When we talk about toxins at My Pet Nutritionist, we are talking about flea and tick treatments, worming and even households chemicals. The extra sprays of air-freshener, the over-powering smell of disinfectants and most things in the home being wiped with fabric softener. In a pet-free home, as a grown adult, it’s entirely your choice what you expose yourself to and if you want your home smelling like that, then go for it! But when you make the decision to care for a pet, who can’t tell you when they are feeling nauseous or have a headache, you have to think a little more carefully. How many of you go to a friend’s home and notice the sweet smell of their air freshener or carpet cleaner? But when you get home, you can’t smell your own? This is because we develop a tolerance – our homes may not smell strongly to us, but they may to our pets. Especially our dogs. Dogs possess an extremely strong sense of smell. Which is why they have found themselves with some of the most impressive jobs in the world; some become medical detection dogs as they can detect minute changes in a person’s odour, signalling disease. It is believed that a dog’s sense of smell is 10,000-100,000 times that of an average human. They could detect the equivalent of one drop of liquid in 20 Olympic sized swimming pools! Findings here So, even if we can’t detect a compound in our environment, it’s safe to say, our dog probably could. Your dog is detecting volatile organic compounds (VOCs). Now, they detect these in cancer sweeps (different cancers will produce different VOCs), but most of us know of VOCs for the bad rap they have. VOCs are chemicals that evaporate under normal atmospheric conditions (room temperature, low boiling point), compromising air quality. It’s fairly obvious when you spill some fuel at the garage, or you’ve recently painted your kitchen. The odour is compounds in the air, that you breathe in and subsequently stimulate/inhibit your olfactory receptors. Findings here VOCs are found everywhere. They are released by many everyday items including: Cleaning Products – detergents, bleaches etc Air Fresheners Paints Deodorants/Perfumes Fabrics Rugs Vinyl flooring Wood Burners Cigarette Smoking Printers and photocopiers This list is not exhaustive but covers the main culprits in most homes. But why are they a problem? Many VOCs have been proved as carcinogenic. That is, they are known to cause cancer. This largely depends on length of exposure, but it is still a risk. Findings here Many studies are showing the moderate to strong increase in respiratory distress or allergic effects of exposure to VOCs. As you would expect, irritation of the eyes, nose and throat is regularly reported. It stands to reason there would be an increase in allergies reported when exposed to certain VOCs. How bad is it? The health effects of a certain VOC will depend on its chemical nature and also the degree of exposure. Exposure can include ingestion, respiration and absorption through the skin. Here, we wondered whether a long-coated dog, or cat is any worse off? If the compounds stick to their coat? They are carrying the compound around with them. But we have not yet found any data to explore this query. Consider that your pet will spend a good 20-23 hours a day in your home, accounting for a 1-2-hour walk or a prowl at night time. Obviously less if they attend day care or come to work with you. But that is a high level of exposure – you are likely out of the home for a much larger part of the day. Whether you work 8-10 hours, or you are part time and then nip to run errands. In humans, it is clear that VOCs disrupt hormones and reproduction which subsequently affects the development of babies and children – it’s not a push to suggest this could happen with our pets, so it’s advised to be even more mindful with pregnant bitches, litters of puppies and when you bring your new puppy home! Findings here In an age where we want our homes grey and white and smelling of spring flowers all year round, we are inadvertently exposing our pets to some pretty harmful compounds. So, what can we do about it It’s not as hard as you’d think. Firstly, if you are re-decorating, try to do so at times of the year where you can have windows and doors open to bring fresh air through the home. Also, opt for water-based paints as these contain much lower level of VOCs. If you are unsure, speak to your local DIY or paint supplier and ask for a low content specifically. Store partly used paints and solvents in the garage or shed, where people and pets are unlikely to spend much time. If you know you won’t ever use it again, offer it to friends or family to use or simply dispose of. When cleaning, check the labels of the products you use for common harmful VOCs including: Acetone Butanal Carbon Disulfide Dichlorobenzene Ethanol Formaldehyde Terpenes Toluene Alternatively, opt for environmentally friendly products. There are so many new companies popping up who use natural ingredients to help keep your home in tiptop condition. Most are also conscious of plastic usage. We recommend products from Iron, Method, Ecover and Velvet, you dissolve a sachet of product in water in a bottle that you are reusing. The ingredients are plant-derived and essential oils are used for fragrance where possible. They smell great. White vinegar is a great product to have in the home, it’s a powerful odour neutraliser. Perfect if you are toilet training or are worried that your home smells of wet dog! Activated charcoal is also a great odour neutraliser and air purifier. Pop bags around your home, in your car etc and you’ll soon notice odours disappear. Some gift companies have even started making bouquet style bags, specifically for this purpose! Citrus
Another one of the most common issues brought to us here at My Pet Nutritionist is Atopic Dermatitis. Most commonly seen in dogs, it can also occur in the cat. Atopic dermatitis is a multifactorial disease process, but it is defined as a genetically predisposed inflammatory and pruritic allergic skin disease often associated with IgE (immunoglobulin) against environmental allergies. The prevalence of AD is thought to be 10-15% of the canine population. Symptoms will include: Scratching Chewing Licking Recurrent skin, ear and anal gland inflammation and infections Hair loss Thickening of the skin It is thought that genetic abnormalities, along with an altered immune system and skin barrier defects all play a role. So, lets take a look at AD in a little more detail. Where it comes from and what, if anything, we can do about it. Genes Multiple gene expressions involved in skin barrier function and inflammation have been seen to go awry in canine atopic dermatitis. They have been both up and down regulated. Gene expression is like the instruction pamphlet that comes with your washing machine. Issues in gene expression is like you being sent an instruction manual in a different language and inadvertently using the 60-degree wash on your cold wash items! It’s not going to end well. Well, cheeky genes who aren’t doing what they’re supposed to, often doesn’t end well either. In dogs suffering with atopic dermatitis, data has shown: 361 genes that instruct inflammation, wound healing or immune response were up regulated. 226 genes that affect skin barrier function showed decreased mRNA. mRNA is a messenger; so low concentrations result in fewer messages. Findings here This is why certain breeds are known to suffer with AD, specifically, German Shepherds, Labradors, Boxers, West Highland White Terriers, French Bulldogs, Bull Terrier, Lhasa Apso, Springer Spaniel, Poodle, Dachshund, Miniature Schnauzer and Pugs. That said, these predispositions are also linked to geographical area, which also demonstrates how the environment can interact with genes. There is much attention being paid to the idea of epigenetics; how behaviour and the environment can affect how genes work. This is why, even if your dog is genetically predisposed, you shouldn’t throw in the towel, just yet. Skin Barrier Defects The skin is the first line of defence in our trusty immune system. This goes for our dogs too. If the skin isn’t as robust as it needs to be, then pesky allergens or irritants can get in and start to knock on doors of our second line of defence; inflammation. It is believed that part of the defects found in the skin barrier in AD cases is due to decreased concentrations of filaggrin. Not only can this be due to a genetic encoding error, but certain enzymes in the skin can breakdown filaggrin. The more enzymes, the more filaggrin gets broken down. Filaggrin is a protein found in the skin, and it binds to keratin filaments. This forms a structure within the skin cells. Filaggrin is essential to skill cell maturation, and in forming the outermost protective layer. It also forms part of the natural moisturising substance found in the skin; without it,cells dry out. This is why low levels of filaggrin result in dry, cracked skin. There is also evidence that filaggrin associated atopic eczema is more likely to lead to food sensitisation and inhalant allergens. Findings here Despite there being a genetic cause for filaggrin deficiency, the importance of maintaining a robust skin barrier is essential. Please take a look at our top tips for promoting skill health here. Altered Immune Response As we have mentioned, if pesky allergens or irritants get past the first line of defence, they soon feel the full wrath of the immune response. What starts with inflammation, will venture to a targeted attack in order to eradicate the invader. In the case of a defective skin barrier, the system will regularly be exposed to potential threats, of which the immune system must deal with. This constant state of firefighting ensures a steady level of inflammation throughout the body, which is why cases of dermatitis are often paired with food sensitivities. This is why tackling chronic inflammation is a key part of a dermatitis plan. As you have likely gathered, ensuring a robust skin barrier is essential in managing atopic dermatitis, but so is modulating the immune response and inflammation. Here are our top tips in tackling those three areas. Polyphenols Polyphenols are known to interfere with pro-inflammatory mechanisms. They have been seen to act upon keratinocytes which attenuate skin inflammation. Not only that but they have been seen to hamper toxicity of bacteria which regularly colonises the skin of atopic dermatitis affected patients. Polyphenols have been seen to inhibit the activation, proliferation, and function of Th2 cells which are key players in allergic reactions. Specifically, in the inflammatory response in allergic reactions. This has also been demonstrated during re-exposure to the allergen, suggesting that offending allergens may even be reintroduced at a later stage. Polyphenols are micronutrients found in certain plant foods; they are packed full of antioxidants. Their original role in the plant is to protect against UV radiation and of course aggression by pathogens. For that reason, they tend to contribute bitterness, astringency, colour, flavour, odour and oxidative stability. Under the umbrella of polyphenols, you will find phenolic acids, flavonoids, stilbenes and lignans (and a few more). Along with being anti-inflammatory and anti-microbial, the antioxidant capacity of phenolic compounds is also key to skin health. Oxidative stress is the imbalance between free radicals (the exhaust fumes of work) and antioxidants. Oxidative stress can damage the structure of the skin and negatively influence immune system function. Interesting, polyphenols have been seen to alter certain gene expression in the dog. Findings here So, all things considered, they are pretty nifty things to offer in your dog’s fresh food diet. Phenolic Compounds for The Dog Blackberries Raspberries Strawberries Blueberries Apple Pear Curly Kale Broccoli Green Tea (organic and decaffeinated) Parsley Chamomile Pomegranate Be mindful
Here at My Pet Nutritionist, we often see rest and recovery as a forgotten need of dogs. With the advent of daycare centres and dog walkers, most of us relish the idea that our dog can be kept occupied whilst we are in work. When owners research potential breeds to bring home, their exercise quota is usually discussed along with the need for mental stimulation. Exercise is important for canine health – we’ll come back to that later. So is mental stimulation, especially for those smart, working breeds. But there needs to be a balance so lets discuss, why we let sleeping dogs lie. Pop into any social media group discussing dogs being left alone and destruction inevitably comes up. Well-meaning owners often suggest that the dog is bored and by providing things for the dog to do, they will cease the destructive behaviour. It’s clear that destruction when left alone is a symptom of anxiety; not boredom. Toys and food are only ever used in a separation anxiety protocol to help the dog make positive associations with a confinement area. Part of this protocol is to assess how the dog behaves immediately after finishing the puzzle to establish whether in fact it was a distraction or actually taught the dog to relax. Boredom in dogs often isn’t the big deal that social media groups make it out to be. Those behaviours associated with boredom are often symptomatic of frustration or anxiety. So, how much interaction does your dog need on a daily basis? This is a difficult question to answer. As with humans, dogs have different personalities and purposes. However, we can’t argue with the science. Dogs are diurnal. Like us, they are active during daylight hours. Rest occurs during the dark. But activity increases in the last two dark hours. A rest period is common at noon and then reduced activity continues during the afternoon. Findings here Sleep is widely studied, for its evolutionary benefits. It is crucial for most daily functions. It is clear in humans, that when suffering sleep restriction, they have attention lapses, slowed working memory, reduced cognition and depressed thought. Studies have shown a significant reduction inactivity in dogs experiencing sleep restriction. Findings here One of the main purposes of sleep is to consolidate memories or learning. This has also been found true in dogs. Learning affects sleep structure which ultimately decides whether you retain the information or not. Interestingly, in studies, those dogs allowed to sleep after learning anew command were more likely to retain the command at a later date than dogs allowed to walk or play. Findings here So, if you want to train your dog, they need their sleep. Under laboratory conditions, dogs will sleep around 13 hours per day. But this is very generic. Older dogs will sleep more as they tend to experience periods of broken sleep. Puppies too will sleep a lot more – generally 18-20 hours. The rule of thumb is to let sleeping puppies sleep! For the puppy, consider how much socialisation and training you are undertaking. When you think you’ve only got around 4-6 hours per day of awake time; take some mealtimes out of that, and your safe play in the garden… it’s easy to see how you can quickly overwhelm a puppy. What’s really interesting is, like in humans, negative or positive interactions, affect sleep length and quality. Following a negative interaction with a human, dogs tend to fall asleep quicker. This goes against what we’ve found in humans; the idea that stress impedes sleep. It is termed stress-induced quiescence (protective sleep in response to stress). Findings here This throws a bit of a curve ball when we are considering the overall health of our dog. We usually understand that they are content when they fall asleep – but now we must consider that it could be a potential stress-response. It’s worth looking out for these patterns and seeing how your dog sleeps. This has never been more relevant when considering daycare. More and more are popping up and I often hear owners say that their dog does nothing but sleep when they get home. It is generally understood that the dog has had such a busy day, they are just exhausted. But, what if, in these daycares with upwards of 50 dogs on site, the dog is just over-aroused? How realistic is it for your dog to get his rest in such a busy site? When his normal rhythm tells him to rest around noon and then have a quiet afternoon, and he’s actually running, chasing and playing for 8-10 hours of the day? This is sadly where non-aggressive dogs get labelled as aggressive, simply because they have reached their peak of “activity” for that day and some annoying puppy continues to hang off their ear! Also a consideration to be made when a new puppy is introduced into an adult dog home. Any daycare worth their salt should value rest and recovery as much as play and interaction. Sleep is not the only way that your dog can rest and recover. Simply having quiet, settled time can be of benefit. All too often, owners consider that their dog always needs to be doing something. Here it must be questioned, does your dog need to be kept occupied simply to keep them out of trouble? Some dogs just don’t learn how they need to behave because they aren’t given the opportunity. This is a whole new issue which is too big to tackle in this article. Maybe at a later date. If your dog has their own space, whether it’s their bed, a crate, a den or a corner in the home, they soon learn that it is their safe place. They can learn to settle and rest there. But they need to know that no one will hassle them, so children need to keep their distance. You can use lickimats or stuffed kongs to help them associate the space with calm and quiet,
Another particularly common issue we see here at My Pet Nutritionist is yeast! More technically known as candida, it is actually harmless when kept in check. The issue is when our dog’s system goes a little awry and can’t keep those little blighters from colonising. Whilst it sounds like a military operation, the dog’s system functions very much like that. Let’s take a look at yeast in a little more detail and how we can armour dog’s defences for a fighting chance! What is Yeast? Candida is an opportunistic fungal pathogen. It is a normal part of the gastrointestinal flora and genital tracts. Healthy systems are more than capable of keeping it in check with their beneficial bacteria. The issue arises when there aren’t enough good guys to keep the bad guys in check. The good bugs we find in our dog’s gastrointestinal tract will compete with the bad bugs for food sources and attachment sites. As we know there are a number of factors that can skew the microbial community found in our dog’s system. Antibiotics Broad spectrum antibiotics target all bugs,so whilst they get rid of the ones running amok, they also wipe out the beneficial ones too. Whilst the microbiome can recover to some extent, eventually; this takes time and there’s evidence which suggests key species are never fully repopulated. Findings here Stress There are clear links that stress, whether physical or emotional, affects the composition of the gut. On many occasions, stressor infliction significantly reduces the good guys. This has been associated with increased inflammation in the gut, which then continues the cycle. Findings here The Environment There is a huge amount of data which shows exposure to environmental pollutants significantly alters the gut microbiome. This includes bisphenols, phthalates, organic pollutants, heavy metals and pesticides. Bisphenol is an industrial chemical used to make hard, clear plastic. It is also found in epoxy resins which is often used as a protective later in some metal food and beverage cans/tins. Bisphenol has been linked to reduced microbiome diversity, and a significant decrease in protective bacteria. Phthalates are plasticisers and stabilisers found in vinyl flooring, clothing, detergents, personal care products, toys, medical equipment, and plastic packaging. Because they are non covalently bound to materials, they can leach into the environment. Phthalate exposure induces microbiota changes and has been known to inhibit the synthesis of certain short-chain-fatty acids. Heavy metals are associated with reduced microbiota diversity along with the altered metabolism of vitamin E and bile acid. Findings here Pesticides are renowned for altering the gut microbiome. This not only includes the pesticides administered to pets (flea and tick treatments), but also those found in the environment, particularly those sprayed on public footpaths. What is also worth considering is that antibiotic use has been seen to increase bioavailability of pesticides within the body. Findings here You are what eat! Of course, nutrition also plays a part in modulating the gut microbiome. But we always knew that. We are all pretty selfish in evolutionary terms, and this includes the bugs we find throughout our body. Our ultimate aim, and theirs, is to survive. So, we just need to modify how many of them actually do. This means keeping the colonies of good bacteria strong, so offering our dogs a diet full of pre and probiotic foods! Prebiotics are like the fertilisers in the garden, they help to feed and grow the beneficial bacteria in our garden. Probiotics however contain live organisms which can contribute to the population of the garden. Findings here There are a number of prebiotic foods suitable for dogs and they include mushrooms, chicory root, garlic and dandelion greens. Probiotics include fermented food, but supplements are available; soil-based are a good call for your canine friend (hold off on the fermented food until later, if your dog has already developed an overgrowth). Yeasts seem to like sugar as fuel, so diets high in grains, starches and other carbohydrates seem to contribute to an overgrowth. Generally, certain beneficial bacteria will metabolise these sugars, keeping candida in check by disrupting its food supply, but in the absence of good bacteria, candida is partying it down at the all-you-can-eat buffet! Immunity A weakened immune system is also a huge risk factor for developing a candida overgrowth. Whether this has been a natural progression over a period of time for a range of factors, or even due to medications like steroids. Immune function has natural peaks and troughs, young dogs and ageing dogs naturally have a lower function, but pre-existing conditions along with a range of medications can affect it too. The immune system is like a nosey neighbour. It keeps tabs on everything going on in the body and knows when something isn’t quite right. When it identifies something as non-self, it sends the army to fight the foreign invader and, all being well, wins, before sitting back down with its cup of tea. The issue arises when it can’t get up from its chair and so the foreign bodies are left to invade. There are a number of factors which can compromise immune function from sleep, to stress and nutritional status; there are several key nutrients essential to its performance. So, supporting this is essential in the prevention and treatment of any bacterial overgrowth. Top Tips: Adequate rest Reduced exposure to stress Nutrient dense diet withVitamins A, C, D and B’s, along with Zinc, Selenium, and Iron Address any pre-existing issues like inflammation in the digestive system or poor pancreas function which can contribute to poor nutritional status Findings here Careful use of medications like antibiotics, NSAIDs and steroids Findings here on Vitamin D Findings here on Zinc What if your dog has already got an overgrowth? If indeed your dog has developed a candida overgrowth, you will notice symptoms like: Ear infections Greasy coat Sores Odour (yes, that cheesy type of smell) Green/yellow discharge Crusty/flaky skin Hair loss Itching/scratching Incessant licking/grooming of an area due to irritation Rust
Here at My Pet Nutritionist, skin issues are one of the most common complaints from dog owners. Whilst there are a number of factors that can result in not-so-comfortable skin for your companion, there are also some top tips that can start you off the right foot. So, let’s take a look at the skin in a little more detail and what can do to promote its health. The skin is the largest organ of your dog’s body. It consists of three major layers: The Epidermis – (Epi – upon or above) this is the outer layer of skin, the protective layer. The Dermis – the dermis supports and nourishes the outer layer. It provides strength and elasticity. Here you will find collagen fibres, sweat glands, sebaceous glands, and hair follicles. You will also find cells that release histamine and other inflammatory mediators when faced with an allergy or injury. The Subcutis – (sub meaning under or below) this in the innermost layer of the skin, where you will find fat and muscles. Subcutaneous fat provides insulation, padding and storage for reserve energy. Not only does the structure of the skin prevent water and electrolyte loss to help maintain body homeostasis, but it forms a protective barrier which helps protect against infections, parasites, and the elements. This is the often-forgotten role of the skin –that it forms part of the immune system. We have three lines of defence in the immune system: The first line of defence are the physical barriers, the skin and mucous membranes of the gut and respiratory tract. The second line of defence is defined as innate immunity. This system surveys and neutralises pathogens by mounting an inflammatory response. This system communicates with the third line of defence which is adaptive immunity. Adaptive immunity provides a specific and tailored response, deploying T and B cells. Ultimately, for us, or our dogs to survive and thrive, we, and they need robust immune defences, so it makes sense to want to strengthen our first line as much as possible. 1) Sleep! In the dermis of your dog’s skin, you will find connective tissue which contains collagen. Collagen fibres play a vital role in maintaining structural integrity and it is supported by hyaluronic acid (in ageing human, skin hyaluronic acid is often absent leading to the presence of fine lines and wrinkles). Cortisol, however, significantly decreases the synthesis of hyaluronic acid. Findings here As we know, cortisol is one of the main stress hormones, released in times of fight or flight. In short, stress results in lower hyaluronic acid, impacting collagen and therefore skin structure. There are many stress triggers for your canine companion, but lack of sleep is often missed. Not only does low sleep duration influence the perception of stress for days following, but sleep deprivation is in fact a form of neurobiological and physiological stress (or torture, for us at My Pet Nutritionist). In 1894, Marie De Manaceine was fascinated with sleep deprivation. She had established that mental disturbance resulted from partial insomnia, but she wanted to know more. So, in her Lab, she recruited puppies. 10 to be specific; aged 2, 3 or 4 months old. Whilst they continued to be fed by their mother, she kept them in constant activity. In short, she deprived them totally of sleep. After 96-120 hours, the puppies were irreparably lost. We shed a tear when we read this! What is interesting (despite it being macabre), is that when puppies were starved, they could be saved after 20-25days. This wasn’t possible when they were sleep deprived. Marie found that sleep deprivation significantly affected the puppy’s brains. When they were starved, the brain was left almost spared. But, in the absence of sleep; fat degeneration, blood vessel abnormalities and haemorrhaging occurred. Findings here In a world that never sleeps, both us and our dogs really need to. Adult dogs, in a laboratory setting, when left, will sleep on average for around 13 hours per day. Puppies can sleep anywhere between 18-20 hours per day. Dogs are diurnal, meaning they are active during daylight hours. Rest occurs during dark periods with activity increasing the two hours before light. Dogs have a natural rest period around noon and then reduced activity during the afternoon. Findings here Interestingly, the experiences that your dog has, can affect the type and quality of sleep they experience. Studies have found that after a negative experience, dogs will fall asleep more quickly. It is thought that this is a protective sleep, in response to stress. This should be in the forefront of your mind. It is all too easy to attribute an “exhausted” dog to the busyness of the day. Be mindful, their sleeping habits could be more indicative of their experience. Findings here Sleep is vital for your dog’s overall health, but also in helping their body synthesise the compounds it needs to build a robust skin. Build in plenty of rest time for your dog, at the times they would naturally do so. 2) Feed Fresh Food! We probably sound like a stuck record here at My Pet Nutritionist, but fresh really is best! Processed, high glycaemic index foods wreak havoc with skin! There are a few different reasons, but glycation is one of them. Glycation is the modification of proteins or lipids after exposure to sugars. You may notice them referenced as AGEs, advanced glycation end products. Glycation leads to a loss of protein function and impaired elasticity of tissues like blood vessels, tendons and of course skin. AGEs have been associated with many metabolic disorders and are closely related with renal failure and diabetes. They also increase with age. AGEs can be synthesised in the body, but total load also includes dietary exposure. It is clear that foods ranking high on the glycaemic index result in a higher accumulation of AGEs. Not only that, but maillard reactions, those generated in the heat processing of foods, also result in AGEs. Another reason why
The prevalence of chronic kidney disease in the cat is seemingly on the up. Generally, what goes up, must come down, but when we look at the factors underlying kidney disease, there is a real concern that this may not happen. Currently, it is suggested that 1 in 3 cats suffer with some form of kidney disease. So, what can we do about it? Let’s take a look at kidney disease in a little more detail, why the kidneys are so important and some of the underlying factors that contribute to the development of it. What is kidney Disease Chronic kidney disease in cats is a prolonged process marked by the irreversible loss of kidney function. It is suggested that the early stages of CKD are often missed in cats, likely because many are outdoor cats so urination and drinking behaviours may not be as easily noted, along with vomiting etc. Kidney disease is generally associated with ageing pets; like all things, kidneys too get tired as they get older. But there are new concerns, well, new in 2014, that younger cats are seemingly presenting with the disease too. Where 30-50% of cats 15 years of age or older suffer with CKD, 13% of those under the age of 4 also suffer. Symptoms of Kidney Disease in the Cat: Increased thirst Increased urination Reduced appetite Weight loss Vomiting Fatigue Weakness Bad breath There are 4 stages of kidney disease in the cat, they are based on serum creatinine concentration: stage 1 through 4, with 2 being mild, 3 being moderate and 4 being severe. Findings here Why are the kidneys so important? The two bean shaped organs have vital functions in the body. They monitor fluid levels in the body, control and process waste and release vitamins, minerals and hormones. Their main function is to collect waste products and turn them into urine. Blood enters the kidney though arteries and splits into nephrons. The nephron splits into two nifty mechanisms to filter the blood. This includes the glomerulus and tubule. The glomerulus is like a sieve, allowing certain compounds from the blood into the tubule. The tubule then senses whether any of these compounds are needed around the body. If so, they are absorbed into the body. The tubule also senses waste products, like urea which is produced during the break down of protein. It redirects urea as urine which travels down the ureter, into the bladder to be excreted. The kidneys also activate vitamin D, and release hormones such as erythropoietin which is needed to produce red blood cells and renin which regulates blood pressure. Without the kidneys, the body would be full of blood that hadn’t been sieved and full of harmful waste. It also wouldn’t be receiving the vitamins and minerals, which, without being dramatic, are in fact critical to life. Causes of Kidney Disease There are genetic predispositions to developing kidney disease; certain breeds that are more likely to suffer with kidney issues include the Persian, Siamese, Ragdoll, Russian Blue and MaineCoon. But other than acute renal failure caused by poisoning (plants, pesticides etc), there are other factors that can contribute to kidney issues. As we have established, one of the kidney’s main role is to filter helpful and harmful compounds in the blood. It stands to reason that the more harmful compounds it must process, the sooner it reaches its retirement party! It is often suggested that chemical exposure isa progression factor in the disease and sadly cats are regularly exposed to cleaning agents, pesticides, and many more environmental toxins. These can be ingested, inhaled, or exposed transdermally (through the skin). The foods fed to cats can also impair kidney function. Mycotoxins are a diverse group of chemicals produced by a diverse group of fungi. However, mycotoxins, can be nephrotoxic (toxic to the kidneys). Studies have demonstrated that anywhere between 62% to 100% of cat foods sampled had mycotoxin contamination. Findings here There are also reports of melamine toxicity in cats, resulting in kidney damage. You guessed it; the source of melamine was contaminated food. Findings here Mild dehydration is also a risk factor for kidney disease. This is a concern because of the moisture content in many commercial foods. Dry-based cereal foods rank low on moisture,with dogs demonstrating increased drinking to counterbalance their water requirement. Cats, however, have an evolutionary low thirst-drive. Cats are obligative carnivores, meaning they get what they need from animal tissue. Therefore, they would naturally get moisture from their whole prey kills. But they are no longer getting the same level of moisture with a dry based diet and their thirst-drive hasn’t yet caught up (in evolutionary terms)! Starch also poses a risk for developing periodontal disease. Wait, what has periodontal disease got to do with the kidneys? And what has starch got to do with cats? Stick with us. Starch is the storage form of energy in plants; and then becomes a source of sugar in an animal’s diet. Bacteria found in the mouth feed off these starches and form a biofilm called plaque. This slowly degrades the tooth and surrounding structures. Not only that but the frequency of eating can contribute to the development of periodontal disease. Saliva can perform a clean-up between meals, but this becomes less of an option for the cat who is free fed throughout the day. The long and the short of it, many dry-based foods contain starch, which is a risk for periodontal disease. Periodontal disease is regularly implicated as a risk factor for kidney disease due to the relocation of oral bacteria throughout the body. Despite this, there are also things that can help mitigate the risks associated with kidney disease. Water intake is of utmost importance in all kidney patients. Therefore, a high moisture diet is essential. When offering drinking water, ensure it is filtered to remove any potential harmful compounds before they even get into the body. Protein restriction in kidney cases is much discussed and often controversial. Surely
Halitosis, as it’s more technically known, in dogs, can be a symptom of a range of health concerns. Ranging from dental disease to some cheeky gut bugs overworking, bad breath is often the first sign things may not be as they should, so lets take a look at the more common reasons and what options are available to you. 1) Periodontal Disease Periodontal disease begins when bacteria in the dog’s mouth forms to create a substance called plaque. The plaque sits on the surface of the teeth and with the help of saliva, it hardens to form tartar. Not only does it sit on the teeth, plaque and tartar seeps into gum lines which causes inflammation. Over a period of time, this inflammation and presence of bacteria causes damage to the structures surrounding the teeth; causing receding gum lines and eventually tooth loss. Not only are the mouth and teeth a concern, but the bacteria found in the mouth of your dog can be released into the circulatory system, which then travels through the body. It has been found to damage cardiac tissue causing endocarditis (infection and inflammation in the heart). Studies have also shown that periodontal disease is linked to increased insulin resistance, kidney and liver issues. Findings here The mouth is full of bacteria, primarily to form a first line of defence to protect us and our pets from the bad bugs, but the bad bugs can use carbohydrates, known as starches, as fuel, and subsequently thrive. These bacteria destroy enamel which further develop into cavities, or holes. This is why, in most human literature we are told to avoid sugars for the benefit of our oral health. It stands to reason that we would want to avoid starchy food for our pets too. A fresh food diet is as standard, low in starch, but the inclusion of raw meaty bones, if appropriate, can also create friction when eaten and contribute to the prevention of build-up on the teeth. Please note common dry foods on the market, although not marketed contain between 18-60% carbohydrates. So, if your dog’s breath could keep a vampire away, you may want to check his oral hygiene. Look for build-up, grey/brown deposits, and any breakdown of teeth. 2) SIBO Whilst it sounds like a mission to outer space, SIBO is actually a little more common than that. Small intestine bacterial overgrowth is getting increasingly common in the pet world. Whilst we usually define the microbiome as the microbial community found in the whole of the digestive tract, abundance generally increases from the stomach to the colon So, we would generally find more microbes the further down we go. SIBO occurs when we get more than we bargained for in the small intestine. It is more commonly associated with surgery, or rather a complication of surgery, but it can also occur as a result of any disease which slows the passage of food and waste products down. This means they stay in the wrong place for too long, and we all know what happens when you’re in the wrong place at the wrong time. SIBO is often associated with cases of IBD or IBS, but there must also be consideration given in times of chronic stress as we know motility is affected here. Symptoms of SIBO include loss of appetite, abdominal pain, nausea, bloating, diarrhoea, and weight loss. Due to the overgrowth of bacteria, bad breath is often a symptom. Unfortunately, there are a number of complications associated with SIBO. It can result in poor digestion and absorption of fats, proteins and carbohydrates. Bile salts that are usually required to digest fats are often broken down by the bacteria, leaving few left to digest the fat in the diet. This then leads to reduced absorption, transport and utilisation of any of the fat-soluble vitamins, A, D, E and K. The overgrown bacteria also utilise the B12 marked for host use, subsequently leading to B12 deficiency. SIBO is also indicated in cases of immune deficiency, cirrhosis, and pancreatitis. Findings here Nutritional management plays a huge role in SIBO, so if you are concerned your dog may be showing symptoms, then please book a consultation here. Gut Guardian 3) Liver Disease When the liver isn’t performing to its fully capacity, it can result in potential toxins still circulating in the body. This includes the lungs. On exhale, this can present as a strong faecal smell (be mindful we are dealing with dogs, and some of them do perform coprophagy: eating poop). However, in cases of liver disease you would notice other symptoms such as loss of appetite, weight loss, increased thirst, increased urination, jaundice (yellowing of the gums and eyes), weakness and loss of stability and in some cases seizures. Liver disease can occur as part of ageing, or there are genetic predispositions. However, oxidative stress is a significant contributor to liver complications. Risk factors associated with oxidative stress include: Obesity Diets high in processed foods Exposure to radiation Pollution Exposure to pesticides Not only that, but the body’s natural immune system can also trigger oxidative stress. This is a normal process that is swiftly managed in a healthy system. The concern is when your dog’s immune system is regularly being called to duty, over not-so-threatening threats. This state of chronic inflammation can result in higher levels of oxidative stress, putting pressure on many body systems. A diet high in antioxidants can help modulate oxidative stress, but if you are concerned about your dog’s liver function, then it’s best to speak to a qualified practitioner. If you would like to read more about liver disease, then check out our blog here. Liver Guard 4) Kidney Disease Another part of the detoxification system, when the kidneys aren’t doing what they’re supposed to, excessive urea can end up in the bloodstream resulting in a halitosis. This odour is described as ammonia smelling and having a metallic taste – but as our dogs can’t talk, we’ll just have
We first started becoming interested in bugs when germ-free mice, those born and raised in sterile environments showed exaggerated responses to stress compared to normal controls. What is particularly interesting is that the use of pro and prebiotics were able to reverse the abnormal reactions found in germ-free mice. Not only that but the faeces of depressed mice could be transplanted to “happy” controls and subsequently make them depressed and vice versa. So, we started wondering, can bugs really affect our behaviour? The short answer is yes. The long answer needs a sit down with a coffee. The gut microbiome comprises of all microorganisms and their genomes inhabiting the intestinal tract. These microorganisms perform important functions in the immune system and basic metabolism by providing essential inflammatory mediators, nutrients, and vitamins. But, as we established, they also affect behaviour, and they do this through this thing called the gut-brain axis. This occurs through multiple pathways such as endocrine, immune, metabolic, and neural, specifically the vagus nerve. The vagus nerve is the longest nerve in the body and has countless branches from the brainstem all the way down to the lowest part of the intestines, touching most organs along the way. This is why it is also called the wandering nerve. The vagus nerve modulates the parasympathetic nervous system which counterbalances the sympathetic nervous system. In short, stress inhibits the vagus nerve. This effect is seen when gut motility is altered during stress. What surprised most was that brain-gut communication is bidirectional. This is why the jury is still out on whether cases of IBD or IBS are a cause or a consequence of abnormal gut-brain processing. The vagus nerve contains fibres. 80% of them carry information from the body to the brain and 20% from the brain to the body. These fibres are distributed in all the layers of the digestive wall and they sense the diffusion of bacterial compounds and metabolites. The bacterial sequences identified in the canine gastrointestinal tract fall into five phyla: Firmicutes Fusobacteria Bacteroidetes Proteobacteria Actinobacteria In an ideal world, we want balance, but there are several factors which can affect the composition of the intestinal microbiota which is subsequently known as gut dysbiosis. This composition, as we have established then influences behaviour, for better or worse. The Effect of Diet Several studies have demonstrated that diet composition, especially those with large differences in macronutrient composition (carbohydrate, protein, and fat) largely affects gut microbiome profiles. Dogs fed a raw diet have demonstrated a richer and more balanced microbiome when compared to kibble-fed controls. Raw fed dogs show an overall decrease in the abundance of firmicutes and Bacteroidetes. This isn’t surprising as these genera are associated with the digestion of dietary fibre, indicating a decrease in the fermentation of carbohydrate (raw diets are general lower in carbohydrate). Adding fresh meat to a bowl of kibble has also demonstrated a decrease in faecali bacterium and an increase in clostridiaceae. One of these clostridiaceae strains was later identified as being associated with normal bile acid metabolism which is an important pathway for lipid digestion and regulation of intestinal inflammation. Clostridiaceae is also associated with improved fecal health score (firmer). And yes, the bit you have been waiting for, clostridiaceae is associated with normal cognitive function. Findings here Biologically appropriate diets have also demonstrated increased levels of faecal GABA, which is an inhibitory neurotransmitter implicated in anxiety and mood disorders. Findings here In short, what is abundantly clear, the more diverse the diet, the more diverse the microbiome. This gives us a better shot at having beneficial bacteria to influence our health and behaviour. Birth Regardless of the species, GI colonisation starts before the new-born exits the birth canal. In humans the delivery method of the baby isa clear influence on microbiome development. But in the canine world, it is considered that the new-born puppy is exposed to vaginal and faecal microbiota through the dam’s tongue and therefore the delivery method, whilst still applicable, is likely less pronounced. It does however highlight that the Mother’s microbiota is a clear influence on the developing new-born, so her diversity will subsequently affect her offspring. Disease Dogs with gastro-intestinal disease regularly present with significantly decreased faecal bacterial diversity. The microbial communities differ massively between sick and healthy dogs. Findings here Manipulations of the microbiome are often included as part of the treatment of GI disease, most commonly antibiotics, probiotics, and faecal transplants. The aim of antibiotics is to remove pathogenic bacteria, however many antibiotics are broad spectrum, so they take the good guys with them too. They rapidly cause significant drops in taxonomic richness and diversity and there turn to the initial composition is rarely fully achieved. The link between bacteria and behaviour is again highlighted in human data reporting anxiety, panic attacks and in some cases depression as side effects to antibiotic use. Manic episodes have also correlated with antibiotic use. Findings here Turning this on its head, there is increasing attention being paid to using antibiotics as a possible treatment for psychiatric conditions like schizophrenia. Findings here Pathogenic bacteria have been seen to affect behaviour in other species than humans too. Rabies for example is largely associated with aggressive behaviour because biting is an effective form of transmission. Low serotonin levels are associated with aggressive behaviour, so it is considered that the rabies infection impairs serotonin neurotransmission. Findings here Not only that, but rat infection of toxoplasma gondii removes a rat’s natural aversion to cats and produces a pheromone to attract the rat to the cat. This gives the parasite a better chance at survival but is very unfortunate for the rat. Findings here Other mice studies have demonstrated that sub-clinical infection of campylobacter jejuni produced anxiety-like behaviour despite the fact there was no overt immune system activation. Findings here It would be easy here to say that the solution is to eradicate all bacteria, but the issue isn’t that the bacteria exist, the issue is the balance. For example,
In humans, the definition of anxiety is a feeling of unease, a worry or fear. It can be mild or severe. It’s quite easy to label these feelings ourselves, but as our four-legged friends haven’t yet figured out how to talk, what makes them anxious can be difficult to pin down. What we do know is they demonstrate stress behaviours alongside triggers, so we can intimate they feel anxious. What is clear, is that these behaviours aren’t great for our four-legged friends, so whilst we can also tackle the triggers, there are certain nutrients that can help modulate anxiety too. We have collated 5 of our top Fido-friendly-foods that can be safely added to their diets. Fatty Fish In dogs, the body has a requirement for two distinct Essential Fatty Acid families. The Omega-6 and Omega-3 series. Omega-6 Linoleic Acid (LA) Arachidonic Acid (AA) Omega-3 Alpha-Linolenic Acid (ALA) Eicosapentaenoic Acid (EPA) Docosahexaenoic Acid (DHA) Fatty fish contain Omega-3 fatty acids which have a number of biological effects in the body. To start us off, studies have shown that aggressive dogs are characterised by low Omega-3 fatty acid status. This does not indicate causation, but there is certainly a correlation. Findings here Omega-3’s, in particular DHA, play critical neuroprotective and anti-inflammatory roles in the brain. Supplementation of omega-3 has been seen to: – Improve cognitive function Findings here – Reduce anxious symptoms Findings here – Reduce aggressive behaviours Findings here – Reduced stress-related hormone production Findings here Omega-3s are classed as polyunsaturated fatty acids. Fatty acids can be saturated, monounsaturated, or polyunsaturated. The difference is in their structure. Saturated fatty acids contain no double bonds between the carbon atoms and are therefore saturated with hydrogen. Monounsaturated fatty acids have one double bond (mono=one). Polyunsaturated fatty acids have two or more double bonds (poly=many). The more double bonds a fatty acid has, the less stable the molecule, which means it is more susceptible to oxidation, resulting in rancidity. This is why fish oils should be stored in a dark, glass bottle and why PUFA rich oils aren’t the best to fry your eggs with. Fats also act as carriers for fat soluble vitamins A, D, E and K which means that low-fat diets can affect the metabolism of these crucial vitamins. Much data has highlighted that low vitamin D status is associated with anxiety and depression, so fatty fish helps modulate the metabolism of vitamin D too (if it is present in the diet of course). Findings here Sources to include: – Mackerel – Salmon – Sardines Oysters Whilst you may struggle to get your hands on oysters, what we’re really interested in is their zinc content. In the human literature, zinc is a trait marker of a mood disorder. Zinc deficiency is regularly associated with depression and anxiety, and supplementation often improves mood and cognitive function. Zinc plays a role in many metabolic processes, including enzyme catalysis, cell signalling and DNA replication and transcription. What this essentially means, this mineral is involved in neural development, learning, memory and mood. We know zinc plays a role in mood because we find zinc enriched neurons in parts of the brain associated with emotions. Before we knew better, in rat studies, we found that increasing zinc levels reduced rat-fighting behaviour and when supplemented alongside anti-depressant medication, rats developed improved resilience. The issue we have is that zinc also plays a role in the inflammatory response and likewise the down regulating of the same response. So, when we are in a state of chronic inflammation, when zinc should be in the nervous system, modulating, its instead crusading with the inflammatory (or anti-inflammatory) team and the brain is left with neurotransmitters where they shouldn’t be, or not even where they should be! Whilst it stands to reason that low dietary intake results in low levels of zinc, phytates found in cereals, corn and rice also inhibit zinc absorption. There are also some breeds who are predisposed to zinc deficiency, for example, certain sled dogs. Foods high in zinc: Oysters, beef, chicken, pork, hemp seeds, shiitake mushrooms and red meat. Whilst brazil nuts, tuna and oysters are also high in selenium, red meat is an easy addition in your dog’s diet. Another mineral, low levels of selenium are regularly reported in cases of anxiety, depression and fatigue. Findings here Selenium’s prime function is as an antioxidant. It works as a component of glutathione peroxidase, an enzyme which protects cell membranes and red blood cells from damage by free radicals. However, it is thought to modulate mood through its involvement in the synthesis and metabolism of thyroid hormones. Selenium deficiency is thought to dysregulate thyroid function and therefore play a role in mood disorders. Not only that but selenium has been found to exhibit modulatory effects on the dopaminergic, serotonergic and noradrenergic systems which are all involved in the regulation of mood and behaviour. One of the mechanisms is to inhibit the degradation of serotonin, resulting in an overall increase in levels. Selenoproteins also demonstrate antioxidant properties on dopaminergic neurons vulnerable to oxidative stress. Findings here Food Sources of Selenium: Pork, beef, turkey, chicken, fish, oysters, eggs, shiitake mushrooms and white meat. The word protein comes from the Greek word proteios which means of prime importance. Amino acids are the basic units of proteins and are held together by peptide linkages to form long protein chains. For the dog there are certain amino acids that are essential; they cannot be synthesised by the body, so they must be supplied by the diet. These include: Arginine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Threonine Tryptophan Valine For the cat, this also includes taurine. These amino acids found in certain foods,are precursors to certain neurotransmitters. Tryptophan, which is found in chicken and turkey, is the precursor to serotonin. Manipulation of serotonin through supplementation or depletion of tryptophan has established a role in higher order brain functions, memory, and mood. Low dietary tryptophan is associated with anxiety-like behaviour and increased defensive aggression. Tryptophan
Whilst every diet under the sun has been touted for its weight loss properties, keto has been liked for its benefit incases of epilepsy and cancer. A ketogenic diet consists of high fat, with moderate to low protein and very low carbohydrate. This in a nutshell, forces the body to use fat instead of glucose for energy. There are two reasons this poses food for thought for the canine with cancer. Firstly, we’ll head back to the early 1900’s and pop into the lab with some sea urchins. Otto Warburg was massively interested in the chromosomes of sea urchin eggs. He wanted to understand how they fuelled their growth. Warburg found that they increased their oxygen consumption significantly as they grew. Turning his attention to a rat tumour, he expected the same. But he was wrong. Instead, the cancer cells fuelled their growth by glucose and broke it down without oxygen. To Warburg, this made no sense, but this effect as he found, is estimated to occur in many cancers. High concentrations of glucose are seen to significantly increase the proliferation of cancer cells. Findings here Not only that, but glucose has been noted to disappear from the urine of patients with diabetes after they have been diagnosed with cancer, suggesting it is recruited to cancerous areas and consumed in high amounts. Findings here Diets low in carbohydrate were thought to starve cancer cells, in essence. Glucose normally stimulates pancreatic cells to release insulin which allows glucose to enter cells and provide energy. When glucose is scarce, the body senses the need to make an alternative form of energy for cells. The liver then produces ketones and fatty acids, which provide for normal cells, but do not benefit cancer cells. It also pays to mention at this point, not only is the keto diet low in carbohydrate but it is also moderate in protein. Where low protein is no friend to anyone, protein can still be converted to glucose if consumed in high amounts through the process of gluconeogenesis, so it should be monitored. Being in a state of ketosis has seen a decrease in glucose uptake at tumour sites and also demonstrated no evidence of progression. Findings here In short, there are many studies which have demonstrated benefits of a ketogenic diet in cancer, whether as an adjuvant to traditional therapy or stand alone. Findings here The other reason why the ketogenic diet is such an interesting concept for the canine is due to their greater capacity for fat oxidation. Compared to humans, high fat diets for the dog have been seen to increase stamina and maximise energy production in healthy controls. Relative to metabolic body size, dogs metabolise free fatty acids at twice the rate of humans. It is thought that dog albumin (a protein made by the liver, whose main role is transport of various substances) can bind more fatty acids. This is deemed an endurance-adaptation in the species. Findings here So not only are dogs adept at using fat for energy, in the canine with cancer, low carbohydrate diets have demonstrated clear benefits. That said, the ketogenic diet has been seen to cause some potential side effects. The acute side effects of high fat intake are typically lethargy, nausea and vomiting, but this can be seen in many dietary changes. There are also reports of some deficiencies in trace minerals like selenium, copper and zinc, but conclusions merely indicate the potential need for supplementation if considering this diet. There are reports of elevated LDL cholesterol and kidney stones in humans consuming a ketogenic diet long term, but it is unclear how this translates to the canine. Findings here Despite this, literature reviews still conclude that the ketogenic diet has a protective role against tumorigenesis (the production or formation of a tumour or tumours) and that it does indicate a prolonged survival, reducing the risk of experiencing the pre-defined endpoint. Findings here The issue in commercial pet food is, on average, more than 45% is carbohydrate. The ketogenic diet for the canine shifts this to less than 10%. It is observed that dogs routinely enter a state of ketosis using 82% fat, 17% protein and 1% carbohydrate. After around 120 days, they may be able to maintain ketosis on a lower formulation like 69% fat, 30% protein and 1%carbohydrate. But as we know, all dogs are different and regular monitoring will inform the appropriate formulation. Findings here Due to the high content of carbohydrate found in commercial food, a switch to fresh food is essential. Whilst fruits are, for example, are still carb rich, the inclusion of low carb fibrous veggies can still provide certain micronutrients. There is also evidence that fasting alongside keto can be of benefit in cancer cases. It is argued to bring about the state of ketosis sooner. There is also evidence that fasting has been seen to reduce the side effects of chemotherapy or radiation therapy. However, there is a concern that when fat stores are exhausted, muscle breakdown will begin in order to fuel gluconeogenesis, resulting in muscle atrophy. It is concluded that this pairing may not be suitable for all patients, especially in underweight cases. It should also not be attempted without the supervision of a qualified practitioner. Findings here The other thing to be mindful of is using the ketogenic in liver cancer. Whilst ketosis is well tolerated by a normal, healthy and functioning liver, it is essential to seek the advice of a qualified practitioner when increasing the demands on an already compromised body system. Individual case studies have highlighted that a ketogenic has been utilised in cases of liver cancer to some efficacy, but this was under close monitoring. Findings here As highlighted by many professionals, if using keto in a medical condition, it becomes a medical diet. It should therefore be treated as such. To avoid many of the noted side effects, supplementation can be useful, but this is specific to the individual dog. Ketosis is also a
Cancer is the leading cause of death in dogs over 10 years of age, with over 50% of older dogs developing the disease. Eventually, 1 in 4 dogs die of cancer. Whilst understanding of the disease is still developing, we can’t help but want to explore functional ingredients that may be adjunct to therapy, useful in prevention or demonstrate benefits when diagnosed. We still have a long way to go, but there is increasing evidence that certain compounds can demonstrate anti-tumour and anti-cancer properties. We’ve included some of our favourites. Bitter Melon Bitter melon, also known as bitter gourd or Momordica charantia (which is why we stick to bitter melon) is a tropical vine belonging to the gourd family. It is closely related to zucchini, squash, pumpkin and cucumber. It is most widely used in Asian cuisine but is cultivated around the world. It has pointed ends with spikes on the rind. Its distinctive appearance is matched with it’s sharp taste. It’s called bitter melon for a reason. Bitter melon packs a few punches in terms of nutrient content, one cup provides 93% of a human’s daily reference intake of vitamin C, 44% of a human’s vitamin A intake, 17% folate, 8% potassium, 5% zinc and 4% iron. Bitter melon is also a good source of catechin, gallic acid, epicatechin and chlorogenic acid which are all antioxidant compounds. Bitter melon has been seen to control blood sugar and decrease cholesterol, but it is also deemed to have cancer-fighting properties. In studies of concentrated use, bitter melon was seen to effectively kill cancer cells. It has been seen to modulate cell genes, promote apoptosis and reduce proliferation. Findings here Not only that, but bitter melon also contains phytol and lutein which suppress pro-inflammatory cytokines. Studies have demonstrated anti-tumour activity in cases of breast, colon, pancreatic, prostate, skin and cervical cancer. There has also been inhibition of cancer cells in leukaemia and other miscellaneous cancers like adreno cortical, lung adenocarcinoma, nasopharyngeal and head and neck squamous cell carcinomas. Findings here That said, bitter melon has been associated with diarrhoea, vomiting and stomach pain so like with any new additions to any diet, it should be eaten in moderation. If using therapeutically, seek the advice of a qualified professional. Findings here Turmeric Is there anything this spice can’t do? Curcumin in the active ingredient in turmeric has received much attention for its antioxidant, anti-inflammatory, antimicrobial and antiviral properties. We are looking at it for its anticancer potential. It has been reported to modulate growth factors, enzymes, transcription factors, kinase, inflammatory cytokines and pro apoptotic and anti apoptotic proteins. In short, this compound, alone or combined, could be of benefit in cancer therapy. Curcumin has down regulated human lung cancer lines and also inhibited cell proliferation and induced apoptosis in lung cancer. It has also been seen to suppress and modulate leukemic cells. In cases of lymphomas, curcumin was seen as an adjunct to radiation therapy. Curcumin has demonstrated suppression, inhibition, and apoptosis in cases of gastric cancer, colorectal cancer, pancreatic,hepatic, prostate, brain tumours and squamous cell carcinomas. Findings here The biggest concern in using curcumin is its scarce bioavailability. For this reason, much attention is being paid to liposomal curcumin. Findings here Liposomal formulation is thought to have greater growth inhibitory and pro-apoptotic effects on cancer cells. Not only that but liposomal formulations often contain additional supports like vitamin A, folic acid, and hyaluronic acid. Ginger Ginger is loved for its anti-inflammatory properties in cancer therapy. Inflammation, or rather pro-inflammatory cytokines contribute to carcinogenesis by influencing the survival, growth, mutation, proliferation, differentiation and movement of tumour cells. It is proposed that ginger has anti-inflammatory and therefore anti-cancer potential. Ginger contains active phenolic compounds such as gingerol, paradol and shogoall that have antioxidant, anticancer, anti-inflammatory and anti-angiogenesis properties. Ginger has demonstrated significant reductions in inflammatory signalling in cancer cases. Findings here Not only that but in cases of liver cancer, it has induced apoptosis, inhibited formation, decreased expression and suppressed cell proliferation. In cases of pancreatic cancer it has down regulated signalling and cell survival indicators, inhibited expression, decreases metastasis, inhibited cell proliferation and induced apoptosis. Ginger has decreased incidence of colon tumours and it has been reported that intragastric treatment of ginger increases survival time. Findings here Adjunct to other therapy, ginger has been seen to improve cellular immunity and decrease fatigue, pain and stress in cancer patients. It is also noted to reduce nausea. Ginger is widely used in traditional Chinese and Indian medicine, it is thought to stimulate digestion, absorption, relieve constipation and flatulence. In Chinese medicine it is thought to improve the flow of bodily fluids and is therefore used to stimulate blood circulation. The active compounds found reduce the formation of pro-inflammatory prostaglandins and thromboxane therefore lowering the clotting ability of the blood, it should therefore be used with caution alongside blood thinning medication. Mushrooms Not just the divine starter found in your local restaurant, there is an overwhelming interest in the medicinal properties of mushrooms. The chief properties include anti-oxidant, anti-diabetic, hypercholesteraemic, anti-tumour, anti-cancer, immunomodulatory, anti-allergic, nephroprotective and anti-microbial. Those genus credited with success against cancer include: Phellinus, Pleurotus, Agaricus, Ganoderma, Clitocybe, Antrodia, Trametes, Cordyceps, Xerocomus, Calvatia, Schizophyllum, Flammulina, Suillus, Inonotus, Inocybe, Funlia, Lactarius, Albatrellus, Russula, and Fomes. These medicinal mushrooms have demonstrated cell inhibition, significant reduction in tumour sizes, inhibited proliferation and reduced metastasis. Shiitake mushrooms for example have been seen to suppress leukaemia cell proliferation and maitake mushrooms have induced cell apoptosis. Reishi mushrooms exhibit anti-cancer effects alone and in combination with chemotherapy and radiotherapy. Lions mane mushrooms are seen to significantly reduce tumour weights and cordyceps displays potent growth inhibition, tumour shrinkage and increased lifespan. Findings here In a study carried out on dogs, a compound derived from the coriolus versicolor, turkey tail mushroom, demonstrated the longest survival times reported for hemangiosarcoma. Findings here Mushrooms are renowned for their immune boosting effects, if you’d like to learn more about them, then check out our blog here. Foraging mushrooms is seemingly on the rise, so it pays to note that mushroom poisoning can occur due to
Autoimmune disease, irritable bowel disorders, lupus, thyroid issues, eisonophilic skin disorders, chronic skin disease and allergic dermatitis, not a list any owner wants to pair with their pet, but sadly all of these diseases can be vaccine-related conditions. We can identify them as vaccine related conditions because symptoms are concomitant with vaccination date. We deem this reaction as vaccinosis. And sadly, it is far more prevalent than we could even imagine. At MPN, we see the correlation of vaccination and disease in many of our clients. So let’s take a look at where we started, and how we ended up in such dire straights. The smallpox vaccine was introduced in 1796 after Edward Jenner observed that milkmaids who had previously caught cow pox didn’t catch smallpox. The idea was that exposure to killed or weakened virus/bacteria that cause disease can prime the immune response, but it doesn’t actually make the host sick. So, vaccinations allow the host to develop immunity without having to suffer the disease. To this end, smallpox is now declared eradicated. There is no doubt that vaccination has been progressive in public health concerns, for both humans and pets, but they were never meant to make the host sick. For a number of reasons, the current vaccinations schedule for our pets, is. There is increasing evidence that over-vaccination is associated with the development or aggravation of immune-mediated disorders and chronic diseases in individual pets that are genetically predisposed. This raises a particularly interesting element that has perhaps been missed when developing the blanket vaccination schedules for our pets. Twin studies, in humans have demonstrated there is a clear genetic role in vaccine response. A growing list of genes have been associated with immune related functions critical to immunological response and much data is concluding it is the status of these genes that is key to immune response. Human data is highlighting that this is one of the reasons vaccines can either elicit partial, complete or failure to protect individuals treated under the same conditions. This would also suggest that the opposite is therefore true; gene status could elicit partial or complete adverse reaction, or hopefully failure to demonstrate adverse reaction. Genes are a set of instructions and there are a number of factors that can affect how they are expressed. This is likely understood in the canine world to some extent because most vaccines are advised as safe for healthy dogs but not those with a compromised immune system. So, what constitutes a compromised immune system? The primary role of the immune system in dogs is to protect against foreign invaders, or abnormal cells that invade or attack. The immune system must distinguish between self and non-self. Substances that stimulate a response are antigens. These can be contained within bacteria, viruses or microorganisms or cancer cells. They may also exist on their own, like pollen or food particles. There are three lines of defence, physical barriers, non specific immunity and specific immunity. Physical barriers are the first line of defence, they include the skin, the cornea of the eye and the membranes lining the respiratory, digestive, urinary and reproductive tracts. The key is to keep these barriers unbroken. These barriers are also defended by bacteria and secretions that contain enzymes that can destroy harmful bacteria. Examples include eye tears, secretions in the digestive tract and the microbiome in the gut. Nonspecific immunity should be present at birth; it treats all foreign substances in the same way. Inflammation results in white blood cells travelling into tissues to kill invading organisms and remove injured cells. Specific immunity is acquired and developed as the immune system encounters different antigens, it learns the best way to attack and develops a memory for that specific antigen. It takes time to develop a response, but in future encounters, the response is more rapid. Specific immunity involves the action of lymphocytes (B and T cells), antibodies, antigen presenting cells and cytokines. Most vaccines work by stimulating the development of specific immunity. But the immune system does not always function properly, it can be underactive and overactive. An underactive system puts the animal at risk of infection, but an overactive immune system can attack parts of its body that it misidentifies as being foreign. This is what happens in autoimmune conditions. The immune system can also overreact and produce too many antibodies or other chemicals; these are what we see as hypersensitivity or allergic reactions. Not only do we have to ensure the physical barriers remain healthy, but we also must ensure that responses are just right. We know that genes play a role in this, but so does the environment your dog (exposure to toxins, chemicals and pesticides etc) alongside nutrition. Each cell in every body uses chemical reactions to build some of the materials that it needs, converting substances provided by the diet into other chemicals necessary for normal functioning. This is why the immune system has its own micronutrient (vitamin and mineral) requirements. For example, Vitamin A helps to maintain structural and functional integrity of mucosal cells in innate barriers like the skin and respiratory tract, Vitamin D stimulates immune cell proliferation and cytokine production, helping to protect against infection, B12 has roles in natural killer cell functions just as folate maintains natural killer cells. Many micronutrients play a role in protecting against reactive oxygen species and reactive nitrogen species which are produced when pathogens are killed by immune cells. Findings here So, there are many things that can compromise an immune system, which also informs whether the dog is a candidate for vaccination and indeed subsequent and frequent booster vaccinations. Signs your Dog may have a compromised immune system: Tiredness/lethargy Increased stress levels Digestive issues Slow healing wounds Frequent infections (eyes, ears etc) Delayed growth/development Skin sensitivities/allergies Joint stiffness and disease Other diagnosed disease If your dog is suffering with any pre-existing health conditions, it pays to consider titre testing. No animal should be vaccinated with a compromised immune system.
