It’s seen world over, no matter when their Summer arrives, we are bombarded with images or stories of dogs suffering from heat stroke. For some it’s fatal. Sometimes it’s obvious how the dog has succumbed, other times, well-meaning owners just haven’t realised the true impact of certain exercise on their dog in the heat. Especially owners of brachycephalic dogs or those who are carrying a little extra weight. So how do we deal with the heat? How do we keep our dogs exercised and stimulated when we are, in truth, worrying ourselves sick about doing so? Firstly, we need to get a handle on heatstroke. As you may, or may not, know; to cool themselves, dogs pant. They don’t sweat like us humans (they do have some sweat pads in their paws, so if they are stressed, you may notice sweaty paws on the Vet table). When panting isn’t enough to maintain the status quo, their body temperature rises. If this isn’t corrected quickly enough, it can be fatal. Remember when we mentioned the brachy breeds? With their altered snout (flat face), they aren’t as efficient at breathing or panting. This also goes for those obese pets. In turn, they aren’t as efficient at reducing their overall body temperature, which makes them more prone to heat-stroke. How do I know if my dog has heat stroke? The symptoms of heat stroke include excessive panting, drooling, reddening gums, vomiting, diarrhoea, brain fog, loss of consciousness and collapse. If you are concerned your dog may have heat stroke, place a towel soaked in cool water over your dog and keep pouring cool water onto it. You need to seek Vet advice immediately. Obviously, prevention is better than cure (not all dogs are lucky enough to survive heat-stroke), so we’ve got some top tips that can help you stay out of trouble. Firstly, only walk your dog at the coolest times of the day. Even if this means getting up earlier and going to bed later. You may have to reduce your walk length, but it’s better to be safe than sorry. He’s still getting a look at the outside world. Check the temperature of the pavements and roads before you head out. Hold the back of your hand to it. If you can’t hold your hand to it, then your dog can’t walk on it. Keep your dog inside, even out of the garden, at the hottest parts of the day. If you have air con, then put that on. Fans are great too! You can freeze some water in some milk cartons, and then place them in front of the fan – this helps cool the room down. If you have a sheltered yard or garden, it’s worth investing in a doggy pool. They can bob for toys in their pool or simply lay down and cool off. Remember to change the water regularly, algae (and more) poses numerous risks to our four-legged friends. Consider looking at cooling mats. Some dogs love them, some hate them. Some dogs would just rather lay on cool tiles. On that note, ensure he has access to lay in areas where he can cool his body down (tiles, hard flooring, concrete, shaded paving etc). 1. Play brain games. If you aren’t able to exercise as much as you normally would, figure out whether your dog is toy or food orientated and get creative with some brain games. Hide treats in a muffin tin under some tennis balls. Hide treats under pots and he has to figure out where they are. Give him a treasure hunt around the home (hide treats or toys behind cushions, curtains, behind doors etc). Invest in some puzzle feeders, just that extra time spent on his mealtime could break the boredom. You can also stuff food/treats into a Kong and freeze it. This is a perfect cooling treat for a warm day. 2. Practice learning some tricks or commands inside. 3. Take him swimming. If you have easy access to a doggy swimming pool or open water, consider whether he will be safe and enjoy swimming. It’s a great way to meet his exercise needs and he can keep much cooler. Stay safe, invest in a life jacket and only take him swimming if he is competent. Be mindful, if your dog is experiencing reduced activity, he may start to gain weight. If necessary, reduce his food intake. You can soon increase them again when he’s back to his normal adventures. It’s always better to err on the side of caution during those hotter months. There are plenty of ways to keep your dog occupied and stimulated without running around excessively in intense heat. It goes without saying, but if you are concerned about your dog’s health in the heat, seek vet attention immediately. Thanks for reading, MPN Team
Dogs can be vaccinated against many things, including Kennel Cough, as it’s not a core vaccination many owners often wonder whether their dog should be. Let’s take a look at kennel cough in a little more detail and some data around the vaccination. What is Kennel Cough? Kennel cough is a broad term covering any infectious or contagious condition of dogs where coughing is one of the main symptoms. Several viruses and bacteria can cause kennel cough, and often at the same time. They include (but are not limited to): Adenovirus type-2 (distinct from the adenovirus type 1 that causes infectious hepatitis), Parainfluenza virus Bordetella bronchiseptica. The coinfection of these pathogens, among others, manifests as CIRD and they act synergistically to cause respiratory illness. Kennel Cough: A Natural Guide What Does The Vaccine Do? The smallpox vaccine was introduced in 1796 after Edward Jenner observed that milkmaids who had previously caught cow pox didn’t catch smallpox. The idea was that exposure to killed or weakened virus/bacteria that cause disease can prime the immune response, but it doesn’t actually make the host sick. So, vaccinations allow the host to develop immunity without having to suffer the disease. This is the basic premise of the kennel cough vaccine – or any vaccine your dog may have for that matter. Sadly, it’s not quite as cut and dry as it sounds. There is increasing evidence that over-vaccination is associated with the development or aggravation of immune-mediated disorders and chronic diseases in individual pets that are genetically predisposed. This raises a particularly interesting element that has perhaps been missed when developing the blanket vaccination schedules for our pets. Twin studies in humans have demonstrated there is a clear genetic role in vaccine response. A growing list of genes have been associated with immune related functions critical to immunological response and much data is concluding it is the status of these genes that is key to immune response. Human data is highlighting that this is one of the reasons vaccines can either elicit partial, complete or failure to protect individuals treated under the same conditions. This would also suggest that the opposite is therefore true; gene status could elicit partial or complete adverse reaction, or hopefully failure to demonstrate adverse reaction. This is likely understood in the canine world to some extent because most vaccines are advised as safe for healthy dogs but not those with a compromised immune system, and this applies to the kennel cough vaccine for dogs. Is the Kennel Cough Vaccine Effective? One study of 972 dogs found that the kennel cough vaccine was around 20% effective in reducing coughing compared with a placebo vaccine. Findings Here In addition, another study demonstrated that between 40-60% of all dogs who suffered with kennel cough, had a history of vaccination. Findings Here However, other studies regularly report a 100% effectiveness rate. A literature review from 1977-2014 explored all relevant studies on the kennel cough vaccines and concluded that questions around the longevity of vaccine induced immunity and the prevalence of natural exposure on immunity remained largely unanswered. They also suggested that many studies into the vaccine are flawed. Whilst researchers seemingly disagree on the effectiveness of the vaccine, they continue to ask whether the live attenuated vaccine and its shedding contributes to exposure and therefore herd immunity? On the other side of this scale, could it be contributing to levels of the pathogens in the environment and fuelling further infections? It is well known that the kennel cough vaccine can shed for around 6 weeks after administration after all. Is the Kennel Cough Vaccine Safe? There are side effects reported after administration of the kennel cough vaccine including: Sneezing, Coughing, Nasal discharge, Lethargy, Fever, Discomfort at vaccination site. We must also consider the risk of vaccinosis. Check out our blog here for more information: Vaccinosis in Pets Whilst researchers are still disagreeing on the effectiveness of the vaccine, they all agree that prevention is better than cure. Largely because most healthy dogs recover uneventfully. There may be concerns if poorly or elderly dogs catch kennel cough, but even if we were to consider a vaccine here, like all data sheets suggest, a vaccine should only be administered to healthy dogs anyway. Can I titre test for Kennel Cough? A titre test is a simple blood test which establishes the levels of existing antibodies in the blood. Antibodies are produced when an antigen provokes a response from the immune system. This response can be from natural exposure or a previous vaccination. The issue is that kennel cough can be caused by a number of bacteria or viruses; often at the same time, so a titre test is little use in this case. So, Should I Vaccinate My Dog Against Kennel Cough? The choice is ultimately up to you, but we would ask the following questions to help you decide? Is the vaccine safe? Is the vaccine effective? Is your dog at risk of catching it? Is your dog healthy? You can also learn more about vaccinations in general in our blog here: Everything You Need to Know About Vaccinations Preventing Kennel Cough The best weapon in your arsenal is to support your dog’s immune function as much as possible. If they have a well-developed and mature immune system they are better able to fight threats. Your Pet’s Immune System Do We Need To Boost Our Pet’s Immune System? 10 Top Foods For Your Dog’s Immunity If you would like some support with your pet’s health, then check out our services to see how we can help. Thanks for reading, MPN Team
Kennel cough is relatively common in the canine world but its name is slightly misleading. For decades it was associated with kennels and many owners thought that if their dog never went to kennels, it wasn’t a risk for them. The reason it’s common in kennels is because dogs are in such close proximity to each other and so it spreads like wildfire! But any dog can suffer with Kennel Cough, or more technically canine infectious respiratory disease. For the most part, healthy dogs recover without issue – but it can be more of a worry for puppies or older dogs. Let’s take a look at it in a little more detail, and we’ll share some of our favourite remedies. What is Kennel Cough? Canine infectious respiratory disease (CIRD) is an acute, highly contagious disease complex caused by a variety of infectious agents. CIRD is characterised by an acute onset of mild to severe episodes of a dry cough and nasal discharge. Due to the highly contagious nature of the disease, dogs living in crowded conditions, such as shelters and day care centres, are especially susceptible to infection. Most dogs with CIRD recover spontaneously within days to weeks unless complicating factors occur, such as lower respiratory tract involvement or severe secondary infections. A variety of viral and bacterial agents have been detected in dogs with CIRD. The commonly reported pathogens include: Canine distemper virus (CDV) Canine adenovirus type 2 (CAV-2) Canine parainfluenza virus (CPIV) Canine herpesvirus-1 (CHV) Bordetella bronchiseptica Can I Vaccinate Against It? Yes you can, but one study demonstrated that 43.3% of all dogs with CIRD and 60.9% of CPIV positive dogs with CIRD had a history of parenteral vaccination against CPIV. Since the time between vaccination and the onset of clinical CIRD was not documented, it was not clear whether the dogs developed clinical CPIV due to an insufficient immune response following vaccination or if some dogs tested positive for a vaccination strain of CPIV. After-all, it has been suggested that dogs vaccinated with a modified live CPIV vaccine could shed the virus for some time after vaccination. Can I Prevent My Dog Catching It? CIRD is an attack on the immune system. The pathogens hijack many defences which results in the symptoms we recognise. So, a well-functioning immune system is the first part of your dog’s defence against kennel cough. Vitamin C contributes to immune defence by supporting various cellular functions of both the innate and adaptive immune system. Vitamin C helps encourage the production of white blood cells known as lymphocytes and phagocytes, which help protect the body against infection. Foods Containing Vitamin C: Blueberries Seaweed Peppers Sweet Potatoes Pumpkin Vitamin A helps maintain structural and functional integrity of mucosal cells in innate barriers (skin, respiratory tract etc). It is also important for the functioning of natural killer cells, macrophages, and neutrophils. In the adaptive immune response, vitamin A is necessary for the functioning of T and B cells and therefore for the generation of antibody responses to an antigen. Sources of Vitamin A Include: Liver Fish Oil Egg Yolks In the innate immune system, vitamin B6 helps regulate inflammation and has roles in cytokine production and natural killer cell activity. In the adaptive immunity system, vitamin B6 plays a role in the metabolism of amino acids, which are the building blocks of cytokines and antibodies. B6 is also involved in lymphocyte proliferation, differentiation and maturation and it maintains Th1 immune responses. Sources of Vitamin B6 include: Beef Chicken Turkey Sardines Salmon Organ Meats Stock or broth made by boiling chicken bones is a great option and contains gelatin, chondroitin and other nutrients that are helpful in gut healing in immune function. Zinc is a particular powerhouse when it comes to immune function. It has antioxidant effects protecting against reactive oxygen species, it helps modulate cytokine release and also helps maintain skin and mucosal membrane integrity (that first line of defence). In the adaptive immune response, zinc has a central role in cellular growth and differentiation of immune cells. It plays a role in T cell development and activation and supports the Th1 response. Sources of Zinc Include: Seafood Meat Fish We find vitamin D receptors throughout the immune system which demonstrates the role it plays in its function. Vitamin D stimulates immune cell proliferation and cytokine production, and it helps protect against infection caused by pathogens. It also demonstrates an inhibitory effect in adaptive immunity, suggesting that it is in fact an immune modulator. This is often why we notice increased cases of autoimmunity where there is low vitamin D. Sources of Vitamin D Include: Liver Fish Egg Yolks Mushrooms We can also feed a range of foods to support overall immune function. To learn more check out our blog here: 10 Top Foods For Your Dog’s Immunity What Happens if My Dog Gets Kennel Cough? If your dog is generally healthy, it is usually self-limiting, but if you are concerned it is best to seek vet advice. We do have some tried and tested remedies which can usually help too. Chamomile Chamomile is widely used to treat inflammations of the skin and mucous membranes, and for various bacterial infections of the skin, oral cavity and gums, and respiratory tract. Tincture or tea is generally better tolerated by dogs. Honey Manuka honey possesses soothing properties along with functioning as an: Antiviral Antibacterial There is increasing evidence that it inhibits a range of pathogens. Findings Here It also disperses and kills bacteria living in biofilms, those matrixes that adhere to wounds, teeth, and mucosal surfaces. Slippery Elm Gruel and Colloidal Silver Silver is recognized to have antimicrobial activity. There are three main ways in which it achieves this. Firstly, silver cations can form pores and puncture the bacterial cell wall by reacting with the peptidoglycan component. Secondly, silver ions can enter into the bacterial cell, both inhibiting cellular respiration and disrupting metabolic pathways resulting in generation of reactive oxygen species. Lastly, once in the
Your dog may have recently undergone surgery or sadly suffered an injury when out on a walk. We know the importance of rest for healing, but if there is trauma to the skin in the form of a wound, can we support that process? Let’s take a look. The Wound Healing Process Wound healing, as a normal biological process in the body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodelling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Hemostasis consists of vascular constriction, platelet aggregation, degranulation and fibrin clot formation. When tissue damage results in bleeding, fibrinogen is converted at the wound into fibrin by the action of thrombin, a clotting enzyme. Fibrin molecules then combine to form long fibrin threads that entangle platelets, building up a spongy mass that gradually hardens and contracts to form the blood clot. During inflammation there is neutrophil infiltration, monocyte infiltration and differentiation to macrophage and lymphocyte infiltration. Proliferation consists of re-epithelialization (formation of new epithelial and skin appendages), angiogenesis (formation of new blood vessels), collagen synthesis and ECM (extracellular matrix) formation. During remodelling, there is collagen remodelling and vascular maturation and regression. Wounds that exhibit impaired healing, including delayed acute wounds and chronic wounds have generally failed to progress through the normal stages of healing. These wounds frequently enter a state of pathologic inflammation due to a postponed, incomplete, or uncoordinated healing process. Factors That Can Affect Wound Healing Oxygenation Oxygen is important for cell metabolism, especially energy production by means of ATP, and is critical for nearly all wound-healing processes. It: prevents wounds from infection Induces angiogenesis Increases keratinocyte differentiation Increases migration Promotes re-epithelialization Enhances fibroblast proliferation Enhances collagen synthesis Promotes wound contraction In wounds where oxygenation is not restored, healing is impaired. Infection Infection, not surprisingly, also influences wound healing. Age Many clinical and animal studies at the cellular and molecular level have examined age-related changes and delays in wound healing. It is commonly recognized that, in healthy older bodies, the effect of ageing causes a temporal delay in wound healing, but not an actual impairment in terms of the quality of healing. Interestingly, exercise has been reported to improve cutaneous wound healing in older humans as well as aged mice, and the improvement is associated with decreased levels of pro-inflammatory cytokines in the wound tissue. Stress Studies in both humans and animals have demonstrated that psychological stress causes a substantial delay in wound healing. Caregivers of persons with Alzheimer’s and students undergoing academic stress during examinations demonstrated delayed wound healing. Medications Many medications, such as those which interfere with clot formation or platelet function, or inflammatory responses and cell proliferation have the capacity to affect wound healing. Systemic glucocorticoids (GC), which are frequently used as anti-inflammatory agents, are well-known to inhibit wound repair via global anti-inflammatory effects and suppression of cellular wound responses, including fibroblast proliferation and collagen synthesis. In animal models, systemic use of ibuprofen (NSAID) has demonstrated an anti-proliferative effect on wound healing, resulting in decreased numbers of fibroblasts, weakened breaking strength, reduced wound contraction and delayed epithelialization. Obesity An increased frequency of wound complications has been reported for obese human individuals undergoing surgery. Recent findings have documented that adipose tissue secretes a large variety of bioactive substances that are collectively named adipokines. Both adipocytes themselves as well as macrophages inside the adipose tissue are known to produce bioactive molecules including cytokines, chemokines, and hormone-like factors such as leptin, adiponectin, and resistin. Adipokines have a profound impact on the immune and inflammatory response. Not only this but in obese individuals, there is increased pressure on the wound, decreased vascularity in adipose tissue and additional skin folds which may harbour infectious pathogens. Obesity in Pets 1 Obesity in Pets 2 Nutrition Carbohydrates Glucose is the major source of fuel used to create the cellular ATP that provides energy for angiogenesis and deposition of the new tissues – to this end, there may be an argument for easily digested carbohydrates in the recovering dog. Protein Protein is one of the most important nutrient factors affecting wound healing. A deficiency of protein can impair capillary formation, fibroblast proliferation, proteoglycan synthesis, collagen synthesis, and wound remodelling. A lack of protein also influences immune system function, with resultant decreased leukocyte phagocytosis and increased susceptibility to infection. Not only this, but collagen is the major protein of connective tissue. Collagen synthesis requires hydroxylation of lysine and proline, and co-factors such as iron and vitamin C. Glutamine is a major source of metabolic energy for rapidly proliferating cells such as fibroblasts, lymphocytes, epithelial cells, and macrophages. To this end, it is important for wound healing. Fat Essential fatty acids are thought to affect pro-inflammatory cytokine production, cell metabolism, gene expression, and angiogenesis in wound sites, suggesting an important role in wound healing. Micronutrients Low levels of Vitamin C result in impaired healing, and have been linked to decreased collagen synthesis and fibroblast proliferation, decreased angiogenesis, and increased capillary fragility. Also, low vitamin C leads to an impaired immune response and increased susceptibility to wound infection. Whilst healthy dogs are generally able to synthesise their own Vitamin C, there may be a consideration for additional dietary sources during times of high need. Vitamin A behaves as an antioxidant, which protects membrane integrity, in addition it has been associated with increased fibroblast proliferation, modulation of cellular differentiation and proliferation, increased collagen and hyaluronate synthesis, and decreased MMP-mediated extracellular matrix degradation. MMPs play a role in protein breakdown (which is a necessary process – as long as there isn’t too much). Vitamin E has anti-inflammatory properties and is thought to have a role in decreasing excess scar formation in chronic wounds. Animal experiments have indicated that vitamin E supplementation is beneficial to wound healing. Magnesium functions as a cofactor for many enzymes involved in protein and collagen synthesis. Copper is a required cofactor for cytochrome oxidase, for cytosolic antioxidant superoxide dismutase,
Skin issues are one of the most common issues we are faced with here at My Pet Nutritionist. The reasons are multifactorial and complex which is why we undertake a full assessment of pet health to establish what may be contributing to the issues. That said, we notice patterns, and so we’ve decided to share some of the nutrients we consider when supporting challenging skin issues. Vitamin D Despite its name, Vitamin D is actually a hormone that promotes calcium absorption. In human health, you will have heard it referred to as the sunshine vitamin as it is produced in the skin in response to sunlight (UV) exposure. In studies of hip fractures in humans, there appears to be a seasonal variation; more occur during winter months and fracture patients often have low vitamin D status. When supplemented with Vitamin D and calcium, incidences of fractures often reduce. Findings here So, vitamin D is particularly important in bone health, but we also appreciate its role in skin health. Vitamin D is a modulator of the sensing dendritic (Langerhans) cells and reduces inflammatory mediators. What’s super interesting is that Vitamin D levels are inversely associated with atopic dermatitis severity. What We Know About Atopic Dermatitis In addition, maternal vitamin D status is often linked to development of allergy. Vitamin D in Cats and Dogs Dogs are entirely dependent on dietary sources of Vitamin D as they are unable to synthesise it sufficiently through the skin. Food Sources of Vitamin D: Flesh of fatty fish (salmon,tuna and mackerel) Fish Liver Oils Beef Liver Egg Yolks Vitamin E Vitamin E includes several compounds, of which the most biologically active and widely distributed is alpha tocopherol. Vitamin E functions as an important antioxidant within cells, protecting lipids, particularly the polyunsaturated fatty acids in cell membranes against oxidative damage caused by free radicals and active forms of oxygen that may be generated during metabolic processes. The dietary requirement for vitamin E is influenced by the intake of selenium because of its role in glutathione peroxidase, with one nutrient partially able to spare a deficiency of the other. It is also influenced by the PUFA content of the diet and increasing this leads to an increase in vitamin E requirement. It has been recommended that the dietary ratio of alpha tocopherol:PUFA (mg/g) of 0.6:1 is maintained as a minimum to protect against PUFA peroxidation. Vitamin E therefore supports the health of skin tissues and protects it from damage. It accumulates in the mitochondria within skin cells and promotes collagen and fibroblast synthesis and decreases MMPs (compounds which can break down proteins like collagen). It also protects essential fatty acids from oxidation. Vitamin E is absorbed from the small intestine by non-saturable, passive diffusion into the intestinal lacteals and is transported via the lymphatics to general circulation. Sources of Vitamin E: Plant based oils Nuts Seeds Dark green veggies Pumpkin Red bell pepper Mango Rancid fats are particularly destructive of vitamin E, so these should be avoided in diet. Zinc The skin has the third highest abundance of zinc in the body. Its concentration is higher in the epidermis than the dermis. Zinc stabilises membrane structure which is key to skin health and is regularly used in a range of skin conditions including infections, inflammatory dermatoses, pigmentary disorders and neoplasias. What is particularly interesting is its role in allergic and inflammatory responses. Mast cells play an important part in adaptive immunity, they are found in the skin and many other places including the mucosal linings of the gut and lungs. Mast cells contain many granules which are rich in histamine, heparin and, you guessed it, zinc! Zinc is crucial to correct mast cell function and deficiencies are linked with the development of allergic disease. Findings here Zinc is crucial to effective wound-healing too – which is particularly important if through scratching your dog suffers trauma to their skin. MMPs are zinc dependent, and whilst their role does involve breaking down proteins, this is a necessary process to ensure skin health – like goldilocks, we want just enough turnover of cells in the skin for optimal health. Why Zinc is Important For Your Dog Essential Fatty Acids (EFAs) We’re likely preaching to the converted, but in ensuring skin health it’s essential to provide essential fatty acids for skin lubrication, sebum production and immune function. In atopic eczema there is evidence of a lack of conversion of LA to GLA, suggesting an abnormality in EFA metabolism. This may explain why some respond to GLA supplementation instead (GLA is found in hemp seeds/oil). Essential Fats for My Dog’s Diet As we mentioned earlier, skin issues in dogs can be complex and multifactorial. If you would like some support in tackling this challenge, then check out our services to see how we can help. Thanks for reading, MPN Team
The sun is shining, the air is warm, you’re out for a walk and the water is the perfect spot for your pup to have a quick swim to cool down. But like everything for a dog owner, a million things run through your mind trying to figure out if it’s safe to do so. We’ve put together our top five hazards around water for dogs to help you stay safe on your adventures. 1) Blue/Green Algae – when in doubt, just stay out! You’ve likely spotted a story on social media highlighting the risk of blue/green algae. Before long, you start wondering if it’s easy to notice and could you inadvertently let your dog swim in it. But, blue/green algae is exactly that. When it is present in water, there is an unmistakable hue. It thrives in warm, nutrient-rich water and will form “blooms.” These blooms produce cyanotoxins which are harmful to both humans and animals. When ingested, it can cause vomiting, diarrhoea, respiratory distress, weakness, lethargy and seizures. It can also be fatal. If you are concerned there is blue/green algae present, just keep out of the water. There are a number of safe algae found in water sources, but these are green/yellow in colour and will be found with good water clarity. Blue/green algae is often found in water where there is a film or scum like appearance. Country parks and alike sometimes have warnings up, or their websites will identify any recent blooms so it can always be worth checking sources before heading out for the day. 2) Water Intoxication Aside from the assumed risk of drowning in water, for dogs who play and retrieve a lot in water there is also the risk of water intoxication. This is when your dog has ingested far too much water for their body to handle. Initial symptoms include vomiting, lethargy and abdominal distention. Further symptoms include weakness, coma, seizures and ataxia. Prevention is key, so be mindful if your dog swallows water when they are retrieving and keep their time in the water to a moderate level. 3) Too much salt? If you are at the beach, you may instinctively think that your dog can just drink the sea water if they get thirsty. Unfortunately, drinking large amounts of saltwater can actually be fatal to a dog. In small amounts, you may just see some irregular bowel movements. When a dog drinks salt water, in order to counteract the salt content, water is drawn to the intestines which results in diarrhoea and vomiting. In high quantities however, the cells in the body release their water content to help counteract, which can cause brain injuries, kidney issues and severe dehydration. Again, prevention is key so, if you are heading to the beach, take some freshwater for your dog to drink and watch for them having a sneaky drink in the sea! 4) Rip tides – in a very general sense! Whilst you may not be at the beach, we’re talking about all bodies of water that may have fast and strong currents. It could be a rip at the beach or simply a fast-flowing section of river. Before you let your dog venture into any water, watch it for a few minutes. Watch the flow, watch for any white water as this will help you figure out any underlying currents. You need to be sure the water is safe for your dog and that they are capable of swimming in it. Smaller dogs or less able dogs may struggle with even the slightest of currents, so again, when in doubt, just stay out! 5) Waterborne illness! If our dog finds his way into a stagnant pool of water, most of us will be watching for vomiting or diarrhoea for the next few days. Be mindful if their symptoms are severe and always seek veterinary attention if you are concerned. But there is a risk of illness from any pool of water, so, practice healthy swimming. – Opt for fresh and flowing water where possible. – Don’t allow your dog to drink from the water source, provide fresh filtered water from home. – Rinse them off when you get home to remove any harmful pathogens from their coat. – Watch for any changes in health or behaviour over the next couple of days. Here at My Pet Nutritionist we want to support your journey of raising a happy and healthy pet. Please check out our services to learn more. Thanks for reading, MPN Team
Hands up if you have been told to feed your poorly dog chicken and rice? Hands up if you did? We think it’s safe to say 99% of dog owners have been in this situation. But should you really feed your dog, chicken and rice? We’re going to share our thoughts. Should I Feed Chicken and Rice? Probably not. That’s the short answer, but there are many nuances to this question so let’s take a look at chicken, and rice and why they aren’t the best choice for your poorly pooch. What’s Wrong With Chicken? Many dogs sadly struggle with this protein. It tops the list as one of the most common sensitivities. We have to wonder if this is due to how chickens are raised. Hen Husbandry As the saying goes, you are what you eat, well your dog is what he eats and chickens are often raised in huge farms, lacking sunlight, hygienic conditions and are largely fed a processed diet of corn. Chickens raised on pasture however, will feed on grasses, insects, and anything else they can get their beaks on! To this end, pasture-raised chicken meat tends to be higher in iron, higher in Omega 3, have a lower Omega 6:3 ratio, and be higher in antioxidants (Vitamin E, for example). Pasture-raised eggs therefore have higher Omega 3s, a lower Omega 6:3 ratio, increased vitamin D, and more antioxidants. Farmed chickens, fed diets high in corn tend to be higher in omega 6 which influences inflammatory processes. Findings Here There are additional concerns around antibiotic use in broiler chickens. Antibiotic Usage Antibiotics in poultry are generally administered to the entire flock and are used for the treatment of disease (therapy), disease prevention (methaphylaxis), and growth promotion. Antibiotic growth promoters were banned in the EU in 2006, in the US in 2017 but are currently allowed in Brazil and China. A recent study concluded that the high levels of antibiotic use in poultry has contributed to antibiotic resistance in many countries. Findings Here Other studies further elucidated the quantitative and qualitative relationships between the practice of in-feed antimicrobials for animals and the mounting problem of hard-to-treat, drug-resistant bacterial infections in humans. If bacterial communities are key to the development of immune function in both humans and animals, but dysbiosis is present through the administration of antibiotics, could this influence an individual’s tolerance and therefore pave the way for sensitivities? Do We Need To Boost Our Pet’s Immune System? When we are working with a dog suffering from digestive issues, we often run an elimination diet. The first things we eliminate are those common proteins like chicken and beef and we opt for novel proteins. So, chicken and rice is certainly off the list of meals! Elimination Diets For Dogs What’s Wrong With Rice? Rice is touted for its blandness when supporting a poorly dog, but when we look a little closer, you’d be amazed at what’s found in these little grains! We’re not debating that dogs can eat rice – physiologically they are capable of digesting it, the question is more, should they eat it? And our answer is, probably not. Rice and Metabolic Health When grains are refined and processed, like white rice, they become a calorie-rich but nutrient poor food. Refined grains are milled, a process that strips out both the bran and germ to give them a finer texture and longer shelf life. The refining process also removes many nutrients, including fibre. Whole grains on the other hand haven’t had their bran and germ removed by milling; therefore, all of the nutrients remain intact. Whole grains are sources of fibre and other important nutrients, such as selenium, potassium, and magnesium. Whole grains include millet, bulgur, buckwheat, barley, and oats (we’re not completely against some of these grains, check back soon for our take on them). Grains are naturally a source of carbohydrates and as we know, when carbohydrates are ingested, without naturally occurring fibre, they are digested very quickly, and pass into the bloodstream. This results in a spike in blood sugar, calling for insulin to come and manage the situation. This is why refined grains are regularly linked to metabolic disease in humans. Findings Here And metabolic disease has significant inflammatory underpinnings – which we think you’ll agree isn’t something we want to promote! Rice and Arsenic Arsenic, which is classified as a Group 1 carcinogen by the International Agency for Research on Cancer, is water-soluble – so it accumulates in rice, which is grown in flooded fields more than other cereals. Arsenic exposure affects almost every organ in the body. Rice is known to accumulate around ten times as much arsenic as other cereals. In rice grains arsenic is concentrated in the outer bran layer surrounding the endosperm. This means that brown rice, (unmilled or unpolished rice that retains its bran) contains more arsenic than white rice. Half of the rice consumed in the UK exceeds European Commission regulations for levels of arsenic in rice meant for the consumption for infants or young children. Studies have attempted to find a way to reduce the arsenic content of rice and to date, the most effective method involves parboiling the rice in pre-boiled water for five minutes before draining and refreshing the water, then cooking it on a lower heat to absorb all the water. But then, we do also find arsenic in tap water too. The Importance of Water Arsenic exposure is associated with alterations in gastrointestinal, cardiovascular, haematological, pulmonary, neurological, immunological, and reproductive/developmental function. Findings Here Rice and Mycotoxins Mycotoxin contamination in rice is usually lower than wheat or corn, but there are still reports that rice has been contaminated with mycotoxins such as aflatoxins. Aflatoxins are found in cereals, grains, and nuts and we can head back to 1952 to understand the true risk of them. In 1952, an outbreak of fatal liver disease in dogs occurred in the southeastern United States. The disease, termed hepatitis X, was characterised by icterus,
If you have followed us here at My Pet Nutritionist for any length of time, you’ll know that we’re great advocates for the inclusion of veggies for their prebiotic and fibrous benefits. But there are also times where we would avoid certain veggies. Keen to learn more? Read on. Nightshade Vegetables and Arthritis Some believe that the solanine contained in nightshade vegetables like bell peppers, tomatoes and potatoes may increase levels of inflammation in the body. Whilst there is disagreement over the mechanism, humans suffering with arthritis often report a worsening of symptoms after eating nightshade vegetables. There is one school of thought that it could be more to do with a sensitivity to the food, which results in an inflammatory response, contributing body wide circulating cytokines. Whilst nightshade veggies are a great source of certain nutrients, there are other foods which can provide these and so if you notice a worsening of arthritic symptoms, it’s an easy change to make. Natural Arthritis Guide Lectins and Should My Dog Eat Them? Goitrogenic/Cruciferous Veggies in Thyroid Issues The thyroid gland produces three important metabolic hormones, thyroxine, triiodothyronine, and calcitonin. Thyroid stimulating hormone (TSH) produced by the anterior pituitary gland controls the production of these hormones. Iodine, derived mainly from sea-foods or consumed in the form of iodised salt, is utilised for producing T3 and T4 hormones. T3 and T4 hormones affect every cell and organ in the body. They regulate the rate at which the body uses energy, which subsequently affects weight loss or gain. They raise or lower body temperature. These hormones influence the speed at which food moves through the digestive system. They affect brain development and also control the way muscles contract. Common thyroid disorders in our pets include hypothyroidism and hyperthyroidism, meaning the thyroid is either under-active or overactive. Ultimate Guide: Hyperthyroidism Ultimate Guide: Hypothyroidism Goitrogens are plant chemicals that can decrease the production or activation of thyroid hormone, meaning they slow thyroid function. These foods are commonly known as goitrogenic, which means they contain substances which slow the thyroid’s ability to uptake iodine. If eaten in excess, these foods interfere with the efficient function of the thyroid gland. The strongest goitrogens are soy products, but moderate inhibitors include: Broccoli Cabbage Kale Cauliflower Brussels sprouts All/Starchy Veggies in Yeast Issues Around 150 strains of yeast are thought to utilise starch as a sole carbon source for aerobic growth. In short what this means is starch is food for yeast! Starch, or amylum, is a complex carbohydrate that exists in many foods, including grains, vegetables, and fruits. Sources of starch are primarily: Maize Tapioca Wheat Potatoes The extraction of pure starch from food produces a white, tasteless, and odourless powder that doesn’t dissolve in cold water or alcohol. Starch is a natural polymer, or polysaccharide, meaning that it is a long chain comprising one type of molecule. Starch consists of glucose molecules. It can occur in two forms: amylose and amylopectin. You may be familiar with this wording as amylase is a digestive enzyme which helps break down starch. Yeast or candida is an opportunistic fungal pathogen but a normal part of the gastrointestinal flora and genital tracts. The issue is when there’s an overgrowth. If we are tackling an overgrowth, the last thing we want to do it continue feeding it and as you’ve now realised, starch is a great food source for yeast! Is Your Dog A Yeasty Beasty? All Veggies in the Case of An Elimination Diet When we are supporting a dog with digestive issues, we need to know exactly what is contributing to their symptoms. For this reason, we would avoid feeding all vegetables when running an elimination diet. Just like a dog can have a sensitivity to a certain meat type like chicken or beef, they can also have a sensitivity to fruits and vegetables. It’s important to remember that an elimination diet is a diagnostic tool – not a long-term lifestyle and in some cases, a means to give the immune system a welcomed break. In running an elimination diet, we follow the 4 R’s. – Remove – remove offending foods, one at a time and note changes in symptoms. Quite often, even offending foods can be reintroduced at a later stage. – Repair – support immunity and gut healing with ingredients like slippery elm, de-glycerised liquorice, glutamine, and N-acetyl-glucosamine. It is also important to consider how existing medications are affecting gut healing for example, steroid use impairs intestinal absorption which is linked to several gastrointestinal dysfunctions. – Restore – as the microbiome is key in the development of the immune system, supporting this is essential, however, the introduction of specific pre and probiotic foods is often best left whilst we get to the root cause. – Replenish – indigestibility of food proteins can also contribute to their antigenic nature, so consider any long-term medication use including proton pump inhibitors which affect gastric acid secretion. Ensuring HCL, pepsin and digestive enzymes are in good supply will help get the digestive system back to doing what it does best! Elimination Diets For Dogs We can’t deny the fibrous benefits of many vegetables along with their nutrient content, but when we are tackling a specific health issue in a pet, we must prioritise. We can often get those benefits in other ways if we think outside of the box. If you would like any support with your pet’s health and some outside of the box thinking, then please check our services to see how we can help. Thanks for reading, MPN Team
In most cases, a liver shunt is caused by a birth defect. This is known as a congenital portosystemic shunt. But acquired shunts can also occur – this is usually linked to primary liver disease, or a disease involving the normal blood vessels into the liver. We describe the liver as the powerhouse of the body, quite simply because it carries out so many functions, so, is there anything we can do to support it when it’s function isn’t quite up to par? Let’s take a look at whether we can support a dog with a liver shunt. What Does The Liver Do? The liver processes blood and the substances found within it. In a healthy animal, blood draining from the intestines passes immediately through the liver for nutrients to be processed and for toxic compounds to be removed. The blood then re-enters main circulation. What is a Liver Shunt? In an animal with a portosystemic shunt (liver shunt), a significant volume of blood bypasses the liver, enters main circulation and heads to the heart where it can be pumped around the body. As the blood being pumped around the body is technically unfiltered, toxic compounds can build up. In addition, the liver is unable to break down nutrients or regulate the body’s energy balance. Signs and Symptoms of a Liver Shunt: Stunted growth Poor muscle development Abnormal neurological behaviour – disorientation, staring into space, circling or head pressing, seizures Drinking/urinating too much Vomiting Diarrhoea Lethargy In both cases of congenital and acquired, reduced blood flow to the liver also results in atrophy which subsequently affects function. But the liver is a rather unique organ, it is the only one that can regenerate, therefore appropriate intervention and management is essential. Liver Guard Considerations to make for the dog with a liver shunt: Diet The conventional concern with many liver issues is protein intake. When protein is broken down in the body, left behind is ammonia. The liver plays a key role in metabolising ammonia ready for it to be excreted by the kidneys into urine, but when blood flow bypasses the liver, ammonia builds up in the blood and enters systemic circulation – this is what leads to many neurological issues alongside poor liver function. Traditionally, dietary management has included protein restriction to reduce ammonia absorption from the colon, but more recently it is considered that colonic absorption is only significant in those fed poor-quality diets that contain poorly digestible protein. In addition, it has been established that those with chronic liver disease may develop muscle wasting from being in a long-term catabolic state – with low protein diets leading to increased muscle protein catabolism. Findings Here We would advocate a fresh-food diet, with highly digestible protein sources. The general school of thought is 2g of protein per kg of body weight. Beneficial proteins to feed in liver disease include eggs for the most bioavailable protein and choline content, poultry and a little fish such as sardines, salmon and cod. Fats such as omega-6 and omega-3 in 4:1 ratio are important in liver conditions. Moderate amounts of hemp oil, phytoplankton (offering DHA and EPA) and fish, both whole and in pure oil source may help to protect the liver and reduce systemic inflammation and inflammation in the liver. Detoxification The liver neutralises a range of toxic chemicals, both those produced internally (waste from used hormones or neurotransmitters for example) and those from the environment, like air pollution, pesticides and food additives. It does this by filtering the blood to remove large toxins, synthesising, and secreting bile and lastly enzymatically disassembling unwanted chemicals found in the body. If its function isn’t up to par, toxins can start to build up. Enzymatic Detoxification This enzymatical detoxification occurs in three phases. Phase I directly neutralises chemicals and changes them into new metabolites. These are then processed by phase II enzymes. This is known as the conjugation phase, which in short, liver enzymes attach small chemicals to the toxin. There are many ways in which this is done, it all depends on the type of chemical the liver is trying to manage. Phase I results in high levels of reactive oxygen species so antioxidant levels are key in modulating potential damage. Does My Dog Need Antioxidants? Liver Guard Beneficial Additions: Broccoli contains glucobrassicin, the glucosinolate precursor of indole-3-carbinol (I3C) and subsequently Diindolylmethane (DIM) which is attributed to supporting phase one of the liver detoxification. Berries and cranberries whole and in extract contain anthocyanins that demonstrate hepato-protective abilities. An experiment found that antioxidants commonly found in berries slowed the development of lesions and fibrosis, the development of scar tissue, in the livers of rats. Phase II is nutrient demanding and sufficient levels of key vitamins and minerals like vitamin A, C, E, B1, B2, B3 and iron are essential. There has also been data to suggest dandelion amongst others can support the enzymatic detoxification pathway too. Phase III is the elimination phase. For optimal excretion of toxins through the digestive system, gut health is vitally important. Maintaining the mucosal barrier is key for gut health along with supporting motility. It’s important to include a range of functional ingredients in your dog’s diet that can lubricate the digestive tract, promote regular motility, aid elimination and support the microbiome. Prevention of absorption through trapping of potential toxins is also an effective way of mitigating toxin exposure and this is a key feature of many clay products. 7 Reasons to Use Clay In addition, some fibre helps to speed up colonic transit and prevent constipation. This reduces the amount of toxins absorbed from the colon and circulated into the system for the liver to deal with. 7 Foods To Add Fibre To Your Dog’s Diet The most important thing to do to support detoxification is to avoid exposure in the first place, so consider how much you and your dog are exposed to: Pesticides Heavy smoke Phthalates Mould Medications like steroids, antibiotics, and painkillers Heavy metals Cleaning
Whilst we get skin issues across the board in dogs; we can’t deny that certain breeds are more predisposed than others. But if we have a list in our mind of those dogs who we think are more likely to suffer, have we even considered that their coat type may play a role? We’re going to take a look at those double coated breeds specifically, and why they may suffer with skin challenges. The Canine Coat When we are discussing the canine coat, we include both the skin and hair/fur. Both have their own individual functions, and both are crucial to your dog’s ability to thrive. The skin is the largest organ of your dog’s body. It consists of three major layers: The Epidermis – (Epi – upon or above) this is the outer layer of skin, the protective layer. The Dermis – the dermis supports and nourishes the outer layer. It provides strength and elasticity. Here you will find collagen fibres, sweat glands, sebaceous glands, and hair follicles. You will also find cells that release histamine and other inflammatory mediators when faced with an allergy or injury. The Subcutis – (sub meaning under or below) this is the innermost layer of the skin, where you will find fat and muscles. Subcutaneous fat provides insulation, padding and storage for reserve energy. Not only does the structure of the skin prevent water and electrolyte loss to help maintain body homeostasis, but it forms a protective barrier which helps protect against infections, parasites, and the elements. The hair sprouting from the follicles in the skin, known as hair or fur, also protects against harsh weathers, temperatures, and ultraviolet light damage. Double coats are generally termed fur and single coats are generally termed hair. Although, most owners, and groomers for that matter, use the phrases interchangeably. Double Coats vs. Single Coats Dogs can have primary and secondary hairs. Primary hairs are single hairs that grow from a follicle. If present, secondary hairs exit from the same follicle and you can have anywhere from 3-15 of them exiting alongside a primary hair from the same follicle. Primary hairs are often referred to as guard hairs or the outer coat and secondary hairs are referred to as the undercoat. Double coated breeds have both primary and secondary hairs, like the German Shepherd, Alaskan Malamute, Husky and Akita whereas single coated breeds simply have primary hairs, which include breeds like the Poodle or Bichon Frise. In double coated breeds, hair growth and the thickness of the undercoat is largely responsive to the environment. Cold months call for a thick undercoat where air can be trapped right next to the outer layer of the skin. Think of it like a wetsuit. A wetsuit works by trapping a thin layer of water between your body and the suit. This layer of water is then warmed by your body and water is a great conductor of heat! On the other side of this scale, warm months call for a thinner undercoat that is well-brushed and not impacted. This allows air to circulate, drawing cool air over the skin. A regular issue in double-coated breeds is an impacted undercoat. This is where the secondary hairs become matted. Air is unable to circulate, meaning it gets trapped and warmed up from the heat of the body. The issue is further compounded if you have a damp coat from rainy walks, dips in the pond or after the regular hydrotherapy session and in this scenario, skin health can be compromised. The Canine Skin Not only does the skin provide a barrier to the elements, but its very composition also provides an immunological and microbial barrier because of its bacterial community. This is known as its microbiome. The skin microbiome is made up of a range of bacteria, fungi, and viruses. They usually function symbiotically; helpful microorganisms keep potentially harmful microorganisms in check. The issue is when there is an imbalance; we know this as dysbiosis. It has been established time and time again, when dogs and humans are suffering with red and itchy skin, there have been alterations in the skin microbiome. Generally, some bacteria have grown in numbers and others have reduced. A healthy skin microbiome is necessary for the correct function of mast cells founds in the dermis and mast cells mediate inflammatory responses like hypersensitivity and allergic reactions. Subsequently, those dogs suffering with atopic dermatitis are then more sensitive to environmental allergens. It is rather easy to see how skin issues can become so complex. Unfortunately, there are a range of things that can affect the composition of the skin microbiome: – Genes – Lifestyle, including nutrition – Environment – Family make up (other pets) – Personal and home hygiene In healthy dogs the most common bacteria are proteobacteria, closely followed by firmicutes, actinobacteria, Bacteroidetes and cyanobacteria. Interestingly, healthy dogs have a higher community of beta proteobacteria ralstonia spp. than those dogs suffering with allergies. The type of bacteria also varies depending on the site of the body, for example, there will be different bacteria found between toe digits to that found in the groin area. Findings Here This is because all bacteria have their own needs to survive. They need food, water and the correct environment which includes a specific temperature, to them. Some bacteria will thrive in cooler temperatures, some prefer warmer climates. This is why we need to pay attention to the coat condition of your double coated breed. Your dog will have their own community of bacteria on their skin. Some bacteria will outnumber others. Which bacteria thrive will largely depend on your dog’s lifestyle, including nutrition. If your double coated breed has gotten wet on a rainy walk or loves swimming, they will get a damp coat. You may towel them off and allow them to dry off in front of the fire or radiator. Star fishing in a centrally heated home is quite far removed from the
There can be a number of reasons why your dog may be suffering with their ears. We’ve compiled some of the more common ones. The Link Between Sensitivities and Itchy Ears Itchy ears often go hand in hand with sensitivities – so you may notice digestive issues alongside itchy ears, paws and more. In order to optimise gut health, check out our blog here: 7 Steps to Optimal Gut Health For Pets We can often look to bacterial overgrowth in fuelling those itchy ears, and yeast is often the culprit. Gut Guardian What is Yeast? Candida is an opportunistic fungal pathogen. It is a normal part of the gastrointestinal flora and genital tracts. Healthy systems are more than capable of keeping it in check with their beneficial bacteria, but issues arise when there aren’t enough good guys to keep the bad guys in check, this is what we know as dysbiosis and it can occur in the microbiome of the gut, but also the skin and more! Is Your Dog A Yeasty Beast? Factors that can contribute to dysbiosis: Chronic or excessive antibiotic use Stress Environmental toxins; bisphenol, phthalates, heavy metals, pesticides Poor gut integrity Nutrition Weakened immune function But there are a few other factors to consider when we are addressing our dog’s itchy ears… Why Is My Dog’s Ear Itchy? Anatomy or Breed Certain breeds with those long ears; the ones who end up dragging them in their food or water bowl can be more likely to suffer with bacterial overgrowth. We’re thinking spaniel or setters here. Those long ears provide a warm and moist environment for certain bacteria to thrive. It’s also a consideration for those breeds with greater amounts of hair inside their ear, those who your groomer recommends plucking out! We’re thinking poodles and alike. Whilst it may be a haven for certain bacteria having the hair there, if there is trauma through the act of plucking, we could inadvertently be opening the skin up to infection. In this scenario, it can often feel like you’re stuck between a rock and a hard place. Type of Food Fed Yeasts seem to like sugar as fuel, so diets high in grains, starches and other carbohydrates seem to contribute to an overgrowth. Generally, certain beneficial bacteria will metabolise these sugars, keeping candida in check by disrupting its food supply, but in the absence of good bacteria, candida is partying it down at the all-you-can-eat buffet! Whilst we advocate a fresh food diet, in cases of bacterial overgrowth it can be sensible to avoid certain fruits whilst getting a handle on the situation – fruit contains sugar too! Water Babies! Those dogs who love to swim or spend time at hydro can be more prone to ear issues. Again, it creates a perfect environment for certain bacteria to thrive when they are warm and damp. It’s always best to dry your dog’s ears after spending time in water. Especially with those warmer temperatures in hydro pools. Location of walks Where your dog walks or runs can mean exposure to certain grass seeds which can find their way into our dog’s ears. Not only are they initially painful and irritating, if not removed they can cause a whole host of further issues. Parasites Our dogs can be exposed to fleas, ticks or mites which can cause itching. If you would like to learn more about parasites and natural approaches to managing them, check out our blogs below: Parasites and What You Really Need To Know Natural Flea and Worming Treatments Ear Issues as a Report Card Ear issues, or rather itchy ears, can often seem like a never-ending battle, and this is largely because they’re seen as a symptomology to treat. Perhaps we need to see them as a report card. Of course, they could be telling us that our dog has been swimming and we forgot to dry their ears, or they could be telling us there’s a lodged grass seed which needs attention. There could also be a parasite burden. But they could also tell us that our dog’s immune system is a little out of whack; perhaps our dog never managed to rebalance that Th response. They could be telling us our companion’s microbial community isn’t harmonious. Our dog’s ears could be the sign our dog’s food isn’t suiting them and we need to find alternatives. Those ears could also be showing us that there is an excessive burden on detoxification pathways in the body. The reason ear issues often become chronic is because the root cause is rarely explored. We’d be looking to address immune balance and function: Do We Need To Boost Our Pet’s Immune System? We’d be supporting digestive health: Optimal Gut Health For Pets We’d be considering toxin burden: Does my Pet Need To Detox? Liver Guard And we may be considering an elimination diet: Elimination Diets For Dogs But these are only some pieces of the puzzle, we have decades of experience exploring the root cause of symptoms, so head on over to our services page to see how we can help your dog. Thanks for reading, MPN Team
If you are a current pet owner or have been in the past, there is a 99% chance your pet has had pain medication at some point in their life. Or they have at least had it prescribed or suggested for them. For us to fully weigh up what we are administering to our pets, it makes sense to start with the basics. So, how do pain medications work in pets? Pain medications come in different forms, but there are a few common ones: NSAIDs Opioids Paracetamol NSAIDs Non-steroidal anti-inflammatory drugs are exactly what they say on the tin – they are used to reduce inflammation. Inflammation is an immune response. When something becomes damaged or threatened in the body, compounds are released which kick start an immune response to help fight the threat or heal the trauma. A Guide to Inflammation in Pets NSAIDs are typically divided into groups based on their chemical structure and selectivity. They include: acetylated salicylates (aspirin) non-acetylated salicylates propionic acids (ibuprofen) acetic acids (diclofenac) enolic acids (meloxicam) anthranilic acids (meclofenamate) naphthylalanine (nabumetone) selective COX-2 inhibitors (celecoxib) The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX). Cyclooxygenase is required to convert arachidonic acid (a polyunsaturated omega-6 fatty acid) into thromboxanes, prostaglandins, and prostacyclins (which are all inflammatory mediators). The therapeutic effects of NSAIDs are therefore attributed to the reduction of them. Many NSAIDs are not selective, meaning they take out all COX enzymes; this is beneficial if we are targeting inflammatory mediators, but COX enzymes also carry out other roles in the body. COX1 enzymes play a role in: protecting the gastrointestinal tract renal blood flow platelet aggregation This is why proton pump inhibitors are often administered alongside NSAIDs, the reduction in stomach acid secretion is thought to reduce the risk of gastrointestinal side effects. In addition, there is also evidence of long term NSAID use and chronic kidney disease. The administration of certain NSAIDs can also trigger hypersensitivity reactions. Non-selective NSAIDs exert effects by inhibiting COX-1 and subsequently shift arachidonic acid metabolism from prostaglandin (especially PGE2) synthesis toward pro-inflammatory cysteinyl leukotrienes (LTs) such as LTC4, LTD4, and LTE4. Overproduction of LTs leads to activation of mast cells and eosinophils, which can result in typical allergic symptoms like itching and hives, along with bronchoconstriction. This is worth noting if you have a particularly sensitive dog. Opioids Opioids function primarily in the nervous system; they inhibit neurotransmitter release. The Neuroscience of Pain Morphine is commonly considered to be the archetypal opioid analgesic and the agent to which all other painkillers are compared. There is evidence to suggest that as long ago as 3000 bc the opium poppy, Papaver somniferum, was cultivated for its active ingredients. But, it wasn’t until morphine was isolated from opium in 1806 by Sertürner that modern opioid pharmacology was truly born. In 1847 the chemical formula for morphine was established and this, coupled with the invention of the hypodermic needle in 1853, led to the widespread clinical use of morphine. How Does It Work? Opioid receptors are distributed throughout the central nervous system and within peripheral tissue of neural and non-neural origin. Opioids reduce excitability of neurons, and decrease the release of nociceptive neurotransmitters like substance P. See our blog on The Neuroscience of Pain above to learn more about this. Because opioids work in the nervous system, in essence slowing everything down, the concern is that they may do it a little too well and knock everything a little out of whack. As we know the body likes balance, and it does everything in its power to keep it that way. To this end, behavioural side effects of opioids include panting, vocalisation, salivation, nausea, vomiting, defecation, and sedation or hyperactivity. Physiological side effects of opioids in dogs may include central nervous system depression, respiratory depression, bradycardia, usually accompanied with little to no change in cardiac output, ileus, and urinary retention. Findings Here Paracetamol It has been assumed that paracetamol probably acts through the cyclooxygenase (COX) pathway. This is the pathway through which the nonsteroidal anti-inflammatory drugs (NSAIDs) act. Much investigation has focussed on paracetamol’s inhibition of the COX enzyme because its analgesic and antipyretic effects are similar to those of aspirin, the archetype NSAID. However, paracetamol does not have significant anti-inflammatory activity, or does it inhibit production of the pro-clotting TXAs. In addition, paracetamol does not appear to have a major effect peripherally; its action appears to be mostly central. It seems reasonable to assume that although there may be some effect on COX enzymes, this effect is different from that seen with typical NSAIDs. Because of this, other mechanisms of action have been considered. It is thought that serotonin has a major role in modulating pain perception. Serotonergic drugs are used in the treatment of migraine headaches in humans and combined serotonin-norepinephrine reuptake inhibitors have been used in chronic pain management. It has been considered that paracetamol, in effect, activates serotonin pathways to influence pain perception. Other data has indicated that when cannabinoid receptors are blocked, paracetamol loses its action, suggesting the endocannabinoid system may play a role in paracetamol’s actions too. Findings Here Whilst we may not know the full mechanism of action of paracetamol, it is possibly the widest used pain medication The side effects usually associated with paracetamol include: yellowing of white of eyes or gums (jaundice) reduction in appetite vomiting or diarrhoea blood in faeces Are There Any Other Pain Medications Worth Mentioning? There are a number of products on the market which target pain, but they could fill a book, so we’ll just take a look at two more. Librela Librela is an injectable which targets pain in cases of osteoarthritis. The active ingredient in librela is bedinvetmab which is a monoclonal antibody. This antibody (or protein) is trained to recognise and attach to a protein known as Nerve Growth Factor (NGF). Once attached it prevents NGF from attaching to its own receptors on nerve cells and therefore
