secrete insulin contain vitamin D receptors. Studies have also shown that when treated with a therapeutic dose, vitamin
