Another particularly common issue we see here at My Pet Nutritionist is yeast! More technically known as candida, it is actually harmless when kept in check. The issue is when our dog’s system goes a little awry and can’t keep those little blighters from colonising. Whilst it sounds like a military operation, the dog’s system functions very much like that. Let’s take a look at yeast in a little more detail and how we can armour dog’s defences for a fighting chance! What is Yeast? Candida is an opportunistic fungal pathogen. It is a normal part of the gastrointestinal flora and genital tracts. Healthy systems are more than capable of keeping it in check with their beneficial bacteria. The issue arises when there aren’t enough good guys to keep the bad guys in check. The good bugs we find in our dog’s gastrointestinal tract will compete with the bad bugs for food sources and attachment sites. As we know there are a number of factors that can skew the microbial community found in our dog’s system. Antibiotics Broad spectrum antibiotics target all bugs,so whilst they get rid of the ones running amok, they also wipe out the beneficial ones too. Whilst the microbiome can recover to some extent, eventually; this takes time and there’s evidence which suggests key species are never fully repopulated. Findings here Stress There are clear links that stress, whether physical or emotional, affects the composition of the gut. On many occasions, stressor infliction significantly reduces the good guys. This has been associated with increased inflammation in the gut, which then continues the cycle. Findings here The Environment There is a huge amount of data which shows exposure to environmental pollutants significantly alters the gut microbiome. This includes bisphenols, phthalates, organic pollutants, heavy metals and pesticides. Bisphenol is an industrial chemical used to make hard, clear plastic. It is also found in epoxy resins which is often used as a protective later in some metal food and beverage cans/tins. Bisphenol has been linked to reduced microbiome diversity, and a significant decrease in protective bacteria. Phthalates are plasticisers and stabilisers found in vinyl flooring, clothing, detergents, personal care products, toys, medical equipment, and plastic packaging. Because they are non covalently bound to materials, they can leach into the environment. Phthalate exposure induces microbiota changes and has been known to inhibit the synthesis of certain short-chain-fatty acids. Heavy metals are associated with reduced microbiota diversity along with the altered metabolism of vitamin E and bile acid. Findings here Pesticides are renowned for altering the gut microbiome. This not only includes the pesticides administered to pets (flea and tick treatments), but also those found in the environment, particularly those sprayed on public footpaths. What is also worth considering is that antibiotic use has been seen to increase bioavailability of pesticides within the body. Findings here You are what eat! Of course, nutrition also plays a part in modulating the gut microbiome. But we always knew that. We are all pretty selfish in evolutionary terms, and this includes the bugs we find throughout our body. Our ultimate aim, and theirs, is to survive. So, we just need to modify how many of them actually do. This means keeping the colonies of good bacteria strong, so offering our dogs a diet full of pre and probiotic foods! Prebiotics are like the fertilisers in the garden, they help to feed and grow the beneficial bacteria in our garden. Probiotics however contain live organisms which can contribute to the population of the garden. Findings here There are a number of prebiotic foods suitable for dogs and they include mushrooms, chicory root, garlic and dandelion greens. Probiotics include fermented food, but supplements are available; soil-based are a good call for your canine friend (hold off on the fermented food until later, if your dog has already developed an overgrowth). Yeasts seem to like sugar as fuel, so diets high in grains, starches and other carbohydrates seem to contribute to an overgrowth. Generally, certain beneficial bacteria will metabolise these sugars, keeping candida in check by disrupting its food supply, but in the absence of good bacteria, candida is partying it down at the all-you-can-eat buffet! Immunity A weakened immune system is also a huge risk factor for developing a candida overgrowth. Whether this has been a natural progression over a period of time for a range of factors, or even due to medications like steroids. Immune function has natural peaks and troughs, young dogs and ageing dogs naturally have a lower function, but pre-existing conditions along with a range of medications can affect it too. The immune system is like a nosey neighbour. It keeps tabs on everything going on in the body and knows when something isn’t quite right. When it identifies something as non-self, it sends the army to fight the foreign invader and, all being well, wins, before sitting back down with its cup of tea. The issue arises when it can’t get up from its chair and so the foreign bodies are left to invade. There are a number of factors which can compromise immune function from sleep, to stress and nutritional status; there are several key nutrients essential to its performance. So, supporting this is essential in the prevention and treatment of any bacterial overgrowth. Top Tips: Adequate rest Reduced exposure to stress Nutrient dense diet withVitamins A, C, D and B’s, along with Zinc, Selenium, and Iron Address any pre-existing issues like inflammation in the digestive system or poor pancreas function which can contribute to poor nutritional status Findings here Careful use of medications like antibiotics, NSAIDs and steroids Findings here on Vitamin D Findings here on Zinc What if your dog has already got an overgrowth? If indeed your dog has developed a candida overgrowth, you will notice symptoms like: Ear infections Greasy coat Sores Odour (yes, that cheesy type of smell) Green/yellow discharge Crusty/flaky skin Hair loss Itching/scratching Incessant licking/grooming of an area due to irritation Rust
The prevalence of chronic kidney disease in the cat is seemingly on the up. Generally, what goes up, must come down, but when we look at the factors underlying kidney disease, there is a real concern that this may not happen. Currently, it is suggested that 1 in 3 cats suffer with some form of kidney disease. So, what can we do about it? Let’s take a look at kidney disease in a little more detail, why the kidneys are so important and some of the underlying factors that contribute to the development of it. What is kidney Disease Chronic kidney disease in cats is a prolonged process marked by the irreversible loss of kidney function. It is suggested that the early stages of CKD are often missed in cats, likely because many are outdoor cats so urination and drinking behaviours may not be as easily noted, along with vomiting etc. Kidney disease is generally associated with ageing pets; like all things, kidneys too get tired as they get older. But there are new concerns, well, new in 2014, that younger cats are seemingly presenting with the disease too. Where 30-50% of cats 15 years of age or older suffer with CKD, 13% of those under the age of 4 also suffer. Symptoms of Kidney Disease in the Cat: Increased thirst Increased urination Reduced appetite Weight loss Vomiting Fatigue Weakness Bad breath There are 4 stages of kidney disease in the cat, they are based on serum creatinine concentration: stage 1 through 4, with 2 being mild, 3 being moderate and 4 being severe. Findings here Why are the kidneys so important? The two bean shaped organs have vital functions in the body. They monitor fluid levels in the body, control and process waste and release vitamins, minerals and hormones. Their main function is to collect waste products and turn them into urine. Blood enters the kidney though arteries and splits into nephrons. The nephron splits into two nifty mechanisms to filter the blood. This includes the glomerulus and tubule. The glomerulus is like a sieve, allowing certain compounds from the blood into the tubule. The tubule then senses whether any of these compounds are needed around the body. If so, they are absorbed into the body. The tubule also senses waste products, like urea which is produced during the break down of protein. It redirects urea as urine which travels down the ureter, into the bladder to be excreted. The kidneys also activate vitamin D, and release hormones such as erythropoietin which is needed to produce red blood cells and renin which regulates blood pressure. Without the kidneys, the body would be full of blood that hadn’t been sieved and full of harmful waste. It also wouldn’t be receiving the vitamins and minerals, which, without being dramatic, are in fact critical to life. Causes of Kidney Disease There are genetic predispositions to developing kidney disease; certain breeds that are more likely to suffer with kidney issues include the Persian, Siamese, Ragdoll, Russian Blue and MaineCoon. But other than acute renal failure caused by poisoning (plants, pesticides etc), there are other factors that can contribute to kidney issues. As we have established, one of the kidney’s main role is to filter helpful and harmful compounds in the blood. It stands to reason that the more harmful compounds it must process, the sooner it reaches its retirement party! It is often suggested that chemical exposure isa progression factor in the disease and sadly cats are regularly exposed to cleaning agents, pesticides, and many more environmental toxins. These can be ingested, inhaled, or exposed transdermally (through the skin). The foods fed to cats can also impair kidney function. Mycotoxins are a diverse group of chemicals produced by a diverse group of fungi. However, mycotoxins, can be nephrotoxic (toxic to the kidneys). Studies have demonstrated that anywhere between 62% to 100% of cat foods sampled had mycotoxin contamination. Findings here There are also reports of melamine toxicity in cats, resulting in kidney damage. You guessed it; the source of melamine was contaminated food. Findings here Mild dehydration is also a risk factor for kidney disease. This is a concern because of the moisture content in many commercial foods. Dry-based cereal foods rank low on moisture,with dogs demonstrating increased drinking to counterbalance their water requirement. Cats, however, have an evolutionary low thirst-drive. Cats are obligative carnivores, meaning they get what they need from animal tissue. Therefore, they would naturally get moisture from their whole prey kills. But they are no longer getting the same level of moisture with a dry based diet and their thirst-drive hasn’t yet caught up (in evolutionary terms)! Starch also poses a risk for developing periodontal disease. Wait, what has periodontal disease got to do with the kidneys? And what has starch got to do with cats? Stick with us. Starch is the storage form of energy in plants; and then becomes a source of sugar in an animal’s diet. Bacteria found in the mouth feed off these starches and form a biofilm called plaque. This slowly degrades the tooth and surrounding structures. Not only that but the frequency of eating can contribute to the development of periodontal disease. Saliva can perform a clean-up between meals, but this becomes less of an option for the cat who is free fed throughout the day. The long and the short of it, many dry-based foods contain starch, which is a risk for periodontal disease. Periodontal disease is regularly implicated as a risk factor for kidney disease due to the relocation of oral bacteria throughout the body. Despite this, there are also things that can help mitigate the risks associated with kidney disease. Water intake is of utmost importance in all kidney patients. Therefore, a high moisture diet is essential. When offering drinking water, ensure it is filtered to remove any potential harmful compounds before they even get into the body. Protein restriction in kidney cases is much discussed and often controversial. Surely
Halitosis, as it’s more technically known, in dogs, can be a symptom of a range of health concerns. Ranging from dental disease to some cheeky gut bugs overworking, bad breath is often the first sign things may not be as they should, so lets take a look at the more common reasons and what options are available to you. 1) Periodontal Disease Periodontal disease begins when bacteria in the dog’s mouth forms to create a substance called plaque. The plaque sits on the surface of the teeth and with the help of saliva, it hardens to form tartar. Not only does it sit on the teeth, plaque and tartar seeps into gum lines which causes inflammation. Over a period of time, this inflammation and presence of bacteria causes damage to the structures surrounding the teeth; causing receding gum lines and eventually tooth loss. Not only are the mouth and teeth a concern, but the bacteria found in the mouth of your dog can be released into the circulatory system, which then travels through the body. It has been found to damage cardiac tissue causing endocarditis (infection and inflammation in the heart). Studies have also shown that periodontal disease is linked to increased insulin resistance, kidney and liver issues. Findings here The mouth is full of bacteria, primarily to form a first line of defence to protect us and our pets from the bad bugs, but the bad bugs can use carbohydrates, known as starches, as fuel, and subsequently thrive. These bacteria destroy enamel which further develop into cavities, or holes. This is why, in most human literature we are told to avoid sugars for the benefit of our oral health. It stands to reason that we would want to avoid starchy food for our pets too. A fresh food diet is as standard, low in starch, but the inclusion of raw meaty bones, if appropriate, can also create friction when eaten and contribute to the prevention of build-up on the teeth. Please note common dry foods on the market, although not marketed contain between 18-60% carbohydrates. So, if your dog’s breath could keep a vampire away, you may want to check his oral hygiene. Look for build-up, grey/brown deposits, and any breakdown of teeth. 2) SIBO Whilst it sounds like a mission to outer space, SIBO is actually a little more common than that. Small intestine bacterial overgrowth is getting increasingly common in the pet world. Whilst we usually define the microbiome as the microbial community found in the whole of the digestive tract, abundance generally increases from the stomach to the colon So, we would generally find more microbes the further down we go. SIBO occurs when we get more than we bargained for in the small intestine. It is more commonly associated with surgery, or rather a complication of surgery, but it can also occur as a result of any disease which slows the passage of food and waste products down. This means they stay in the wrong place for too long, and we all know what happens when you’re in the wrong place at the wrong time. SIBO is often associated with cases of IBD or IBS, but there must also be consideration given in times of chronic stress as we know motility is affected here. Symptoms of SIBO include loss of appetite, abdominal pain, nausea, bloating, diarrhoea, and weight loss. Due to the overgrowth of bacteria, bad breath is often a symptom. Unfortunately, there are a number of complications associated with SIBO. It can result in poor digestion and absorption of fats, proteins and carbohydrates. Bile salts that are usually required to digest fats are often broken down by the bacteria, leaving few left to digest the fat in the diet. This then leads to reduced absorption, transport and utilisation of any of the fat-soluble vitamins, A, D, E and K. The overgrown bacteria also utilise the B12 marked for host use, subsequently leading to B12 deficiency. SIBO is also indicated in cases of immune deficiency, cirrhosis, and pancreatitis. Findings here Nutritional management plays a huge role in SIBO, so if you are concerned your dog may be showing symptoms, then please book a consultation here. Gut Guardian 3) Liver Disease When the liver isn’t performing to its fully capacity, it can result in potential toxins still circulating in the body. This includes the lungs. On exhale, this can present as a strong faecal smell (be mindful we are dealing with dogs, and some of them do perform coprophagy: eating poop). However, in cases of liver disease you would notice other symptoms such as loss of appetite, weight loss, increased thirst, increased urination, jaundice (yellowing of the gums and eyes), weakness and loss of stability and in some cases seizures. Liver disease can occur as part of ageing, or there are genetic predispositions. However, oxidative stress is a significant contributor to liver complications. Risk factors associated with oxidative stress include: Obesity Diets high in processed foods Exposure to radiation Pollution Exposure to pesticides Not only that, but the body’s natural immune system can also trigger oxidative stress. This is a normal process that is swiftly managed in a healthy system. The concern is when your dog’s immune system is regularly being called to duty, over not-so-threatening threats. This state of chronic inflammation can result in higher levels of oxidative stress, putting pressure on many body systems. A diet high in antioxidants can help modulate oxidative stress, but if you are concerned about your dog’s liver function, then it’s best to speak to a qualified practitioner. If you would like to read more about liver disease, then check out our blog here. Liver Guard 4) Kidney Disease Another part of the detoxification system, when the kidneys aren’t doing what they’re supposed to, excessive urea can end up in the bloodstream resulting in a halitosis. This odour is described as ammonia smelling and having a metallic taste – but as our dogs can’t talk, we’ll just have
Whilst every diet under the sun has been touted for its weight loss properties, keto has been liked for its benefit incases of epilepsy and cancer. A ketogenic diet consists of high fat, with moderate to low protein and very low carbohydrate. This in a nutshell, forces the body to use fat instead of glucose for energy. There are two reasons this poses food for thought for the canine with cancer. Firstly, we’ll head back to the early 1900’s and pop into the lab with some sea urchins. Otto Warburg was massively interested in the chromosomes of sea urchin eggs. He wanted to understand how they fuelled their growth. Warburg found that they increased their oxygen consumption significantly as they grew. Turning his attention to a rat tumour, he expected the same. But he was wrong. Instead, the cancer cells fuelled their growth by glucose and broke it down without oxygen. To Warburg, this made no sense, but this effect as he found, is estimated to occur in many cancers. High concentrations of glucose are seen to significantly increase the proliferation of cancer cells. Findings here Not only that, but glucose has been noted to disappear from the urine of patients with diabetes after they have been diagnosed with cancer, suggesting it is recruited to cancerous areas and consumed in high amounts. Findings here Diets low in carbohydrate were thought to starve cancer cells, in essence. Glucose normally stimulates pancreatic cells to release insulin which allows glucose to enter cells and provide energy. When glucose is scarce, the body senses the need to make an alternative form of energy for cells. The liver then produces ketones and fatty acids, which provide for normal cells, but do not benefit cancer cells. It also pays to mention at this point, not only is the keto diet low in carbohydrate but it is also moderate in protein. Where low protein is no friend to anyone, protein can still be converted to glucose if consumed in high amounts through the process of gluconeogenesis, so it should be monitored. Being in a state of ketosis has seen a decrease in glucose uptake at tumour sites and also demonstrated no evidence of progression. Findings here In short, there are many studies which have demonstrated benefits of a ketogenic diet in cancer, whether as an adjuvant to traditional therapy or stand alone. Findings here The other reason why the ketogenic diet is such an interesting concept for the canine is due to their greater capacity for fat oxidation. Compared to humans, high fat diets for the dog have been seen to increase stamina and maximise energy production in healthy controls. Relative to metabolic body size, dogs metabolise free fatty acids at twice the rate of humans. It is thought that dog albumin (a protein made by the liver, whose main role is transport of various substances) can bind more fatty acids. This is deemed an endurance-adaptation in the species. Findings here So not only are dogs adept at using fat for energy, in the canine with cancer, low carbohydrate diets have demonstrated clear benefits. That said, the ketogenic diet has been seen to cause some potential side effects. The acute side effects of high fat intake are typically lethargy, nausea and vomiting, but this can be seen in many dietary changes. There are also reports of some deficiencies in trace minerals like selenium, copper and zinc, but conclusions merely indicate the potential need for supplementation if considering this diet. There are reports of elevated LDL cholesterol and kidney stones in humans consuming a ketogenic diet long term, but it is unclear how this translates to the canine. Findings here Despite this, literature reviews still conclude that the ketogenic diet has a protective role against tumorigenesis (the production or formation of a tumour or tumours) and that it does indicate a prolonged survival, reducing the risk of experiencing the pre-defined endpoint. Findings here The issue in commercial pet food is, on average, more than 45% is carbohydrate. The ketogenic diet for the canine shifts this to less than 10%. It is observed that dogs routinely enter a state of ketosis using 82% fat, 17% protein and 1% carbohydrate. After around 120 days, they may be able to maintain ketosis on a lower formulation like 69% fat, 30% protein and 1%carbohydrate. But as we know, all dogs are different and regular monitoring will inform the appropriate formulation. Findings here Due to the high content of carbohydrate found in commercial food, a switch to fresh food is essential. Whilst fruits are, for example, are still carb rich, the inclusion of low carb fibrous veggies can still provide certain micronutrients. There is also evidence that fasting alongside keto can be of benefit in cancer cases. It is argued to bring about the state of ketosis sooner. There is also evidence that fasting has been seen to reduce the side effects of chemotherapy or radiation therapy. However, there is a concern that when fat stores are exhausted, muscle breakdown will begin in order to fuel gluconeogenesis, resulting in muscle atrophy. It is concluded that this pairing may not be suitable for all patients, especially in underweight cases. It should also not be attempted without the supervision of a qualified practitioner. Findings here The other thing to be mindful of is using the ketogenic in liver cancer. Whilst ketosis is well tolerated by a normal, healthy and functioning liver, it is essential to seek the advice of a qualified practitioner when increasing the demands on an already compromised body system. Individual case studies have highlighted that a ketogenic has been utilised in cases of liver cancer to some efficacy, but this was under close monitoring. Findings here As highlighted by many professionals, if using keto in a medical condition, it becomes a medical diet. It should therefore be treated as such. To avoid many of the noted side effects, supplementation can be useful, but this is specific to the individual dog. Ketosis is also a
Traditional Chinese medicine focuses on healing the root cause of disease; encompassing a range of modalities from herbal medicine, mind-body exercise, acupuncture and of course nutrition. Nutrition encompasses food energetics which are based on the idea that certain foods have certain profiles and can subsequently be used to change the profile of the body. Yin energy is cold or cool, and there are certain foods which have cooling properties. Yang energy is warm or hot, and there are certain foods which are warming. There are also neutral foods,which are thought to have little impact on body profile. It is also thought that flavours can act upon certain organ systems and therefore create a desired health benefit. Not only that, but TCM also advocates a seasonal approach to good health. Creating a holistic view of health, it is easy to nod in agreement with many of the TCM ideas, so let’s explore them in a little more detail. Yin and Yang Yin Yang theory forms the basis of TCM; the idea that balance is key. When a deficiency exists, it should be toned up. When an excess exists, it should be reduced. If there is too much heat, it should be cooled. When there is too much cold, it should be warmed. If dampness is present, it should be dried and so on. Yin and Yang is also assigned based on heat signs. Heat and cold can be both deficient and excess; the goal is to be in harmony. Generally speaking, active, young, and outgoing pets are described as yang. Whereas older, quiet, and shy pets are described as yin. Some animals will self-regulate, the older quiet yin cat may choose to sleep in a warm window, whereas the young yang,excited puppy might jump in the water to cool off. However, we can help yang animals remained balanced by adjusting the environment. For the yang pet, provide cooling environments and foods. Include plenty of shade, air conditioning,fans, and misting. Offer fish, turkey,banana, duck, celery, kelp, spinach and broccoli. For the yin pet, provide warming environments and foods; space to sunbathe, heaters and blankets. Offer mutton, deer, chicken, ginger, chicken liver, squash, and pumpkin. Maintaining the yin-yang balance is key to ultimate health and TCM dictates that its disharmony is the basis of all disease. Yang Excess Yang excess is produced by the invasion of excessive heat, yin us unable to counteract the warming properties so an excess heat condition appears. Treatment requires the heat to be dispelled. Clinical signs: Acute onset Short course Younger age No general weakness Hyperactive High fever Red or purple tongue Strong and fast pulse Yin Excess Yin excess occurs when there is an invasion of excessive coldness. Clinical signs: Acute onset Short course Younger age No general weakness Pain Swelling or oedema Loose stool Pale or purple tongue Strong and slow pulse Yang Deficiency Yang deficiency occurs when yang is lower than normal, but yin is at its normal level. The warming properties of yang are insufficient to equalise the cooling properties, resulting in a cold condition. Clinical signs: Chronic onset Long course Older age Coldness at extremities Edema Loose stool Urinary incontinence Chronic pain/weakness Weakness in rear limbs Infertility Pale tongue Weak and deep pulse Yin Deficiency Yin deficiency is when yin is lower than normal, but yang remains stable. This heat condition is named a false heat. Clinical signs: Chronic onset Long course Older age General weakness Thirsty Lower degree of fever Restless or anxious Prefers cool Red and dry tongue Thready and fast pulse These patterns are then used, by a qualified practitioner, to classify clinical conditions and develop a treatment plan. TCM for Itchy Dogs Whilst the clinical manifestation of skin issues overall becomes quite complex in TCM, the general thought is that most conditions are heat invasions, with damp elements and yin deficiencies. When presented with seasonal allergies, eczema, itching, erosions with pus, alopecia, hot spots and dermatitis, a cooling diet is recommended. In cases of geriatric dryness or dandruff and chronic skin conditions a neutral or cooling diet is recommended. Cooling meats include turkey, ocean fish, rabbit, and white fish. Cooling vegetables include spinach, broccoli, celery, kelp, cabbage, cucumber, and melon. Sesame and flaxseed oil are also cooling. Low Fat Fish Neutral meats include pork, bison, duck, beef liver, pork liver, goose, mackerel, sardines, herring, salmon, and tuna. Neutral vegetables include carrots, green beans, peas, and shiitake mushrooms. Olive oil is also classed as neutral. If we are to consider foods to drain damp, they include beef, beef kidney, lamb kidney, mackerel, and sardines. Along with parsley, lettuce, parsnip, pumpkin,and seaweed. TCM for Skeletal Health With many skeletal issues facing dogs, it is no surprise we want to know if we can use food energetics to our advantage. What is particularly interesting, is that cases of rheumatoid arthritis can present as either hot or cold. The cold pattern is described in humans (dogs have yet to learn how to speak) as cold feelings in the limbs and joints, stiffness, or pain in a joint or muscle which is relieved by applying warmth. Symptoms increase with exposure to cold. The heat pattern is associated with hot, red, and swollen joints with severe pain generally relieved by applying cold. Although diagnosed across the board as rheumatoid arthritis, both hot and cold patterns exhibit different biological markers. Both patterns share the same expressed genes, but they appear to have different signalling pathways. T cell proliferation and the secretion of pro-inflammatory cytokines appear to be increased in hot pattern RA patients. There also appears to be more severe collagen destruction in hot pattern RA too. Cold pattern RA appears to have a higher rate of protein and fat mobilisation demonstrating a more obvious muscle breakdown. Cold pattern patients also demonstrate a reduced hypothalamic-pituitary-axis function which is associated with a decreased stress response which goes someway to explain the higher fatigue level reported in cold pattern RA. Findings here RA, to most is considered
Trillions of bacteria, viruses and fungi live on or inside of us. Maintaining a balanced relationship with them is to ours, and our pet’s advantage. Together they form the gut microbiome; a rich ecosystem that performs a variety of functions in the body. These bacteria can digest food, produce important nutrients, regulate the immune system and protect against harmful pathogens. A range of bacterial species is necessary for a healthy microbiome, but there are many things that affect our microbiome, including the environment, medications like antibiotics, and even the method of delivery when our pets were born. Diet is emerging as one of the biggest influences on the health of our gut, and subsequently our overall health. Whilst we can’t control everything that influences the composition of our gut, we can pay attention to what we eat. And probiotics are one of those things. Probiotics are live microorganisms that provide health benefits to the host when ingested in adequate amounts. They are not to be confused with prebiotics which are selectively fermented ingredients that result in specific changes in the composition and/or activity of the gut microbiota. Synbiotics are products that contain both. The term probiotics was first introduced in 1965; in contrast to antibiotics, probiotics are deemed to stimulate growth of other organisms (antibiotics are used to kill). Probiotics are live microbes that can be formulated into many different types of products from food to supplements. The most common probiotics you’ve come across will likely be lactobacillus and bifidobacterium. Probiotics are reported to suppress diarrhoea, alleviate lactose intolerance (in humans), exhibit antimicrobial activities, reduce irritable bowel symptoms and prevent inflammatory bowel disease. With a rap sheet like that, we need to explore these functions in a little more detail. Probiotics in Gut Barrier Health The intestine possesses a barrier. It acts as a selectively permeable barrier permitting the absorption of nutrients, electrolytes and water but providing an effective defence against toxins and antigens. This barrier consists of a mucosal layer, antimicrobial peptides, and tight junctions. The mucosal layer has an important role in regulating the severity of infections. An altered mucosal integrity is generally associated with inflammatory bowel disease. There is evidence that certain strains of the commonly deemed bad, Escherichia coli can prevent the disruption of the mucosal layer and can in fact, restore it when damaged. Findings here Mucin glycoproteins are large components of epithelial mucus and several lactobacillus species have been seen to increase mucin production in humans. This mucin is key in preventing the adhesion of potential pathogens in the gut. Probiotic microorganisms expressing antimicrobial peptides could also be efficient in bacterial control. Findings here Tight junctions are key to barrier formation and certain strains of bacteria, lactobacilli for example, modulate the regulation of several genes encoding adherens junction proteins. The gut is maintained by the expression of both adherens junction and tight junction proteins. Findings here There are also links between inflammation and intestinal permeability. Certain probiotics have been seen to prevent cytokine-induced epithelial damage. Findings here Competitive Microorganisms A healthy gut is when the balance is tipped in favour of the good bugs. The issue is that every microorganism’s purpose in life is to survive. To survive in the intestinal tract, species must compete for receptor sites. To do this,they have a few tricks up their sleeve. Species will create a hostile environment for other species, they will eliminate receptor sites, produce, and secrete antimicrobial substances and deplete essential nutrients other species need to survive. Lactobacilli and bifidobacterial have been shown to inhibit a range of pathogens including E. coli, Salmonella, Helicobacter pylori and Listeria. Findings here Gastrointestinal Disorders where probiotics have shown benefit: Antibiotic associated diarrhoea– several randomised controlled trials have demonstrated AAD may be prevented by administration of probiotics. Colitis – Studies are somewhat inconclusive, but it is recommended to follow antibiotic treatment in these cases, with a course of probiotics. Infectious diarrhoea-significantly shortened using probiotics. IBS – Bifidobacterium demonstrates significant effect in reducing IBS symptoms. Findings here Probiotics and the Immune System Probiotics play a role in the delicate balance between necessary and excessive defence mechanisms in the innate and adaptive immune systems. One mechanism in which they do this is through gene expression. Certain strains of bacteria have been seen to regulate genes mediating immune responses. It was clear that the administration of certain strains modulated inflammation (L. acidophilus), wound healing,cellular growth, proliferation, and development (L. Rhamnosus). Other strains of bacteria have been seen to modulate Th1 and Th2 balance. These are cytokines which are hormonal messengers, responsible for most of the biological effects in the immune system. Th1 cytokines tend to produce inflammatory responses, responsible for killing intracellular parasites and for perpetuating autoimmune responses. However, excessive inflammatory responses can lead to tissue damage, so it needs to be balanced. This is where Th2 cytokines come in. Th2 include interleukins which have more anti-inflammatory responses. Th2responses help regulate Th1 responses. Findings here The importance of immune modulation at a gut level can be understood easily when you consider that approximately 70% of the entire immune system is found here and the thin layer of connective tissue known as the lamina propria contains around 80% of all plasma cells responsible for IgA antibody production (IgA is the first line of defence in the resistance against infection). Findings here Not only that but several bacterial strains are known to synthesise vitamins. Bacteroides, Bifidobacterium and Enterococcus are known to synthesise thiamine, folate, biotin, riboflavin, pantothenic acid and vitamin K. Not only that, but bacteria play a role in their absorption! Findings here Probiotics and Obesity Gut microbes play a major role in the energy extraction from food, through a variety of mechanisms. Many plant polysaccharides and complex carbohydrates cannot be digested by the host; however, the gut microbes can metabolise them to short chain fatty acids like acetate, butyrate and propionate. Butyrate provides an energy source for colonic epithelial cells and also plays an important role in modulating immune and inflammatory
When looking at the nation’s dogs we have a major issue on our hands, a topic that can stir up emotive responses from owners and something that animal professionals may have a tricky time addressing… OBESITY From an owners perspective, they only want the best for their dog, and to be told their dog is overweight can be hurtful to hear. Your animal professional hasn’t seen those puppy dog eyes, peering over the plate looking for crumbs. Or the look you get when you need to nip out and you’re compelled to give them a treat as compensation. From an animal professional perspective, we see that overweight dog walk into our clinic and our heart sinks. Desperately wanting to tell you the list of byproduct diseases of obesity and give you a long list of things to change for your dog’s health. Instead, we softly mention they could stand to lose a little weight, to be met with a look of shock and disheartened words. Please don’t think we are here to make you feel that you’re not doing your best, we are here to guide you and want you to have the most time with your beloved pet. As much as it may be a tough conversation to have, we as animal professionals have a duty of care to animals in our clinic, and weight management is something that we need to be discussing more. For us it isn’t simply a case of sprinting around the park and cutting back portion sizes, there is so much more that we can do and it starts by inspecting what is in the dog’s bowl. Say for example your dog is on processed kibble, cutting back portion size when looking at the calorie deficit model for weight loss may have some impact. However,with your older dogs they will reserve reduced energy levels caused by food restriction, meaning weight loss can be very slow or stationary. Most processed dog food has a high percentage of carbohydrates, and this is where the issue lies. When a high volume of carbohydrates hit the GI tract, this causes a rapid increase in blood sugar and insulin levels. If the body cannot use this energy quickly enough, the leftovers get shunted into fat cells held in adipose tissue. Now going on a slight but relevant tangent, arthritis is a byproduct of obesity. Arthritis is an inflammatory disease affecting the joints and shows a higher prevalence in overweight dogs. Findings here If adipose tissue has a larger surface area caused by obesity, this increases the amount of pro inflammatory adipokines. So not only does additional physical pressure cause inflammation, but inflammation responses are increased tenfold with adipokines also jumping on an arthritic joint. Findings here So we know that carbohydrates increase blood sugar and insulin and lead to a cacophony of different issues, of which I’ve briefly discussed one. How can we look to combat this and get the best from our dog’s health, well for a start you can cut the carbs or at least look to reduce them. At MPN, we are hugely passionate about species appropriate diets and have seen incredible progress with pain management, all from just swapping to fresh foods. Even if you can’t make the leap to fully raw feed or fresh feed, there is plenty of middle ground that you can address, that will help towards a healthy life for your dog. Supercharging the bowl Whether you’re a keen raw feeder or just wanting to liven up the bowl by adding in some fresh, there is plenty of choice. Focusing on musculoskeletal health, our first port of call is adding things high in glucosamine and chondroitin. Both are complex sugars found within the structures of cartilage. Studies have indicated that these have a positive effect on pain management and ROM increase associated with Osteoarthritis. Findings here If you have compromised cartilage, you can heal with cartilage and these are super easy to source for your dog’s bowl, from bone broth, raw beef trachea to green lipped mussels (GLM). By supporting the joint health of an overweight dog, we can encourage further ROM and decrease inflammation, all working towards weight loss, there is a lot of research around turmeric (curcumin) and ginger (gingerol). Findings here Other favourites of ours for targeting joint inflammation are ACV, chamomile, fresh small fish and sunflower seeds. There is a huge amount of free radical damage (oxidative stress) created from excess adipose tissue and so looking at antioxidants to support this can be helpful. A diet high in colourful, fresh vegetables and Vitamin C can be fabulous in this instance. Findings here Lifestyle management If your dog is overweight, their joint health is likely already under pressure, but we can add some simple changes in place to reduce this strain. Start by increasing the length of your dog’s exercise, but reduce the pace. By having your dog run around the park doesn’t necessarily mean they will burn off more calories. High-impact activities will increase inflammation responses and then facilitate a pain response. Count your dog’s steps, have them on a lead next to you and go that bit further with less pressure, rather than seeing them flail around on the horizon chasing a squirrel. Be present and enjoy the walk with them, as much as it’s good for your dog, it’s good for you too! Oh no, here comes the fun police… ball flingers. Ball flingers can cause such horrific damage to your dog’s musculoskeletal structure over time, from huge repetitive stress crashing through the body when they come to a stop. If you’re not ready to put the ball flinger down, maybe drop the amount of times you throw it, or ensure warm up and cool down regime, the aim being to reduce inflammation and injury. Even things like ramps into the car and little stairs for the sofa make a tremendous impact on keeping inflammation and strain at bay. Therapies If your dog is
The main forms of thyroid diseases are auto immune Thyroiditis (Hashimoto’s), Hypothyroidism (Non autoimmune), and Hyperthyroidism (Graves’ Disease). To find out more about Hypothyroidism, please click here Graves’ Disease is an autoimmune disorder that causes hyperthyroidism. As with us humans, your dog’s thyroid gland is located at the front of the neck. It is part of the endocrine system, butterfly-shaped and consists of two lobes located either side of the windpipe (trachea) that controls metabolism. Metabolic processes are activities that occur in cells, involving the release of energy from nutrients your dog eats. Microscopically, thyroid tissue is made up of two types of cells: follicular cells and parafollicular cells. Most of the thyroid tissue consists of follicular cells. The follicles store and secrete iodine –containing hormones called thyroxine. Thyroxine (T4) and tri-iodothyronine(T3). Thyroid hormones are important in the maintenance of normal, healthy activity levels of many different organs in the body: the heart, brain, liver, kidney and skin. All of which are vital for normal body function. The thyroid requires iodine to produce the hormones. Iodine is an essential trace element absorbed in the small intestine, it is an integral part of T3 and T4. Sources of iodine include iodised table salt, seafood, seaweed, and vegetables. However, too much iodine can actually activate thyroiditis, so if you supplement, (kelp being one of the most popular for dogs), please use with caution. Hyperthyroidism in dogs is a condition caused by the thyroid over producing thyroxine, increasing your dog’s metabolic rate to dangerous levels. It is much more common in older cats but when it does effect dogs it is usually serious. In some cases tumour growths in dogs can be benign and therefore easier to manage and may respond well to treatment, but malignant tumours can often spread to vital organs in the neck and risk further complication. ‘Hyper’ thyroidism (overactive) is rarer in dogs than ‘hypo’ thyroidism (underactive) and is usually a result from aggressive thyroid tumour called carcinoma (malignant) it begins in the epithelial tissue or the tissue that lines the gland. Thyroid tumours are commonly seen in middle aged to older larger breed dogs such as boxers, beagles, golden retrievers, and Siberian huskies. Hyperthyroidism can also be caused by an error in medications, which usually includes a synthetic form of thyroxine. An over correction of low thyroxine levels can sometimes result in hyperthyroidism. Graves’ disease in humans is often hereditary and between 25 and 50 percent of people have eye abnormalities, which are known as Graves’ ophthalmopathy. A small percentage of people with Grave’ disease develop a skin abnormality called pretibial myxoedema or Graves’ dermopathy. The primary cause of this disease is due to the increased metabolism, the body goes into overdrive that has an impact on the overall function of the body. Most commonly, the condition results in weight loss, despite an increase in appetite. Other possible signs and symptoms Hyperactivity Increased heart rate Swelling of the throat – goitre Anxiety Excessive panting, heat intolerance Increased thirst Increased urination Vomiting Diarrhoea Increased volume in stool Irritability or aggression Skin lesions, dry, greasy, matted coat Heart murmurs Congestive heart failure Cardiomegaly (enlarged heart) Dyspnoea (shortness of breath) Unfortunately, the majority of these aren’t necessarily specific to thyroid disease and signs and symptoms can vary from case to case. A visit to the vets as soon as you notice any signs is the best option. The checklist for thyroid disease A fresh and unadulterated fresh food diet Adrenal, liver, digestive immune and thyroid support Omega fats and antioxidants Vitamin deficiency test Diet for thyroid disease Fresh real food is advised for dogs with hyperthyroidism, preferably lightly cooked or raw. This is the most natural diet for dogs. Highly processed food is not recommended for dogs who have thyroid disease as they contain a very high percentage of carbohydrates, imbalanced omega 6-3 ratios and inappropriate ingredients, all of which cause inflammation in the body. They put huge pressure on the digestive system, pancreas and liver. Feeding whole fresh foods that provide a wide variety of nutrients will ensure a better chance of living a longer and healthier life. Hyperthyroidism has been linked to pet foods (raw commercially prepared) that include the thyroid glands of slaughtered animals. Exogenous hyperthyroidism, a result of excessive intake of thyroid hormones is rarely recognised but is the only other recognised cause. If you are concerned, contact your raw food supplier and ask them what parts they are using or home prepare your own food to be sure – for example chicken necks or trachea. Findings here Foods containing iodine should be avoided, some are listed here Processed food containing grains, cereal and soy Seafood Dairy products High amounts of poultry or beef Egg yolks Supplements such as kelp Seaweed Cruciferous Vegetables such as broccoli, cauliflower, kale and brussels sprouts may stop the thyroid from using iodine properly. Findings here Veterinary approach to thyroid disease ‘Outdated or incomplete information taught in veterinary schools perpetuates inaccurate screening for canine thyroid disorder, since many vets are still applying outdated diagnostic methods. Tests used to determine thyroid disease include T4, free T4, T3, free T3, TgAA, T4AA, T3AA, and TSH their usage and importance depend on the situation of the dog being tested. T4 alone is not a reliable method’ – Dr Jean Dodds, DVM – The Canine Thyroid Epidemic 2011 Treatment depends on the underlying cause. Hyperthyroidism is often treated with antithyroid drugs, which stop the overproduction of thyroid hormone. Depending on the severity, treatment may entail partial removal of the tumour or removal of the entire thyroid gland. Chemotherapy or radioactive iodine (I-131) treatment or medications to counteract the excess hormone levels in which case the dog will be on replacement therapy for the rest of his life. If left untreated the condition can cause heart and kidney failure. Therefore, the best approach to hyperthyroidism is to help prevent it by providing a wholesome natural diet and avoiding unnecessary chemicals or environmental hazards which are all
When we’re out walking our dog and they are panting, we rarely pay any attention, we know that it’s a typical behaviour associated with exercise. Equally, if it’s gotten a little warmer, we expect panting (within reason). But is there a time when panting can indicate something which does require some further attention? It’s a behaviour that we ask pet guardians about in a My Pet Nutritionist consult, so let’s get to the bottom of what panting is, and if it’s anything to worry about. What is panting? Panting is characterised by fast, shallow breaths, a wide-open mouth, and an extended tongue. It’s generally associated with a dog trying to cool down, also known as thermoregulation. Cooling results from the inhalation of cooler air and exhalation of heat along with the evaporation of water in the dog’s respiratory system. The respiratory system in dogs is made up of their mouth, nose, trachea and lungs and it serves two main functions. Firstly, like in humans, it is how the body exchanges carbon dioxide and oxygen. In general, healthy dogs will have a resting respiration rate of anywhere between 15 and 40 inhalations and exhalations a minute. The typical respiration rate when panting increases 10-fold, so up to 400 inhalations and exhalations per minute is expected. It’s second function is to regulate body temperature. A normal body temperature for a dog is between 38.3°C and 39.2°C. An increase by just 1-2°C can have major effects on the dog’s system. They therefore rely on panting as their primary means of expelling heat. There are three known patterns of panting: inhalation and exhalation through the nose, inhalation through the nose and exhalation through the mouth, inhalation through the nose and mouth and exhalation through the nose and mouth. It is suggested that the most effective cooling system is when air is directed through the nose and out through the mouth. So why don’t dogs sweat to cool down? The human mechanism for cooling down is to sweat. As sweat evaporates, we cool down. Due to the thick coats dogs have, sweat just wouldn’t evaporate resulting in a thick, furry coat full of sweat! Nice! Dogs do have sweat glands, but on their paws. It is rare to see a dog with sweaty paws after exercise. You will tend to find sweaty paws in response to stress – which is why you’ll see damp patches on the table at the vets or groomers. What are the triggers and causes for a dog panting? Exercise This is a well-known cause for panting in dogs. Exertion increases heart rate and overall body temperature. Therefore, to regulate their body temperature, dogs will pant. Heat It is suggested that it can take from 7-60 days for a dog to acclimatise to a temperature change in the environment. This can be influenced by body shape, size, coat type and length and the overall health of the dog. Some of the breeds that are more sensitive to an increase in environmental temperature include: Pugs, Lhasa Apso, Boston Terrier, English Bulldog, Boxer, Cavalier King Charles Spaniel and French Bulldog. These are known as brachycephalic breeds and due to their small nasal passages and short windpipes, they don’t pant as efficiently as other breeds. This puts them at a much higher risk of heatstroke. Dog Days of Summer Anxiety/Fear/Phobia Many dogs who suffer with anxiety or fear will pant. It is thought that the fear response increases the heart rate which in turn raises the body temperature. There are usually other signs that accompany panting in a fear response, such as yawning, pacing, crying, whining, shaking, lip licking or hiding. Storms and holidays with fireworks are often a source of anxiety for dogs, so it is quite common to see more panting during these times. There are many ways to help relieve anxiety in dogs including: Thunder Jackets, Plug-in diffusers – these release calming pheromones which mimic those of nursing dams when comforting their litter. Creating a safe place – a covered crate or a space under the stairs or a table. Top Tips for Anxiety in Cats and Dogs 6 Nutritional Tips for Anxiety in Dogs Panting accompanied with shaking is a typical stress response in dogs so consider whether there has been any change to their daily routine, even the smallest changes can be worrying for some dogs. Is panting a symptom of a long-term health condition? It can be. Heart failure When the heart is no longer pumping oxygenated blood efficiently, body parts and tissues will become oxygen deprived. The easiest way to correct this depletion is to increase respiration which often results in panting. Symptoms of heart failure include: Fatigue, Difficulty breathing, Loss of appetite, Weight loss, Coughing. Older dogs are more susceptible to heart issues. The ageing process naturally causes your dog’s organs and systems to deteriorate. Keeping Your Senior Dog Healthy Heart failure can also occur as a result of heartworm disease. Heartworms are spread through mosquitoes. Infective heartworm larvae migrate through the dog’s body until they reach the heart and blood vessels in the lungs. Symptoms of heartworm include: Coughing, Intolerance of exercise, Laboured breathing/panting. Natural Worming Options for Pets Obesity Overweight dogs will often pant excessively. This is due to the strain placed upon the cardiovascular system. In determining whether your dog is a healthy weight, you should be able to see a waistline, feel the ribs and from a bird’s eye view, your dog should have an hourglass outline. Maintaining a healthy weight in your dog should be achieved through species appropriate diet with portion control and regular exercise. Obesity in Pets Part I Obesity in Pets Part II Low Fat Fish Cushing’s Disease This is when the adrenal glands produce too much cortisol, also known as hyperadrenocorticism. Cortisol is produced and stored by the adrenal glands, two small glands which sit on top of the kidneys. Investigations of the cause will usually be tumours found on the pituitary or adrenal gland or
Many dogs experience some kind of joint problem in their lifetime. This can be due to some kind of injury, strains, sprains, fractures, hip or elbow dysplasia, knee problems like torn cruciate ligaments, patellar luxation and Arthritis. Did you know 1 in 5 dogs suffer from Arthritis? So, what exactly is Arthritis and which is the most prevalent in dogs. Arthritis refers to many related conditions involving inflammation of one or more of the joints. Osteoarthritis (OA) or degenerative joint disease (DJD) is the most common we see in dogs today and is named because the problem is caused by the bones (Osteo). Arthritis in pets can also be caused by infection (septic arthritis or bacterial arthritis) or by the body attacking itself in an immune system malfunction (Rheumatoid Arthritis). The risk of Arthritis increases with age but it can develop at any age. Larger and giant breeds are most likely to get OA so it would be sensible to start adding supplements to support their joints at approximately a year old. A study that was carried out during 2013 found that 200,000 UK dogs were affected. Risk factors associated with osteoarthritis diagnosis included breed (e.g. Labrador, Golden Retriever), being neutered, higher bodyweight and being older than eight years. Research here What is inflammation Inflammation is a normal part of the immune response. Think of the last time you scraped your skin, got a bug bite, or had a pesky splinter you just couldn’t get out. Chances are the affected area got swollen and red, even hot or painful. This is inflammation at work, and in cases of acute injury, it’s a good thing! The inflammatory response is basically your immune system gathering defences to the injured tissue, helping to protect and heal the affected area. This is done by increasing blood flow to the area, gathering immune cells, causing pain to stop you from using injured tissue, and protecting the tissue in other ways that we call Acute Inflammation. Many of the chronic diseases afflicting today’s dogs result from Chronic Inflammation which isn’t such a good thing and can be avoided in some cases. The conventional veterinary community, typically relies on non-steroidal anti-inflammatory drugs (NSAID’s), commercial prescription diets and Adequan injections to treat OA in dogs. In some cases, certain vets may also recommend glucosamine and chondroitin. Ironically, most commercial prescription OA diets contain grains, gluten and/or white potato-all of which can promote inflammation. These diets can also contain a pro-inflammatory ratio of omega-6 to omega-3 fatty acids. NSAID’s – prolonged use can cause damage or injury to tissues of the liver, kidneys and bone marrow (Dodds& Lassin, 2013). Arthritis or DJD can affect one or more joints and is one of the most frequent causes of lameness in dogs. Osteo Arthritisis characterised by: deterioration of the joint cartilage called articular cartilage; a formation of bony growths or spurs on the joints, calledosteophytes; changes in the subchondral bone (the bone below the articular cartilage); and joint inflammation. These changes occur following alterations in both the biomechanical and biochemical properties of the joints (Logaret al., 2007; Sanchez & Balligand, 2005; Zhang et al.,2012). Some might say it is in the genes. Historically doctors have viewed and treated arthritis as a structural disease that involves the breakdown of cartilage and its subsequent effects on the joints, but that view is changing with thanks to a new tool to measure gene expression, including reverse transcription-polymerase chain reaction (RT-PCR),differential display and DNA microarray analysis. Even if we have genetics to consider, nutritional intervention can help support and hopefully prevent this from occurring or at least progressing. Possible Causes of joint issues Leaky Gut Leaky gut syndrome has become an epidemic in people and animals. About 70-80% of the immune system is housed in the gut, so making sure it’s in tip-top shape is key to good health. Since balance of bacteria in our gut influences the balance of our immune system, an unbalanced gut microbiota with too many opportunistic pathogens, can shift the immune system to an increased inflammatory state. Gut Guardian can help address leaky gut. Gut Guardian Inflammatory diet The role of inflammation in many diseases is significant, especially in pets that aren’t receiving a high number of dietary antioxidants. Inappropriate foods such as kibble are ultra-processed and inflammatory. They may contain grains, lectins, gluten and white potato that promote inflammation in the body. Kibble is cooked at high heat, a process called extrusion, that destroys many vital nutrients and enzymes. Your dry food will contain anywhere between 18-60% carbohydrate and we know that sugar raises inflammation. Common meats used in these foods are often chicken and pork. Both high in omega-6, pushing inflammation further, if not coupled with a good omega 3 source. Feed a species appropriate, fresh whole foods diet if possible, preferably raw or lightly cooked. Fresh foods are lower in carbohydrate content and are naturally anti inflammatory compared to carbohydrate foods. Natural sources to support joints are oily fish; salmon, sardines, herring and mackerel as these are the best source of DHA and EPA that are proven to help reduce inflammation. If your dog can’t eat fish due to an intolerance or just doesn’t like it, algae oil is a good plant-based alternative that you can find on the link below. Other sources, that contain smaller amounts of vitamin D foods are organic beef liver and egg yolks. Plant based Vitamin D can be found in parsley, alfalfa, nettle, dandelion and rosehips. Unlike us humans, dogs get very little vitamin D from the sunlight on their skin, so nearly all their vitamin D must come from their diet. Link here for a variety of carefully selected supplements by Green’s for joint health. Drugs, other toxins and over vaccination Avoid unnecessary steroids, antibiotics and (NSAIDs) all of which lead to an unbalanced gut microbiota. Prescription deworming, flea and tick prevention that contain pesticides can play havoc on the immune system so these should be avoided and used only
Very much like itching, hypothyroidism has become an epidemic amongst dogs. If your pet has been given the diagnosis of some sort of thyroid dysfunction/disease and you want the very best for them, then read on. Holistic principles and nutrition offer a tremendous advantage over conventional approaches to thyroid problems, because they tend to address the multi-factorial convergence of factors influencing thyroid health. The approach in this article is to not look at the thyroid in isolation but to consider adrenal health, gut function, liver function and immunity. Thyroid Disease Hypothyroidism is the natural deficiency of thyroid hormone that regulates your dog’s metabolism. This deficiency is produced by immune-mediated destruction of the thyroid gland by natural atrophy of the gland, by dietary deficiencies, or as a congenital problem. Low thyroid levels can affect all of your dog’s organ systems and if left unattended to, may develop into something really serious. The symptoms of hypothyroidism can vary greatly from dog to dog. There are different forms and reasons for thyroid disease but ultimately it manifests in a slowing of metabolism. Conversely, hyperthyroidism, commonly found in cats, is metabolism in overdrive, due to the over production of hormones. The main forms of thyroid disease such as Autoimmune Thyroiditis (Hashimotos), Hypothyroidism (non autoimmune), and Hyperthyroidism (Graves Disease). Autoimmune Thyroiditis (Hashimotos) is the most common cause of primary hypothyroidism in dogs. The body’s immune system develops antibodies against its own thyroid gland because of an over reactive immune response. Cells as they become attacked and destroyed, leave remaining cells having to work harder, trying to over compensate. Around 95% of hypothyroidism is caused by Autoimmune Thyroiditis and not nutritional deficiency. A blood marker called Canine Thyroglobulin Autoantibody (TgAA), highlights the nature of this thyroiditis. Other, rarer causes of hypothyroidism include cancer and congenital defects. Hypothyroidism (non-autoimmune), when not caused by autoimmunity, hypothyroidism is due to the under production of the two main hormones, T3 (triiodothyronine) and T4 (thyroxine). This is often caused by nutritional deficiency or genetics and accounts for about 5% of hypothyroid cases. It happens most often in female dogs over 5 years of age, but can affect dogs of any age and sex. This chronic condition typically comes on gradually and can go undetected for a long time. In both hypothyroidism (non autoimmunity and autoimmunity) there are multi-factorial factors influencing thyroid health. Hyperthyroidism (Graves Disease) occurs when your dog’s body produces too much of the thyroid hormone, increasing your dog’s metabolic rate to potentially dangerous levels. This disease is rare in dogs and is more commonly seen in cats. When it does affect dogs it tends to be incredibly serious. There is another blog on this coming shortly. Goitre can be a symptom of thyroid function and is the enlargement of this gland. Often caused by possible iodine deficiencies, eating a lot of goitrogenic foods, too much iodine in a diet, and inherited genetic polymorphisms, can affect the synthesis of thyroid hormones. Cancer of the thyroid is very rare but not unheard of. Certain breeds certainly, genetically fall prey to such issues but not restricted to. Breeds most likely to develop the hypothyroidism are Cocker Spaniels, Miniature Schnauzers, Dachshunds, Golden Retrievers, Doberman Pinschers, Airedale Terriers, and Irish Setters. There are number of signs and symptoms in Thyroid disease. If any of these arise consistently, you should go to the vets and get it checked out. Possible signs and symptoms in Hypothyroidism Aggression Depression Constipation/Diarrhoea Dull and dry coat Weight gain Lethargy Feeing the cold/signs such as dithering Thickening of the skin Thinning coat Itching Hair loss in patches Various skin disorders Anaemia Muscle weakness Possible stiffness Dry cough Slow heart rate Development of furrowed head wrinkles Unfortunately, the majority of these aren’t necessarily specific to thyroid disease as signs and symptoms can vary from case to case. A visit to the vets as soon as any symptoms arise, is always the best option. Thyroid function The thyroid gland is part of the endocrine system, a small butterfly-shaped gland in the neck, just in front of the windpipe (trachea). One of its main functions is to produce hormones that help to regulate the body’s metabolism (the process that turns food into energy). These hormones are called triiodothyronine (T3), thyroxine (T4). What may cause Thyroid Disease: Poor Diet; ultra processed food can trigger inflammation and an imbalanced immune system. Diet may not solely be to play in the etiology of this disease, but it certainly plays a huge role. Dry food contains a high amount of starch, imbalanced Omega 6:3 ratios and often inappropriate ingredients that create inflammation and in turn can lead to autoimmunity. Nutritional Deficiencies; although only 5% of hypothyroidism boils down to nutritional deficiency, it is always advised to have testing done to cover all bases. Common nutrients are B2, B9, B12, Iodine, Zinc, Magnesium and Selenium. Poor Methylation; leads us on from nutritional deficiencies. Very much like humans, dog’s have to convert folate into methyl folate to allow DNA methylation and synthesis to occur. Poor methylation due to diet and genetics may mean poor bodily function and B9 nutritional deficiency. A good B9 status is highly correlated to a healthy thyroid function. Food sensitivities and allergies; the intestinal lining can become inflamed after immunological reactions, caused by sensitivities and allergies. This can lead to poor stomach acid, poor gut microbiota, possible SIBO (small intestinal bacterial overgrowth) and leaky gut. Poor Stomach Acid: the most common instigator of poor absorption among thyroid patients is reduced levels of stomach acid. Stomach acid is necessary for the absorption of both macro and micro-nutrients, digesting protein and killing bad bacteria and yeasts. Poor Gut Microbiota; the microbiota influences the uptake of iodine, selenium, and iron, and the microbiota may alter the availability of L-thyroxine. Gut Guardian Leaky Gut Syndrome; caused by poor diet, stress, toxins and so much more, an immune response within the gut can cause inflammation and damage to the ‘one cell epithelial’. Human findings have correlated celiac disease/leaky gut with Hypothyroidism. Findings here
Here at MPN, we see many cases of liver disease. If your pet has been given the diagnosis of liver disease and you want the very best for them, then read on. Feeding prescription diets don’t often work successfully and if you want to learn about how you can help with fresh food and supplements, then this is the guide for you. Liver Disease Liver disease can present differently, so I have listed some of the common disease we see today. Chronic Hepatitis is the most common primary liver disease found in dogs. This chronic inflammatory condition is generally not determined although genetics, copper, infectious agents, infections such as leptospirosis or viral infections, severe trauma and various drugs (phenobarbital, NSAIDs, paracetamol) may be implicated. Copper-associated hepatitis, where copper accumulates within hepatocytes can become toxic and cause liver damage. Acute liver failure results in sudden loss of liver function, which is often associated with neurologic problems and blood clotting issues. It can occur due to a sudden injury or due to an additional issue, taxing an already diseased liver. Hepatic encephalopathy, a syndrome of neurologic problems caused by poor liver function, is seen in a quite a few liver disease cases. While the development of this condition is not totally understood, failure of the liver to clear poisons from the bloodstream, changes in amino acid metabolism and neurologic issues may synergistically work together to cause this disease. Portosystemic shunts are often described as congenital (inborn). However, they can rarely develop over time due to illness and this is called an acquired liver shunt (often occurring in older dogs and less frequently in cats). They can be caused by high blood pressure in the vessels entering into the liver. In a healthy cat or dog, blood supply draining the intestines, travels through the portal vein into the liver, where it is then filtered. It then returns blood to the heart via the vena cava. A portosystemic shunt (also known as PSS), is an abnormal vein connecting the blood supply returning from the intestines to the vein returning blood to the heart. It bypasses the liver by shunting the blood flow and there in lies it’s name. The key is to detect liver disease early as it can take months or even years to identify itself. Signs and symptoms of Liver Disease There are number of signs and symptoms in Liver Disease. If any of these arise consistently, you should go to the vets and get it checked out. Ascites (swelling of the abdomen) Play bowing Increased salivation (common in cats) Diarrhoea/orange coloured often Yellowish eyes, tongue, and/or gums (jaundice) Bloody urine or stools Licking of Lips (often a sign of nausea) Vomiting Increased water consumption and increased urination Possible pruritus (itching) An unstable walk Weight loss Lethargy Confusion Muscle wastage (this tends to appear when advanced) Seizures (if your dog’s liver disease isn’t caught at an early stage, it can lead to a serious condition Blindness (in TCM (Traditional Chinese Medicine) the eyes and liver share important meridians Unfortunately, the majority of these aren’t necessarily specific to liver disease as signs and symptoms can vary from case to case. A visit to the vets as soon as any symptoms arise, is always the best option. Liver Function I refer to the liver as the power house. It manages, processes and filters pretty much everything in the body. The liver has two main sections, called the right and the left lobes. The gallbladder sits under the liver, along with parts of the pancreas and intestines. The liver and these organs work together beautifully to digest, absorb, and process food. The liver filters the blood coming from the digestive system, before passing it to the rest of the body. The liver also detoxifies chemicals and metabolises hormones and drugs and any other toxins the body needs to rid. Whilst all of this is going on, the liver secretes bile that ends up in the intestines, emulsifying fats in the digestive process. The liver also makes proteins essential for blood clotting and many other functions. Its an incredibly clever and intuitive organ and can even regenerate liver cells, even if a portion of liver is removed in surgery. It’s a miraculous organ and your pet relies on it’s functioning for good health. What may cause Liver Disease (some factors) Poor Diet; can trigger genetics and put a massive strain on the liver. Diet may not be solely responsible in the etiology of this disease, but it certainly plays a role in treatment and support. Stress; should never be underestimated in the pathogenisis of liver disease. Trying to modulate the stress response is always helpful in any disease state. Calm Complex Copper Toxicity; copper-associated hepatitis, where copper accumulates within hepatocytes can become toxic and cause liver damage. This can be due to a low level zinc diet or genetics that impair the detoxification of copper and the assimilation and absorption of zinc. Low Copper Endocrine Disease; diabetes mellitus, hyperadrenocorticism (Cushing’s disease) and hyperthyroidism are all diseases in which impaired liver function can arise. i always ask for your vet to check this first, as treating the underlying endocrine disease is often the most important and effective part of caring for the liver. Infectious agents (leptospirosis or viral); sometimes vets will say the cause of liver disease is unknown but testing for a viral infection can sometimes implicate liver damage. We find working with the immune system in these cases and supporting the liver function is essential. Several types of infections may affect the liver, including bacterial, fungal, and parasitic diseases. Severe trauma; your pet could have been in a terrible accident that involved the liver area. Trauma can cause damage so understanding that trauma is important. Pharmaceuticals; the overuse or poor tolerance of phenobarbital, NSAIDs, paracetamol and other drugs may be implicated in liver disease. Vaccinosis; we are keen on safe vaccinations. We adhere and recommend the WSAVA vaccination guidelines as a minimum (world small
