We often talk about the highway between the gut and the brain, but it is probably more appropriate to think of the gut like a roundabout. If you live anywhere other than the UK, a roundabout is a road junction at which traffic moves in one direction around a central island to reach one of the roads converging onto it. In short, you have a number of roads branching off. We are learning more about the gut’s impact on the body every day, and along with a gut-immune axis, (one road off the roundabout), the gut-brain axis (another road off the roundabout), we also have a gut-skin axis. The gut-skin axis is becoming intertwined in a range of inflammatory skin issues in humans, and as our dogs also sadly suffer with many inflammatory skin issues, here at My Pet Nutritionist, we think the Gut-Skin Axis is worth exploring. So, let’s get cracking. The Skin The skin is the largest organ of your dog’s body. It consists of three major layers: The Epidermis – (Epi – upon or above) this is the outer layer of skin, the protective layer. The Dermis – the dermis supports and nourishes the outer layer. It provides strength and elasticity. Here you will find collagen fibres, sweat glands, sebaceous glands, and hair follicles. You will also find cells that release histamine and other inflammatory mediators when faced with an allergy or injury. The Subcutis – (sub meaning under or below) this in the innermost layer of the skin, where you will find fat and muscles. Subcutaneous fat provides insulation, padding and storage for reserve energy. Not only does the structure of the skin prevent water and electrolyte loss to help maintain body homeostasis, but it forms a protective barrier which helps protect against infections, parasites, and the elements. This is the often-forgotten role of the skin – that it forms part of the immune system. It is this role that largely establishes the connection between the gut and skin. The Gut The gastrointestinal tract (GIT) is one of the largest interfaces between the host and its environment, you only have to think of the sheer volume of food and (and other items) that pass through your dog’s GIT in their lifetime. For this reason, it must posses a strong barrier to prevent pathogens reaching the inner workings of the body. Skin Vs. Gut Barrier The gut and skin barrier share surprisingly many features. Both organs are highly innervated and vascularized, as they are both essential for immune and neuroendocrine function. The inner surface of the gut and the outer surface of the skin are both covered by epithelial cells (ECs) which have direct contact with the exogenous environment. This way, the immune system is continuously primed to distinguish between harmful and beneficial compounds. Immune cell priming starts early on in life and forms the basis of tolerance. Your Pet’s Immune System But, both the skin and gut also posses a microbiome and it is this, along with the interplay between them that influences their health. How Does The Gut Affect The Skin? We have largely established the impact the gut has on skin through bacterial supplementation. Study One Mice who received Lactobacillus reuteri supplementation experienced increased dermal thickness, enhanced folliculogenesis, and increased sebocyte production which manifested as thicker, shinier fur. Findings Here Study Two Oral supplementation of Lactobacillus brevis SBC8803 in rats demonstrated a significant decrease in transepidermal water loss, which is a marker of skin barrier function. This was also replicated in humans. Findings Here Study Three Volunteers who took Lactobacillus paracasei NCC2461 supplements for 2 months had decreased skin sensitivity. Findings Here Study Four Another study evaluated the impact of Bifidobacterium breve M-16V and Bifidobacterium longum BB536 administration over the time period of 1 month prenatally, 6 months during infancy, and a period of 18 months follow up on the management of allergic diseases in humans. The study concluded that the incidence of atopic dermatitis was lower in the probiotic administered cases, compared to controls. Findings Here Whilst these studies are promising, there are equally studies which conclude no significant effect on inflammatory skin disease when supplementing probiotics. More and more data is appearing suggesting that clinical significance is largely strain specific, and some studies simply researched the wrong strain. Equally, we understand that inflammatory conditions are multifactorial, and there is no silver bullet. But what these studies do show us is that what goes on in the gut, can influence skin health. We have found that the metabolites found in the gut (those produced from the fermentation of fibre for example) have effects on the gut and the skin. SCFA’s are seen to have anti-inflammatory effects in the gut and in the skin. GABA metabolites modulate neurotransmitter function but also restrict itching in the skin. Dopamine modulates neurotransmitter function but also inhibits hair growth in the skin. Acetylcholine also modulates neurotransmitter function but also influences barrier function in the skin. This is also demonstrated when we look at dietary implications in skin conditions, for example, in cases of atopic dermatitis, diets are frequently low in fruits, vegetables, omega-3 fatty acids and high in omega-6 fatty acids. Findings Here But when we see the comorbidity of skin and gut issues, it’s easy to wonder which came first and what’s super interesting is that we see a bidirectionality. Studies have demonstrated that food allergies may result from an impaired skin barrier: atopic dermatitis sensitizes to peanut allergy due to epicutaneous peanut protein exposure in household dust, leading ultimately to immunoglobulin E (IgE)-mediated mast cell expansion in the gut. Findings Here Whether the gut or skin comes first, what is clear is that we need to support the health of both. The intestinal and epidermal barriers are connected through systemic circulation (blood and lymph), so healthy circulation is important. This is where appropriate exercise comes in. But avoid over-exercising as this ramps up the stress response in our pets and can be detrimental to the
It’s a sad realisation when we notice our dog getting a little stiffer or moving a little slower. Of course, we take it upon ourselves to make them as comfortable as possible. Joint degradation is a normal part of life, but as we know, certain things can speed it up. Alongside this, there are things we can do to potentially limit some of the damage, and food, nutrients and herbs that can help modulate the inflammatory process. We have compiled 5 of our favourite herbs for joint care in the dog. Joint Degradation Joint degradation is characterised by inadequate production of compounds necessary to its structure, along with reduced collagen synthesis. This can be a result of physical stress, trauma, autoimmunity, or aging. Here, inflammation is upregulated, creating further breakdown. It results in weak, damaged, or inflamed tissue with restricted or painful movement. Tissues are in the firing line when carrying out any physical activity and they may be susceptible to physical stress, strain, or trauma. Unexpected force or sudden changes in direction or speed are also more likely to cause issues (read: overweight dogs and those who chase balls regularly). This can be a particular risk during the winter, when walking in snowy, icy, or even muddy conditions. Tendons and ligaments are dependent on physical activity to develop, but it must be in moderation and appropriate. Joint degradation therefore has a number of risk factors: Nutritional insufficiency Physical stress or trauma Overuse – aging, Excess weight Autoimmunity The main concern in joint degradation is inflammation and the associated pain. And this is where our wonderful herbs can come in. 1) Horsetail Horsetail is a popular fern that has been used as an herbal remedy since the times of the Greek and Roman Empires. It grows wildly in Northern Europe and America, as well as in other moist places with temperate climates. It has a long, green, and densely branched stem that grows from spring to autumn. This plant contains a range of beneficial compounds, but we are most interested in its silica content and also its ability to function as an antioxidant. Silica, which is also present in bones, improves the formation, density, and consistency of bone and cartilage tissue by enhancing collagen synthesis and improving the absorption and use of calcium. Horsetail is rich in phenolic compounds which as we know are a group of antioxidants inhibiting oxidative damage. Not only this, but studies into rheumatoid arthritis have shown that horsetail has a down-regulatory effect on pro-inflammatory factors. It is often described as a great regulator of inflammation. Findings Here 2) Turmeric Turmeric is a flowering plant, but it’s the root we’re most interested in. Part of the ginger family, it looks very similar, but it’s the smell that helps you differentiate. Turmeric is frequently used in humans, to help with a range of diseases and conditions including skin, pulmonary, aches, pains, sprains, liver issues and cancer. Curcumin specifically is argued to be anti-inflammatory, antioxidant, anti-microbial, anti-tumour and helpful in wound healing. Used in Ayurvedic and Chinese Medicine for centuries, it is now finding a place in Western Medicine. Many joint issues feature chronic inflammation, and in supporting our dogs, we aim to reduce pain and inflammation. So here comes turmeric with its anti-inflammatory properties! Several studies have shown that when supplemented with turmeric, arthritic dogs show a marked improvement in their daily life activity without any side effects! Findings Here 3) Ginger A University of Miami study concluded that ginger extract could be a substitute to nonsteroidal anti-inflammatory drugs (NSAIDs). The study compared the effects of a highly concentrated ginger extract to placebo in 247 patients with osteoarthritis (OA) of the knee. The ginger reduced pain and stiffness in knee joints by 40 percent over the placebo. Research shows that ginger affects certain inflammatory processes at a cellular level, and as we know, many pathologies involving the joints have inflammation as the key player. There are more than 1300 types of ginger plant, and they contain a wide range of nutrients, including: vitamin C vitamin B6 the minerals magnesium, potassium, and copper gingerols, shogaols, paradols, and other phytonutrients and polyphenols Gingerol, shogaol, and paradols all have antioxidant properties, and gingerol and paradols are also anti-inflammatory. 4) Boswellia Serrata Boswellia resin can inhibit a branch of the arachidonic acid cascade related to leukotriene synthesis seemingly without affecting prostaglandin synthesis. It is considered that the excessive formation of leukotrienes is responsible for chronic inflammation. In 2004, researchers investigated the role of boswellia in inflammatory joint disease. After two weeks of treatment, an overall efficacy of the dietary supplement was evident in 71% of 24 eligible dogs. A statistically significant reduction of severity and resolution of typical clinical signs in individual animals, such as intermittent lameness, local pain and stiff gait, were reported after 6 weeks. Effects of external factors that aggravate lameness, such as “lameness when moving” and “lameness after a long rest” diminished gradually. They therefore concluded that boswellia herbal dietary supplement provided symptomatic support in canine osteoarthritic disease. Findings Here 5) Ashwagandha Ashwagandha is an evergreen shrub that grows in India, the Middle East, and parts of Africa. It has a long history of use in traditional medicine. We most commonly use it for its calming effect on anxiety symptoms along with building stress resilience, so it can help modulate any mood disturbances alongside chronic pain. But this wonderful herb may also act as a pain reliever, preventing signals from travelling along the central nervous system. It is also thought to have anti-inflammatory properties. One hundred and twenty-five patients with joint pain were screened at an Ayurvedic hospital in New Delhi, India. They ingested ashwagandha powder daily for three weeks to establish any symptomatic improvement. A significant change in post-treatment scores of tender joint counts, swollen joint counts, physician global assessment score, patient global assessment score, pain assessment score and patient self-assessed disability index score were reported. The researchers concluded that ashwagandha has a potential role
Whilst we thought we were leaving acne behind in our teenage years, sadly, our feline friends can and do suffer with it. Appearing as red bumps, black dots or dirt on your cat’s chin, cat acne is the result of the hair follicles (more commonly the ones on their chin) becoming “plugged!” There are a number of reasons why this condition affects cats, so let’s take a look at it in a little more detail, with some of our top tips to tackle it. What is Cat Acne? Cat acne is more technically termed follicular keratinization. This is when there is an over production of keratin which is a protein found in the outer layer of skin. This excess keratin becomes trapped in the hair follicle and starts to form pustules or pimples. Cat acne is similar to human acne; characterised by the development of folliculitis (inflammation of the hair follicle). What are the Signs and Symptoms of Cat Acne? Dirty appearance on the chin Lesions on the chin Blackheads/infected follicles Swollen lips What is particularly interesting is that cats can experience acne on other parts of their body too, but it is more common on their chin. Potential Causes of Cat Acne The Skin’s Immune Barrier Function The skin is the largest organ of your cat’s body. It consists of three major layers: The Epidermis – (Epi – upon or above) this is the outer layer of skin, the protective layer. The Dermis – the dermis supports and nourishes the outer layer. It provides strength and elasticity. Here you will find collagen fibres, sweat glands, sebaceous glands, and hair follicles. You will also find cells that release histamine and other inflammatory mediators when faced with an allergy or injury. The Subcutis – (sub meaning under or below) this in the innermost layer of the skin, where you will find fat and muscles. Subcutaneous fat provides insulation, padding and storage for reserve energy. Not only does the structure of the skin prevent water and electrolyte loss to help maintain body homeostasis, but it forms a protective barrier which helps protect against infections, parasites, and the elements. This is the often-forgotten role of the skin – that it forms part of the immune system. If this barrier is compromised, we start to see issues on the surface (in the form of skin disease), along with body wide inflammatory issues. What Can Compromise the Skin Barrier? Over-grooming This can be a common behaviour in a stressed cat. They may over-groom in an attempt to soothe. You will notice bald patches, but once your cat has removed their hair, it wont be long until they start compromising their skin too! Watch for signs of stress in your cat, they may become more withdrawn than usual, they may hide more often or become less tolerant of people. In more severe cases they may toilet in inappropriate places. Pheromone diffusers can be great options to help calm a stressed cat, but also giving them plenty of opportunities to hide. In shelter environments, cats have noted huge reductions in stress-related behaviours in less than 10 days, when they have been allowed to hide. It also didn’t affect their ability to be rehomed. In short, those cats allowed to hide were less-stressed, more eager to approach strangers and more active. Findings Here Cats are largely solitary animals. They have always marked their territories by way of scent. They rub their facial glands around their environment and also mark by way of urine, faeces and anal glands. Not only does hiding allow them to watch for threats from one direction only, (the one way into the box) it is also a confined space where they are very quickly surrounded by their own scent. The key is to have ample hiding spaces. So, if you have more than one cat, they each need their own space to hide. Free from dogs, children and other territory intruders. You could simply place carboard boxes around your home, perhaps in the usual places your cat chooses to hide, or you can buy activity centres with boxes attached. Cocoon style beds are also perfect; just remember to buy one with removable, washable covers. Overgrooming can also be a sign of boredom – it often becomes more common in winter, when cats are spending more time indoors. If this is a concern, provide plenty of opportunities for your cat to engage in natural behaviour, within the home. Study after study shows us that enriched environments reduce the stress-hormone found in stressed cat’s urine considerably. Allergens If pesky allergens or irritants come into contact with the body, they soon feel the full wrath of the immune response. What starts with inflammation, will venture to a targeted attack in order to eradicate the invader. But this does consist of redness, heat, and pain. This can result in pets scratching in an attempt to remove the less than comfortable inflammatory response. In the process, not only has the skin been exposed to an allergen, resulting in an inflammatory response, but paired with scratching, the skin barrier is compromised further, which then becomes a vicious cycle. Remove potential allergens from the home where possible, this can be the washing detergent you use on fabrics and cat beds, to the bowl your cat eats and drinks from. Ceramic or glass plates often bring great relief to cats suffering with cat acne. As plates are flat, they are also in less contact whilst eating. The same also applies to the food you feed your cat. As we know, a huge number of immune cells are found in the gut – what this means is that the gut trains the immune system in what to respond to, and what to ignore. When we feed a food high in antigenic compounds, the immune system responds in true inflammatory style! Not only this but there is a direct link between the gut and skin health – when gut health is compromised, we
Obesity is one of the most common issues that cat owners bring to My Pet Nutritionist with good reason. We know that being overweight increases the risk factors for developing: Cancer Diabetes Heart disease Osteoarthritis and degeneration of joints Urinary issues Surgery complications Respiratory difficulties Kidney disease In a nutshell, being overweight significantly compromises quality of life and actually, the length of it too! So, let’s take a look at some of the common reasons why your cat may be overweight, and we’ll share our top tips for tackling obesity in cats. Is Your Cat Overweight? Obesity is defined as an accumulation of excessive amounts of adipose tissue. It is generally a state of positive energy balance. When food is ingested, it is digested and metabolised. The body uses the nutrients it needs and converts the main macronutrients to energy. Macronutrients consumed over and above those that are needed, are converted into adipose tissue, for use at a later stage. Cat body scores run from 1-9. Ideal bodyweights score 4-5, ribs are not visible but easily palpable, there is an obvious waist and there is minimal/small amount of abdominal fat. Body scores are a much more appropriate approach to establishing body proportion in cats as weight doesn’t accommodate for breed differences or activity levels. Your cat is overweight if: Ribs are difficult to palpate under body fat, Waist barely visible or absent, There is rounding of the abdomen. Why is My Cat Overweight? Perception Do you know your pet is overweight? In an 8000-household study, 68% of surveyed owners report thinking their pet is the perfect weight. 67% of surveyed owners did not see obesity as a concern. This is in contrast to that reported by vets, who show concern that over half of all pets are overweight. Do we simply not see that our pet is overweight and therefore aren’t employing any tactics to manage it? Food Intake Most foods on the market include a feeding guideline based on weight. One of the most common mistakes made by owners is to feed based on the current weight of their pet, not the ideal weight (when tackling a weight issue). Not only that, but weight is a bit of a misnomer anyway. With so many different breeds it is difficult to establish standardisation. It’s important to feed the pet in front of you. Energy requirements vary depending on lifestyle, age, activity, and time of year. Cats for example may be less active in the winter. The type of food you are feeding your pet will also play a part. Starch is the storage from of carbohydrates found in plants and as we know, dry pet foods have large quantities of starch. Starch can be divided into rapidly digestible starch, slowly digestible starch and resistant starch. Rapidly digestible starch can be produced by the exposure to heat, pressure, or moisture decrease (read: exactly what happens during pet food manufacturing). Rapidly digestible starch results in a blood sugar spike, calling the pancreas to action. Insulin shuttles glucose into cells that need it, but also facilitates its entry into adipose tissue! Insulin also stops the breakdown of fat and prevents the breakdown or triglycerides into fatty acids (causing a build-up in fat cells). This is why we always advocate feeding a fresh food diet. Cats are obligate carnivores; in that they get everything they need from animal tissue. Quite often, removing a dry food from a cat’s diet results in significant weight improvement. It’s a Family Affair One of the biggest challenges with feeding cats is getting everyone in the home on board. Cats tend to tell everyone in the home that they still haven’t been fed! This results in many mealtimes, served by many different family members. To tackle this, work out an appropriate food intake in any one day and portion this into a Tupperware. Ensure all family members understand this – when the food has gone, the food has gone – if most of the food has gone by lunchtime, what’s left needs to be kept until dinnertime! Account for Physical Activity We have a nuance in the cat. Some are indoor cats, where others are outdoor cats. This brings a significant difference in activity levels. Whilst the calorie in:calorie out model of obesity is simplistic, it is a consideration to make. For the indoor cat who engages in little physical activity, their food intake may need to be significantly lower than thought. We can enrich their lifestyle with more opportunities for exercise; through activity centres or play but we should also consider reducing their food intake if they are becoming overweight. We should also account for mobility challenges in the ageing cat and how this will influence their nutrient needs. Treat Intake Keep a log on how many treats you are offering your cat, whether it’s scraps from your plate or treats you have bought in. These are easy to nip in the bud if you are trying to manage your cat’s weight; the key is to ensure your cat is satiated from their mealtimes. Cats Are Not Small Dogs Be Mindful of Behaviour For some cats, being demanding can be a problematic behaviour rather than a request for nutrients. Does your cat have plenty of opportunities to engage in their normal behaviour? Do they have access to safe toys and regular opportunities to play with both people and by themselves? Can they rest, undisturbed when they choose? Can they meet their basic needs easily? Can they access food, water, beds, and litter without being disturbed or scared by other pets/people? Obesity in cats is a significant concern, and one that can impair their health and lifespan. Our top tips include: Opt for a fresh food diet (ditch the dry!) Feed the cat in front of you, based on their age, activity level and lifestyle Get the whole family on board If you would like to learn more about obesity in pets, we have a number of other
Here at My Pet Nutritionist we describe the liver as the powerhouse, simply because it has so many jobs. For this reason, when it’s feeling a little under the weather, the ramifications can be widespread. What is it they say, prevention is better than cure? With this in mind, are there foods we can include in our pet’s diet that can support liver health? Of course! Certain wholefoods contain a range of nutrients which can support our dog’s whole health, so here are a few of our favourite foods to support liver health. 1) Blueberries Almost all chronic liver disease is under the background of elevated oxidative stress. This occurs when the number of free radicals found in the body outweighs its ability to cope with them. Antioxidants neutralise free radicals. This versatile berry contains anthocyanins which function as antioxidants which been seen to protect the liver from oxidative stress. Studies have found that in the livers of rats, such protective compounds found in fruits like blueberries slowed the development of scar tissue and may be useful in the prevention of hepatic fibrosis. Other fruits rich in antioxidants include: Cranberries Raspberries Strawberries Mango, Watermelon Blackberries 2) Leafy Green Vegetables (kale, spinach etc.) Not only does this family of vegetables provide a wide range of nutrients and health benefits, but they also have the added ability of increasing the liver’s natural detoxification enzymes. Detoxification is carried out by a range of mechanisms, and this comes in particularly handy if one pathway is overwhelmed, another can pick up the slack. Detoxification falls into three phases. The first two phases are concerned with breaking down the toxin in the body, and phase three is concerned with excreting it. For us to manage ours and our dog’s toxic load, all three phases need to be working optimally. Phases I and II are particularly nutrient demanding, and it goes without saying that the higher the burden on the phases (the more toxins our dogs are exposed to), the higher the nutrient requirement again. Sufficient levels of key vitamins and minerals like vitamin A, C, E, B1, B2, B3 and iron, along with cysteine, are essential and this is where our trusty greens come in. In leafy greens you get substantial amounts of vitamins such as A, C, K, and many of the B’s including folate (B9), plus minerals such as calcium, iron, magnesium, manganese, and potassium. You’ll also find lots of fibre made up of complex carbohydrates, and antioxidant phytonutrients such as beta-carotene, lutein, and zeaxanthin. 3) Fatty Fish (mackerel, tuna, sardines etc.) Consuming fatty fish that are high in omega-3 fatty acids regularly can help modulate inflammation and it is this mechanism that is crucial to so many health issues in both us and our dogs. Inflammation is a normal response of the body to protect tissues from infection, injury, or disease. The inflammatory response begins with the production and release of chemical agents by cells in the infected, injured, or diseased tissue. These agents cause redness, swelling, pain, heat, and loss of function. Inflamed tissues generate additional signals that recruit leukocytes to the site of inflammation. Leukocytes destroy any infective or injurious agent and remove cellular debris from damaged tissue. This inflammatory response usually promotes healing but, if uncontrolled, may become harmful. Acute inflammation typically lasts only a few days. If a wound gets hot, turns red, hurts, and swells, we recognize that inflammation is at work. In this instance, inflammation is a beneficial process, serving to immobilize the area of injury as the rest of the immune system mobilizes to heal. In contrast, chronic inflammation lasts weeks, months or even indefinitely and causes tissue damage, and this too can occur in the liver. In chronic inflammation, the inflammation becomes the problem rather than the solution. Chronically inflamed tissues continue to generate signals that request help from leukocytes in the bloodstream. When leukocytes reach the tissue, they bring inflammation to the party. This chronic inflammatory response can break down healthy tissue in a misdirected attempt at repair and healing. Inflammation and Fatty Acids Arachidonic acid is an omega-6 acid that is involved in the synthesis of eicosanoids. Eicosanoids play an important role in the body, they modulate many processes including reproduction, blood pressure, haemostasis and of course inflammation. The issue occurs when there are too many. This is why we are particularly interested in balancing out our omega 6 and omega 3 fatty acids. Many commercial foods come in higher on the omega 6 front, and so we really need to be adding some wonderful omega 3’s to the bowl (in the form of oily fish). Not only this, but omega-3 fatty acids inhibit an enzyme called cyclooxygenase (COX), which produces the prostaglandin hormones that spark inflammation. The action is similar to what happens when NSAIDs are ingested which also disrupts the COX-2 signalling pathway, reducing inflammation. The inclusion of omega 3’s in your dog’s diets is beneficial to whole body health, not just liver health. Essential Fats for My Dog’s Diet 4) Eggs Eggs are sources of choline, and this nutrient is particularly useful to the liver. Most choline is metabolized in the liver where it is converted into phosphatidylcholine, which assists in building fat-carrying proteins and breaking down cholesterol. True choline deficiencies have regularly been linked to liver disease. Whilst eggs are a good source, you will also find choline in beef, beef liver, chicken, fish, shiitake mushrooms, and cruciferous vegetables like broccoli and brussels sprouts. If you would like to learn more about the nutrients to support liver health in your dog, check out our blog here: Foods to Feed in Liver Disease And if you would like to learn more about conditions that can affect your dog’s liver, check out our blog here: Natural Guide to Liver Disease If you are concerned about your dog’s health and would like to speak with us, then please check out our services. Thanks for reading, MPN Team
Here at My Pet Nutritionist we often describe the liver as the body’s powerhouse, and there are some very good reasons for this. When it goes wrong it can go very wrong, but for us to understand why, we first need to know the function of the liver. So here it is, our brief guide to liver function in pets. What is the Liver? The liver is one of the largest organs in the body. It has some super metabolic functions. It converts the nutrients in the diet into substances that the body can use, stores these substances, and supplies cells with them when needed. In addition, it also takes up toxic substances and converts them into harmless substances or makes sure they are released from the body. Liver tissue is made up of lots of smaller units of liver cells called lobules. Many canals carrying blood and bile run between the liver cells. Blood coming from digestive organs flows through the portal vein to the liver, carrying nutrients, medication, and also toxic substances. Once they reach the liver, these substances are processed, stored, altered, detoxified, and passed back into the blood or released in the bowel to be eliminated. In this way, for us humans the liver can remove alcohol from our blood and for both us and our pets, it can get rid of by-products from the breakdown of medications. With the help of vitamin K, the liver produces proteins that are important in blood clotting. It is also one of the organs that break down old or damaged blood cells. Main Functions of The Liver Metabolic Processes In fat metabolism the liver cells break down fats to produce energy. Liver cells produce bile which helps the small intestine break down and absorb fats, cholesterol, and those fat soluble vitamins. Bile consists of bile salts, cholesterol, bilirubin, electrolytes, and water. In carbohydrate metabolism, the liver helps to ensure that the level of sugar found in the blood (blood glucose) stays constant. If blood sugar levels increase, for example after a meal, the liver removes sugar from blood supplied by the portal vein and stores it in the form of glycogen. If blood sugar levels are too low, the liver breaks down glycogen and releases sugar into the blood. In the metabolism of protein, liver cells change amino acids in foods so they can be used around the body, or to produce energy. Ammonia is the by-product of this process, and the liver converts ammonia to a less toxic product known as urea. This is released into the blood and then transported to the kidneys to pass out of the body in urine. Liver Guard Absorbing and Metabolising Bilirubin Bilirubin is an orange-yellow pigment, a waste product primarily produced by the normal breakdown of haem, which is a component of a protein called haemoglobin. Haemoglobin is found in red blood cells and gives them their characteristic red colour and is used to carry oxygen round the body. Bilirubin is ultimately processed by the liver to allow its elimination from the body. High levels of bilirubin can cause yellowing of the skin and eyes and can be harmful to the body. Supporting Blood Clots Vitamin K is necessary for the creation of coagulants that help clot the blood. Bile is essential for vitamin K absorption and is created in the liver. If the liver does not produce enough bile, clotting factors cannot be produced. Vitamin and Mineral Storage The liver stores vitamins A, D, E, K, and B12. The liver stores iron from haemoglobin in the form of ferritin, ready to make new red blood cells. The liver also stores and releases copper (which is why copper toxicity in dogs is associated with liver failure). Filters the Blood The liver filters and removes compounds from the body, this includes those synthesised in the body like hormones and also those from outside of the body, like medication. Whilst we describe the liver as a powerhouse, we don’t want to overburden it. This is why looking at environmental exposure of harmful compounds is crucial to supporting our pet’s health. Does My Pet Need to Detox Immunological Function The liver is part of the mononuclear phagocyte system. It contains high numbers of Kupffer cells that are involved in immune activity. These cells destroy any disease-causing agents that might enter the liver through the gut. Your Pet’s Immune System Liver Guard Production of Albumin Albumin is a protein found in the blood. It transports fatty acids and steroid hormones to help maintain pressure and prevent the leaking of blood vessels. It is the higher circulating albumin found in dogs that suggests they possess an increased fat oxidation capacity, in comparison to humans. Synthesis of Angiotensinogen This hormone raises blood pressure by narrowing the blood vessels when alerted by production of an enzyme called renin in the kidneys. Did you know? In mice, if two thirds of their liver is removed, the remaining tissue can regrow to its original size within 5-7 days! In humans, this process takes slightly longer, but it can still occur. In dogs, the mechanism is thought to occur similarly to that in the mouse., but maximum response is seen after three days, as opposed to 24-hour peak in rat regeneration. Findings Here As you can see, there are many reasons why we describe the liver as the powerhouse of the body. It plays a huge role in digestive function, metabolism and even immune function. Sadly, there are a number of factors that can contribute to its poor function: Poor diet Stress Endocrine disease Infectious agents Trauma Pharmaceuticals Vaccinosis Copper toxicity If you would like to learn more about what can go wrong with the liver, check out the following My Pet Nutritionist blogs. Ultimate Guide to Liver Disease Vaccinosis Liver Shunts If you are concerned about your pet’s health, please check out our services to see if we may be able to help. Thanks for reading, Team
This is one of the questions we are asked all the time here at My Pet Nutritionist. What foods can support joint health in my dog? Well, we thought we’d give you a rundown of 5 of our favourite. 1) Green Lipped Mussels GLM’s contains around 90 different fatty acids, glycosaminoglycans (chondroitin sulphate), glutamine (a glycosaminoglycan precursor), vitamins C and E and minerals including zinc, copper and selenium. The synergy of these nutritional components work in perfect harmony to support joint and mobility issues in pet. When looking at joint health you need to consider all mechanisms responsible for the disease and then how to address them. Inflammation It’s generally the inflammation and rubbing of joints that create pain and stiffness. The fatty acids in green lipped mussels with EPA (eicosapentaenoic acid) and DHA (docosahexanoic acid) are the most abundant. These are the important fatty acids that are known to reduce inflammation. GLM’s are natural COX inhibitors just like NSAIDS (non-steroidal anti-inflammatory drugs), so they can obtain the same pain free results without the negative side effects. They are also natural LOX inhibitors too. Degradation This is the main reason for the breakdown of the joint matrix. The joint matrix and connective tissue need to be supported by components that replicate the structure of joints, naturally. GLMs are rich in glycosaminoglycans and glycosaminoglycan precursors, known as GAGs. An important GAG found in GLMs is chondroitin sulfate a well-documented structural ingredient for joint support. Oxidation Free radical damage can create more degradation and inflammation so we need to support this with natural antioxidants found in GLM. Vitamin C and E are both abundant in GLM’s and essential for joint care. Joint Lubrication Synovial fluid within the joint matrix is incredibly important to support cushioning and movement. Alterations in synovial fluid (SF) lipid composition have been linked to both osteoarthritis (OA) and rheumatoid arthritis (RA). GLMs provide polysulfated glycosaminoglycans (PSGAGs), the building blocks for cartilage and joint fluid. 2) Turmeric Turmeric, Chew-Meric, Tum-eric, no matter how you say it (and yes, everyone seems to say it differently), it packs a whole lot of punch (good punch!) Turmeric is a flowering plant, but it’s the root we’re most interested in. Part of the ginger family, it looks very similar, but it’s the smell that helps you differentiate. When boiled, dried and ground, it’s the spice that is found in many Asian dishes. It has a warm, bitter, pepper like taste with a mustard-like aroma. It’s that spice that makes your hands yellow when you use it! And your worktops, sinks and utensils! It’s known as curcuma longer in the ginger family, and it’s the active compound curcumin that brings the benefits we speak of. It’s often named cure-cumin for the promise it brings. Turmeric is frequently used in humans, to help with a range of diseases and conditions including skin, pulmonary, aches, pains, sprains, liver issues and cancer. Curcumin specifically is argued to be anti-inflammatory, antioxidant, anti-microbial, anti-tumour and also helpful in wound healing. Used in Ayurvedic and Chinese Medicine for centuries, it is now finding a place in Western Medicine. Many joint issues feature chronic inflammation, and in supporting our dogs, we aim to reduce pain and inflammation. So here comes turmeric with its anti-inflammatory properties! Several studies have shown that when supplemented with turmeric, arthritic dogs show a marked improvement in their daily life activity without any side effects! Findings Here It seems to be down to turmeric’s ability to regulate cytokines. 3) Ginger A University of Miami study concluded that ginger extract could be a substitute to nonsteroidal anti-inflammatory drugs (NSAIDs). The study compared the effects of a highly concentrated ginger extract to placebo in 247 patients with osteoarthritis (OA) of the knee. The ginger reduced pain and stiffness in knee joints by 40 percent over the placebo. Research shows that ginger affects certain inflammatory processes at a cellular level, and as we know, many pathologies involving the joints have inflammation as the key player. There are more than 1300 types of ginger plant, and they contain a wide range of nutrients, including: vitamin C vitamin B6 the minerals magnesium, potassium, and copper gingerols, shogaols, paradols, and other phytonutrients and polyphenols Gingerol, shogaol, and paradols all have antioxidant properties, and gingerol and paradols are also anti-inflammatory. Antioxidants help the body get rid of free radicals, which can lead to cell damage and inflammation. Does My Dog Need Antioxidants 4) Oily Fish Joint degradation is characterised by inadequate production of compounds necessary to its structure, along with reduced collagen synthesis. This can be a result of physical stress, trauma, autoimmunity, or aging. Here, inflammation is upregulated, creating further breakdown. It results in weak, damaged, or inflamed tissue with restricted or painful movement. Essential fatty acids are well known to help modulate inflammatory responses found in cases of joint degradation. During the inflammatory response, certain enzymes catalyse the production of compounds which cause pain, redness, and heat. It has been discovered that omega-3 fatty acids inhibit these enzymes that result in this response. Great sources of omega-3 fatty acids include all those oily fish like sardines, salmon, and mackerel. Some plant based oils also contain omega 3 too, hemp seed oil has a great omega 6:3 ratio! 5) Bone Broth Bone broth is a liquid containing brewed bones and connective tissues. Bones themselves are rich in vitamins and nutrients, including calcium, magnesium, and phosphorous. In addition, brewing connective tissue into bone broth provides the body with natural compounds from the cartilage. You will also find collagen and cooking collagen turns it to gelatin, which provides the body with amino acids, which are the building blocks of proteins. It is not possible to say how much of any nutrient will be in a particular batch of bone broth, since this largely depends on the type and quantity of the bones and tissues that went into it, but a good rotation of bones and tissues will provide a range of nutrients. A 2017
There’s a difference between nutrients and foods – nutrients are what you find in foods. Whilst it can be a somewhat reductionist approach to health, if we know the role of certain nutrients, it can help us understand why we need to include them in our pet’s diet. In this blog, we thought we’d look at some of the most important nutrients for bone and joint health in pets. Bone is a light, yet strong connective tissue consisting of around 30% collagen and other matrix proteins with around 70% minerals. These minerals include calcium and phosphorus, but magnesium, sodium and potassium are also present in conjugated form. Bones come together to form joints. The type of joint formed determines the degree and direction of motion. For example, joints with a ball and socket formation allow for a rotation whilst hinge joints only allow for bending and straightening. In a joint, the ends of the bones are covered in cartilage, which helps reduce friction as joints move. With age, this cartilage can degrade. Tendons connect muscle to bone and are made up mostly of collagen. Ligaments surround joints and help to stabilise them. They also connect bone to bone. Bone Health Bone starts as a cartilage model which gets slowly replaced. Osteoblasts are the cells that form new bone; think of it as a blast that spreads, and osteoblasts spread to form new bone. Osteoblasts secrete osteoids which are simply unmineralized bone tissue. Soon after the osteoid is laid down, inorganic salts (calcium and phosphorus) are deposited which forms the hardened material that we know as bone. Inappropriate levels of calcium and phosphorus during growth therefore understandably contribute to bone deformities and skeletal disorders. Calcium Calcium is one of the most abundant minerals in the body. An optimal calcium intake is necessary for bone health at all stages of life. Dietary requirements for calcium are determined by the need for bone development and bone maintenance, which vary throughout life, being higher during puppyhood, adolescence, during pregnancy and lactation, and in the aging. When imbalanced levels of calcium are present, it can result in abnormal skeletal formation and/or function. Causes of Calcium Imbalance Vitamin D imbalance Kidney disease Liver disease Thyroid or parathyroid gland issues Diets rich in phytate and/or oxalate Primary hyperparathyroidism Cancer Certain medications Glucocorticoids promote calcium depletion High sodium diets – when sodium leaves the body it takes calcium along with it Sources of Calcium Raw meaty bones Sardines with bones Salmon Kale (cooked) Chia Seeds Bok Choi Egg Broccoli Liver Vitamin D Vitamin D is actually a hormone that promotes calcium absorption. In human health, you will have heard it referenced as the sunshine vitamin as it is produced in the skin in response to sunlight (UV) exposure. In studies of hip fractures in humans, there appears to be a seasonal variation; more occur during winter months and fracture patients often have low vitamin D status. When supplemented with Vitamin D and calcium, incidences of fractures often reduce. Findings Here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240026/ Vitamin D plays an indirect role in bone health by managing calcium levels in the body. It controls absorption of calcium in the intestine and the amount of calcium excreted by the kidneys. If Vitamin D levels are low, then the intestines struggle to absorb calcium. Calcium is key to bone mineralisation (hardening), without calcium, bones are unable to form correctly. Not only that, but due to the lack of circulating calcium, the body mobilises it from the bones by way of increased parathyroid hormone. This not only weakens the bones, but it also creates a new issue, namely secondary hyperparathyroidism. Vitamin D deficiency include symptoms like: Simultaneous deficiency/imbalance in calcium/phosphorus, Rickets (soft and weak bones in young dogs), Osteomalacia (soft and weak bones in adult dogs), Osteoporosis (weak bones leading to fractures), Neurological abnormalities, Hypocalcemia (low calcium levels), Elevated parathyroid hormone (symptoms include bone pain, depression, kidney stones, hypertension, cardiac arrhythmias, and kidney failure), Posterior paralysis, Ataxia (neurological issues including gait abnormality, difficulty walking, tremors), Quadriparesis (weakness in all four limbs). Food Sources of Vitamin D Flesh of fatty fish (salmon, tuna and mackerel) Fish Liver Oils Beef Liver Egg Yolks Joint Health Other than the skeleton, which provides a rigid structural framework for the body, there are other connective tissues that provide support. Where a degree of flexibility is required, cartilage is a rubberlike tissue that offers semi-flexible support for structures. The other function of cartilage is to prevent friction and enable smooth movement around joints. Cartilage is formed by chondrocytes which mainly consist of collagen and proteoglycans. Ligaments are made from tough, fibrous, dense connective tissue. They are made up of collagen, elastin, proteoglycans and a range of minerals including copper, manganese and calcium. Key to proteoglycan structure are the GAG’s chondroitin and dermatan sulphate. Tendons are very similar in structure and function as connectors that join muscle to bone. They are capable of carrying high tensile or compressive forces, facilitating movement around a joint. They have proportionally more collagen and less proteoglycan content as a result of the need for an even tougher structure. Joint degradation is characterised by inadequate GAG, proteoglycan and collagen synthesis to renew tissue in the face of degradation caused by physical stress, trauma, autoimmunity or ageing. Vitamin C Vitamin C is a water-soluble vitamin, antioxidant, and essential co-factor for collagen biosynthesis, carnitine and catecholamine metabolism, and dietary iron absorption. Whilst humans are unable to synthesize it themselves, dogs seemingly can in adequate amounts. Vitamin C is an essential for two enzymes required in collagen synthesis, so sufficient amounts are necessary for optimal joint (and bone) health in the canine. Sources of Vitamin C: Peppers Carrots Pumpkin Sweet Potatoes Seaweed Blueberries Glucosamine Glucosamine is a natural sugar that exists in the fluid around the joints, as well as in animal bones, bone marrow, shellfish, and fungi. The body uses glucosamine to build and repair cartilage. With age, cartilage can become less flexible and start to break down. This
Bladder stones are exactly that, stones that form in your pet’s bladder. The more technical term is urolithiasis, which denotes the presence of uroliths in the urinary tract. These stones can develop over weeks or months, and a common question we are asked here at My Pet Nutritionist is whether dietary changes can make a difference. We thought we’d focus on what bladder stones are, the different types and whether in fact dietary management is something to consider. What Are Bladder Stones? Cats and dogs can be prone to developing urinary stones and infection. These occur when the concentration of certain minerals in your pet’s urine becomes too high (alkaline). In healthy pets, the urine pH is generally in the 6.5 to 7.0 range. If the pH is acidic (pH below 6) or alkaline (pH above 7) it may allow bacteria to thrive and for crystals or stones to form. Stones in the bladder can cause inflammation, predispose to urinary tract infections, and even cause an obstruction of the urinary tract. There are several different types of stones, and they are composed of different minerals and compounds: Struvite Calcium oxalate Urate Cystine The most common causes include: Bacteria in the urinary tract Urinary pH Minerals present in the urine Genetics Bladder inflammation Struvite Stones These stones form due to excess magnesium, ammonium and phosphorus. Normal canine urine is slightly acidic and contains waste products from metabolism. Struvite is a normal compound found in canine urine and will remain dissolved as long as the urine is acid and not too concentrated. When the urine become too concentrated or alkaline, struvite crystals form. These stones tend to form as a result of a urinary tract infection and involves an enzyme known as urease. Urease is produced by the pathogenic bacteria and breaks down urea, which is normally found in urine. In the process, excess ammonia is produced which causes the urine to become alkaline. Excess ammonia in the urine also results in bladder inflammation, contributing to the issue. These stones are generally more common in female dogs. Kidney disease, long term use of diuretic medication and PPI’s can also result in alkaline urine, predisposing the dog to struvite stones. Calcium Oxalate Stones The current line of thinking is that urine high in calcium, citrates, or oxalates and is acidic predisposes a dog to developing calcium oxalate urinary crystals and stones. Recent studies have shown diets that cause high urine acidity (urine pH less than 6.5) may predispose dogs to develop this type of bladder stone. But, like most things, there are likely other causes of calcium oxalate bladder stones too. For example, over-usage of antibiotics may reduce numbers of the intestinal bacteria Oxalobacter formigenes whose sole nutrient is oxalate. In dogs with low populations of Oxalobacter, excess oxalate is secreted in the urine, increasing the likelihood that calcium oxalate crystals and stones can form if the urine is highly concentrated or becomes acidic. Calcium oxalate uroliths are noted more commonly in male dogs and the breeds most diagnosed with both struvite and calcium oxalate bladder stones included Shih Tzus, Miniature Schnauzer, Bichon Frise, Lhasa Apso, and Yorkshire Terrier. Urate Stones Urate stones are generally caused by a genetic condition in some dog breeds like Dalmatians, Jack Russel Terriers and Bulldogs. But they are also seen with liver disease, especially in dogs or cats with liver shunts. Urate stones are made from compounds called purines. Purines are one of the most common chemical compounds on the planet. There are both endogenous and exogenous. Exogenous purines are absorbed by the body through the foods eaten, and endogenous purines are made by the body itself. Purines and pyrimidines are the two families of nitrogenous base that make up nucleic acids – in short, they are the building blocks of DNA and RNA. Purines have a number of functions in the body: Signalling molecule Provide energy Control cell growth Part of essential coenzymes Contribute to nervous system function (including neuronal development) As you can see, purines perform many important functions in the cell, and so the balance between its synthesis and degradation is essential. When purines are catabolised, the result is uric acid. In all other mammals, apart from humans and Dalmatians, uric acid is then converted to allantoin, which is a very soluble excretion product. For us humans and those unlucky dogs, we excrete uric acid through the kidneys (with some excreted through the gastrointestinal tract). Uric acid is suggested to behave as a potent antioxidant. It is also thought to maintain blood pressure under low salt conditions and has been seen to function as an anti-inflammatory in certain diseases, but when levels become too high, in a condition known as hyperuricemia, problems can ensue. In humans, this can result in diseases such as kidney stones and gout and may cause hypertension. In those unlucky dogs, high uric acid levels result in bladder stones. For this reason, a low purine diet is often suggested for those pets suffering urate stones. Foods High in Purines Organs/offal (brain, heart, liver, kidneys) Wild or Farmed Game Herring Mackerel Trout Sardines Sprats Legumes (such as kidney beans, lentils, chickpeas) Foods Lower in Purines Green leafy vegetables (except spinach) Eggs Nuts Muscle meats from chicken, turkey, lamb, pork, beef, Fruits If urate stones are associated with liver disease, you may want to learn more about liver disease in our other blogs. Liver Disease Liver Shunts Foods to Feed in Liver Disease Cystine Stones This is rarer in the dog, but it can occur. This is when bladder stones are composed of cystine crystals, and it is largely genetic. They are more commonly found in the following breeds: Mastiff Saluki Puli Basset Hound Dachshunds Findings Here Cystine is an amino acid that is freely filtered in urine and almost completely reabsorbed by the kidney tubules. Sadly, an inborn error of metabolism causes high concentrations of urinary cystine in those affected dogs. These stones also form in acidic environments and in
In a previous My Pet Nutritionist blog we looked at the function of the urinary system; if you missed it, you can check it out! As you will know, any system that is compromised, results in a range of signs and symptoms. Kidney disease or compromise ideally needs the support of knowledgeable practitioner, but there are many of us who simply want to get our pets off to the best start and support their health before things go rogue. So, we thought we’d do a one stop shop of nutrients that are particularly helpful for supporting general kidney health. B Vitamins Along with vitamin C, the B vits are water soluble and there are eight of them: B1 Thiamin B2 Riboflavin B3 Niacin B5 Pantothenic Acid B6 Pyridoxine B7 Biotin B9 Folate B12 Cobalamin These vitamins are involved in many functions as they help a variety of enzymes do their jobs – they help release energy from macronutrients and they help transport oxygen and energy containing nutrients around the body. B1 is involved in energy metabolism – it helps our dogs turn what they eat into energy. It also plays a role in nervous system function. In addition is helps metabolise certain neurotransmitters which as we know are chemical messages that are sent between the body and brain! Finally, B1 is involved in the synthesis of collagen and other proteins which contributes to structural health and wound healing. B2 or riboflavin is involved in energy production, and it is a cofactor of the master antioxidant glutathione, therefore adequate intake is essential to antioxidant capacities. Does My Dog Need Antioxidants B3 is necessary in the biosynthesis of fatty acids and also in energy production. It is essential for skin health, mucous membrane integrity and digestive and nervous system health. In addition, B3 is involved in DNA replication and repair, blood sugar regulation and also functions as an antioxidant. B5 is involved in energy production, the synthesis of fatty acids, cholesterol, steroid hormones and also vitamins A and D. It is essential in protein and amino acid synthesis along with the formation of the neurotransmitter acetylcholine which is the chief of the parasympathetic nervous system (the rest and digest side of the stress response). Vitamin B6 plays a vital role in the production of protein compounds (like haemoglobin), cells of the immune system, hormones, neurotransmitters, RNA, DNA and many enzymes. It is also involved in the manufacture of prostaglandins, which are produced at the site of injury or infection, largely controlling the inflammatory response. Vitamin B6 also activates the release of glycogen from the liver and muscles, for this reason it is essential to physical activity (and gets depleted in times of high demand). It also helps balance sodium and potassium which in turn, regulates bodily fluids and promotes the normal functioning of the nervous and musculoskeletal systems. Known as Vitamin H, for Haar and Haut (hair and skin), we know it more commonly as vitamin B7, or Biotin. This vitamin too helps the body convert food into energy; specifically, biotin is involved in gluconeogenesis, which as we know is the synthesis of glucose from non-carbohydrate sources. Biotin is also involved in fatty acid synthesis, which is important in energy metabolism but also key in skin health. Deficiency of biotin has been associated with immune depression and reduced collagen synthesis. Findings Here Of interest, the use of antibiotics decreases the bacterial population of the large intestine which increase the dietary requirement for biotin. Rancid fats also inactive biotin along with chlorine. Good dietary sources of B7 include liver, eggs, salmon, sardines, mushrooms. B9 is essential in growing and dividing cells. A lack of folate has the most impact on those rapidly dividing cells like those in the digestive system, the genital tract and of course red blood cells. B9 is key in the synthesis of structural and functional proteins, and the formation of the master antioxidant, glutathione, is indirectly dependent on folate. And finally, vitamin B12 is essential for DNA and RNA synthesis and for cellular energy production. All cells in all bodies need to know what they are doing, and they need energy to do them; B12 ensures this occurs. There are no known naturally occurring bioactive forms of B12 in plant sources. This is because B12 is synthesised by the bacteria in the gastrointestinal tract of animals, and then absorbed by the host animals. B12 is concentrated in their tissues, which is then eaten by other animals. Sources of B12 include red meat, fish, dairy, and eggs. Why Your Dog Needs B12 You can ensure a fresh food diet, rich in these B Vitamins, or with the guidance of a practitioner, consider supplementation in methylated form. Coenzyme Q10 Coenzyme Q10 (COQ10) is an essential compound of the body which is synthesized in the mitochondrial inner membrane. It has many important functions in the body. Firstly, it can be named the key-component of electron transport chain in mitochondria necessary for ATP production and secondly, it can act as an intercellular antioxidant. In the body, COQ10 is found in all systems of organs. The highest concentration of ubiquinone is noted in the tissues of the heart, liver, muscles and you guessed it, kidneys! In poor kidney function, levels of COQ10 are often depressed, and much research has indicated that COQ10 may have favourable effects on cardiac function, glucose metabolism, lipid profiles, inflammation and oxidative stress in patients with non-dialysis chronic kidney disease. Findings Here Cordyceps Cordyceps cicadae, a caterpillar-shaped medicinal mushroom that derives its nutrients from larvae of Cicada flammata Dist., has been utilized in Chinese herbal medicine for thousands of years. All Cordyceps species are endoparasitoids, living mainly on insects and other arthropods. It has been well evidence that the use of cordyceps has demonstrated beneficial effects in decreasing the progression of end-stage kidney disease. Findings Here it is largely thought this is due to its antioxidant, anti-inflammatory and immunostimulant properties. But that doesn’t mean we have to wait
One of the common issues we are asked about here at My Pet Nutritionist is kidney and urinary health. Our blog on urinary tract issues can be found. Here But we thought we’d go back to basics and look at the role of the urinary system and why supporting its function is important to overall health. The Urinary System As body cells carry out metabolic activities, they consume oxygen and nutrients. During this process, waste products are made. These waste products must be eliminated from the body because if they are left to accumulate, they can become toxic. As the respiratory system eliminates carbon dioxide, the urinary system picks up the remainder of the waste products. But this is not the only function of the urinary system, so let’s take a look. This system consists of: Two ureters, One urinary bladder, One urethra. The kidneys filter the blood of wastes and excretes them into urine. Once formed, urine passes through the ureters and is stored in the urinary bladder. It is then excreted through the urethra. Functions of the Kidneys Excretion of wastes: By forming urine, the kidneys help excrete waste from the body. Some of these are a result of metabolic processes, like urea and ammonia, which is as a result of the deamination of amino acids. It also includes creatinine which is a result of breaking down creatine phosphate. Finally, it includes uric acid from the catabolism of nucleic acids. These compounds are all known as nitrogenous wastes as they are wastes that contain nitrogen. The remainder of wastes are foreign substances that have entered the body, like medications and environmental toxins. Regulation of blood composition: The kidneys help regulate the blood levels of several ions including sodium, potassium, calcium, chloride, and phosphate. This is achieved by controlling the excretion of said ions into urine. Regulation of blood pH Regulation of blood volume: The kidneys adjust blood volume by conserving or eliminating water in the urine. An increase in blood volume increases blood pressure and a decrease in blood volume decreases blood pressure. Regulation of blood pressure: The kidneys secrete the enzyme renin which activates the renin-angiotensin-aldosterone pathway. Increased renin increases blood pressure. Production of hormones: The kidneys produce two hormones, calcitriol helps regulate calcium homeostasis and erythropoietin stimulates the production of red blood cells. Regulation of blood glucose level: Live the liver, the kidneys can use certain amino acids like glutamine in gluconeogenesis, which is the production of new glucose molecules. The Contributions of The Urinary System for All Body Systems Skeletal System The kidneys help adjust levels of blood calcium and phosphates needed for building extracellular bone matrix. Muscular System The kidneys help adjust calcium levels for contraction of muscle. Nervous System Through the process of gluconeogenesis, the kidneys provide glucose for ATP production in neurons, especially during fasting or starvation. Endocrine System The kidneys participate in the synthesis of calcitriol, the active form of Vitamin D. They also release erythropoietin which is the hormone that stimulates the production of red blood cells. Cardiovascular System As noted previously, the kidneys play a key role in the regulation of blood volume, pressure and composition. Lymphatic System and Immune Function By increasing or decreasing their reabsorption of water filtered from blood, kidneys help adjust volume of interstitial fluid and lymph. Urine also flushes microbes out of the urethra. Respiratory System The kidneys and lungs cooperate by adjusting pH of body fluids. Digestive System As we have mentioned, the kidneys synthesise calcitriol which is the active form of vitamin D. This is necessary for the absorption of dietary calcium. Evaluation of Kidney Function As you have gathered, the kidneys play a pretty important role in the body, and there are a number of ways we check how well they are doing it. The blood urea nitrogen test measures the amount of urea in a sample of blood. Urea is a waste product of the breakdown of protein. When glomerular filtration rate (how much blood is filtered) decreases severely in the case of renal disease or obstruction in the urinary tract, BUN rises steeply. The other test that is often used is to measure plasma creatinine. This is the result of the catabolism of creatine phosphate in skeletal muscle. Normally the creatinine levels remain steady, because the rate of excretion in the urine remains equal to its discharge from muscle, but high creatinine levels can indicate poor renal function. Renal plasma clearance is a test which establishes how effective the kidneys are at removing a given substance from blood plasma. Urine Water accounts for around 95% of the total volume of urine. The remaining 5% consists of: Electrolytes Solutes derived from cellular metabolism Exogenous compounds (like medications) Typical constitutes of urine include: Filtered and secreted electrolytes Urea Creatinine Uric acid Urobilinogen Small amounts of fatty acids, pigments, enzymes, and hormones If disease alters body metabolism or kidney function, traces of substances not normally present may appear in the urine, or normal constituents may appear in abnormal amounts. For example: Albumin: a normal constituent of plasma, it usually appears in small amounts in urine. The presence of excess albumin indicates increased permeability of kidney filtration membranes due to injury or disease, increased blood pressure, or irritation of kidney cells by substances like bacterial toxins or heavy metals. Glucose: presence in the urine usually indicates diabetes but it can also be a result of stress (causing excess epinephrine secretion – epinephrine stimulates the breakdown of glycogen and liberation of glucose from the liver). Red blood cells: this usually indicates a pathological condition. One cause is acute inflammation or urinary organs due to disease or irritation from kidney stones. Ketone bodies: high levels of ketone bodies in urine may indicate diabetes, anorexia, or starvation. Bilirubin: when red blood cells are destroyed by macrophages, the globin portion of haemoglobin is split off and haem is converted to biliverdin, this is then converted to bilirubin which gives bile its pigmentation. Microbes: these will be
In 2017, 56% of dogs in the US were classed as being overweight or obese. This is a whopping 50.2 million dogs who are at risk of developing secondary conditions such as arthritis, certain cancers, kidney disease and an overall poorer quality of life with a reduced life expectancy. Yet in the same time frame, 58% of dog owners said they had tried to help their dog lose weight. The true obesity figures are hard to come by, but most practitioners that we speak with here at My Pet Nutritionist would say that obesity in pets is much higher. If we know that our pet is overweight and we are actively trying to help them lose weight, what’s going on? Most owners say it’s lack of time to exercise their dog, but exercise is just the tip of the iceberg when it comes to weight loss. So, we’ve put together our top tips for helping our pets lose weight. 1) Find out if your pet is overweight. A dog in its range of ideal weight for its breed should have an hourglass figure from above. You should be able to see a definite waistline. If you feel their body, the ribs should be palpable, but you shouldn’t be able to see them. During exercise, they will pant but they won’t be winded. They should be enthusiastic about movement. If you notice heavy panting, respiratory distress, general lethargy or reluctance to move along with what appears to be excess weight you really should be thinking about a dog diet (if other health issues have been ruled out of course). 2) Know the why! The long-term impact of pet obesity includes: Heat intolerance Diabetes Liver disease Osteoarthritis Poor immune function CancerReduced life expectancy Understanding that those extra pounds are seriously impacting our pet’s quality of life can help keep us on track. 3) Find out exactly what you’re feeding. Studies have consistently shown that when fed the same number of calories, those dogs fed a low carb, but higher protein diet lost more body weight than those dogs fed a high carb, low protein diet. Findings Here This is why we would always advocate a whole food, fresh diet that is moderate in protein and fat. If you’re not quite there with a fresh diet, studies have shown that pets fed on a canned diet as opposed to the equivalent dry, lose more fat. Findings Here 4) Monitor Intake! Any human who has tried to lose weight will remember being bombarded with information of what club to join or which diet to follow. None are quite as effective as keeping a food diary. This is key to your dog lose weight too! 2 meals a day, or even 1, what more is there to record? What about that crust off your sandwich, or the scraps the kids feed under the table? Or the treat the neighbour gives him every day? Once you start noticing and logging his food intake, you’ll be surprised at how many extra bits he gets! 5) Measure! It may sound simple, but the most important part of helping your dog to lose weight is to measure their food. Despite us doing it for years, feeding by eye can sometimes deceive us. It may seem a lot of work, but it really is the only way to ensure we are keeping tabs on what our pets are actually eating! 6) It’s all in the mind! Most owners struggle with dog weight loss plans because they feel guilty! Those sad eyes looking up at you when they think you haven’t given them enough! Dogs are scavengers. It’s this trait that domesticated them from the ancient wolf. Findings Here Some breeds, like the Labrador also don’t seem to have a satiety switch. They also learn through reinforcement – they have probably learned that if they look at you long enough, you’ll give in and offer them extras! Findings Here If you feel guilty when you leave the house for a few hours, save some of their daily intake for when you’re leaving. Do they always scrounge at the table when you’re eating, and you can’t say no? Put them in a different room whilst you’re eating or offer them a long-lasting chew (incorporated into their caloric intake). 7) Get by with a little help from my friends! You’ve been in that situation, trying to cut back on certain foods, then your colleague brings cake in! Minus the cake, it is often other well-meaning friends and relatives that can sabotage your dog’s weight loss plan too. You may be monitoring his calories, cutting back and watching everything that goes into his mouth, but if the children are still giving him scraps, the neighbours throwing treats over the fence and your Aunt feeding him sandwiches when she pops in to let him out, you’re on to a loser! Let everyone know your plan. Explain why you need to cut back and the risks associated with being over-weight. If they adore him enough to treat him, they’ll soon support your plan. If you don’t want to stop the treats, you could work out some calorie allowance by reducing some of his meal intake. Work out how many treats this is and put them in a jar on the tabletop. Let friends and family know that they can treat him from this jar. If it’s empty – he’s had his lot for the day! 8) Feed animals separately! Whilst the plan so far seems easy, as soon as you throw other pets into the mix it becomes more difficult. If they are fed in the same room, they can swap bowls and finish each other’s meals. If you have cats, you can bet your life the dog is eating the cat food too! Part of your dog weight plan needs to make provision for feeding animals separately. Summary It is generally thought that the single best way to shed unwanted weight is a calorie-controlled
